This is a Validated Antibody Database (VAD) review about mouse Apoe, based on 31 published articles (read how Labome selects the articles), using Apoe antibody in all methods. It is aimed to help Labome visitors find the most suited Apoe antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Apoe synonym: AI255918; Apo-E

Knockout validation
Abcam
mouse monoclonal (E6D7)
  • immunohistochemistry knockout validation; mouse; 1:250; loading ...; fig 1c
  • western blot knockout validation; mouse; loading ...; fig 3d
Abcam Apoe antibody (Abcam, ab1907) was used in immunohistochemistry knockout validation on mouse samples at 1:250 (fig 1c) and in western blot knockout validation on mouse samples (fig 3d). Front Immunol (2019) ncbi
Abcam
mouse monoclonal (E6D7)
  • immunohistochemistry knockout validation; mouse; fig 4b
  • western blot knockout validation; mouse; fig 3
Abcam Apoe antibody (Abcam, ab1907) was used in immunohistochemistry knockout validation on mouse samples (fig 4b) and in western blot knockout validation on mouse samples (fig 3). Oncotarget (2016) ncbi
Meridian Life Science
polyclonal
  • western blot knockout validation; human; 1:1000; fig 1b
Meridian Life Science Apoe antibody (Meridian Life Science, K74180B) was used in western blot knockout validation on human samples at 1:1000 (fig 1b). Acta Neuropathol (2021) ncbi
Abcam
mouse monoclonal (E6D7)
  • immunohistochemistry; human; 1:100; loading ...; fig 5k
Abcam Apoe antibody (Abcam, ab1907) was used in immunohistochemistry on human samples at 1:100 (fig 5k). Acta Neuropathol (2021) ncbi
domestic rabbit monoclonal (EPR19392)
  • immunohistochemistry; human; loading ...; fig s12
Abcam Apoe antibody (Abcam, ab183597) was used in immunohistochemistry on human samples (fig s12). Sci Transl Med (2021) ncbi
domestic rabbit monoclonal (EPR19392)
  • immunohistochemistry - paraffin section; mouse; 1:3000; fig 2g
  • immunocytochemistry; mouse; 1:500; fig 7a
  • immunohistochemistry - paraffin section; human; 1:3000; loading ...; fig 2a
Abcam Apoe antibody (Abcam, ab183597) was used in immunohistochemistry - paraffin section on mouse samples at 1:3000 (fig 2g), in immunocytochemistry on mouse samples at 1:500 (fig 7a) and in immunohistochemistry - paraffin section on human samples at 1:3000 (fig 2a). Cancer Res (2021) ncbi
domestic rabbit monoclonal (EPR19392)
  • immunohistochemistry; mouse; 1:500; loading ...; fig 4b
Abcam Apoe antibody (abcam, ab183597) was used in immunohistochemistry on mouse samples at 1:500 (fig 4b). Cell Transplant (2021) ncbi
domestic rabbit monoclonal (EPR19392)
  • immunohistochemistry; mouse; 1:4000; loading ...; fig 6b
Abcam Apoe antibody (Abcam, ab183597) was used in immunohistochemistry on mouse samples at 1:4000 (fig 6b). J Neurosci (2020) ncbi
mouse monoclonal (E6D7)
  • immunohistochemistry knockout validation; mouse; 1:250; loading ...; fig 1c
  • western blot knockout validation; mouse; loading ...; fig 3d
Abcam Apoe antibody (Abcam, ab1907) was used in immunohistochemistry knockout validation on mouse samples at 1:250 (fig 1c) and in western blot knockout validation on mouse samples (fig 3d). Front Immunol (2019) ncbi
domestic rabbit monoclonal (EPR19392)
  • immunohistochemistry; mouse; loading ...; fig 5
Abcam Apoe antibody (Abcam, EPR19392) was used in immunohistochemistry on mouse samples (fig 5). Front Cell Neurosci (2018) ncbi
mouse monoclonal (D6E10)
  • western blot; human; 1:1000; loading ...; fig 3b
Abcam Apoe antibody (Abcam, ab1906) was used in western blot on human samples at 1:1000 (fig 3b). J Biol Chem (2018) ncbi
mouse monoclonal (D6E10)
  • immunohistochemistry; mouse; loading ...; fig 5b
In order to use photoluminescent carbon nanotubes to produce high-resolution images of brown fat in the body, Abcam Apoe antibody (Abcam, ab1906) was used in immunohistochemistry on mouse samples (fig 5b). Sci Rep (2017) ncbi
mouse monoclonal (E6D7)
  • immunohistochemistry knockout validation; mouse; fig 4b
  • western blot knockout validation; mouse; fig 3
Abcam Apoe antibody (Abcam, ab1907) was used in immunohistochemistry knockout validation on mouse samples (fig 4b) and in western blot knockout validation on mouse samples (fig 3). Oncotarget (2016) ncbi
mouse monoclonal (D6E10)
  • western blot; mouse; loading ...; fig 3a
Abcam Apoe antibody (Abcam, ab1906) was used in western blot on mouse samples (fig 3a). PLoS ONE (2016) ncbi
mouse monoclonal (D6E10)
  • immunoprecipitation; mouse; fig 3
  • western blot; mouse; fig 3
Abcam Apoe antibody (Abcam, ab1906) was used in immunoprecipitation on mouse samples (fig 3) and in western blot on mouse samples (fig 3). J Biol Chem (2016) ncbi
mouse monoclonal (D6E10)
  • immunohistochemistry; mouse; 1:500; loading ...; fig 5
  • western blot; mouse; 1:1000; loading ...; fig 4a
In order to test if a LXR agonist affects cognitive impairment in amyloid and Tau Alzheimer's disease mouse models, Abcam Apoe antibody (Abcam, AB1906) was used in immunohistochemistry on mouse samples at 1:500 (fig 5) and in western blot on mouse samples at 1:1000 (fig 4a). PLoS ONE (2015) ncbi
mouse monoclonal (D6E10)
  • immunohistochemistry; human
  • western blot; human; 1:1000
In order to study the role of apolipoprotein E in cerebral amyloid angiopathy, Abcam Apoe antibody (Abcam, ab1906) was used in immunohistochemistry on human samples and in western blot on human samples at 1:1000. J Neurochem (2015) ncbi
mouse monoclonal (D6E10)
  • immunohistochemistry; mouse; 1:250
In order to investigate hypercholesterolemia at various stages of Alzheimer's disease, Abcam Apoe antibody (Abcam, ab1906) was used in immunohistochemistry on mouse samples at 1:250. Mol Cell Neurosci (2014) ncbi
mouse monoclonal (D6E10)
  • western blot; mouse; 1:1000
Abcam Apoe antibody (Abcam, ab1906) was used in western blot on mouse samples at 1:1000. Cell Res (2014) ncbi
mouse monoclonal (D6E10)
  • western blot; human; 1:1000
Abcam Apoe antibody (Abcam, ab1906) was used in western blot on human samples at 1:1000. Biochim Biophys Acta (2014) ncbi
mouse monoclonal (E6D7)
  • ELISA; human; loading ...; fig 2a,b
Abcam Apoe antibody (Abcam, ab1907) was used in ELISA on human samples (fig 2a,b). Int J Mol Epidemiol Genet (2014) ncbi
mouse monoclonal (D6E10)
  • western blot; human
Abcam Apoe antibody (Abcam, ab1906) was used in western blot on human samples . PLoS ONE (2014) ncbi
mouse monoclonal (E6D7)
  • immunohistochemistry - free floating section; mouse; 1:500
  • western blot; mouse; 1:1000; fig 5c
Abcam Apoe antibody (Abcam, ab1907) was used in immunohistochemistry - free floating section on mouse samples at 1:500 and in western blot on mouse samples at 1:1000 (fig 5c). Acta Neuropathol Commun (2013) ncbi
mouse monoclonal (D6E10)
  • western blot; human; 1:750
Abcam Apoe antibody (Abcam, ab1906) was used in western blot on human samples at 1:750. J Pain Symptom Manage (2014) ncbi
mouse monoclonal (D6E10)
  • western blot; human; 1:500; fig s2c
Abcam Apoe antibody (Abcam, ab1906) was used in western blot on human samples at 1:500 (fig s2c). Proteomics (2013) ncbi
mouse monoclonal (E6D7)
  • western blot; human; 1:500
Abcam Apoe antibody (Abcam, ab1907) was used in western blot on human samples at 1:500. J Virol (2013) ncbi
Santa Cruz Biotechnology
mouse monoclonal (F-9)
  • western blot; mouse; 1:100
Santa Cruz Biotechnology Apoe antibody (Santa Cruz Biotechnology, sc-390925) was used in western blot on mouse samples at 1:100. Sci Adv (2022) ncbi
mouse monoclonal (F-9)
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 3e
Santa Cruz Biotechnology Apoe antibody (Santa Cruz Biotechnology, sc-390925) was used in immunohistochemistry - frozen section on mouse samples at 1:100 (fig 3e). Acta Neuropathol Commun (2021) ncbi
mouse monoclonal (WU E-4)
  • western blot; human; loading ...; fig s4b
Santa Cruz Biotechnology Apoe antibody (Santa Cruz, sc-53570) was used in western blot on human samples (fig s4b). Sci Rep (2017) ncbi
Invitrogen
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 3f
Invitrogen Apoe antibody (ThermoFisher, PA5-78803) was used in western blot on mouse samples at 1:1000 (fig 3f). Stem Cell Res Ther (2020) ncbi
domestic rabbit recombinant (16H22L18)
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig ex8a
Invitrogen Apoe antibody (Thermo Fisher, 701241) was used in immunohistochemistry - frozen section on mouse samples at 1:200 (fig ex8a). Nature (2019) ncbi
domestic rabbit recombinant (16H22L18)
  • immunocytochemistry; human; loading ...; fig s6a
In order to elucidate the mechanisms of apolipoprotein E isoforms to Alzheimer's disease pathogenesis, Invitrogen Apoe antibody (Thermo Fisher Scientific, 701241) was used in immunocytochemistry on human samples (fig s6a). Cell (2017) ncbi
BioLegend
rat monoclonal (3B3C32)
  • western blot; mouse; loading ...; fig 7c
BioLegend Apoe antibody (BioLegend, 674802) was used in western blot on mouse samples (fig 7c). Acta Neuropathol Commun (2021) ncbi
Meridian Life Science
polyclonal
  • western blot knockout validation; human; 1:1000; fig 1b
Meridian Life Science Apoe antibody (Meridian Life Science, K74180B) was used in western blot knockout validation on human samples at 1:1000 (fig 1b). Acta Neuropathol (2021) ncbi
polyclonal
  • immunoprecipitation; mouse; loading ...; fig 5c
Meridian Life Science Apoe antibody (Meridian Life Science, K74180B) was used in immunoprecipitation on mouse samples (fig 5c). Neuron (2017) ncbi
Articles Reviewed
  1. Singh N, Das B, Zhou J, Hu X, Yan R. Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance. Sci Adv. 2022;8:eabo3610 pubmed publisher
  2. Zhao J, Lu W, Ren Y, Fu Y, Martens Y, Shue F, et al. Apolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids. Acta Neuropathol. 2021;142:807-825 pubmed publisher
  3. Jeong A, Cheng S, Zhong R, Bennett D, Bergo M, Li L. Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice. Acta Neuropathol Commun. 2021;9:129 pubmed publisher
  4. Qiu C, Albayram O, Kondo A, Wang B, Kim N, Arai K, et al. Cis P-tau underlies vascular contribution to cognitive impairment and dementia and can be effectively targeted by immunotherapy in mice. Sci Transl Med. 2021;13: pubmed publisher
  5. Kemp S, Carpenter E, Steele N, Donahue K, Nwosu Z, Pacheco A, et al. Apolipoprotein E Promotes Immune Suppression in Pancreatic Cancer through NF-κB-Mediated Production of CXCL1. Cancer Res. 2021;81:4305-4318 pubmed publisher
  6. Shibuya K, Watanabe M, Goto R, Zaitsu M, Ganchiku Y, Taketomi A. The Efficacy of the Hepatocyte Spheroids for Hepatocyte Transplantation. Cell Transplant. 2021;30:9636897211000014 pubmed publisher
  7. Sobue A, Komine O, Hara Y, Endo F, Mizoguchi H, Watanabe S, et al. Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease. Acta Neuropathol Commun. 2021;9:1 pubmed publisher
  8. Beltran Camacho L, Jimenez Palomares M, Rojas Torres M, Sánchez Gomar I, Rosal Vela A, Eslava Alcon S, et al. Identification of the initial molecular changes in response to circulating angiogenic cells-mediated therapy in critical limb ischemia. Stem Cell Res Ther. 2020;11:106 pubmed publisher
  9. Meilandt W, Ngu H, Gogineni A, Lalehzadeh G, Lee S, Srinivasan K, et al. Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model. J Neurosci. 2020;40:1956-1974 pubmed publisher
  10. Culemann S, Grüneboom A, Nicolás Ávila J, Weidner D, Lämmle K, Rothe T, et al. Locally renewing resident synovial macrophages provide a protective barrier for the joint. Nature. 2019;572:670-675 pubmed publisher
  11. Lee Y, Yeo I, Kim K, Han S, Hong J. Inhibition of Lung Tumor Development in ApoE Knockout Mice via Enhancement of TREM-1 Dependent NK Cell Cytotoxicity. Front Immunol. 2019;10:1379 pubmed publisher
  12. Thygesen C, Ilkjær L, Kempf S, Hemdrup A, von Linstow C, Babcock A, et al. Diverse Protein Profiles in CNS Myeloid Cells and CNS Tissue From Lipopolysaccharide- and Vehicle-Injected APPSWE/PS1ΔE9 Transgenic Mice Implicate Cathepsin Z in Alzheimer's Disease. Front Cell Neurosci. 2018;12:397 pubmed publisher
  13. Muñoz S, Li H, Ruberu K, Chu Q, Saghatelian A, Ooi L, et al. The serine protease HtrA1 contributes to the formation of an extracellular 25-kDa apolipoprotein E fragment that stimulates neuritogenesis. J Biol Chem. 2018;293:4071-4084 pubmed publisher
  14. Zhao N, Liu C, Van Ingelgom A, Martens Y, Linares C, Knight J, et al. Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes. Neuron. 2017;96:115-129.e5 pubmed publisher
  15. Lee M, Yang J, Jo E, Lee J, Kim H, Bartenschlager R, et al. A Novel Inhibitor IDPP Interferes with Entry and Egress of HCV by Targeting Glycoprotein E1 in a Genotype-Specific Manner. Sci Rep. 2017;7:44676 pubmed publisher
  16. Yudasaka M, Yomogida Y, Zhang M, Tanaka T, Nakahara M, Kobayashi N, et al. Near-Infrared Photoluminescent Carbon Nanotubes for Imaging of Brown Fat. Sci Rep. 2017;7:44760 pubmed publisher
  17. Huang Y, Zhou B, Wernig M, Sudhof T. ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and A? Secretion. Cell. 2017;168:427-441.e21 pubmed publisher
  18. Pang J, Wu Y, Peng J, Yang P, Kuai L, Qin X, et al. Potential implications of Apolipoprotein E in early brain injury after experimental subarachnoid hemorrhage: Involvement in the modulation of blood-brain barrier integrity. Oncotarget. 2016;7:56030-56044 pubmed publisher
  19. Bakshi M, Azimzadeh O, Merl Pham J, Verreet T, Hauck S, Benotmane M, et al. In-Utero Low-Dose Irradiation Leads to Persistent Alterations in the Mouse Heart Proteome. PLoS ONE. 2016;11:e0156952 pubmed publisher
  20. Liu C, Song X, Nisbet R, Götz J. Co-immunoprecipitation with Tau Isoform-specific Antibodies Reveals Distinct Protein Interactions and Highlights a Putative Role for 2N Tau in Disease. J Biol Chem. 2016;291:8173-88 pubmed publisher
  21. Sandoval Hernández A, Buitrago L, Moreno H, Cardona Gómez G, Arboleda G. Role of Liver X Receptor in AD Pathophysiology. PLoS ONE. 2015;10:e0145467 pubmed publisher
  22. de Jager M, Drukarch B, Hofstee M, Brevé J, Jongenelen C, Bol J, et al. Tissue transglutaminase-catalysed cross-linking induces Apolipoprotein E multimers inhibiting Apolipoprotein E's protective effects towards amyloid-beta-induced toxicity. J Neurochem. 2015;134:1116-28 pubmed publisher
  23. Hohsfield L, Daschil N, Orädd G, Strömberg I, Humpel C. Vascular pathology of 20-month-old hypercholesterolemia mice in comparison to triple-transgenic and APPSwDI Alzheimer's disease mouse models. Mol Cell Neurosci. 2014;63:83-95 pubmed
  24. Chen J, Zhao Y, Zhang C, Chen H, Feng J, Chi X, et al. Persistent hepatitis C virus infections and hepatopathological manifestations in immune-competent humanized mice. Cell Res. 2014;24:1050-66 pubmed publisher
  25. Sreckovic I, Birner Gruenberger R, Besenboeck C, Miljković M, Stojakovic T, Scharnagl H, et al. Gestational diabetes mellitus modulates neonatal high-density lipoprotein composition and its functional heterogeneity. Biochim Biophys Acta. 2014;1841:1619-27 pubmed publisher
  26. Richens J, Vere K, Light R, Soria D, Garibaldi J, Smith A, et al. Practical detection of a definitive biomarker panel for Alzheimer's disease; comparisons between matched plasma and cerebrospinal fluid. Int J Mol Epidemiol Genet. 2014;5:53-70 pubmed
  27. Lefevre M, Felmlee D, Parnot M, Baumert T, Schuster C. Syndecan 4 is involved in mediating HCV entry through interaction with lipoviral particle-associated apolipoprotein E. PLoS ONE. 2014;9:e95550 pubmed publisher
  28. Raha A, VAISHNAV R, FRIEDLAND R, Bomford A, Raha Chowdhury R. The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer's disease. Acta Neuropathol Commun. 2013;1:55 pubmed publisher
  29. Lukkahatai N, Patel S, Gucek M, Hsiao C, Saligan L. Proteomic serum profile of fatigued men receiving localized external beam radiation therapy for non-metastatic prostate cancer. J Pain Symptom Manage. 2014;47:748-756.e4 pubmed publisher
  30. Heo S, Choi J, Kim Y, Jung C, Lee J, Jin H, et al. Comparative proteomic analysis in children with idiopathic short stature (ISS) before and after short-term recombinant human growth hormone (rhGH) therapy. Proteomics. 2013;13:1211-9 pubmed publisher
  31. Jammart B, Michelet M, Pécheur E, Parent R, Bartosch B, Zoulim F, et al. Very-low-density lipoprotein (VLDL)-producing and hepatitis C virus-replicating HepG2 cells secrete no more lipoviroparticles than VLDL-deficient Huh7.5 cells. J Virol. 2013;87:5065-80 pubmed publisher