This is a Validated Antibody Database (VAD) review about mouse Ago2, based on 43 published articles (read how Labome selects the articles), using Ago2 antibody in all methods. It is aimed to help Labome visitors find the most suited Ago2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Ago2 synonym: 1110029L17Rik; 2310051F07Rik; AI225898; AL022874; AW546247; Eif2c2; Gerp95; Gm10365; mKIAA4215

Knockout validation
Sino Biological
domestic rabbit monoclonal (036)
  • immunohistochemistry knockout validation; mouse; 1:100; loading ...; fig s1b
  • western blot knockout validation; mouse; 1:1000; fig 5d
Sino Biological Ago2 antibody (Sino Biologicals, 50683-RO-36) was used in immunohistochemistry knockout validation on mouse samples at 1:100 (fig s1b) and in western blot knockout validation on mouse samples at 1:1000 (fig 5d). Proc Natl Acad Sci U S A (2021) ncbi
Abcam
domestic rabbit monoclonal (EPR10411)
  • western blot; human; loading ...; fig 8c
Abcam Ago2 antibody (Abcam, ab186733) was used in western blot on human samples (fig 8c). Aging Dis (2021) ncbi
domestic rabbit monoclonal (EPR10411)
  • RNA immunoprecipitation; human; loading ...; fig 5e
Abcam Ago2 antibody (Abcam, ab186733) was used in RNA immunoprecipitation on human samples (fig 5e). Mol Cancer (2021) ncbi
mouse monoclonal (2E12-1C9)
  • RNA immunoprecipitation; mouse; loading ...; fig 3c
Abcam Ago2 antibody (Abcam, ab57113) was used in RNA immunoprecipitation on mouse samples (fig 3c). Mol Metab (2021) ncbi
domestic rabbit monoclonal (EPR10411)
  • immunoprecipitation; human; loading ...; fig 6f
  • western blot; human; loading ...; fig 6f
Abcam Ago2 antibody (Abcam, ab186733) was used in immunoprecipitation on human samples (fig 6f) and in western blot on human samples (fig 6f). J Exp Clin Cancer Res (2021) ncbi
domestic rabbit polyclonal
  • immunohistochemistry; human; 1:500; loading ...; fig 1a
  • western blot; human; 1:500; loading ...; fig 2a
Abcam Ago2 antibody (Abcam, ab32381) was used in immunohistochemistry on human samples at 1:500 (fig 1a) and in western blot on human samples at 1:500 (fig 2a). Cell Death Dis (2021) ncbi
domestic rabbit polyclonal
  • immunoprecipitation; human; loading ...; fig 2i
Abcam Ago2 antibody (Abcam, ab32381) was used in immunoprecipitation on human samples (fig 2i). BMC Cancer (2020) ncbi
domestic rabbit monoclonal (EPR10411)
  • immunohistochemistry; human; loading ...; fig 1a
  • western blot; human; loading ...; fig 2a
Abcam Ago2 antibody (Abcam, ab186733) was used in immunohistochemistry on human samples (fig 1a) and in western blot on human samples (fig 2a). Biomed Res Int (2020) ncbi
domestic rabbit polyclonal
  • immunoprecipitation; human; 1:1000; loading ...; fig 4i
Abcam Ago2 antibody (Abcam, ab32381) was used in immunoprecipitation on human samples at 1:1000 (fig 4i). Mol Cancer (2020) ncbi
domestic rabbit polyclonal
  • RNA immunoprecipitation; human; loading ...; fig 5c
Abcam Ago2 antibody (Abcam, ab32381) was used in RNA immunoprecipitation on human samples (fig 5c). Mol Cancer (2020) ncbi
domestic rabbit polyclonal
  • RNA immunoprecipitation; human; loading ...; fig 6e
Abcam Ago2 antibody (Abcam, ab32381) was used in RNA immunoprecipitation on human samples (fig 6e). Nat Commun (2019) ncbi
domestic rabbit monoclonal (EPR10411)
Abcam Ago2 antibody (ABCAM, AB186733) was used . Cell Rep (2019) ncbi
domestic rabbit monoclonal (EPR10411)
  • western blot; human; loading ...; fig s3c, 3b, 3c
Abcam Ago2 antibody (Abcam, ab186733) was used in western blot on human samples (fig s3c, 3b, 3c). Cell (2019) ncbi
domestic rabbit polyclonal
  • RNA immunoprecipitation; human; loading ...; fig 3h
Abcam Ago2 antibody (Abcam, ab32381) was used in RNA immunoprecipitation on human samples (fig 3h). Aging (Albany NY) (2019) ncbi
mouse monoclonal (2E12-1C9)
  • RNA immunoprecipitation; human; loading ...; fig 6a
Abcam Ago2 antibody (Abcam, ab57113) was used in RNA immunoprecipitation on human samples (fig 6a). Nucleic Acids Res (2018) ncbi
domestic rabbit monoclonal (EPR10411)
  • RNA immunoprecipitation; human; loading ...; fig 2b
Abcam Ago2 antibody (Abcam, ab186733) was used in RNA immunoprecipitation on human samples (fig 2b). Cell Physiol Biochem (2018) ncbi
mouse monoclonal (2E12-1C9)
Abcam Ago2 antibody (Abcam, ab57113) was used . Proc Natl Acad Sci U S A (2018) ncbi
domestic rabbit polyclonal
  • immunoprecipitation; mouse; 1:1000; loading ...; fig 2b
Abcam Ago2 antibody (Abcam, ab32381) was used in immunoprecipitation on mouse samples at 1:1000 (fig 2b). Mol Ther Nucleic Acids (2018) ncbi
mouse monoclonal (2E12-1C9)
  • immunoprecipitation; human; fig 4a
  • western blot; human; 1:1000; fig 4a
Abcam Ago2 antibody (Abcam, ab57113) was used in immunoprecipitation on human samples (fig 4a) and in western blot on human samples at 1:1000 (fig 4a). Mol Ther (2017) ncbi
Invitrogen
mouse monoclonal
  • immunocytochemistry; human; 1:500; loading ...; fig s6
Invitrogen Ago2 antibody (Thermo Fisher, MA5-23515) was used in immunocytochemistry on human samples at 1:500 (fig s6). Aging (Albany NY) (2021) ncbi
mouse monoclonal
  • RNA immunoprecipitation; human; loading ...; fig 3c
Invitrogen Ago2 antibody (Thermo Fisher, MA5-23515) was used in RNA immunoprecipitation on human samples (fig 3c). Cancer Cell Int (2021) ncbi
domestic rabbit monoclonal (R.386.2)
  • RNA immunoprecipitation; human; fig s11
In order to identify an atheroprotective role for circular RNAs, Invitrogen Ago2 antibody (Thermo Scientific, MA5-14861) was used in RNA immunoprecipitation on human samples (fig s11). Nat Commun (2016) ncbi
domestic rabbit monoclonal (R.386.2)
  • immunoprecipitation; mouse; fig s2
In order to elucidate miR-21 that induces fibrosis in an acute cardiac allograft transplantation model, Invitrogen Ago2 antibody (Thermo Pierce, MA5-14861) was used in immunoprecipitation on mouse samples (fig s2). Cardiovasc Res (2016) ncbi
Santa Cruz Biotechnology
mouse monoclonal (B-3)
  • western blot; mouse; 1:500; loading ...; fig 5g
Santa Cruz Biotechnology Ago2 antibody (Santa Cruz, sc376696) was used in western blot on mouse samples at 1:500 (fig 5g). Cell Death Discov (2021) ncbi
mouse monoclonal (4F9)
  • chromatin immunoprecipitation; human; loading ...; fig 3b
Santa Cruz Biotechnology Ago2 antibody (SantaCruz, sc-53521) was used in chromatin immunoprecipitation on human samples (fig 3b). Sci Rep (2017) ncbi
mouse monoclonal (4F9)
  • western blot; mouse; fig 7
Santa Cruz Biotechnology Ago2 antibody (Santa Cruz, sc-53521) was used in western blot on mouse samples (fig 7). Autophagy (2015) ncbi
Sino Biological
domestic rabbit monoclonal (036)
  • immunohistochemistry knockout validation; mouse; 1:100; loading ...; fig s1b
  • western blot knockout validation; mouse; 1:1000; fig 5d
Sino Biological Ago2 antibody (Sino Biologicals, 50683-RO-36) was used in immunohistochemistry knockout validation on mouse samples at 1:100 (fig s1b) and in western blot knockout validation on mouse samples at 1:1000 (fig 5d). Proc Natl Acad Sci U S A (2021) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (C34C6)
  • western blot; human; 1:1000; loading ...; fig 1c
  • western blot; mouse; 1:1000; loading ...; fig 1s2, 2d, 2e, 2s3
Cell Signaling Technology Ago2 antibody (Cell Signaling, 2897) was used in western blot on human samples at 1:1000 (fig 1c) and in western blot on mouse samples at 1:1000 (fig 1s2, 2d, 2e, 2s3). elife (2021) ncbi
domestic rabbit monoclonal (C34C6)
  • immunoprecipitation; human; loading ...; fig 3b
Cell Signaling Technology Ago2 antibody (Cell signaling Technology, 2897) was used in immunoprecipitation on human samples (fig 3b). EBioMedicine (2020) ncbi
domestic rabbit monoclonal (C34C6)
  • immunoprecipitation; mouse; 1:1000; loading ...; fig 2b
  • western blot; mouse; 1:1000; loading ...; fig 2a
Cell Signaling Technology Ago2 antibody (CST, 2897) was used in immunoprecipitation on mouse samples at 1:1000 (fig 2b) and in western blot on mouse samples at 1:1000 (fig 2a). Mol Ther Nucleic Acids (2018) ncbi
domestic rabbit monoclonal (C34C6)
  • western blot; rat; 1:1000; loading ...; fig 4b
Cell Signaling Technology Ago2 antibody (Cell Signaling, C34C6) was used in western blot on rat samples at 1:1000 (fig 4b). EMBO J (2018) ncbi
domestic rabbit monoclonal (C34C6)
Cell Signaling Technology Ago2 antibody (Cell Signaling Technology, C34C6) was used . Nucleic Acids Res (2018) ncbi
domestic rabbit monoclonal (C34C6)
  • western blot; mouse; loading ...; fig 1e
Cell Signaling Technology Ago2 antibody (Cell Signaling, C34C6) was used in western blot on mouse samples (fig 1e). Nat Commun (2017) ncbi
domestic rabbit monoclonal (C34C6)
  • RNA immunoprecipitation; human; loading ...; fig 4c
Cell Signaling Technology Ago2 antibody (Cell Signaling, 2897S) was used in RNA immunoprecipitation on human samples (fig 4c). Sci Transl Med (2016) ncbi
domestic rabbit monoclonal (C34C6)
  • western blot; human; fig s3b
Cell Signaling Technology Ago2 antibody (Cell Signaling, 2897) was used in western blot on human samples (fig s3b). Nucleic Acids Res (2016) ncbi
domestic rabbit monoclonal (C34C6)
  • western blot; rat; 1:500; loading ...; fig 5
Cell Signaling Technology Ago2 antibody (cell signalling, C34C6) was used in western blot on rat samples at 1:500 (fig 5). Mol Neurobiol (2017) ncbi
domestic rabbit monoclonal (C34C6)
  • western blot; human; loading ...; fig 7c
Cell Signaling Technology Ago2 antibody (Cell Signaling, 2897) was used in western blot on human samples (fig 7c). Nat Commun (2015) ncbi
domestic rabbit monoclonal (C34C6)
  • western blot; mouse; fig 3a
Cell Signaling Technology Ago2 antibody (Cell Signaling, C34C6) was used in western blot on mouse samples (fig 3a). RNA (2015) ncbi
domestic rabbit monoclonal (C34C6)
  • western blot; mouse; fig 6a
Cell Signaling Technology Ago2 antibody (Cell Signaling, C34C6) was used in western blot on mouse samples (fig 6a). J Biol Chem (2015) ncbi
domestic rabbit monoclonal (C34C6)
  • western blot; human; 1:1000; fig 3
In order to elucidate how post-translational modification of ATAXIN1 levels contributes to spinocerebellar ataxia type 1, Cell Signaling Technology Ago2 antibody (Cell Signaling Technology, 2897S) was used in western blot on human samples at 1:1000 (fig 3). Cell (2015) ncbi
domestic rabbit monoclonal (C34C6)
  • western blot; human
Cell Signaling Technology Ago2 antibody (Cell Signaling Technology, C34C6) was used in western blot on human samples . J Biol Chem (2015) ncbi
domestic rabbit monoclonal (C34C6)
  • western blot; human
Cell Signaling Technology Ago2 antibody (Cell signaling, 2897) was used in western blot on human samples . Nucleic Acids Res (2014) ncbi
domestic rabbit monoclonal (C34C6)
  • western blot; human
Cell Signaling Technology Ago2 antibody (Cell Signaling, 2897) was used in western blot on human samples . Cell Death Dis (2013) ncbi
domestic rabbit monoclonal (C34C6)
  • western blot; rat; 1:1000
Cell Signaling Technology Ago2 antibody (Cell Signalling Technology, 2897) was used in western blot on rat samples at 1:1000. Addict Biol (2015) ncbi
Wako Chemicals USA
monoclonal
  • western blot; mouse; fig s5
Wako Chemicals USA Ago2 antibody (Wako, 014-22023) was used in western blot on mouse samples (fig s5). Nat Commun (2015) ncbi
Articles Reviewed
  1. Sil S, Singh S, Chemparathy D, Chivero E, Gordon L, Buch S. Astrocytes & Astrocyte derived Extracellular Vesicles in Morphine Induced Amyloidopathy: Implications for Cognitive Deficits in Opiate Abusers. Aging Dis. 2021;12:1389-1408 pubmed publisher
  2. La Rocca G, King B, Shui B, Li X, Zhang M, Akat K, et al. Inducible and reversible inhibition of miRNA-mediated gene repression in vivo. elife. 2021;10: pubmed publisher
  3. Liu Z, Wang T, She Y, Wu K, Gu S, Li L, et al. N6-methyladenosine-modified circIGF2BP3 inhibits CD8+ T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer. Mol Cancer. 2021;20:105 pubmed publisher
  4. Ding Z, Sun D, Han J, Shen L, Yang F, Sah S, et al. Novel noncoding RNA CircPTK2 regulates lipolysis and adipogenesis in cachexia. Mol Metab. 2021;53:101310 pubmed publisher
  5. Qian B, Wang P, Zhang D, Wu L. m6A modification promotes miR-133a repression during cardiac development and hypertrophy via IGF2BP2. Cell Death Discov. 2021;7:157 pubmed publisher
  6. Bloniarz D, Adamczyk Grochala J, Lewinska A, Wnuk M. The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence. Aging (Albany NY). 2021;13:15833-15874 pubmed publisher
  7. Tien J, Chugh S, Goodrum A, Cheng Y, Mannan R, Zhang Y, et al. AGO2 promotes tumor progression in KRAS-driven mouse models of non-small cell lung cancer. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
  8. Wang X, Li X, Lin F, Sun H, Lin Y, Wang Z, et al. The lnc-CTSLP8 upregulates CTSL1 as a competitive endogenous RNA and promotes ovarian cancer metastasis. J Exp Clin Cancer Res. 2021;40:151 pubmed publisher
  9. Liu X, Meng X, Peng X, Yao Q, Zhu F, Ding Z, et al. Impaired AGO2/miR-185-3p/NRP1 axis promotes colorectal cancer metastasis. Cell Death Dis. 2021;12:390 pubmed publisher
  10. Fan X, Zhao Z, Song J, Zhang D, Wu F, Tu J, et al. LncRNA-SNHG6 promotes the progression of hepatocellular carcinoma by targeting miR-6509-5p and HIF1A. Cancer Cell Int. 2021;21:150 pubmed publisher
  11. Chen J, Liu X, Ke K, Zou J, Gao Z, Habuchi T, et al. LINC00992 contributes to the oncogenic phenotypes in prostate cancer via targeting miR-3935 and augmenting GOLM1 expression. BMC Cancer. 2020;20:749 pubmed publisher
  12. Yang Y, Mei Q. Accumulation of AGO2 Facilitates Tumorigenesis of Human Hepatocellular Carcinoma. Biomed Res Int. 2020;2020:1631843 pubmed publisher
  13. Xiang Q, Kang L, Wang J, Liao Z, Song Y, Zhao K, et al. CircRNA-CIDN mitigated compression loading-induced damage in human nucleus pulposus cells via miR-34a-5p/SIRT1 axis. EBioMedicine. 2020;53:102679 pubmed publisher
  14. Jin D, Guo J, Wu Y, Yang L, Wang X, Du J, et al. m6A demethylase ALKBH5 inhibits tumor growth and metastasis by reducing YTHDFs-mediated YAP expression and inhibiting miR-107/LATS2-mediated YAP activity in NSCLC. Mol Cancer. 2020;19:40 pubmed publisher
  15. Lu C, Wei Y, Wang X, Zhang Z, Yin J, Li W, et al. DNA-methylation-mediated activating of lncRNA SNHG12 promotes temozolomide resistance in glioblastoma. Mol Cancer. 2020;19:28 pubmed publisher
  16. Zhang J, Bai R, Li M, Ye H, Wu C, Wang C, et al. Excessive miR-25-3p maturation via N6-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progression. Nat Commun. 2019;10:1858 pubmed publisher
  17. Zhang Q, Higginbotham J, Jeppesen D, Yang Y, Li W, McKinley E, et al. Transfer of Functional Cargo in Exomeres. Cell Rep. 2019;27:940-954.e6 pubmed publisher
  18. Jeppesen D, Fenix A, Franklin J, Higginbotham J, Zhang Q, Zimmerman L, et al. Reassessment of Exosome Composition. Cell. 2019;177:428-445.e18 pubmed publisher
  19. Lin X, Zhan J, Zhong J, Wang Y, Wang Y, Li S, et al. lncRNA-ES3/miR-34c-5p/BMF axis is involved in regulating high-glucose-induced calcification/senescence of VSMCs. Aging (Albany NY). 2019;11:523-535 pubmed publisher
  20. Bonath F, Domingo Prim J, Tarbier M, Friedländer M, Visa N. Next-generation sequencing reveals two populations of damage-induced small RNAs at endogenous DNA double-strand breaks. Nucleic Acids Res. 2018;46:11869-11882 pubmed publisher
  21. Yin D, Li Y, Fu C, Feng Y. Pro-Angiogenic Role of LncRNA HULC in Microvascular Endothelial Cells via Sequestrating miR-124. Cell Physiol Biochem. 2018;50:2188-2202 pubmed publisher
  22. Castanotto D, Zhang X, Alluin J, Zhang X, Rüger J, Armstrong B, et al. A stress-induced response complex (SIRC) shuttles miRNAs, siRNAs, and oligonucleotides to the nucleus. Proc Natl Acad Sci U S A. 2018;115:E5756-E5765 pubmed publisher
  23. Fukuoka M, Takahashi M, Fujita H, Chiyo T, Popiel H, Watanabe S, et al. Supplemental Treatment for Huntington's Disease with miR-132 that Is Deficient in Huntington's Disease Brain. Mol Ther Nucleic Acids. 2018;11:79-90 pubmed publisher
  24. Rajgor D, Sanderson T, Amici M, Collingridge G, Hanley J. NMDAR-dependent Argonaute 2 phosphorylation regulates miRNA activity and dendritic spine plasticity. EMBO J. 2018;37: pubmed publisher
  25. Habibian M, Yahyaee Anzahaee M, Lucic M, Moroz E, Martín Pintado N, Di Giovanni L, et al. Structural properties and gene-silencing activity of chemically modified DNA-RNA hybrids with parallel orientation. Nucleic Acids Res. 2018;46:1614-1623 pubmed publisher
  26. Bottini S, Hamouda Tekaya N, Mategot R, Zaragosi L, Audebert S, Pisano S, et al. Post-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq. Nat Commun. 2017;8:1189 pubmed publisher
  27. van Eijl R, van den Brand T, Nguyen L, Mulder K. Reactivity of human AGO2 monoclonal antibody 11A9 with the SWI/SNF complex: A case study for rigorously defining antibody selectivity. Sci Rep. 2017;7:7278 pubmed publisher
  28. Beltrami C, Besnier M, Shantikumar S, Shearn A, Rajakaruna C, Laftah A, et al. Human Pericardial Fluid Contains Exosomes Enriched with Cardiovascular-Expressed MicroRNAs and Promotes Therapeutic Angiogenesis. Mol Ther. 2017;25:679-693 pubmed publisher
  29. Holdt L, Stahringer A, Sass K, Pichler G, Kulak N, Wilfert W, et al. Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans. Nat Commun. 2016;7:12429 pubmed publisher
  30. Miyazaki Y, Du X, Muramatsu S, Gomez C. An miRNA-mediated therapy for SCA6 blocks IRES-driven translation of the CACNA1A second cistron. Sci Transl Med. 2016;8:347ra94 pubmed publisher
  31. Warner M, Bridge K, Hewitson J, Hodgkinson M, Heyam A, Massa B, et al. S6K2-mediated regulation of TRBP as a determinant of miRNA expression in human primary lymphatic endothelial cells. Nucleic Acids Res. 2016;44:9942-9955 pubmed
  32. Sadakierska Chudy A, Frankowska M, Miszkiel J, Wydra K, Jastrzębska J, Filip M. Prolonged Induction of miR-212/132 and REST Expression in Rat Striatum Following Cocaine Self-Administration. Mol Neurobiol. 2017;54:2241-2254 pubmed publisher
  33. Gupta S, Itagaki R, Zheng X, Batkai S, Thum S, Ahmad F, et al. miR-21 promotes fibrosis in an acute cardiac allograft transplantation model. Cardiovasc Res. 2016;110:215-26 pubmed publisher
  34. Chen C, Zhu C, Huang J, Zhao X, Deng R, Zhang H, et al. SUMOylation of TARBP2 regulates miRNA/siRNA efficiency. Nat Commun. 2015;6:8899 pubmed publisher
  35. Galicia Vázquez G, Chu J, Pelletier J. eIF4AII is dispensable for miRNA-mediated gene silencing. RNA. 2015;21:1826-33 pubmed publisher
  36. Tattikota S, Rathjen T, Hausser J, Khedkar A, Kabra U, Pandey V, et al. miR-184 Regulates Pancreatic β-Cell Function According to Glucose Metabolism. J Biol Chem. 2015;290:20284-94 pubmed publisher
  37. Kim Y, Kang Y, Lee N, Kim K, Hwang Y, Kim H, et al. Uvrag targeting by Mir125a and Mir351 modulates autophagy associated with Ewsr1 deficiency. Autophagy. 2015;11:796-811 pubmed publisher
  38. Gennarino V, Singh R, White J, De Maio A, Han K, Kim J, et al. Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by increasing wild-type Ataxin1 levels. Cell. 2015;160:1087-98 pubmed publisher
  39. Srivastava M, Duan G, Kershaw N, Athanasopoulos V, Yeo J, Ose T, et al. Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis. Nat Commun. 2015;6:6253 pubmed publisher
  40. Koo C, Kobiyama K, Shen Y, LeBert N, Ahmad S, Khatoo M, et al. RNA polymerase III regulates cytosolic RNA:DNA hybrids and intracellular microRNA expression. J Biol Chem. 2015;290:7463-73 pubmed publisher
  41. Cho S, Park J, Kang Y. AGO2 and SETDB1 cooperate in promoter-targeted transcriptional silencing of the androgen receptor gene. Nucleic Acids Res. 2014;42:13545-56 pubmed publisher
  42. Iosue I, Quaranta R, Masciarelli S, Fontemaggi G, Batassa E, Bertolami C, et al. Argonaute 2 sustains the gene expression program driving human monocytic differentiation of acute myeloid leukemia cells. Cell Death Dis. 2013;4:e926 pubmed publisher
  43. García Pérez D, López Bellido R, Hidalgo J, Rodriguez R, Laorden M, Nunez C, et al. Morphine regulates Argonaute 2 and TH expression and activity but not miR-133b in midbrain dopaminergic neurons. Addict Biol. 2015;20:104-19 pubmed publisher