This is a Validated Antibody Database (VAD) review about mouse Adam17, based on 12 published articles (read how Labome selects the articles), using Adam17 antibody in all methods. It is aimed to help Labome visitors find the most suited Adam17 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Adam17 synonym: CD156b; Tace; disintegrin and metalloproteinase domain-containing protein 17; TNF-alpha convertase; TNF-alpha converting enzyme

Knockout validation
Abcam
rabbit polyclonal
  • immunohistochemistry knockout validation; mouse; loading ...; fig 2
Abcam Adam17 antibody (Abcam, ab39163) was used in immunohistochemistry knockout validation on mouse samples (fig 2). Hypertension (2016) ncbi
Abcam
rabbit polyclonal
  • immunohistochemistry knockout validation; mouse; loading ...; fig 2
Abcam Adam17 antibody (Abcam, ab39163) was used in immunohistochemistry knockout validation on mouse samples (fig 2). Hypertension (2016) ncbi
mouse monoclonal
  • western blot; human; fig 4
Abcam Adam17 antibody (Abcam, ab57484) was used in western blot on human samples (fig 4). Invest Ophthalmol Vis Sci (2016) ncbi
rabbit polyclonal
  • immunoprecipitation; hamsters; fig 2
  • western blot; hamsters; fig 2
In order to identify and characterize a multiprotease complex containing both alpha- and gamma-secretase, Abcam Adam17 antibody (Abcam, ab75609) was used in immunoprecipitation on hamsters samples (fig 2) and in western blot on hamsters samples (fig 2). J Cell Biol (2015) ncbi
rabbit polyclonal
  • western blot; human; fig 3
  • western blot; mouse; fig 3
Abcam Adam17 antibody (Abcam, ab2051) was used in western blot on human samples (fig 3) and in western blot on mouse samples (fig 3). Nat Commun (2015) ncbi
rabbit polyclonal
  • western blot; mouse; 1:1100
Abcam Adam17 antibody (Abcam, ab2051) was used in western blot on mouse samples at 1:1100. Proc Natl Acad Sci U S A (2015) ncbi
rabbit polyclonal
  • immunohistochemistry - paraffin section; human; 1:1000
  • western blot; human; 1:1000
In order to examine the importance of iron in relation to amyloid-beta production within the retina, Abcam Adam17 antibody (Abcam, ab2051) was used in immunohistochemistry - paraffin section on human samples at 1:1000 and in western blot on human samples at 1:1000. Exp Eye Res (2014) ncbi
rabbit polyclonal
  • flow cytometry; mouse
In order to study the mechanism for the effect of HMGB1 on myeloid-derived suppressor cells, Abcam Adam17 antibody (Abcam, ab2051) was used in flow cytometry on mouse samples . Cancer Res (2014) ncbi
rabbit polyclonal
  • western blot; mouse
Abcam Adam17 antibody (Abcam, ab2051) was used in western blot on mouse samples . Biochim Biophys Acta (2014) ncbi
rabbit polyclonal
  • western blot; human; 1:3000
Abcam Adam17 antibody (Abcam, 2051) was used in western blot on human samples at 1:3000. J Biol Chem (2013) ncbi
EMD Millipore
rabbit polyclonal
  • western blot; hamsters; fig 7
In order to identify and characterize a multiprotease complex containing both alpha- and gamma-secretase, EMD Millipore Adam17 antibody (Millipore, ab19027) was used in western blot on hamsters samples (fig 7). J Cell Biol (2015) ncbi
rabbit polyclonal
  • western blot; human
In order to study the role of ADAM17 in cellular senescence and senescence secretome, EMD Millipore Adam17 antibody (Millipore, AB19027) was used in western blot on human samples . Breast Cancer Res (2015) ncbi
rabbit polyclonal
  • western blot; human; 1:1000
EMD Millipore Adam17 antibody (Millipore, AB19027) was used in western blot on human samples at 1:1000. J Pineal Res (2015) ncbi
Sigma-Aldrich
rabbit polyclonal
  • western blot; human; 1:1000; fig 7
Sigma-Aldrich Adam17 antibody (Sigma-aldrich, SAB3500367) was used in western blot on human samples at 1:1000 (fig 7). PLoS Pathog (2015) ncbi
Articles Reviewed
  1. Takayanagi T, Forrester S, Kawai T, Obama T, Tsuji T, Elliott K, et al. Vascular ADAM17 as a Novel Therapeutic Target in Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin II. Hypertension. 2016;68:949-955 pubmed publisher
  2. DeSantis Rodrigues A, Chang Y, Hahn R, Po I, Zhou P, Lacey C, et al. ADAM17 Inhibitors Attenuate Corneal Epithelial Detachment Induced by Mustard Exposure. Invest Ophthalmol Vis Sci. 2016;57:1687-98 pubmed publisher
  3. Chen A, Kim S, Shepardson N, Patel S, Hong S, Selkoe D. Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis. J Cell Biol. 2015;211:1157-76 pubmed publisher
  4. Morancho B, Martínez Barriocanal Ã, Villanueva J, Arribas J. Role of ADAM17 in the non-cell autonomous effects of oncogene-induced senescence. Breast Cancer Res. 2015;17:106 pubmed publisher
  5. Dombernowsky S, Samsøe Petersen J, Petersen C, Instrell R, Hedegaard A, Thomas L, et al. The sorting protein PACS-2 promotes ErbB signalling by regulating recycling of the metalloproteinase ADAM17. Nat Commun. 2015;6:7518 pubmed publisher
  6. Pickard A, McDade S, McFarland M, McCluggage W, Wheeler C, McCance D. HPV16 Down-Regulates the Insulin-Like Growth Factor Binding Protein 2 to Promote Epithelial Invasion in Organotypic Cultures. PLoS Pathog. 2015;11:e1004988 pubmed publisher
  7. Corbett G, Gonzalez F, Pahan K. Activation of peroxisome proliferator-activated receptor α stimulates ADAM10-mediated proteolysis of APP. Proc Natl Acad Sci U S A. 2015;112:8445-50 pubmed publisher
  8. Shukla M, Htoo H, Wintachai P, Hernandez J, Dubois C, Postina R, et al. Melatonin stimulates the nonamyloidogenic processing of βAPP through the positive transcriptional regulation of ADAM10 and ADAM17. J Pineal Res. 2015;58:151-65 pubmed publisher
  9. Guo L, Alekseev O, Li Y, Song Y, Dunaief J. Iron increases APP translation and amyloid-beta production in the retina. Exp Eye Res. 2014;129:31-7 pubmed publisher
  10. Parker K, Sinha P, Horn L, Clements V, Yang H, Li J, et al. HMGB1 enhances immune suppression by facilitating the differentiation and suppressive activity of myeloid-derived suppressor cells. Cancer Res. 2014;74:5723-33 pubmed publisher
  11. Fiaturi N, Ritzkat A, Dammann C, Castellot J, Nielsen H. Dissociated presenilin-1 and TACE processing of ErbB4 in lung alveolar type II cell differentiation. Biochim Biophys Acta. 2014;1843:797-805 pubmed publisher
  12. Woods N, Padmanabhan J. Inhibition of amyloid precursor protein processing enhances gemcitabine-mediated cytotoxicity in pancreatic cancer cells. J Biol Chem. 2013;288:30114-24 pubmed publisher