This is a Validated Antibody Database (VAD) review about mouse 2B4, based on 21 published articles (read how Labome selects the articles), using 2B4 antibody in all methods. It is aimed to help Labome visitors find the most suited 2B4 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
2B4 synonym: 2B4; C9.1; Cd244; F730046O15Rik; Ly90; NAIL; NKR2B4; Nmrk; SLAMF4

Invitrogen
rat monoclonal (eBio244F4)
  • flow cytometry; mouse; loading ...; fig 3s1d
Invitrogen 2B4 antibody (eBioscience, 14-2441-82) was used in flow cytometry on mouse samples (fig 3s1d). elife (2020) ncbi
rat monoclonal (eBio244F4)
  • flow cytometry; mouse; loading ...; fig 5f
Invitrogen 2B4 antibody (eBioscience, eBio244F4) was used in flow cytometry on mouse samples (fig 5f). Front Immunol (2018) ncbi
rat monoclonal (eBio244F4)
  • flow cytometry; mouse; loading ...; fig s12a
In order to evaluate mouse models of hepacivirus infection, Invitrogen 2B4 antibody (eBioscience, eBio244F4) was used in flow cytometry on mouse samples (fig s12a). Science (2017) ncbi
rat monoclonal (eBio244F4)
  • flow cytometry; mouse; fig 4e
In order to demonstrate that Smad3 in the tumor microenvironment regulates cancer progression, Invitrogen 2B4 antibody (eBioscience, 12-2441-83) was used in flow cytometry on mouse samples (fig 4e). Nat Commun (2017) ncbi
rat monoclonal (eBio244F4)
  • flow cytometry; mouse; loading ...; fig 1,3
In order to elucidate the interaction between tumor-associated and -infiltrating lymphocytes in ovarian cancer, Invitrogen 2B4 antibody (eBioscience, 11-2441-82) was used in flow cytometry on mouse samples (fig 1,3). Oncoimmunology (2017) ncbi
rat monoclonal (eBio244F4)
  • flow cytometry; mouse; loading ...; fig 1
In order to examine natural killer T cell development in mice deficient for SLAM family receptors, Invitrogen 2B4 antibody (eBioscience, eBio244F4) was used in flow cytometry on mouse samples (fig 1). J Exp Med (2017) ncbi
rat monoclonal (eBio244F4)
  • blocking or activating experiments; mouse; fig 2a
In order to study the role of MCH I in natural killer cell tolerance and hyporesponsiveness, Invitrogen 2B4 antibody (eBioscience, eBio244F4) was used in blocking or activating experiments on mouse samples (fig 2a). J Immunol (2016) ncbi
rat monoclonal (eBio244F4)
  • flow cytometry; mouse; loading ...; fig 8a
In order to determine the function of the SLAM family of proteins in natural killer cells, Invitrogen 2B4 antibody (eBioscience, 244F4) was used in flow cytometry on mouse samples (fig 8a). J Exp Med (2016) ncbi
rat monoclonal (eBio244F4)
  • flow cytometry; mouse; loading ...; fig 1b
In order to demonstrate that Blimp-1 controls CD4 T cell exhaustion, Invitrogen 2B4 antibody (Affymetrix eBioscience, eBio244F4) was used in flow cytometry on mouse samples (fig 1b). J Exp Med (2016) ncbi
rat monoclonal (eBio244F4)
  • flow cytometry; mouse; 1:150
In order to assess the role of NLRC5 to NK-T-cell crosstalk, Invitrogen 2B4 antibody (eBioscience, eBio244F4) was used in flow cytometry on mouse samples at 1:150. Nat Commun (2016) ncbi
rat monoclonal (eBio244F4)
  • flow cytometry; mouse; fig 2
In order to study murine nasal passages to identify and analyze natural killer cells, Invitrogen 2B4 antibody (eBiosciences, eBio24F4) was used in flow cytometry on mouse samples (fig 2). PLoS ONE (2015) ncbi
rat monoclonal (eBio244F4)
  • flow cytometry; mouse; fig 3
In order to study how DNAM-1 controls NK cell-mediated cytotoxicity and cytokine production, Invitrogen 2B4 antibody (eBioscience, 244F4) was used in flow cytometry on mouse samples (fig 3). J Exp Med (2015) ncbi
rat monoclonal (eBio244F4)
  • flow cytometry; mouse; fig s1
In order to test if blocking several checkpoint receptors boosts anti-tumor immunity in a low-dose, lymphodepleting whole body radiation model, Invitrogen 2B4 antibody (eBioscience, 244F4) was used in flow cytometry on mouse samples (fig s1). J Immunother Cancer (2015) ncbi
rat monoclonal (eBio244F4)
  • flow cytometry; mouse
Invitrogen 2B4 antibody (eBioscience, eBio244F4) was used in flow cytometry on mouse samples . J Immunol (2014) ncbi
BioLegend
mouse monoclonal (m2B4 (B6)458.1)
  • flow cytometry; mouse; loading ...; fig 6a
BioLegend 2B4 antibody (BioLegend, m2B4) was used in flow cytometry on mouse samples (fig 6a). Immune Netw (2018) ncbi
mouse monoclonal (m2B4 (B6)458.1)
  • flow cytometry; mouse; 1:200; loading ...; tbl s2
In order to identify and characterize follicular cytotoxic T cells, BioLegend 2B4 antibody (Biolegend, M2B4(B6)458.1) was used in flow cytometry on mouse samples at 1:200 (tbl s2). Nat Immunol (2016) ncbi
mouse monoclonal (m2B4 (B6)458.1)
  • flow cytometry; mouse; fig 3
In order to study the functions of WASp knock out natural killer cells, BioLegend 2B4 antibody (Biolegend, m2B4(B6)458.1) was used in flow cytometry on mouse samples (fig 3). Sci Rep (2016) ncbi
mouse monoclonal (m2B4 (B6)458.1)
  • flow cytometry; mouse; loading ...; fig 4a
BioLegend 2B4 antibody (Biolegend, m2B4(B6)458.1) was used in flow cytometry on mouse samples (fig 4a). J Immunol (2016) ncbi
mouse monoclonal (m2B4 (B6)458.1)
  • flow cytometry; mouse
BioLegend 2B4 antibody (BioLegend, m2B4(B6)458.1) was used in flow cytometry on mouse samples . J Immunol (2014) ncbi
Miltenyi Biotec
human monoclonal (REA524)
  • flow cytometry; mouse; loading ...; fig 3a
Miltenyi Biotec 2B4 antibody (Miltenyi Biotec Inc, REA-524) was used in flow cytometry on mouse samples (fig 3a). J Clin Invest (2018) ncbi
BD Biosciences
mouse monoclonal (2B4)
  • flow cytometry; mouse
BD Biosciences 2B4 antibody (BD Biosciences, 2B4) was used in flow cytometry on mouse samples . Nat Immunol (2015) ncbi
Articles Reviewed
  1. Hajaj E, Eisenberg G, Klein S, Frankenburg S, Merims S, Ben David I, et al. SLAMF6​ deficiency augments tumor killing and skews toward an effector phenotype revealing it as a novel T cell checkpoint. elife. 2020;9: pubmed publisher
  2. Lee Y, Ju J, Shon W, Oh S, Min C, Kang M, et al. Skewed Dendritic Cell Differentiation of MyD88-Deficient Donor Bone Marrow Cells, Instead of Massive Expansion as Myeloid-Derived Suppressor Cells, Aggravates GVHD. Immune Netw. 2018;18:e44 pubmed publisher
  3. Chang S, Kim Y, Kim Y, Kim Y, Moon S, Lee Y, et al. Taurodeoxycholate Increases the Number of Myeloid-Derived Suppressor Cells That Ameliorate Sepsis in Mice. Front Immunol. 2018;9:1984 pubmed publisher
  4. Tilstra J, Avery L, Menk A, Gordon R, Smita S, Kane L, et al. Kidney-infiltrating T cells in murine lupus nephritis are metabolically and functionally exhausted. J Clin Invest. 2018;128:4884-4897 pubmed publisher
  5. Billerbeck E, Wolfisberg R, Fahnøe U, Xiao J, Quirk C, Luna J, et al. Mouse models of acute and chronic hepacivirus infection. Science. 2017;357:204-208 pubmed publisher
  6. Tang P, Zhou S, Meng X, Wang Q, Li C, Lian G, et al. Smad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development. Nat Commun. 2017;8:14677 pubmed publisher
  7. Huang R, Francois A, McGray A, Miliotto A, Odunsi K. Compensatory upregulation of PD-1, LAG-3, and CTLA-4 limits the efficacy of single-agent checkpoint blockade in metastatic ovarian cancer. Oncoimmunology. 2017;6:e1249561 pubmed publisher
  8. Chen S, Cai C, Li Z, Liu G, Wang Y, Blonska M, et al. Dissection of SAP-dependent and SAP-independent SLAM family signaling in NKT cell development and humoral immunity. J Exp Med. 2017;214:475-489 pubmed publisher
  9. Shifrin N, Kissiov D, Ardolino M, Joncker N, Raulet D. Differential Role of Hematopoietic and Nonhematopoietic Cell Types in the Regulation of NK Cell Tolerance and Responsiveness. J Immunol. 2016;197:4127-4136 pubmed publisher
  10. Guo H, Cranert S, Lu Y, Zhong M, Zhang S, Chen J, et al. Deletion of Slam locus in mice reveals inhibitory role of SLAM family in NK cell responses regulated by cytokines and LFA-1. J Exp Med. 2016;213:2187-207 pubmed publisher
  11. Leong Y, Chen Y, Ong H, Wu D, Man K, Deléage C, et al. CXCR5(+) follicular cytotoxic T cells control viral infection in B cell follicles. Nat Immunol. 2016;17:1187-96 pubmed publisher
  12. Hwang S, Cobb D, Bhadra R, Youngblood B, Khan I. Blimp-1-mediated CD4 T cell exhaustion causes CD8 T cell dysfunction during chronic toxoplasmosis. J Exp Med. 2016;213:1799-818 pubmed publisher
  13. Kritikou J, Dahlberg C, Baptista M, Wagner A, Banerjee P, Gwalani L, et al. IL-2 in the tumor microenvironment is necessary for Wiskott-Aldrich syndrome protein deficient NK cells to respond to tumors in vivo. Sci Rep. 2016;6:30636 pubmed publisher
  14. Chow K, Delconte R, Huntington N, Tarlinton D, Sutherland R, Zhan Y, et al. Innate Allorecognition Results in Rapid Accumulation of Monocyte-Derived Dendritic Cells. J Immunol. 2016;197:2000-8 pubmed publisher
  15. Ludigs K, Jandus C, Utzschneider D, Staehli F, Bessoles S, Dang A, et al. NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions. Nat Commun. 2016;7:10554 pubmed publisher
  16. Okada K, Sato S, Sato A, Mandelboim O, Yamasoba T, Kiyono H. Identification and Analysis of Natural Killer Cells in Murine Nasal Passages. PLoS ONE. 2015;10:e0142920 pubmed publisher
  17. Zhang Z, Wu N, Lu Y, Davidson D, Colonna M, Veillette A. DNAM-1 controls NK cell activation via an ITT-like motif. J Exp Med. 2015;212:2165-82 pubmed publisher
  18. Wensveen F, Jelenčić V, Valentić S, Šestan M, Wensveen T, Theurich S, et al. NK cells link obesity-induced adipose stress to inflammation and insulin resistance. Nat Immunol. 2015;16:376-85 pubmed publisher
  19. Jing W, Gershan J, Weber J, Tlomak D, McOlash L, Sabatos Peyton C, et al. Combined immune checkpoint protein blockade and low dose whole body irradiation as immunotherapy for myeloma. J Immunother Cancer. 2015;3:2 pubmed publisher
  20. Huang Y, Tsai K, Ma C, Vallance B, Priatel J, Tan R. SLAM-SAP signaling promotes differentiation of IL-17-producing T cells and progression of experimental autoimmune encephalomyelitis. J Immunol. 2014;193:5841-53 pubmed publisher
  21. Wickström S, Oberg L, Kärre K, Johansson M. A genetic defect in mice that impairs missing self recognition despite evidence for normal maturation and MHC class I-dependent education of NK cells. J Immunol. 2014;192:1577-86 pubmed publisher