This is a Validated Antibody Database (VAD) review about human trkA, based on 29 published articles (read how Labome selects the articles), using trkA antibody in all methods. It is aimed to help Labome visitors find the most suited trkA antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
trkA synonym: MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA

Abcam
domestic rabbit monoclonal (EP1058Y)
  • immunohistochemistry; mouse; loading ...; fig 5b
  • western blot; mouse; 1:1000; loading ...; fig 4a
  • immunohistochemistry; human; fig 5a
Abcam trkA antibody (Abcam, ab76291) was used in immunohistochemistry on mouse samples (fig 5b), in western blot on mouse samples at 1:1000 (fig 4a) and in immunohistochemistry on human samples (fig 5a). EJNMMI Res (2022) ncbi
domestic rabbit monoclonal (EP1058Y)
  • immunohistochemistry; fruit fly ; 1:100; loading ...
Abcam trkA antibody (Abcam, ab76291) was used in immunohistochemistry on fruit fly samples at 1:100. Sci Rep (2021) ncbi
domestic rabbit monoclonal (EP1058Y)
  • immunohistochemistry; human; loading ...
Abcam trkA antibody (Abcam, ab76291) was used in immunohistochemistry on human samples . Mod Pathol (2021) ncbi
domestic rabbit monoclonal (EPR19140)
  • western blot; mouse; 1:1000; loading ...; fig 6d
Abcam trkA antibody (Abcam, ab197071) was used in western blot on mouse samples at 1:1000 (fig 6d). Cancers (Basel) (2020) ncbi
domestic rabbit monoclonal (EP1058Y)
  • immunocytochemistry; human; loading ...; fig 1c
Abcam trkA antibody (Abcam, ab76291) was used in immunocytochemistry on human samples (fig 1c). Cell Rep (2020) ncbi
domestic rabbit monoclonal (EP1058Y)
  • immunohistochemistry - frozen section; mouse; loading ...; fig 5b
Abcam trkA antibody (Abcam, ab76291) was used in immunohistochemistry - frozen section on mouse samples (fig 5b). Proc Natl Acad Sci U S A (2017) ncbi
domestic rabbit monoclonal (EP1058Y)
  • western blot; human; 1:2000; loading ...; fig 1B
  • proximity ligation assay; rat; fig 5C
  • western blot; rat; 1:2000; fig 6F
Abcam trkA antibody (Abcam, ab76291) was used in western blot on human samples at 1:2000 (fig 1B), in proximity ligation assay on rat samples (fig 5C) and in western blot on rat samples at 1:2000 (fig 6F). Front Mol Neurosci (2017) ncbi
Santa Cruz Biotechnology
mouse monoclonal (E-6)
  • western blot; mouse; 1:1000; loading ...; fig 5c
Santa Cruz Biotechnology trkA antibody (Santa Cruz, sc-8058) was used in western blot on mouse samples at 1:1000 (fig 5c). Sci Rep (2020) ncbi
mouse monoclonal (B-3)
  • immunohistochemistry - frozen section; zebrafish ; 1:200; loading ...; fig s6c
Santa Cruz Biotechnology trkA antibody (Santa Cruz, sc-7268) was used in immunohistochemistry - frozen section on zebrafish samples at 1:200 (fig s6c). PLoS Biol (2020) ncbi
mouse monoclonal (B-3)
  • immunoprecipitation; human; loading ...; fig 1B
  • proximity ligation assay; rat; fig 5A
Santa Cruz Biotechnology trkA antibody (Santa Cruz, sc-7268) was used in immunoprecipitation on human samples (fig 1B) and in proximity ligation assay on rat samples (fig 5A). Front Mol Neurosci (2017) ncbi
mouse monoclonal (B-3)
  • immunoprecipitation; mouse; fig 4
  • western blot; mouse; 1:1000; fig 4
Santa Cruz Biotechnology trkA antibody (Santa Cruz, sc7268) was used in immunoprecipitation on mouse samples (fig 4) and in western blot on mouse samples at 1:1000 (fig 4). Aging Cell (2016) ncbi
R&D Systems
domestic goat polyclonal
  • western blot; mouse; loading ...; fig 2e
R&D Systems trkA antibody (R&D Systems, AF175) was used in western blot on mouse samples (fig 2e). Proc Natl Acad Sci U S A (2017) ncbi
domestic goat polyclonal
  • western blot; human; 1:200; loading ...; fig s3
R&D Systems trkA antibody (R&D System, AF175) was used in western blot on human samples at 1:200 (fig s3). Oncotarget (2016) ncbi
Alomone Labs
domestic rabbit polyclonal
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 2f
Alomone Labs trkA antibody (Alomone Labs, ANT-018) was used in immunohistochemistry - frozen section on mouse samples at 1:100 (fig 2f). Dis Model Mech (2022) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (C50F3)
  • western blot; mouse; loading ...; fig 5e, 5f
Cell Signaling Technology trkA antibody (Cell Signaling, 4621) was used in western blot on mouse samples (fig 5e, 5f). Acta Neuropathol Commun (2022) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 4a
Cell Signaling Technology trkA antibody (Cell Signaling Technology, 9141) was used in western blot on mouse samples (fig 4a). Redox Biol (2021) ncbi
domestic rabbit monoclonal (C50F3)
  • western blot; mouse; 1:1000; loading ...; fig 1j
Cell Signaling Technology trkA antibody (Cell signaling, 4621) was used in western blot on mouse samples at 1:1000 (fig 1j). Transl Psychiatry (2021) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 1k
Cell Signaling Technology trkA antibody (Cell Signaling, 2505) was used in western blot on mouse samples at 1:1000 (fig 1k). Sci Adv (2020) ncbi
domestic rabbit monoclonal (C50F3)
  • western blot; human; loading ...; fig 5f
Cell Signaling Technology trkA antibody (Cell Signaling, 4621) was used in western blot on human samples (fig 5f). Breast Cancer Res (2019) ncbi
domestic rabbit polyclonal
  • western blot; rat; loading ...; fig 10k
Cell Signaling Technology trkA antibody (Cell Signaling Technology, 2505) was used in western blot on rat samples (fig 10k). J Neurosci (2018) ncbi
domestic rabbit monoclonal (C35G9)
  • western blot; human; fig 1b
Cell Signaling Technology trkA antibody (Cell Signaling, 4619) was used in western blot on human samples (fig 1b). Cancer Res (2017) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 1b
Cell Signaling Technology trkA antibody (Cell Signaling, 9141) was used in western blot on human samples (fig 1b). Cancer Res (2017) ncbi
domestic rabbit polyclonal
  • western blot; rat; loading ...; fig 5a
Cell Signaling Technology trkA antibody (Cell Signaling, 2505) was used in western blot on rat samples (fig 5a). Front Neurosci (2016) ncbi
domestic rabbit polyclonal
  • western blot; rat; loading ...; fig 5a
Cell Signaling Technology trkA antibody (Cell Signaling, 9141) was used in western blot on rat samples (fig 5a). Front Neurosci (2016) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; fig 4
Cell Signaling Technology trkA antibody (Cell Signaling, 9141) was used in western blot on mouse samples at 1:1000 (fig 4). Aging Cell (2016) ncbi
domestic rabbit monoclonal (C50F3)
  • western blot; human; 1:500; fig s7
Cell Signaling Technology trkA antibody (Cell Signaling Technology, C50F3) was used in western blot on human samples at 1:500 (fig s7). Cell Rep (2016) ncbi
domestic rabbit monoclonal (C67C8)
  • western blot; mouse; 1:1000; loading ...; fig 4c
Cell Signaling Technology trkA antibody (Cell Signaling, 4168S) was used in western blot on mouse samples at 1:1000 (fig 4c). Mol Med Rep (2016) ncbi
domestic rabbit monoclonal (C50F3)
  • western blot; mouse; 1:1000; fig 3
In order to analyze a mouse model where human neural stem cells alleviate Alzheimer-like pathology, Cell Signaling Technology trkA antibody (Cell Signaling Technology, 4621) was used in western blot on mouse samples at 1:1000 (fig 3). Mol Neurodegener (2015) ncbi
domestic rabbit monoclonal (C50F3)
  • western blot; mouse; fig 6.g
In order to describe how PTP1B is a mechanism-based therapeutic target for Rett syndrome, Cell Signaling Technology trkA antibody (Cell Signaling Technology, 4621) was used in western blot on mouse samples (fig 6.g). J Clin Invest (2015) ncbi
domestic rabbit monoclonal (C35G9)
  • western blot; human; fig 6.e,f
  • western blot; mouse; fig 6.e,f
In order to describe how PTP1B is a mechanism-based therapeutic target for Rett syndrome, Cell Signaling Technology trkA antibody (Cell Signaling Technology, 4619) was used in western blot on human samples (fig 6.e,f) and in western blot on mouse samples (fig 6.e,f). J Clin Invest (2015) ncbi
domestic rabbit monoclonal (C50F3)
  • western blot; human
Cell Signaling Technology trkA antibody (Cell Signaling, C50F3) was used in western blot on human samples . Mucosal Immunol (2015) ncbi
domestic rabbit monoclonal (C50F3)
  • western blot; human
Cell Signaling Technology trkA antibody (Cell Signaling, 4621) was used in western blot on human samples . Oncotarget (2014) ncbi
domestic rabbit monoclonal (C50F3)
  • western blot; rat; 1:1000
In order to study the role of BDNF in the incubation of cocaine craving following withrawal from extended self-administration, Cell Signaling Technology trkA antibody (Cell Signaling, 4621) was used in western blot on rat samples at 1:1000. J Neurosci (2013) ncbi
ATCC
mouse monoclonal
  • immunohistochemistry - paraffin section; dogs; 1:5; fig 5
ATCC trkA antibody (ATCC, HB8737) was used in immunohistochemistry - paraffin section on dogs samples at 1:5 (fig 5). Brain Behav (2016) ncbi
mouse monoclonal
  • immunohistochemistry; dogs; fig 1
ATCC trkA antibody (ATCC, clone HB8737) was used in immunohistochemistry on dogs samples (fig 1). PLoS ONE (2015) ncbi
Articles Reviewed
  1. Wuest M, Bailey J, Dufour J, Glubrecht D, Omana V, Johnston T, et al. Toward in vivo proof of binding of 18F-labeled inhibitor [18F]TRACK to peripheral tropomyosin receptor kinases. EJNMMI Res. 2022;12:46 pubmed publisher
  2. Rauskolb S, Andreska T, Fries S, von Collenberg C, Blum R, Monoranu C, et al. Insulin-like growth factor 5 associates with human Aß plaques and promotes cognitive impairment. Acta Neuropathol Commun. 2022;10:68 pubmed publisher
  3. Liu Y, Cong P, Zhang T, Wang R, Wang X, Liu J, et al. Plasmalogen attenuates the development of hepatic steatosis and cognitive deficit through mechanism involving p75NTR inhibition. Redox Biol. 2021;43:102002 pubmed publisher
  4. Strohmeier S, Brcic I, Popper H, Liegl Atzwanger B, Lindenmann J, Brcic L. Applicability of pan-TRK immunohistochemistry for identification of NTRK fusions in lung carcinoma. Sci Rep. 2021;11:9785 pubmed publisher
  5. Karpinski B, Maynard T, Bryan C, Yitsege G, Horvath A, Lee N, et al. Selective disruption of trigeminal sensory neurogenesis and differentiation in a mouse model of 22q11.2 deletion syndrome. Dis Model Mech. 2022;15: pubmed publisher
  6. Xiao L, Sharma V, Toulabi L, Yang X, Lee C, Abebe D, et al. Neurotrophic factor-α1, a novel tropin is critical for the prevention of stress-induced hippocampal CA3 cell death and cognitive dysfunction in mice: comparison to BDNF. Transl Psychiatry. 2021;11:24 pubmed publisher
  7. Brcic I, Godschachner T, Bergovec M, Igrec J, Till H, Lackner H, et al. Broadening the spectrum of NTRK rearranged mesenchymal tumors and usefulness of pan-TRK immunohistochemistry for identification of NTRK fusions. Mod Pathol. 2021;34:396-407 pubmed publisher
  8. Teramura Y, Tanaka M, Yamazaki Y, Yamashita K, Takazawa Y, Ae K, et al. Identification of Novel Fusion Genes in Bone and Soft Tissue Sarcoma and Their Implication in the Generation of a Mouse Model. Cancers (Basel). 2020;12: pubmed publisher
  9. Kucharava K, Brand Y, Albano G, Sekulic Jablanovic M, Glutz A, Xian X, et al. Sodium-hydrogen exchanger 6 (NHE6) deficiency leads to hearing loss, via reduced endosomal signalling through the BDNF/Trk pathway. Sci Rep. 2020;10:3609 pubmed publisher
  10. Xhima K, Markham Coultes K, Nedev H, Heinen S, Saragovi H, Hynynen K, et al. Focused ultrasound delivery of a selective TrkA agonist rescues cholinergic function in a mouse model of Alzheimer's disease. Sci Adv. 2020;6:eaax6646 pubmed publisher
  11. Nickolls A, Lee M, Espinoza D, Szczot M, Lam R, Wang Q, et al. Transcriptional Programming of Human Mechanosensory Neuron Subtypes from Pluripotent Stem Cells. Cell Rep. 2020;30:932-946.e7 pubmed publisher
  12. Bhattarai P, Cosacak M, Mashkaryan V, Demir S, Popova S, Govindarajan N, et al. Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative neurogenesis in Alzheimer's model of adult zebrafish brain. PLoS Biol. 2020;18:e3000585 pubmed publisher
  13. Kennedy S, Han J, Portman N, Nobis M, Hastings J, Murphy K, et al. Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer. Breast Cancer Res. 2019;21:43 pubmed publisher
  14. Mironets E, Osei Owusu P, Bracchi Ricard V, Fischer R, Owens E, Ricard J, et al. Soluble TNFα Signaling within the Spinal Cord Contributes to the Development of Autonomic Dysreflexia and Ensuing Vascular and Immune Dysfunction after Spinal Cord Injury. J Neurosci. 2018;38:4146-4162 pubmed publisher
  15. Wang R, Cao X, Kulej K, Liu W, Ma T, MacDonald M, et al. Uncovering BRD4 hyperphosphorylation associated with cellular transformation in NUT midline carcinoma. Proc Natl Acad Sci U S A. 2017;114:E5352-E5361 pubmed publisher
  16. Vaishnavi A, Schubert L, Rix U, Marek L, Le A, Keysar S, et al. EGFR Mediates Responses to Small-Molecule Drugs Targeting Oncogenic Fusion Kinases. Cancer Res. 2017;77:3551-3563 pubmed publisher
  17. Canu N, Pagano I, La Rosa L, Pellegrino M, Ciotti M, Mercanti D, et al. Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents. Front Mol Neurosci. 2017;10:15 pubmed publisher
  18. Pandini G, Satriano C, Pietropaolo A, Gianì F, Travaglia A, La Mendola D, et al. The Inorganic Side of NGF: Copper(II) and Zinc(II) Affect the NGF Mimicking Signaling of the N-Terminus Peptides Encompassing the Recognition Domain of TrkA Receptor. Front Neurosci. 2016;10:569 pubmed publisher
  19. Pinet S, Bessette B, Vedrenne N, Lacroix A, Richard L, Jauberteau M, et al. TrkB-containing exosomes promote the transfer of glioblastoma aggressiveness to YKL-40-inactivated glioblastoma cells. Oncotarget. 2016;7:50349-50364 pubmed publisher
  20. Spitzbarth I, Lempp C, Kegler K, Ulrich R, Kalkuhl A, Deschl U, et al. Immunohistochemical and transcriptome analyses indicate complex breakdown of axonal transport mechanisms in canine distemper leukoencephalitis. Brain Behav. 2016;6:e00472 pubmed publisher
  21. Triaca V, Sposato V, Bolasco G, Ciotti M, Pelicci P, Bruni A, et al. NGF controls APP cleavage by downregulating APP phosphorylation at Thr668: relevance for Alzheimer's disease. Aging Cell. 2016;15:661-72 pubmed publisher
  22. Wang Y, Jones Tabah J, Chakravarty P, Stewart A, Muotri A, Laposa R, et al. Pharmacological Bypass of Cockayne Syndrome B Function in Neuronal Differentiation. Cell Rep. 2016;14:2554-61 pubmed publisher
  23. Lin R, Chen J, Li X, Mao J, Wu Y, Zhuo P, et al. Electroacupuncture at the Baihui acupoint alleviates cognitive impairment and exerts neuroprotective effects by modulating the expression and processing of brain-derived neurotrophic factor in APP/PS1 transgenic mice. Mol Med Rep. 2016;13:1611-7 pubmed publisher
  24. Lee I, Jung K, Kim I, Lee H, Kim M, Yun S, et al. Human neural stem cells alleviate Alzheimer-like pathology in a mouse model. Mol Neurodegener. 2015;10:38 pubmed publisher
  25. Krishnan N, Krishnan K, Connors C, Choy M, Page R, Peti W, et al. PTP1B inhibition suggests a therapeutic strategy for Rett syndrome. J Clin Invest. 2015;125:3163-77 pubmed publisher
  26. Kegler K, Spitzbarth I, Imbschweiler I, Wewetzer K, Baumgärtner W, Seehusen F. Contribution of Schwann Cells to Remyelination in a Naturally Occurring Canine Model of CNS Neuroinflammation. PLoS ONE. 2015;10:e0133916 pubmed publisher
  27. Rochman M, Kartashov A, Caldwell J, Collins M, Stucke E, Kc K, et al. Neurotrophic tyrosine kinase receptor 1 is a direct transcriptional and epigenetic target of IL-13 involved in allergic inflammation. Mucosal Immunol. 2015;8:785-98 pubmed publisher
  28. Pajtler K, Mahlow E, Odersky A, Lindner S, Stephan H, Bendix I, et al. Neuroblastoma in dialog with its stroma: NTRK1 is a regulator of cellular cross-talk with Schwann cells. Oncotarget. 2014;5:11180-92 pubmed
  29. Li X, DeJoseph M, Urban J, Bahi A, Dreyer J, Meredith G, et al. Different roles of BDNF in nucleus accumbens core versus shell during the incubation of cue-induced cocaine craving and its long-term maintenance. J Neurosci. 2013;33:1130-42 pubmed publisher