This is a Validated Antibody Database (VAD) review about human syntaxin, based on 28 published articles (read how Labome selects the articles), using syntaxin antibody in all methods. It is aimed to help Labome visitors find the most suited syntaxin antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
syntaxin synonym: HPC-1; P35-1; STX1; SYN1A; syntaxin-1A; neuron-specific antigen HPC-1; syntaxin 1A (brain)

Synaptic Systems
mouse monoclonal (78.2)
  • western blot; mouse; 1:1000; loading ...; fig 1
Synaptic Systems syntaxin antibody (Synaptic Systems, 110 011) was used in western blot on mouse samples at 1:1000 (fig 1). elife (2019) ncbi
rabbit polyclonal (/)
  • immunohistochemistry; rat; loading ...; fig 8b
Synaptic Systems syntaxin antibody (Synaptic Systems, 110 302) was used in immunohistochemistry on rat samples (fig 8b). EMBO J (2018) ncbi
mouse monoclonal (78.3)
  • immunohistochemistry; mouse; loading ...; fig 6a
Synaptic Systems syntaxin antibody (Synaptic Systems, 110,111) was used in immunohistochemistry on mouse samples (fig 6a). Acta Neuropathol Commun (2017) ncbi
mouse monoclonal (78.3)
  • western blot; mouse; 1:1000; fig 3i
Synaptic Systems syntaxin antibody (Synaptic Systems, 78.3) was used in western blot on mouse samples at 1:1000 (fig 3i). Nat Commun (2017) ncbi
mouse monoclonal (78.3)
  • western blot; mouse; loading ...; fig 2a
Synaptic Systems syntaxin antibody (Synaptic Systems, 110111) was used in western blot on mouse samples (fig 2a). elife (2017) ncbi
mouse monoclonal (78.2)
  • western blot; mouse; loading ...; fig 4
  • immunocytochemistry; rat; loading ...; fig 9
In order to generate an atoxic derivative of Botulism neurotoxin/C1 and assess whether it retains neuron-specific targeting without concomitant toxic host responses, Synaptic Systems syntaxin antibody (Synaptic Systems, 110011) was used in western blot on mouse samples (fig 4) and in immunocytochemistry on rat samples (fig 9). Sci Rep (2017) ncbi
mouse monoclonal (78.2)
  • western blot; rat; 1:2000; loading ...; fig 5a
In order to develop methods to study vesicle-associated proteins and exocytosis in stellate astrocytes, Synaptic Systems syntaxin antibody (Synaptic Systems, 110011) was used in western blot on rat samples at 1:2000 (fig 5a). J Gen Physiol (2017) ncbi
mouse monoclonal (78.2)
  • western blot; mouse; 1:1000; fig 3a
Synaptic Systems syntaxin antibody (SySy, 110011) was used in western blot on mouse samples at 1:1000 (fig 3a). EMBO Mol Med (2017) ncbi
mouse monoclonal (78.3)
  • immunoprecipitation; rat; fig 4a
  • western blot; rat; 1:2000; fig 3a
Synaptic Systems syntaxin antibody (Synaptic Systems, 110111) was used in immunoprecipitation on rat samples (fig 4a) and in western blot on rat samples at 1:2000 (fig 3a). PLoS ONE (2016) ncbi
mouse monoclonal (78.2)
  • immunocytochemistry; mouse; fig 6a
Synaptic Systems syntaxin antibody (Synaptic Systems, 110011) was used in immunocytochemistry on mouse samples (fig 6a). Mol Biol Cell (2016) ncbi
mouse monoclonal (78.2)
  • western blot; human; 1:10,000; fig 6B
Synaptic Systems syntaxin antibody (Synaptic System, 110011) was used in western blot on human samples at 1:10,000 (fig 6B). Acta Neuropathol Commun (2015) ncbi
mouse monoclonal (78.2)
  • immunohistochemistry; mouse; 1:100; fig 4
  • immunohistochemistry; rat; 1:100; fig 4
Synaptic Systems syntaxin antibody (Synaptic Systems, 78.2) was used in immunohistochemistry on mouse samples at 1:100 (fig 4) and in immunohistochemistry on rat samples at 1:100 (fig 4). Neuroscience (2015) ncbi
mouse monoclonal (78.3)
  • western blot; rat; 1:250; fig 1
  • western blot; human; 1:100
Synaptic Systems syntaxin antibody (Synaptic Systems, 78.3) was used in western blot on rat samples at 1:250 (fig 1) and in western blot on human samples at 1:100. Neuroscience (2015) ncbi
Santa Cruz Biotechnology
mouse monoclonal (HPC-1)
  • western blot; human; 1:1000; loading ...; fig 5c
Santa Cruz Biotechnology syntaxin antibody (Santa Cruz, SC12736) was used in western blot on human samples at 1:1000 (fig 5c). Proc Natl Acad Sci U S A (2018) ncbi
mouse monoclonal (HPC-1)
  • western blot; rat
Santa Cruz Biotechnology syntaxin antibody (Santa Cruz, SC 12736) was used in western blot on rat samples . Arq Bras Oftalmol (2015) ncbi
mouse monoclonal (HPC-1)
  • western blot; human; 1:600
Santa Cruz Biotechnology syntaxin antibody (Santa Cruz, sc-12736) was used in western blot on human samples at 1:600. PLoS ONE (2015) ncbi
mouse monoclonal (SP8)
  • western blot; rat
In order to test if alpha-synuclein modulates neurotransmitter release, Santa Cruz Biotechnology syntaxin antibody (Santa Cruz Biotechnology, sc-58299) was used in western blot on rat samples . J Neurosci (2014) ncbi
mouse monoclonal (HPC-1)
  • western blot; mouse; 1:2500
Santa Cruz Biotechnology syntaxin antibody (Santa Cruz, sc-12736) was used in western blot on mouse samples at 1:2500. J Comp Neurol (2013) ncbi
mouse monoclonal (HPC-1)
  • western blot; mouse
Santa Cruz Biotechnology syntaxin antibody (Santa, sc-12736) was used in western blot on mouse samples . Biochim Biophys Acta (2013) ncbi
Invitrogen
mouse monoclonal (SP6)
  • immunocytochemistry; human; 1:200; loading ...; tbl 1
In order to describe a method to produce human embryonic stem cell-derived Beta-like cells, Invitrogen syntaxin antibody (Thermo Fisher, MA5-17612) was used in immunocytochemistry on human samples at 1:200 (tbl 1). PLoS ONE (2016) ncbi
mouse monoclonal (SP6)
  • immunohistochemistry - paraffin section; human; 1:250
In order to study how proliferative restrictions of supporting cells are linked with DNA damage signaling, Invitrogen syntaxin antibody (LabVision/Thermo Scientific, #RM-9106, clone SP6) was used in immunohistochemistry - paraffin section on human samples at 1:250. Aging (Albany NY) (2014) ncbi
mouse monoclonal (SP6)
  • immunohistochemistry; rat; 1:300
In order to measure the expression of individual HDACs in the oligodendrocyte lineage during stroke-induced oligodendrogenesis, Invitrogen syntaxin antibody (Thermo Scientific, RM-9106) was used in immunohistochemistry on rat samples at 1:300. Neurochem Int (2014) ncbi
Abcam
rabbit polyclonal
Abcam syntaxin antibody (Abcam, ab41453) was used . elife (2019) ncbi
rabbit polyclonal
  • western blot; rat; 1:3000; fig 4
Abcam syntaxin antibody (Abcam, ab41453) was used in western blot on rat samples at 1:3000 (fig 4). Int J Neuropsychopharmacol (2015) ncbi
rabbit polyclonal
  • western blot; mouse; fig 1
Abcam syntaxin antibody (Abcam, ab41453) was used in western blot on mouse samples (fig 1). Diabetes (2013) ncbi
rabbit polyclonal
  • immunohistochemistry - frozen section; rat; 1:100
Abcam syntaxin antibody (Abcam, ab41453) was used in immunohistochemistry - frozen section on rat samples at 1:100. PLoS ONE (2012) ncbi
MilliporeSigma
mouse monoclonal (1F9-1C9)
  • western blot; rat; 1:2500; loading ...; fig 5e
MilliporeSigma syntaxin antibody (Sigma-Aldrich, WH0006804M1-100UG) was used in western blot on rat samples at 1:2500 (fig 5e). J Cell Biol (2017) ncbi
EMD Millipore
mouse monoclonal (SP8)
  • immunocytochemistry; rat; 1:2000; fig 3a
EMD Millipore syntaxin antibody (Millipore, MAB336) was used in immunocytochemistry on rat samples at 1:2000 (fig 3a). Int J Neuropsychopharmacol (2017) ncbi
mouse monoclonal (SP8)
  • western blot; rat; 1:4000
EMD Millipore syntaxin antibody (Chemicon, MAB336) was used in western blot on rat samples at 1:4000. Clin Psychopharmacol Neurosci (2012) ncbi
Articles Reviewed
  1. Raja M, Preobraschenski J, Del Olmo Cabrera S, Martínez Turrillas R, Jahn R, Pérez Otaño I, et al. Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts. elife. 2019;8: pubmed publisher
  2. Li Y, Li K, Hu W, Ojcius D, Fang J, Li S, et al. Endocytic recycling and vesicular transport systems mediate transcytosis of Leptospira interrogans across cell monolayer. elife. 2019;8: pubmed publisher
  3. Truckenbrodt S, Viplav A, Jähne S, Vogts A, Denker A, Wildhagen H, et al. Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission. EMBO J. 2018;37: pubmed publisher
  4. Wang Y, Figueiredo D, Sun X, Dong Z, Chen W, Cui W, et al. Controlling of glutamate release by neuregulin3 via inhibiting the assembly of the SNARE complex. Proc Natl Acad Sci U S A. 2018;115:2508-2513 pubmed publisher
  5. Hamada N, Iwamoto I, Tabata H, Nagata K. MUNC18-1 gene abnormalities are involved in neurodevelopmental disorders through defective cortical architecture during brain development. Acta Neuropathol Commun. 2017;5:92 pubmed publisher
  6. Lüningschrör P, Binotti B, Dombert B, Heimann P, Pérez Lara A, Slotta C, et al. Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease. Nat Commun. 2017;8:678 pubmed publisher
  7. Zhang X, Jiang S, Mitok K, Li L, Attie A, Martin T. BAIAP3, a C2 domain-containing Munc13 protein, controls the fate of dense-core vesicles in neuroendocrine cells. J Cell Biol. 2017;216:2151-2166 pubmed publisher
  8. Daniel J, Cooper B, Palvimo J, Zhang F, Brose N, Tirard M. Analysis of SUMO1-conjugation at synapses. elife. 2017;6: pubmed publisher
  9. Escobar A, González M, Meza R, Noches V, Henny P, Gysling K, et al. Mechanisms of Kappa Opioid Receptor Potentiation of Dopamine D2 Receptor Function in Quinpirole-Induced Locomotor Sensitization in Rats. Int J Neuropsychopharmacol. 2017;20:660-669 pubmed publisher
  10. Vazquez Cintron E, Beske P, Tenezaca L, Tran B, Oyler J, Glotfelty E, et al. Engineering Botulinum Neurotoxin C1 as a Molecular Vehicle for Intra-Neuronal Drug Delivery. Sci Rep. 2017;7:42923 pubmed publisher
  11. Wolfes A, Ahmed S, Awasthi A, Stahlberg M, Rajput A, Magruder D, et al. A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes. J Gen Physiol. 2017;149:149-170 pubmed publisher
  12. Sambri I, D Alessio R, Ezhova Y, Giuliano T, Sorrentino N, Cacace V, et al. Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases. EMBO Mol Med. 2017;9:112-132 pubmed publisher
  13. Massumi M, Pourasgari F, Nalla A, Batchuluun B, Nagy K, Neely E, et al. An Abbreviated Protocol for In Vitro Generation of Functional Human Embryonic Stem Cell-Derived Beta-Like Cells. PLoS ONE. 2016;11:e0164457 pubmed publisher
  14. Takeuchi S, Iwama S, Takagi H, Kiyota A, Nakashima K, Izumida H, et al. Tomosyn Negatively Regulates Arginine Vasopressin Secretion in Embryonic Stem Cell-Derived Neurons. PLoS ONE. 2016;11:e0164544 pubmed publisher
  15. Toft Bertelsen T, Ziomkiewicz I, Houy S, Pinheiro P, Sørensen J. Regulation of Ca2+ channels by SNAP-25 via recruitment of syntaxin-1 from plasma membrane clusters. Mol Biol Cell. 2016;27:3329-3341 pubmed
  16. Benítez B, Cairns N, Schmidt R, Morris J, Norton J, Cruchaga C, et al. Clinically early-stage CSPα mutation carrier exhibits remarkable terminal stage neuronal pathology with minimal evidence of synaptic loss. Acta Neuropathol Commun. 2015;3:73 pubmed publisher
  17. Zhou J, Liu Z, Yu J, Han X, Fan S, Shao W, et al. Quantitative Proteomic Analysis Reveals Molecular Adaptations in the Hippocampal Synaptic Active Zone of Chronic Mild Stress-Unsusceptible Rats. Int J Neuropsychopharmacol. 2015;19: pubmed publisher
  18. Dias A, Batista T, Roma L, Módulo C, Malki L, Dias L, et al. Insulin replacement restores the vesicular secretory apparatus in the diabetic rat lacrimal gland. Arq Bras Oftalmol. 2015;78:158-63 pubmed publisher
  19. Tsukamoto K, Ozeki C, Kohda T, Tsuji T. CRISPR/Cas9-Mediated Genomic Deletion of the Beta-1, 4 N-acetylgalactosaminyltransferase 1 Gene in Murine P19 Embryonal Carcinoma Cells Results in Low Sensitivity to Botulinum Neurotoxin Type C. PLoS ONE. 2015;10:e0132363 pubmed publisher
  20. Tao Cheng J, Pham A, Yang Y, Winters C, Gallant P, Reese T. Syntaxin 4 is concentrated on plasma membrane of astrocytes. Neuroscience. 2015;286:264-71 pubmed publisher
  21. Ronzitti G, Bucci G, Emanuele M, Leo D, Sotnikova T, Mus L, et al. Exogenous ?-synuclein decreases raft partitioning of Cav2.2 channels inducing dopamine release. J Neurosci. 2014;34:10603-15 pubmed publisher
  22. Laos M, Anttonen T, Kirjavainen A, af Hällström T, Laiho M, Pirvola U. DNA damage signaling regulates age-dependent proliferative capacity of quiescent inner ear supporting cells. Aging (Albany NY). 2014;6:496-510 pubmed
  23. Kassis H, Chopp M, Liu X, Shehadah A, Roberts C, Zhang Z. Histone deacetylase expression in white matter oligodendrocytes after stroke. Neurochem Int. 2014;77:17-23 pubmed publisher
  24. Eagleson K, Milner T, Xie Z, Levitt P. Synaptic and extrasynaptic location of the receptor tyrosine kinase met during postnatal development in the mouse neocortex and hippocampus. J Comp Neurol. 2013;521:3241-59 pubmed publisher
  25. Song W, Mondal P, Li Y, Lee S, Hussain M. Pancreatic ?-cell response to increased metabolic demand and to pharmacologic secretagogues requires EPAC2A. Diabetes. 2013;62:2796-807 pubmed publisher
  26. Scarr E, Dean B. Altered neuronal markers following treatment with mood stabilizer and antipsychotic drugs indicate an increased likelihood of neurotransmitter release. Clin Psychopharmacol Neurosci. 2012;10:25-33 pubmed publisher
  27. Souza J, Vanzela E, Ribeiro R, Rezende L, de Oliveira C, Carneiro E, et al. Cholesterol reduction ameliorates glucose-induced calcium handling and insulin secretion in islets from low-density lipoprotein receptor knockout mice. Biochim Biophys Acta. 2013;1831:769-75 pubmed publisher
  28. Zhang H, Zhang X, Wang W, Xue Q, Lu H, Huang J, et al. Increased synaptophysin is involved in inflammation-induced heat hyperalgesia mediated by cyclin-dependent kinase 5 in rats. PLoS ONE. 2012;7:e46666 pubmed publisher