This is a Validated Antibody Database (VAD) review about human prostasin, based on 6 published articles (read how Labome selects the articles), using prostasin antibody in all methods. It is aimed to help Labome visitors find the most suited prostasin antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
prostasin synonym: CAP1; PROSTASIN; prostasin; channel-activating protease 1; protease, serine 8

Santa Cruz Biotechnology
mouse monoclonal (2)
  • immunohistochemistry; human; fig S1
Santa Cruz Biotechnology prostasin antibody (Santa Cruz Biotechnology, SC-136272) was used in immunohistochemistry on human samples (fig S1). J Ovarian Res (2016) ncbi
Proteintech Group
rabbit polyclonal
  • western blot; human; 1:1000
Proteintech Group prostasin antibody (Proteintech Group, 15527-1-AP) was used in western blot on human samples at 1:1000. Nephrol Dial Transplant (2015) ncbi
rabbit polyclonal
  • blocking or activating experiments; human
  • immunohistochemistry - paraffin section; human; 1:50
Proteintech Group prostasin antibody (Proteintech, 15527-1-AP) was used in blocking or activating experiments on human samples and in immunohistochemistry - paraffin section on human samples at 1:50. J Perinatol (2015) ncbi
R&D Systems
sheep polyclonal
  • immunocytochemistry; human; 1:200; fig 3
  • western blot; human; 1:1000; fig 3
R&D Systems prostasin antibody (R&D System, AF4599) was used in immunocytochemistry on human samples at 1:200 (fig 3) and in western blot on human samples at 1:1000 (fig 3). elife (2015) ncbi
BD Biosciences
mouse monoclonal (2/Prostasin)
  • western blot; human; loading ...; fig 6c
BD Biosciences prostasin antibody (BD Transduction, 612172) was used in western blot on human samples (fig 6c). Oncotarget (2015) ncbi
mouse monoclonal (2/Prostasin)
  • western blot; human
  • western blot; mouse
In order to determine the effect of ablating HAI-1 and HAI-2 on endogenous matriptase expression, subcellular localization, and activation in polarized intestinal epithelial cells, BD Biosciences prostasin antibody (BD Transduction Laboratories, 612173) was used in western blot on human samples and in western blot on mouse samples . J Biol Chem (2014) ncbi
Articles Reviewed
  1. Tamir A, Gangadharan A, Balwani S, Tanaka T, Patel U, Hassan A, et al. The serine protease prostasin (PRSS8) is a potential biomarker for early detection of ovarian cancer. J Ovarian Res. 2016;9:20 pubmed publisher
  2. Brunati M, Perucca S, Han L, Cattaneo A, Consolato F, Andolfo A, et al. The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin. elife. 2015;4:e08887 pubmed publisher
  3. Martin E, Buzza M, Driesbaugh K, Liu S, Fortenberry Y, Leppla S, et al. Targeting the membrane-anchored serine protease testisin with a novel engineered anthrax toxin prodrug to kill tumor cells and reduce tumor burden. Oncotarget. 2015;6:33534-53 pubmed publisher
  4. Andersen H, Friis U, Hansen P, Svenningsen P, Henriksen J, Jensen B. Diabetic nephropathy is associated with increased urine excretion of proteases plasmin, prostasin and urokinase and activation of amiloride-sensitive current in collecting duct cells. Nephrol Dial Transplant. 2015;30:781-9 pubmed publisher
  5. Yang Y, Zhang J, Gong Y, Liu X, Bai Y, Xu W, et al. Increased expression of prostasin contributes to early-onset severe preeclampsia through inhibiting trophoblast invasion. J Perinatol. 2015;35:16-22 pubmed publisher
  6. Friis S, Sales K, Schafer J, Vogel L, Kataoka H, Bugge T. The protease inhibitor HAI-2, but not HAI-1, regulates matriptase activation and shedding through prostasin. J Biol Chem. 2014;289:22319-32 pubmed publisher