This is a Validated Antibody Database (VAD) review about human prohibitin, based on 24 published articles (read how Labome selects the articles), using prohibitin antibody in all methods. It is aimed to help Labome visitors find the most suited prohibitin antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
prohibitin synonym: HEL-215; HEL-S-54e; PHB1

Abcam
domestic rabbit monoclonal (EP2803Y)
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig 3a, 4a
  • western blot; mouse; 1:10,000; loading ...; fig 3d, 4d
Abcam prohibitin antibody (Abcam, ab75766) was used in immunohistochemistry - paraffin section on mouse samples at 1:500 (fig 3a, 4a) and in western blot on mouse samples at 1:10,000 (fig 3d, 4d). Front Endocrinol (Lausanne) (2021) ncbi
domestic rabbit monoclonal (EP2803Y)
  • western blot; human; 1:3000
Abcam prohibitin antibody (Abcam, ab75766) was used in western blot on human samples at 1:3000. Aging Cell (2021) ncbi
domestic rabbit polyclonal
  • immunohistochemistry; mouse; 1:100; loading ...; fig 1a, S2a, S2c
In order to demonstrate that endothelial production of PDGF-CC during white adipose tissue angiogenesis regulates browning, Abcam prohibitin antibody (Abcam, ab28172) was used in immunohistochemistry on mouse samples at 1:100 (fig 1a, S2a, S2c). Nat Commun (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; fig 1
In order to compare colorectal and gastric cancer and their expression patterns and diagnostic efficacies of SR splicing factors and HNRNPA1, Abcam prohibitin antibody (Abcam, AB28172) was used in western blot on human samples at 1:1000 (fig 1). BMC Cancer (2016) ncbi
domestic rabbit monoclonal (EP2803Y)
  • western blot; human; 1:10,000; fig s6
In order to investigate regulatory mechanisms of MAVS activity, Abcam prohibitin antibody (Abcam, 75766) was used in western blot on human samples at 1:10,000 (fig s6). Nat Commun (2015) ncbi
domestic rabbit monoclonal (EP2804Y)
  • immunocytochemistry; human; 1:100
Abcam prohibitin antibody (Abcam, ab75771) was used in immunocytochemistry on human samples at 1:100. Reprod Biomed Online (2014) ncbi
Invitrogen
mouse monoclonal (II-14-10)
  • immunohistochemistry - paraffin section; human; loading ...; fig 2b
In order to show that PHB1 is highly expressed in non-small cell lung cancers patients and correlates with poor survival, Invitrogen prohibitin antibody (Thermo Fisher, MA5-12858) was used in immunohistochemistry - paraffin section on human samples (fig 2b). Oncogene (2017) ncbi
mouse monoclonal (II-14-10)
  • western blot; human; loading ...; fig 2c
In order to identify components of mitochondrial RNA granules, Invitrogen prohibitin antibody (Thermo Fisher Scientific, MA5-12858) was used in western blot on human samples (fig 2c). J Biol Chem (2017) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:500; loading ...; fig 1b
  • western blot; mouse; 1:500; loading ...; fig 2h
In order to recognize the inner mitochondrial membrane protein, prohibitin 2, as a crucial mitophagy receptor involved in targeting mitochondria for autophagic degradation, Invitrogen prohibitin antibody (ThermoFisher Scientific, PA5-19556) was used in western blot on human samples at 1:500 (fig 1b) and in western blot on mouse samples at 1:500 (fig 2h). Cell (2017) ncbi
mouse monoclonal (II-14-10)
  • western blot; human; loading ...; fig 2b
In order to examine the role of tissue transglutaminase 2 in the biogenesis of exosomes, Invitrogen prohibitin antibody (Lab Vision, MS-261-PABX) was used in western blot on human samples (fig 2b). Biochim Biophys Acta (2016) ncbi
mouse monoclonal (II-14-10)
  • western blot; rat; 1:250; fig 5a
In order to identify novel molecules in peripheral myelination by spatial mapping of juxtacrine axo-glial interactions, Invitrogen prohibitin antibody (Thermo Scientific, II-14-10) was used in western blot on rat samples at 1:250 (fig 5a). Nat Commun (2015) ncbi
mouse monoclonal (II-14-10)
  • western blot; pigs ; 1:100
In order to study hepatitis E pathogenesis and virulence mechanisms, Invitrogen prohibitin antibody (Thermo, MA512858) was used in western blot on pigs samples at 1:100. J Virol (2015) ncbi
mouse monoclonal (II-14-10)
  • immunohistochemistry - paraffin section; human; 1:100
In order to study how the 3' UTR 1630 C T polymorphism and copy number variation are associated with Prohibitin expression deregulation in gastric cancer, Invitrogen prohibitin antibody (ThermoFisher, II-14-10) was used in immunohistochemistry - paraffin section on human samples at 1:100. PLoS ONE (2014) ncbi
mouse monoclonal (II-14-10)
  • western blot; human
In order to study the role of prohibitins as endogenous Siglec-9 ligands that inhibit ERK signaling and IL-12 production by Jurkat cells, Invitrogen prohibitin antibody (Neo Markers, II-14-10) was used in western blot on human samples . Biochem Biophys Res Commun (2013) ncbi
mouse monoclonal (II-14-10)
  • western blot; human; fig 5
In order to investigate the role of brain and reproductive organ-expressed protein BRE in death receptor-mediated apoptosis, Invitrogen prohibitin antibody (Lab Vision, Ab-1) was used in western blot on human samples (fig 5). J Biol Chem (2004) ncbi
Santa Cruz Biotechnology
mouse monoclonal (E-5)
  • immunoprecipitation; human; 1:100; loading ...; fig 1b
In order to recognize the inner mitochondrial membrane protein, prohibitin 2, as a crucial mitophagy receptor involved in targeting mitochondria for autophagic degradation, Santa Cruz Biotechnology prohibitin antibody (Santa Cruz, sc-377037) was used in immunoprecipitation on human samples at 1:100 (fig 1b). Cell (2017) ncbi
mouse monoclonal (E-5)
  • immunocytochemistry; human; 1:2000; fig 3
  • western blot; human; 1:3000; fig 2
Santa Cruz Biotechnology prohibitin antibody (santa Cruz, sc-377037) was used in immunocytochemistry on human samples at 1:2000 (fig 3) and in western blot on human samples at 1:3000 (fig 2). Oncol Lett (2016) ncbi
Cell Signaling Technology
domestic rabbit polyclonal
  • immunohistochemistry; mouse; loading ...; fig 1h
  • western blot; mouse; 1:1000; loading ...; fig 1g
Cell Signaling Technology prohibitin antibody (Cell Signaling Technology, 2426S) was used in immunohistochemistry on mouse samples (fig 1h) and in western blot on mouse samples at 1:1000 (fig 1g). iScience (2022) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 4e
Cell Signaling Technology prohibitin antibody (Cell Signaling Technology, 2426) was used in western blot on human samples (fig 4e). Clin Transl Med (2021) ncbi
domestic rabbit polyclonal
  • western blot; rat; 1:1000; loading ...; fig 5f
Cell Signaling Technology prohibitin antibody (Cell Signaling Technology, 2426) was used in western blot on rat samples at 1:1000 (fig 5f). J Mol Med (Berl) (2021) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 6j
Cell Signaling Technology prohibitin antibody (Cell Signaling, 2426) was used in western blot on mouse samples (fig 6j). Nat Immunol (2020) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 5a
Cell Signaling Technology prohibitin antibody (CST, 2426S) was used in western blot on human samples at 1:1000 (fig 5a). Antioxidants (Basel) (2020) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 2a
Cell Signaling Technology prohibitin antibody (Cell Signaling, 2426) was used in western blot on human samples (fig 2a). J Cell Biol (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; fig 2
In order to study increased dissociation of hexokinase II from mitochondrial outer membrane by overexpression or ErbB2 rendering breast cancer cells susceptible to 3-BrPA, Cell Signaling Technology prohibitin antibody (Cell signaling, 2426) was used in western blot on human samples at 1:1000 (fig 2). Oncol Lett (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 2c
Cell Signaling Technology prohibitin antibody (Cell signaling, 2426) was used in western blot on human samples (fig 2c). J Neurochem (2016) ncbi
Articles Reviewed
  1. Bassi G, Mishra S. Prohibitin-1 plays a regulatory role in Leydig cell steroidogenesis. iScience. 2022;25:104165 pubmed publisher
  2. Sakai H, Kawakami H, Teramura T, Onodera Y, Somers E, Furuuchi K, et al. Folate receptor α increases chemotherapy resistance through stabilizing MDM2 in cooperation with PHB2 that is overcome by MORAb-202 in gastric cancer. Clin Transl Med. 2021;11:e454 pubmed publisher
  3. Zhang Y, Hu M, Yang F, Zhang Y, Ma S, Zhang D, et al. Increased uterine androgen receptor protein abundance results in implantation and mitochondrial defects in pregnant rats with hyperandrogenism and insulin resistance. J Mol Med (Berl). 2021;99:1427-1446 pubmed publisher
  4. Cheng L, Zhang S, Shang F, Ning Y, Huang Z, He R, et al. Emodin Improves Glucose and Lipid Metabolism Disorders in Obese Mice via Activating Brown Adipose Tissue and Inducing Browning of White Adipose Tissue. Front Endocrinol (Lausanne). 2021;12:618037 pubmed publisher
  5. Yu H, Liu Y, He B, He T, Chen C, He J, et al. Platelet biomarkers for a descending cognitive function: A proteomic approach. Aging Cell. 2021;20:e13358 pubmed publisher
  6. Zhou H, Wang H, Yu M, Schugar R, Qian W, Tang F, et al. IL-1 induces mitochondrial translocation of IRAK2 to suppress oxidative metabolism in adipocytes. Nat Immunol. 2020;21:1219-1231 pubmed publisher
  7. Alegre Cortés E, Muriel González A, Canales Cortés S, Uribe Carretero E, Martínez Chacón G, Aiastui A, et al. Toxicity of Necrostatin-1 in Parkinson's Disease Models. Antioxidants (Basel). 2020;9: pubmed publisher
  8. Yurugi H, Marini F, Weber C, David K, Zhao Q, Binder H, et al. Targeting prohibitins with chemical ligands inhibits KRAS-mediated lung tumours. Oncogene. 2017;36:4778-4789 pubmed publisher
  9. Zaganelli S, Rebelo Guiomar P, Maundrell K, Rozanska A, Pierredon S, Powell C, et al. The Pseudouridine Synthase RPUSD4 Is an Essential Component of Mitochondrial RNA Granules. J Biol Chem. 2017;292:4519-4532 pubmed publisher
  10. Wei Y, Chiang W, Sumpter R, Mishra P, Levine B. Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor. Cell. 2017;168:224-238.e10 pubmed publisher
  11. Du M, He K, Qin G, Chen J, Li J. Adriamycin resistance-associated prohibitin gene inhibits proliferation of human osteosarcoma MG63 cells by interacting with oncogenes and tumor suppressor genes. Oncol Lett. 2016;12:1994-2000 pubmed
  12. Seki T, Hosaka K, Lim S, Fischer C, Honek J, Yang Y, et al. Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat. Nat Commun. 2016;7:12152 pubmed publisher
  13. Park W, Kim H, Kang D, Ryu J, Choi K, Lee G, et al. Comparative expression patterns and diagnostic efficacies of SR splicing factors and HNRNPA1 in gastric and colorectal cancer. BMC Cancer. 2016;16:358 pubmed publisher
  14. Diaz Hidalgo L, Altuntas S, Rossin F, D Eletto M, Marsella C, Farrace M, et al. Transglutaminase type 2-dependent selective recruitment of proteins into exosomes under stressful cellular conditions. Biochim Biophys Acta. 2016;1863:2084-92 pubmed publisher
  15. Pryde K, Smith H, Chau K, Schapira A. PINK1 disables the anti-fission machinery to segregate damaged mitochondria for mitophagy. J Cell Biol. 2016;213:163-71 pubmed publisher
  16. Gao S, Chen X, Jin H, Ren S, Liu Z, Fang X, et al. Overexpression of ErbB2 renders breast cancer cells susceptible to 3-BrPA through the increased dissociation of hexokinase II from mitochondrial outer membrane. Oncol Lett. 2016;11:1567-1573 pubmed
  17. Ivankovic D, Chau K, Schapira A, Gegg M. Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin-mediated mitophagy. J Neurochem. 2016;136:388-402 pubmed publisher
  18. Poitelon Y, Bogni S, Matafora V, Della Flora Nunes G, Hurley E, Ghidinelli M, et al. Spatial mapping of juxtacrine axo-glial interactions identifies novel molecules in peripheral myelination. Nat Commun. 2015;6:8303 pubmed publisher
  19. Shi Y, Yuan B, Qi N, Zhu W, Su J, Li X, et al. An autoinhibitory mechanism modulates MAVS activity in antiviral innate immune response. Nat Commun. 2015;6:7811 pubmed publisher
  20. Qi X, Zhang Y, Ji H, Wu X, Wang F, Xie M, et al. Knockdown of prohibitin expression promotes glucose metabolism in eutopic endometrial stromal cells from women with endometriosis. Reprod Biomed Online. 2014;29:761-70 pubmed publisher
  21. Rogée S, Le Gall M, Chafey P, Bouquet J, Cordonnier N, Frederici C, et al. Quantitative proteomics identifies host factors modulated during acute hepatitis E virus infection in the swine model. J Virol. 2015;89:129-43 pubmed publisher
  22. Leal M, Cirilo P, Mazzotti T, Calcagno D, Wisnieski F, Demachki S, et al. Prohibitin expression deregulation in gastric cancer is associated with the 3' untranslated region 1630 C>T polymorphism and copy number variation. PLoS ONE. 2014;9:e98583 pubmed publisher
  23. Yurugi H, Tanida S, Akita K, Ishida A, Toda M, Nakada H. Prohibitins function as endogenous ligands for Siglec-9 and negatively regulate TCR signaling upon ligation. Biochem Biophys Res Commun. 2013;434:376-81 pubmed publisher
  24. Li Q, Ching A, Chan B, Chow S, Lim P, Ho T, et al. A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathway. J Biol Chem. 2004;279:52106-16 pubmed