This is a Validated Antibody Database (VAD) review about human nicastrin, based on 18 published articles (read how Labome selects the articles), using nicastrin antibody in all methods. It is aimed to help Labome visitors find the most suited nicastrin antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
nicastrin synonym: ATAG1874

MilliporeSigma
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 2c
MilliporeSigma nicastrin antibody (sigma, N1660) was used in western blot on human samples (fig 2c). Aging (Albany NY) (2020) ncbi
domestic rabbit polyclonal
  • western blot; rat; fig 5a
  • western blot; mouse; fig 3b
In order to study the activity-driven interaction between presenilin 1 and synaptotagmin 1 and links to calcium, amyloid beta, and synapse, MilliporeSigma nicastrin antibody (Sigma-Aldrich, PRS3985) was used in western blot on rat samples (fig 5a) and in western blot on mouse samples (fig 3b). BMC Biol (2016) ncbi
domestic rabbit polyclonal
  • immunocytochemistry; mouse; 1:100; fig 1
MilliporeSigma nicastrin antibody (Sigma, N1660) was used in immunocytochemistry on mouse samples at 1:100 (fig 1). Acta Neuropathol Commun (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; fig 1
MilliporeSigma nicastrin antibody (Sigma, N1660) was used in western blot on human samples at 1:1000 (fig 1). EMBO Mol Med (2016) ncbi
domestic rabbit polyclonal
In order to identify and characterize a multiprotease complex containing both alpha- and gamma-secretase, MilliporeSigma nicastrin antibody (Sigma, N1660) was used . J Cell Biol (2015) ncbi
Cell Signaling Technology
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 3e
Cell Signaling Technology nicastrin antibody (Cell Signaling, 3632) was used in western blot on mouse samples (fig 3e). Mol Neurodegener (2020) ncbi
domestic rabbit monoclonal (D65G7)
  • western blot; mouse; 1:1000; loading ...; fig s3d
Cell Signaling Technology nicastrin antibody (Cell Signaling Technology, 9447) was used in western blot on mouse samples at 1:1000 (fig s3d). J Clin Invest (2019) ncbi
domestic rabbit polyclonal
  • western blot; mouse; fig 3d
In order to show that ALOX5 upregulation results in homocysteine-dependent worsening of the Alzheimer's disease phenotype, Cell Signaling Technology nicastrin antibody (Cell Signaling, 3632) was used in western blot on mouse samples (fig 3d). Sci Rep (2017) ncbi
domestic rabbit monoclonal (D65G7)
  • immunocytochemistry; mouse; 1:1000; loading ...; fig s3a
Cell Signaling Technology nicastrin antibody (Cell Signaling, 9447) was used in immunocytochemistry on mouse samples at 1:1000 (fig s3a). Science (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 5c
Cell Signaling Technology nicastrin antibody (Cell Signaling, 3632S) was used in western blot on human samples (fig 5c). elife (2016) ncbi
domestic rabbit monoclonal (D65G7)
  • western blot; human; fig s2
Cell Signaling Technology nicastrin antibody (Cell Signaling Tech, 9447) was used in western blot on human samples (fig s2). Oncotarget (2016) ncbi
domestic rabbit monoclonal (D38F9)
  • western blot; mouse; fig 2
In order to characterize postmortem behavior and the rapid alteration of protein phosphorylation, Cell Signaling Technology nicastrin antibody (Cell signaling, 5665) was used in western blot on mouse samples (fig 2). Sci Rep (2015) ncbi
domestic rabbit monoclonal (D38F9)
  • western blot; mouse; fig 3c
In order to assess the efficiency and potential safety of miRNA replacement therapy for Alzheimer's disease, Cell Signaling Technology nicastrin antibody (Cell Signaling, 5665) was used in western blot on mouse samples (fig 3c). Mol Ther Nucleic Acids (2015) ncbi
domestic rabbit monoclonal (D65G7)
Cell Signaling Technology nicastrin antibody (Cell Signaling Tech, 9447) was used . Autophagy (2015) ncbi
domestic rabbit monoclonal (D65G7)
  • immunohistochemistry - frozen section; mouse; fig 5g
In order to study the effect of bisecting N-acetylglucosamine on beta-site amyloid precursor protein cleaving enzyme-1 (BACE1) activity, Cell Signaling Technology nicastrin antibody (Cell Signaling Technology, 9447S) was used in immunohistochemistry - frozen section on mouse samples (fig 5g). EMBO Mol Med (2015) ncbi
domestic rabbit monoclonal (D38F9)
  • western blot; human; loading ...; fig 6b
Cell Signaling Technology nicastrin antibody (Cell Signaling Technology Inc., 5665) was used in western blot on human samples (fig 6b). Mol Carcinog (2015) ncbi
EMD Millipore
mouse monoclonal (9C3)
  • western blot; rat; 1:1000
In order to localize ADAM10 and BACE1 in synaptic vesicles, EMD Millipore nicastrin antibody (Millipore, MAB5556) was used in western blot on rat samples at 1:1000. J Neurochem (2015) ncbi
mouse monoclonal (9C3)
  • western blot; human
EMD Millipore nicastrin antibody (Millipore, MAB5556) was used in western blot on human samples . FEBS J (2015) ncbi
Articles Reviewed
  1. Li J, Chiu J, Ramanjulu M, Blass B, Pratico D. A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles. Mol Neurodegener. 2020;15:1 pubmed publisher
  2. Hu T, Zhou Y, Lu J, Xia P, Chen Y, Cao X, et al. A novel rhamnoside derivative PL402 up-regulates matrix metalloproteinase 3/9 to promote Aβ degradation and alleviates Alzheimer's-like pathology. Aging (Albany NY). 2020;12:481-501 pubmed publisher
  3. Beckelman B, Yang W, Kasica N, Zimmermann H, Zhou X, Keene C, et al. Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer's disease model mice. J Clin Invest. 2019;129:820-833 pubmed publisher
  4. Li J, Barrero C, Merali S, Pratico D. Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype. Sci Rep. 2017;7:46002 pubmed publisher
  5. Kanakkanthara A, Jeganathan K, Limzerwala J, Baker D, Hamada M, Nam H, et al. Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation. Science. 2016;353:1549-1552 pubmed
  6. Bolduc D, Montagna D, Seghers M, Wolfe M, Selkoe D. The amyloid-beta forming tripeptide cleavage mechanism of ?-secretase. elife. 2016;5: pubmed publisher
  7. Kuzuya A, Zoltowska K, Post K, Arimon M, Li X, Svirsky S, et al. Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta. BMC Biol. 2016;14:25 pubmed publisher
  8. Schedin Weiss S, Caesar I, Winblad B, Blom H, Tjernberg L. Super-resolution microscopy reveals ?-secretase at both sides of the neuronal synapse. Acta Neuropathol Commun. 2016;4:29 pubmed publisher
  9. Kretner B, Trambauer J, Fukumori A, Mielke J, Kuhn P, Kremmer E, et al. Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease. EMBO Mol Med. 2016;8:458-65 pubmed publisher
  10. Noh H, Hah Y, Ha J, Kang M, Zada S, Rha S, et al. Regulation of the epithelial to mesenchymal transition and metastasis by Raf kinase inhibitory protein-dependent Notch1 activity. Oncotarget. 2016;7:4632-46 pubmed publisher
  11. Chen A, Kim S, Shepardson N, Patel S, Hong S, Selkoe D. Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis. J Cell Biol. 2015;211:1157-76 pubmed publisher
  12. Wang Y, Zhang Y, Hu W, Xie S, Gong C, Iqbal K, et al. Rapid alteration of protein phosphorylation during postmortem: implication in the study of protein phosphorylation. Sci Rep. 2015;5:15709 pubmed publisher
  13. Parsi S, Smith P, Goupil C, Dorval V, Hébert S. Preclinical Evaluation of miR-15/107 Family Members as Multifactorial Drug Targets for Alzheimer's Disease. Mol Ther Nucleic Acids. 2015;4:e256 pubmed publisher
  14. Lundgren J, Ahmed S, Schedin Weiss S, Gouras G, Winblad B, Tjernberg L, et al. ADAM10 and BACE1 are localized to synaptic vesicles. J Neurochem. 2015;135:606-15 pubmed publisher
  15. Inoue M, Hur J, Kihara T, Teranishi Y, Yamamoto N, Ishikawa T, et al. Human brain proteins showing neuron-specific interactions with γ-secretase. FEBS J. 2015;282:2587-99 pubmed publisher
  16. Polletta L, Vernucci E, Carnevale I, Arcangeli T, Rotili D, Palmerio S, et al. SIRT5 regulation of ammonia-induced autophagy and mitophagy. Autophagy. 2015;11:253-70 pubmed publisher
  17. Kizuka Y, Kitazume S, Fujinawa R, Saito T, Iwata N, Saido T, et al. An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease. EMBO Mol Med. 2015;7:175-89 pubmed publisher
  18. Kaushik G, Venugopal A, Ramamoorthy P, Standing D, Subramaniam D, Umar S, et al. Honokiol inhibits melanoma stem cells by targeting notch signaling. Mol Carcinog. 2015;54:1710-21 pubmed publisher