This is a Validated Antibody Database (VAD) review about human integrin alpha2, based on 36 published articles (read how Labome selects the articles), using integrin alpha2 antibody in all methods. It is aimed to help Labome visitors find the most suited integrin alpha2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
integrin alpha2 synonym: BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2

Abcam
domestic rabbit monoclonal (EPR17338)
  • western blot; human; 1:5000; loading ...; fig 1e
Abcam integrin alpha2 antibody (Abcam, ab181548) was used in western blot on human samples at 1:5000 (fig 1e). elife (2020) ncbi
domestic rabbit monoclonal (EPR17338)
  • western blot; human; loading ...; fig s4e, s4f
Abcam integrin alpha2 antibody (Abcam, ab181548) was used in western blot on human samples (fig s4e, s4f). Cell (2019) ncbi
mouse monoclonal (16B4)
  • immunoprecipitation; human; loading ...; fig 6B
Abcam integrin alpha2 antibody (Cell Signaling, ab30483) was used in immunoprecipitation on human samples (fig 6B). Sci Rep (2017) ncbi
mouse monoclonal (P1E6)
  • blocking or activating experiments; human; loading ...; fig 4I
  • western blot; human; loading ...; fig 7A
Abcam integrin alpha2 antibody (Cell Signaling, ab24697) was used in blocking or activating experiments on human samples (fig 4I) and in western blot on human samples (fig 7A). Sci Rep (2017) ncbi
domestic rabbit monoclonal (EPR5788)
  • immunohistochemistry; mouse; loading ...; fig 4b
  • western blot; mouse; loading ...; fig 4c
In order to elucidate the mechanism by which CYP26A1 contributes to the maintenance of pregnancy, Abcam integrin alpha2 antibody (Abcam, ab133557) was used in immunohistochemistry on mouse samples (fig 4b) and in western blot on mouse samples (fig 4c). J Cell Mol Med (2017) ncbi
mouse monoclonal (P1E6)
  • blocking or activating experiments; human; loading ...; fig 6
  • immunohistochemistry - frozen section; human; 1:30
Abcam integrin alpha2 antibody (Abcam, AB24697) was used in blocking or activating experiments on human samples (fig 6) and in immunohistochemistry - frozen section on human samples at 1:30. Stem Cells Transl Med (2016) ncbi
mouse monoclonal (P1E6)
  • flow cytometry; human; 1:50; loading ...; fig 8a
In order to determine the biological effects of surface wettability on protein deposition, folding, and ligand activity, Abcam integrin alpha2 antibody (abcam, 24697) was used in flow cytometry on human samples at 1:50 (fig 8a). Adv Healthc Mater (2016) ncbi
domestic rabbit monoclonal (EPR17338)
  • western blot; human; loading ...; fig 3b
Abcam integrin alpha2 antibody (Abcam, ab181548) was used in western blot on human samples (fig 3b). J Biol Chem (2016) ncbi
domestic rabbit monoclonal (EPR5788)
  • immunocytochemistry; human; fig s3
  • western blot; human; fig s5
In order to monitor the interaction beteween integrin alpha chain and AP2 and how selective integrin endocytosis drives the interaction, Abcam integrin alpha2 antibody (Abcam, EPR5788) was used in immunocytochemistry on human samples (fig s3) and in western blot on human samples (fig s5). Nat Struct Mol Biol (2016) ncbi
domestic rabbit monoclonal (EPR5788)
  • western blot; human; 1:10,000; fig 2
In order to analyze organotropic metasistasis and tumour exosome integrins, Abcam integrin alpha2 antibody (Abcam, ab133557) was used in western blot on human samples at 1:10,000 (fig 2). Nature (2015) ncbi
mouse monoclonal (16B4)
  • immunocytochemistry; human; fig 2, 3, 4
Abcam integrin alpha2 antibody (Abcam, ab30483) was used in immunocytochemistry on human samples (fig 2, 3, 4). Cardiovasc Res (2014) ncbi
mouse monoclonal (P1E6)
  • immunoprecipitation; human
In order to profile an integrin-mediated SV40 mechanism, Abcam integrin alpha2 antibody (Abcam, P1E6) was used in immunoprecipitation on human samples . PLoS ONE (2013) ncbi
BioLegend
mouse monoclonal (P1E6-C5)
  • flow cytometry; human
BioLegend integrin alpha2 antibody (BioLegend, 359307) was used in flow cytometry on human samples . Front Immunol (2022) ncbi
mouse monoclonal (P1E6-C5)
  • flow cytometry; human; 1:100; fig 4c
  • immunocytochemistry; human; 1:100; fig 4b
In order to study the differentiation of oral mucosa stromal cells into neural crest stem cells and assess their therapeutic value, BioLegend integrin alpha2 antibody (BioLegend, P1E6-C5) was used in flow cytometry on human samples at 1:100 (fig 4c) and in immunocytochemistry on human samples at 1:100 (fig 4b). Stem Cells Transl Med (2016) ncbi
Bio-Rad
mouse monoclonal (16B4)
  • flow cytometry; human; 1:100; fig s3
  • immunocytochemistry; human; fig s3
  • western blot; human; fig s5
In order to monitor the interaction beteween integrin alpha chain and AP2 and how selective integrin endocytosis drives the interaction, Bio-Rad integrin alpha2 antibody (Abd Serotech, MCA2025) was used in flow cytometry on human samples at 1:100 (fig s3), in immunocytochemistry on human samples (fig s3) and in western blot on human samples (fig s5). Nat Struct Mol Biol (2016) ncbi
mouse monoclonal (AK7)
  • flow cytometry; human; loading ...; fig 2c
Bio-Rad integrin alpha2 antibody (Serotec, MCA743GA) was used in flow cytometry on human samples (fig 2c). Food Funct (2014) ncbi
mouse monoclonal (AK7)
  • flow cytometry; human
In order to perform a phoshoproteomic analysis of the collagen receptor signalling network and study the importance of SHP-2 phosphorylation, Bio-Rad integrin alpha2 antibody (AbD Serotec, AK7) was used in flow cytometry on human samples . Biochem J (2013) ncbi
mouse monoclonal (AK7)
  • blocking or activating experiments; human; 10 ug/ml
  • immunocytochemistry; human; 10 ug/ml
Bio-Rad integrin alpha2 antibody (AbD Serotec, AK7) was used in blocking or activating experiments on human samples at 10 ug/ml and in immunocytochemistry on human samples at 10 ug/ml. PLoS ONE (2012) ncbi
mouse monoclonal (16B4)
  • immunohistochemistry - paraffin section; human
Bio-Rad integrin alpha2 antibody (Serotec, MCA2025) was used in immunohistochemistry - paraffin section on human samples . Clin Exp Metastasis (2013) ncbi
mouse monoclonal (AK7)
Bio-Rad integrin alpha2 antibody (Serotec, MCA743) was used . J Biol Chem (2012) ncbi
Santa Cruz Biotechnology
mouse monoclonal (P1E6)
  • immunocytochemistry; human; 1:100; loading ...; fig 4b
Santa Cruz Biotechnology integrin alpha2 antibody (Santa Cruz, sc-53502) was used in immunocytochemistry on human samples at 1:100 (fig 4b). Nat Commun (2021) ncbi
mouse monoclonal (P1H5)
  • western blot; human; 1:200; fig 4
In order to discuss the consequences of Diabetes Associated Protein in Insulin-sensitive Tissues overexpression, Santa Cruz Biotechnology integrin alpha2 antibody (Santa Cruz, sc-13546) was used in western blot on human samples at 1:200 (fig 4). PLoS ONE (2015) ncbi
mouse monoclonal (C-9)
  • western blot; human
Santa Cruz Biotechnology integrin alpha2 antibody (Santa Cruz Biotechnology, sc-74466) was used in western blot on human samples . Colloids Surf B Biointerfaces (2015) ncbi
Invitrogen
domestic sheep polyclonal
  • immunohistochemistry - frozen section; mouse; 1:25; loading ...; fig 3a
Invitrogen integrin alpha2 antibody (Thermo Fisher, PA5-47193) was used in immunohistochemistry - frozen section on mouse samples at 1:25 (fig 3a). J Pathol (2022) ncbi
mouse monoclonal (eBioY418 (Y418))
  • flow cytometry; human; 1:50; fig 3a, 3b
Invitrogen integrin alpha2 antibody (eBioscience/Thermo, 11-0498-42) was used in flow cytometry on human samples at 1:50 (fig 3a, 3b). Stem Cells (2019) ncbi
mouse monoclonal (AK7)
  • flow cytometry; human
In order to describe a method to expand antigen-specific regulatory T cells in vivo, Invitrogen integrin alpha2 antibody (Pierce, AK7) was used in flow cytometry on human samples . Nature (2016) ncbi
mouse monoclonal (31H4)
  • flow cytometry; human
In order to determine the function of alpha M beta-propeller in specific ligand recognition by alpha M beta 2, Invitrogen integrin alpha2 antibody (BIOSOURCE, 31H4) was used in flow cytometry on human samples . J Biol Chem (2003) ncbi
Miltenyi Biotec
human monoclonal (REA188)
  • flow cytometry; human; 1:50; loading ...; fig st2
In order to show low doses of acetaminophen disrupts the integrity of tight junction and cell-matrix adhesions, Miltenyi Biotec integrin alpha2 antibody (Miltenyi Biotec, 130-100-328) was used in flow cytometry on human samples at 1:50 (fig st2). Sci Rep (2017) ncbi
BD Biosciences
mouse monoclonal (AK-7)
  • flow cytometry; human; 1:100; loading ...
BD Biosciences integrin alpha2 antibody (BD Biosciences, 555498) was used in flow cytometry on human samples at 1:100. elife (2020) ncbi
mouse monoclonal (12F1)
  • flow cytometry; human; loading ...; fig s1a
BD Biosciences integrin alpha2 antibody (BD, 555669) was used in flow cytometry on human samples (fig s1a). Stem Cell Reports (2020) ncbi
mouse monoclonal (2/CD49b)
  • other; human; loading ...; fig 4c
BD Biosciences integrin alpha2 antibody (BD Biosciences, 611016) was used in other on human samples (fig 4c). Cancer Cell (2018) ncbi
mouse monoclonal (2/CD49b)
  • reverse phase protein lysate microarray; human; loading ...; fig st6
In order to characterize the molecular identity of uterine carcinosarcomas., BD Biosciences integrin alpha2 antibody (BD, 611016) was used in reverse phase protein lysate microarray on human samples (fig st6). Cancer Cell (2017) ncbi
mouse monoclonal (AK-7)
  • flow cytometry; human; 1:50; loading ...; tbl 1
BD Biosciences integrin alpha2 antibody (Becton, 555498) was used in flow cytometry on human samples at 1:50 (tbl 1). Sci Rep (2017) ncbi
mouse monoclonal (2/CD49b)
  • reverse phase protein lysate microarray; human; loading ...; fig 3a
In order to describe the features of 228 primary cervical cancers, BD Biosciences integrin alpha2 antibody (BD, 611016) was used in reverse phase protein lysate microarray on human samples (fig 3a). Nature (2017) ncbi
mouse monoclonal (2/CD49b)
  • western blot; human; loading ...
In order to analyze the context specificity of signaling networks within a causal conceptual framework using reverse-phase protein array time-course assays and network analysis approaches, BD Biosciences integrin alpha2 antibody (BD Biosciences, 611016) was used in western blot on human samples . Cell Syst (2017) ncbi
mouse monoclonal (12F1)
  • flow cytometry; human; fig st1
In order to find cell-surface markers specific to human neutrophils, BD Biosciences integrin alpha2 antibody (BD, 555669) was used in flow cytometry on human samples (fig st1). Exp Cell Res (2016) ncbi
mouse monoclonal (12F1)
  • flow cytometry; human; 7.5 ug/ml; loading ...; fig s5
In order to identify glycogen synthase kinase beta and forkhead box P3 as direct PIM targets, BD Biosciences integrin alpha2 antibody (BD Pharmingen, BD555668) was used in flow cytometry on human samples at 7.5 ug/ml (fig s5). Exp Cell Res (2016) ncbi
  • immunocytochemistry; human; fig 2
BD Biosciences integrin alpha2 antibody (BD biosciences, 555497) was used in immunocytochemistry on human samples (fig 2). PLoS ONE (2015) ncbi
mouse monoclonal (AK-7)
  • flow cytometry; human
BD Biosciences integrin alpha2 antibody (BD, AK-7) was used in flow cytometry on human samples . Clin Exp Metastasis (2013) ncbi
Developmental Studies Hybridoma Bank
mouse monoclonal (P1E6)
  • blocking or activating experiments; human; loading ...; fig 7c
Developmental Studies Hybridoma Bank integrin alpha2 antibody (Developmental Studies Hybridoma Bank, P1E6) was used in blocking or activating experiments on human samples (fig 7c). JCI Insight (2021) ncbi
Articles Reviewed
  1. Eikmans M, van der Keur C, Anholts J, Drabbels J, van Beelen E, de Sousa Lopes S, et al. Primary Trophoblast Cultures: Characterization of HLA Profiles and Immune Cell Interactions. Front Immunol. 2022;13:814019 pubmed publisher
  2. Madison J, Wilhelm K, Meehan D, Delimont D, Samuelson G, Cosgrove D. Glomerular basement membrane deposition of collagen α1(III) in Alport glomeruli by mesangial filopodia injures podocytes via aberrant signaling through DDR1 and integrin α2β1. J Pathol. 2022;258:26-37 pubmed publisher
  3. Fayad R, Rojas M, Partisani M, Finetti P, Dib S, Abélanet S, et al. EFA6B regulates a stop signal for collective invasion in breast cancer. Nat Commun. 2021;12:2198 pubmed publisher
  4. Kikkawa Y, Hashimoto T, Takizawa K, Urae S, Masuda H, Matsunuma M, et al. Laminin β2 variants associated with isolated nephropathy that impact matrix regulation. JCI Insight. 2021;6: pubmed publisher
  5. Huang Y, Liang C, Ritz D, Coelho R, Septiadi D, Estermann M, et al. Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis. elife. 2020;9: pubmed publisher
  6. Suzuki D, Flahou C, Yoshikawa N, Stirblyte I, Hayashi Y, Sawaguchi A, et al. iPSC-Derived Platelets Depleted of HLA Class I Are Inert to Anti-HLA Class I and Natural Killer Cell Immunity. Stem Cell Reports. 2020;14:49-59 pubmed publisher
  7. Menon V, Thomas R, Elgueta C, Horl M, Osborn T, Hallett P, et al. Comprehensive Cell Surface Antigen Analysis Identifies Transferrin Receptor Protein-1 (CD71) as a Negative Selection Marker for Human Neuronal Cells. Stem Cells. 2019;37:1293-1306 pubmed publisher
  8. Jeppesen D, Fenix A, Franklin J, Higginbotham J, Zhang Q, Zimmerman L, et al. Reassessment of Exosome Composition. Cell. 2019;177:428-445.e18 pubmed publisher
  9. Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher
  10. Cherniack A, Shen H, Walter V, Stewart C, Murray B, Bowlby R, et al. Integrated Molecular Characterization of Uterine Carcinosarcoma. Cancer Cell. 2017;31:411-423 pubmed publisher
  11. Di Maggio N, Martella E, Frismantiene A, Resink T, Schreiner S, Lucarelli E, et al. Extracellular matrix and α5β1 integrin signaling control the maintenance of bone formation capacity by human adipose-derived stromal cells. Sci Rep. 2017;7:44398 pubmed publisher
  12. Chung C, Chang C, Hsu C, Lin K, Peng H, Huang T. Aggretin Venom Polypeptide as a Novel Anti-angiogenesis Agent by Targeting Integrin alpha2beta1. Sci Rep. 2017;7:43612 pubmed publisher
  13. Gamal W, Treskes P, Samuel K, Sullivan G, Siller R, Srsen V, et al. Low-dose acetaminophen induces early disruption of cell-cell tight junctions in human hepatic cells and mouse liver. Sci Rep. 2017;7:37541 pubmed publisher
  14. . Integrated genomic and molecular characterization of cervical cancer. Nature. 2017;543:378-384 pubmed publisher
  15. Hill S, Nesser N, Johnson Camacho K, Jeffress M, Johnson A, Boniface C, et al. Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling. Cell Syst. 2017;4:73-83.e10 pubmed publisher
  16. Meng C, Li Z, Fang W, Song Z, Yang D, Li D, et al. Cytochrome P450 26A1 modulates natural killer cells in mouse early pregnancy. J Cell Mol Med. 2017;21:697-710 pubmed publisher
  17. Murphy K, Hoch A, Harvestine J, Zhou D, Leach J. Mesenchymal Stem Cell Spheroids Retain Osteogenic Phenotype Through ?2?1 Signaling. Stem Cells Transl Med. 2016;5:1229-37 pubmed publisher
  18. Razafiarison T, Silvan U, Meier D, Snedeker J. Surface-Driven Collagen Self-Assembly Affects Early Osteogenic Stem Cell Signaling. Adv Healthc Mater. 2016;5:1481-92 pubmed publisher
  19. Lakschevitz F, Hassanpour S, Rubin A, Fine N, Sun C, Glogauer M. Identification of neutrophil surface marker changes in health and inflammation using high-throughput screening flow cytometry. Exp Cell Res. 2016;342:200-9 pubmed publisher
  20. Santio N, Salmela M, Arola H, Eerola S, Heino J, Rainio E, et al. The PIM1 kinase promotes prostate cancer cell migration and adhesion via multiple signalling pathways. Exp Cell Res. 2016;342:113-24 pubmed publisher
  21. Clemente Casares X, Blanco J, Ambalavanan P, Yamanouchi J, Singha S, Fandos C, et al. Expanding antigen-specific regulatory networks to treat autoimmunity. Nature. 2016;530:434-40 pubmed publisher
  22. Ghosh S, Shinogle H, Galeva N, Dobrowsky R, Blagg B. Endoplasmic Reticulum-resident Heat Shock Protein 90 (HSP90) Isoform Glucose-regulated Protein 94 (GRP94) Regulates Cell Polarity and Cancer Cell Migration by Affecting Intracellular Transport. J Biol Chem. 2016;291:8309-23 pubmed publisher
  23. De Franceschi N, Arjonen A, Elkhatib N, Denessiouk K, Wrobel A, Wilson T, et al. Selective integrin endocytosis is driven by interactions between the integrin α-chain and AP2. Nat Struct Mol Biol. 2016;23:172-9 pubmed publisher
  24. Abe S, Yamaguchi S, Sato Y, Harada K. Sphere-Derived Multipotent Progenitor Cells Obtained From Human Oral Mucosa Are Enriched in Neural Crest Cells. Stem Cells Transl Med. 2016;5:117-28 pubmed publisher
  25. Hoshino A, Costa Silva B, Shen T, Rodrigues G, Hashimoto A, Tesic Mark M, et al. Tumour exosome integrins determine organotropic metastasis. Nature. 2015;527:329-35 pubmed publisher
  26. Kontro H, Cannino G, Rustin P, Dufour E, Kainulainen H. DAPIT Over-Expression Modulates Glucose Metabolism and Cell Behaviour in HEK293T Cells. PLoS ONE. 2015;10:e0131990 pubmed publisher
  27. Sharivkin R, Walker M, Soen Y. Functional proteomics screen enables enrichment of distinct cell types from human pancreatic islets. PLoS ONE. 2015;10:e0115100 pubmed publisher
  28. Shen Y, Gao M, Ma Y, Yu H, Cui F, Gregersen H, et al. Effect of surface chemistry on the integrin induced pathway in regulating vascular endothelial cells migration. Colloids Surf B Biointerfaces. 2015;126:188-97 pubmed publisher
  29. Menhofer M, Bartel D, Liebl J, Kubisch R, Busse J, Wagner E, et al. In vitro and in vivo characterization of the actin polymerizing compound chondramide as an angiogenic inhibitor. Cardiovasc Res. 2014;104:303-14 pubmed publisher
  30. Hashim Y, Worthington J, Allsopp P, Ternan N, Brown E, McCann M, et al. Virgin olive oil phenolics extract inhibit invasion of HT115 human colon cancer cells in vitro and in vivo. Food Funct. 2014;5:1513-9 pubmed publisher
  31. Iwai L, Payne L, Luczynski M, Chang F, Xu H, Clinton R, et al. Phosphoproteomics of collagen receptor networks reveals SHP-2 phosphorylation downstream of wild-type DDR2 and its lung cancer mutants. Biochem J. 2013;454:501-13 pubmed publisher
  32. Stergiou L, Bauer M, Mair W, Bausch Fluck D, Drayman N, Wollscheid B, et al. Integrin-mediated signaling induced by simian virus 40 leads to transient uncoupling of cortical actin and the plasma membrane. PLoS ONE. 2013;8:e55799 pubmed publisher
  33. Xu H, Bihan D, Chang F, Huang P, Farndale R, Leitinger B. Discoidin domain receptors promote α1β1- and α2β1-integrin mediated cell adhesion to collagen by enhancing integrin activation. PLoS ONE. 2012;7:e52209 pubmed publisher
  34. Sottnik J, Daignault Newton S, Zhang X, Morrissey C, Hussain M, Keller E, et al. Integrin alpha2beta 1 (?2?1) promotes prostate cancer skeletal metastasis. Clin Exp Metastasis. 2013;30:569-78 pubmed publisher
  35. Hamaia S, Pugh N, Raynal N, Némoz B, Stone R, Gullberg D, et al. Mapping of potent and specific binding motifs, GLOGEN and GVOGEA, for integrin ?1?1 using collagen toolkits II and III. J Biol Chem. 2012;287:26019-28 pubmed publisher
  36. Li Y, Zhang L. The fourth blade within the beta-propeller is involved specifically in C3bi recognition by integrin alpha M beta 2. J Biol Chem. 2003;278:34395-402 pubmed