This is a Validated Antibody Database (VAD) review about human insulin degrading enzyme, based on 14 published articles (read how Labome selects the articles), using insulin degrading enzyme antibody in all methods. It is aimed to help Labome visitors find the most suited insulin degrading enzyme antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
insulin degrading enzyme synonym: INSULYSIN; insulin-degrading enzyme; Abeta-degrading protease; insulin protease; insulinase

Abcam
rabbit monoclonal (EPR6099)
  • western blot; mouse; fig 3e
Abcam insulin degrading enzyme antibody (abcam, ab109538) was used in western blot on mouse samples (fig 3e). Acta Neuropathol Commun (2018) ncbi
rabbit polyclonal
  • western blot; mouse; 1:2000; loading ...; fig 1a
Abcam insulin degrading enzyme antibody (Abcam, ab32216) was used in western blot on mouse samples at 1:2000 (fig 1a). Autophagy (2016) ncbi
rabbit polyclonal
  • immunohistochemistry; mouse; fig 7
In order to analyze chemogenetic modulation of neural activity by attenuation of beta-amyloid deposition and neurotoxicity, Abcam insulin degrading enzyme antibody (Abcam, ab32216) was used in immunohistochemistry on mouse samples (fig 7). J Neurosci (2016) ncbi
rabbit polyclonal
  • western blot; mouse; fig 5
In order to test the effects of high fat diet using a mouse model of familial Alzheimer disease, Abcam insulin degrading enzyme antibody (Abcam, Ab32216) was used in western blot on mouse samples (fig 5). Biochim Biophys Acta (2015) ncbi
rabbit polyclonal
  • western blot; mouse
In order to investigate the abnormalites in hippocampal energy metabolism in the pathogenesis of Alzheimer disease, Abcam insulin degrading enzyme antibody (Abcam, Ab32216) was used in western blot on mouse samples . Biochim Biophys Acta (2014) ncbi
rabbit polyclonal
  • western blot; mouse; 1:1000; fig 4
In order to characterize mice with a knockin mutation that inactivates the proofreading function of mitochondrial DNA polymerase gamma, Abcam insulin degrading enzyme antibody (Abcam, ab32216) was used in western blot on mouse samples at 1:1000 (fig 4). Mol Neurodegener (2014) ncbi
rabbit polyclonal
  • western blot; mouse
Abcam insulin degrading enzyme antibody (Abcam, ab32216) was used in western blot on mouse samples . PLoS ONE (2014) ncbi
rabbit polyclonal
  • western blot; rat; 1:1,000
Abcam insulin degrading enzyme antibody (Abcam, ab32216) was used in western blot on rat samples at 1:1,000. J Neurosci Res (2014) ncbi
rabbit monoclonal (EPR6098(2))
  • western blot; human; 1:1000
Abcam insulin degrading enzyme antibody (Abcam, ab133561) was used in western blot on human samples at 1:1000. Neuromolecular Med (2014) ncbi
rabbit polyclonal
  • western blot; human; 1:1000
In order to study levels of BACE1 and Abeta42 in aged patients with cerebral atherosclerosis in the absence of dementia, Abcam insulin degrading enzyme antibody (Abcam, ab32216) was used in western blot on human samples at 1:1000. Curr Alzheimer Res (2013) ncbi
rabbit polyclonal
  • flow cytometry; human
Abcam insulin degrading enzyme antibody (Abcam, ab32216) was used in flow cytometry on human samples . Biochemistry (2013) ncbi
rabbit polyclonal
  • western blot; mouse; 1:1000
In order to study the role of TRPM8 channels in insulin regulation, Abcam insulin degrading enzyme antibody (Abcam, AB32216) was used in western blot on mouse samples at 1:1000. Am J Physiol Endocrinol Metab (2013) ncbi
rabbit polyclonal
  • immunohistochemistry - paraffin section; rat; 1:50
Abcam insulin degrading enzyme antibody (Abcam, ab32216) was used in immunohistochemistry - paraffin section on rat samples at 1:50. Behav Brain Res (2013) ncbi
GeneTex
rabbit polyclonal
  • western blot; mouse; loading ...; fig 7a
GeneTex insulin degrading enzyme antibody (GeneTex, GTX111664) was used in western blot on mouse samples (fig 7a). PLoS ONE (2018) ncbi
Articles Reviewed
  1. Ziegler Waldkirch S, Marksteiner K, Stoll J, d Errico P, Friesen M, Eiler D, et al. Environmental enrichment reverses A? pathology during pregnancy in a mouse model of Alzheimer's disease. Acta Neuropathol Commun. 2018;6:44 pubmed publisher
  2. Hamilton K, Wang Y, Raefsky S, Berkowitz S, Spangler R, Suire C, et al. Mice lacking the transcriptional regulator Bhlhe40 have enhanced neuronal excitability and impaired synaptic plasticity in the hippocampus. PLoS ONE. 2018;13:e0196223 pubmed publisher
  3. Son S, Cha M, Choi H, Kang S, Choi H, Lee M, et al. Insulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease. Autophagy. 2016;12:784-800 pubmed publisher
  4. Yuan P, Grutzendler J. Attenuation of β-Amyloid Deposition and Neurotoxicity by Chemogenetic Modulation of Neural Activity. J Neurosci. 2016;36:632-41 pubmed publisher
  5. Petrov D, Pedrós I, Artiach G, Sureda F, Barroso E, Pallas M, et al. High-fat diet-induced deregulation of hippocampal insulin signaling and mitochondrial homeostasis deficiences contribute to Alzheimer disease pathology in rodents. Biochim Biophys Acta. 2015;1852:1687-99 pubmed publisher
  6. Pedr s I, Petrov D, Allgaier M, Sureda F, Barroso E, Beas Zarate C, et al. Early alterations in energy metabolism in the hippocampus of APPswe/PS1dE9 mouse model of Alzheimer's disease. Biochim Biophys Acta. 2014;1842:1556-66 pubmed publisher
  7. Kukreja L, Kujoth G, Prolla T, Van Leuven F, Vassar R. Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease. Mol Neurodegener. 2014;9:16 pubmed publisher
  8. Wei X, Ke B, Zhao Z, Ye X, Gao Z, Ye J. Regulation of insulin degrading enzyme activity by obesity-associated factors and pioglitazone in liver of diet-induced obese mice. PLoS ONE. 2014;9:e95399 pubmed publisher
  9. Edrey Y, Oddo S, Cornelius C, Caccamo A, Calabrese V, Buffenstein R. Oxidative damage and amyloid-? metabolism in brain regions of the longest-lived rodents. J Neurosci Res. 2014;92:195-205 pubmed publisher
  10. Armstrong A, Mattsson N, Appelqvist H, Janefjord C, Sandin L, Agholme L, et al. Lysosomal network proteins as potential novel CSF biomarkers for Alzheimer's disease. Neuromolecular Med. 2014;16:150-60 pubmed publisher
  11. Sadleir K, Bennett D, Schneider J, Vassar R. Elevated A?42 in aged, non-demented individuals with cerebral atherosclerosis. Curr Alzheimer Res. 2013;10:785-9 pubmed
  12. Tripathi A, Saini V, Marchese A, Volkman B, Tang W, Majetschak M. Modulation of the CXC chemokine receptor 4 agonist activity of ubiquitin through C-terminal protein modification. Biochemistry. 2013;52:4184-92 pubmed publisher
  13. McCoy D, Zhou L, Nguyen A, Watts A, Donovan C, McKemy D. Enhanced insulin clearance in mice lacking TRPM8 channels. Am J Physiol Endocrinol Metab. 2013;305:E78-88 pubmed publisher
  14. Shingo A, Kanabayashi T, Kito S, Murase T. Intracerebroventricular administration of an insulin analogue recovers STZ-induced cognitive decline in rats. Behav Brain Res. 2013;241:105-11 pubmed publisher