This is a Validated Antibody Database (VAD) review about human desmoplakin, based on 17 published articles (read how Labome selects the articles), using desmoplakin antibody in all methods. It is aimed to help Labome visitors find the most suited desmoplakin antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
desmoplakin synonym: DCWHKTA; DP

Knockout validation
Abcam
domestic rabbit monoclonal (EPR4383(2))
  • immunohistochemistry knockout validation; human; fig 5a
  • flow cytometry; human; fig 5b
Abcam desmoplakin antibody (Abcam, ab109445) was used in immunohistochemistry knockout validation on human samples (fig 5a) and in flow cytometry on human samples (fig 5b). Sci Adv (2022) ncbi
Abcam
domestic rabbit monoclonal (EPR4383(2))
  • immunohistochemistry knockout validation; human; fig 5a
  • flow cytometry; human; fig 5b
Abcam desmoplakin antibody (Abcam, ab109445) was used in immunohistochemistry knockout validation on human samples (fig 5a) and in flow cytometry on human samples (fig 5b). Sci Adv (2022) ncbi
domestic rabbit polyclonal
  • chromatin immunoprecipitation; human; ; loading ...; fig 2c
  • western blot; human; loading ...; fig s10
Abcam desmoplakin antibody (Abcam, 118804) was used in chromatin immunoprecipitation on human samples at (fig 2c) and in western blot on human samples (fig s10). Int J Biol Sci (2019) ncbi
mouse monoclonal (DP2.15)
  • immunohistochemistry - frozen section; mouse; 1:800; fig 1
In order to study the localization of neuronal nitric oxide synthase to utrophin expressing intercalated discs and stabilization of their structural integrity, Abcam desmoplakin antibody (Abcam, ab16434) was used in immunohistochemistry - frozen section on mouse samples at 1:800 (fig 1). Neuromuscul Disord (2015) ncbi
mouse monoclonal (DP2.15)
  • immunocytochemistry; mouse; 1:100; fig 6
  • western blot; mouse; 1:200; fig 6
In order to investigate the impact of Tmem65 on heart development, Abcam desmoplakin antibody (Abcam, AB16434) was used in immunocytochemistry on mouse samples at 1:100 (fig 6) and in western blot on mouse samples at 1:200 (fig 6). Nat Commun (2015) ncbi
mouse monoclonal (DP2.15)
  • immunocytochemistry; human; 1:100
Abcam desmoplakin antibody (Abcam, AB16434) was used in immunocytochemistry on human samples at 1:100. Cell Mol Bioeng (2015) ncbi
mouse monoclonal (DP2.15)
  • immunohistochemistry - paraffin section; human; 1:50; fig 1
Abcam desmoplakin antibody (Abcam, ab16434) was used in immunohistochemistry - paraffin section on human samples at 1:50 (fig 1). Endocrinology (2015) ncbi
mouse monoclonal (DP2.15)
  • western blot; human; 1:1000
In order to investigate the regulation of ZO-1 by p38delta mitogen-activated protein kinase in differentiating human epidermal keratinocytes, Abcam desmoplakin antibody (Abcam, ab16434-25) was used in western blot on human samples at 1:1000. Arch Dermatol Res (2014) ncbi
Bio-Rad
mouse monoclonal (DP-2.15)
  • immunohistochemistry - paraffin section; mouse; 1:50; loading ...; fig 6h
Bio-Rad desmoplakin antibody (BioRad, DP-2.15) was used in immunohistochemistry - paraffin section on mouse samples at 1:50 (fig 6h). Stem Cells (2021) ncbi
mouse monoclonal (DP-2.15)
  • immunocytochemistry; human; 1:100; fig 4a
  • immunocytochemistry; mouse; 1:100; fig 4b
  • western blot; mouse; 1:1000; fig 5h
In order to discuss the cellular origins of fibroadipocytes in arrhythmogenic cardiomyopathy, Bio-Rad desmoplakin antibody (BioRad, 2722-5204) was used in immunocytochemistry on human samples at 1:100 (fig 4a), in immunocytochemistry on mouse samples at 1:100 (fig 4b) and in western blot on mouse samples at 1:1000 (fig 5h). Circ Res (2016) ncbi
mouse monoclonal (DP-2.15)
  • immunohistochemistry - frozen section; mouse; 1:50
In order to test if Wwp1 regulates connexin 43, Bio-Rad desmoplakin antibody (AbD Serotec, DP-2.15) was used in immunohistochemistry - frozen section on mouse samples at 1:50. J Mol Cell Cardiol (2015) ncbi
mouse monoclonal (DP-2.15)
  • immunohistochemistry; pigs ; 1:100
  • western blot; pigs ; 1:100
In order to identify the role of SCN5A mutations in cardiac functions, Bio-Rad desmoplakin antibody (Serotec, 2722-5204) was used in immunohistochemistry on pigs samples at 1:100 and in western blot on pigs samples at 1:100. J Clin Invest (2015) ncbi
mouse monoclonal (DP-2.15)
  • immunohistochemistry - frozen section; domestic sheep
In order to study the role of desmosomes and adherens junctions in gap junction formation by cx43, Bio-Rad desmoplakin antibody (Serotec, 2722-5204) was used in immunohistochemistry - frozen section on domestic sheep samples . Heart Rhythm (2012) ncbi
Santa Cruz Biotechnology
mouse monoclonal (A-1)
  • western blot; human; 1:1000; loading ...; fig 3a
Santa Cruz Biotechnology desmoplakin antibody (Santa Cruz, sc-390975) was used in western blot on human samples at 1:1000 (fig 3a). Sci Rep (2021) ncbi
mouse monoclonal (B-1)
  • immunocytochemistry; human; 1:100; loading ...; fig s1a
Santa Cruz Biotechnology desmoplakin antibody (SantaCruz, sc-365981) was used in immunocytochemistry on human samples at 1:100 (fig s1a). J Exp Clin Cancer Res (2018) ncbi
mouse monoclonal (A-1)
  • immunohistochemistry - frozen section; human; 1:50; loading ...; fig 1e
  • western blot; human; 1:1000; loading ...; fig s1f
Santa Cruz Biotechnology desmoplakin antibody (Santa Cruz Biotechnology Inc, sc-390975) was used in immunohistochemistry - frozen section on human samples at 1:50 (fig 1e) and in western blot on human samples at 1:1000 (fig s1f). J Allergy Clin Immunol (2018) ncbi
Fitzgerald Industries
  • western blot; mouse; loading ...; fig 5d
In order to report that SB216763 prevents myocyte injury and cardiac dysfunction in two murine models of arrhythmogenic cardiomyopathy, Fitzgerald Industries desmoplakin antibody (Fitzgerald, 10R-D109A) was used in western blot on mouse samples (fig 5d). JCI Insight (2016) ncbi
  • immunohistochemistry - paraffin section; human
Fitzgerald Industries desmoplakin antibody (Fitzgerald, 10R-D108A) was used in immunohistochemistry - paraffin section on human samples . J Cutan Pathol (2014) ncbi
Articles Reviewed
  1. Werder R, Liu T, Abo K, Lindstrom Vautrin J, Villacorta Martin C, Huang J, et al. CRISPR interference interrogation of COPD GWAS genes reveals the functional significance of desmoplakin in iPSC-derived alveolar epithelial cells. Sci Adv. 2022;8:eabo6566 pubmed publisher
  2. Jung S, Kim D, Choi Y, Kim S, Park H, Lee H, et al. Contribution of p53 in sensitivity to EGFR tyrosine kinase inhibitors in non-small cell lung cancer. Sci Rep. 2021;11:19667 pubmed publisher
  3. Sweat M, Sweat Y, Yu W, Su D, Leonard R, Eliason S, et al. The miR-200 family is required for ectodermal organ development through the regulation of the epithelial stem cell niche. Stem Cells. 2021;39:761-775 pubmed publisher
  4. Li P, Meng Y, Wang Y, Li J, Lam M, Wang L, et al. Nuclear localization of Desmoplakin and its involvement in telomere maintenance. Int J Biol Sci. 2019;15:2350-2362 pubmed publisher
  5. Hao X, Han F, Ma B, Zhang N, Chen H, Jiang X, et al. SOX30 is a key regulator of desmosomal gene suppressing tumor growth and metastasis in lung adenocarcinoma. J Exp Clin Cancer Res. 2018;37:111 pubmed publisher
  6. Polivka L, Hadj Rabia S, Bal E, Leclerc Mercier S, Madrange M, Hamel Y, et al. Epithelial barrier dysfunction in Desmoglein-1 deficiency. J Allergy Clin Immunol. 2018;: pubmed publisher
  7. Chelko S, Asimaki A, Andersen P, Bedja D, Amat Alarcon N, Demazumder D, et al. Central role for GSK3β in the pathogenesis of arrhythmogenic cardiomyopathy. JCI Insight. 2016;1: pubmed publisher
  8. Lombardi R, Chen S, Ruggiero A, Gurha P, Czernuszewicz G, Willerson J, et al. Cardiac Fibro-Adipocyte Progenitors Express Desmosome Proteins and Preferentially Differentiate to Adipocytes Upon Deletion of the Desmoplakin Gene. Circ Res. 2016;119:41-54 pubmed publisher
  9. Gonzalez J, Crassous P, Schneider J, Beuve A, Fraidenraich D. Neuronal nitric oxide synthase localizes to utrophin expressing intercalated discs and stabilizes their structural integrity. Neuromuscul Disord. 2015;25:964-76 pubmed publisher
  10. Sharma P, Abbasi C, Lazic S, Teng A, Wang D, Dubois N, et al. Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function. Nat Commun. 2015;6:8391 pubmed publisher
  11. Basheer W, Harris B, Mentrup H, Abreha M, Thames E, Lea J, et al. Cardiomyocyte-specific overexpression of the ubiquitin ligase Wwp1 contributes to reduction in Connexin 43 and arrhythmogenesis. J Mol Cell Cardiol. 2015;88:1-13 pubmed publisher
  12. Zarkoob H, Bodduluri S, Ponnaluri S, Selby J, Sander E. Substrate Stiffness Affects Human Keratinocyte Colony Formation. Cell Mol Bioeng. 2015;8:32-50 pubmed
  13. Kessler C, Stanek J, Stringer K, Handwerger S. ETS1 induces human trophoblast differentiation. Endocrinology. 2015;156:1851-9 pubmed publisher
  14. Park D, Cerrone M, Morley G, Vasquez C, Fowler S, Liu N, et al. Genetically engineered SCN5A mutant pig hearts exhibit conduction defects and arrhythmias. J Clin Invest. 2015;125:403-12 pubmed publisher
  15. O Shea C, Fitzpatrick J, Koch P. Desmosomal defects in acantholytic squamous cell carcinomas. J Cutan Pathol. 2014;41:873-9 pubmed publisher
  16. Siljamäki E, Raiko L, Toriseva M, Nissinen L, Näreoja T, Peltonen J, et al. p38? mitogen-activated protein kinase regulates the expression of tight junction protein ZO-1 in differentiating human epidermal keratinocytes. Arch Dermatol Res. 2014;306:131-41 pubmed publisher
  17. Chkourko H, Guerrero Serna G, Lin X, Darwish N, Pohlmann J, Cook K, et al. Remodeling of mechanical junctions and of microtubule-associated proteins accompany cardiac connexin43 lateralization. Heart Rhythm. 2012;9:1133-1140.e6 pubmed publisher