This is a Validated Antibody Database (VAD) review about human cathepsin L, based on 18 published articles (read how Labome selects the articles), using cathepsin L antibody in all methods. It is aimed to help Labome visitors find the most suited cathepsin L antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
cathepsin L synonym: CATL; CTSL1; MEP

Knockout validation
R&D Systems
domestic goat polyclonal
  • western blot knockout validation; mouse; loading ...; fig 1a
R&D Systems cathepsin L antibody (R&D Systems, AF1515) was used in western blot knockout validation on mouse samples (fig 1a). Sci Rep (2021) ncbi
Invitrogen
mouse monoclonal (33-2)
  • western blot knockout validation; human; 1:100; loading ...; fig s7b
Invitrogen cathepsin L antibody (Thermofisher, BMS1032) was used in western blot knockout validation on human samples at 1:100 (fig s7b). Nat Commun (2021) ncbi
Abcam
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 7d
Abcam cathepsin L antibody (Abcam, ab203028) was used in immunohistochemistry - paraffin section on human samples at 1:100 (fig 7d). J Exp Clin Cancer Res (2021) ncbi
mouse monoclonal (33/2)
  • western blot; mouse; 1:1000; loading ...; fig 4e
Abcam cathepsin L antibody (Abcam, ab631) was used in western blot on mouse samples at 1:1000 (fig 4e). Front Pharmacol (2020) ncbi
mouse monoclonal (33/2)
  • immunohistochemistry - paraffin section; pigs ; 1:100; fig 1f
Abcam cathepsin L antibody (Abcam, ab6314) was used in immunohistochemistry - paraffin section on pigs samples at 1:100 (fig 1f). Vet Res (2016) ncbi
mouse monoclonal (33/2)
  • immunohistochemistry; human; 1:400; fig 2b
Abcam cathepsin L antibody (Abcam, ab6314) was used in immunohistochemistry on human samples at 1:400 (fig 2b). Mol Vis (2016) ncbi
mouse monoclonal (33/2)
  • immunohistochemistry; human; loading ...; fig 1d
  • western blot; human; loading ...; fig 2b
In order to study the effect of cathepsin L on glioma stem cells both in vivo and in vitro, Abcam cathepsin L antibody (Abcam, ab6314) was used in immunohistochemistry on human samples (fig 1d) and in western blot on human samples (fig 2b). Cancer Lett (2016) ncbi
mouse monoclonal (33/2)
  • western blot; human; fig s6
Abcam cathepsin L antibody (abcam, ab6314) was used in western blot on human samples (fig s6). Carcinogenesis (2015) ncbi
mouse monoclonal (33/2)
  • western blot; domestic rabbit; fig 3
Abcam cathepsin L antibody (Abcam, ab6314) was used in western blot on domestic rabbit samples (fig 3). Arthritis Res Ther (2015) ncbi
mouse monoclonal (33/2)
  • immunohistochemistry - frozen section; mouse; 1:50
In order to explore the role of MAGI-2 in the murine kidney, Abcam cathepsin L antibody (Abcam, ab6314) was used in immunohistochemistry - frozen section on mouse samples at 1:50. Am J Pathol (2014) ncbi
mouse monoclonal (33/2)
  • immunohistochemistry - frozen section; rat; 1:75
  • western blot; rat; 1:500
Abcam cathepsin L antibody (Abcam, ab6314) was used in immunohistochemistry - frozen section on rat samples at 1:75 and in western blot on rat samples at 1:500. Glia (2014) ncbi
mouse monoclonal (33/2)
  • immunocytochemistry; bee ; 1:100
Abcam cathepsin L antibody (Abcam, ab6314) was used in immunocytochemistry on bee samples at 1:100. Exp Gerontol (2014) ncbi
mouse monoclonal (33/2)
  • western blot; rat
Abcam cathepsin L antibody (Abcam, ab6314) was used in western blot on rat samples . Exp Gerontol (2013) ncbi
R&D Systems
rat monoclonal (204106)
  • western blot; human; loading ...; fig 3c, 7h
R&D Systems cathepsin L antibody (R&D Systems, MAB952) was used in western blot on human samples (fig 3c, 7h). J Exp Clin Cancer Res (2021) ncbi
mouse monoclonal (193720)
  • immunohistochemistry; fruit fly ; 1:200; loading ...; fig s6e
R&D Systems cathepsin L antibody (R&D Systems, MAB2259) was used in immunohistochemistry on fruit fly samples at 1:200 (fig s6e). J Cell Biol (2021) ncbi
domestic goat polyclonal
  • western blot knockout validation; mouse; loading ...; fig 1a
R&D Systems cathepsin L antibody (R&D Systems, AF1515) was used in western blot knockout validation on mouse samples (fig 1a). Sci Rep (2021) ncbi
Invitrogen
mouse monoclonal (33-2)
  • western blot knockout validation; human; 1:100; loading ...; fig s7b
Invitrogen cathepsin L antibody (Thermofisher, BMS1032) was used in western blot knockout validation on human samples at 1:100 (fig s7b). Nat Commun (2021) ncbi
mouse monoclonal (33-2)
  • western blot; human; 1:1000; fig 7
In order to investigate the effect of Obatoclax in esophageal cancer cells, Invitrogen cathepsin L antibody (eBioscience, BMS1032) was used in western blot on human samples at 1:1000 (fig 7). Oncotarget (2016) ncbi
Santa Cruz Biotechnology
mouse monoclonal (33/2)
  • western blot; human; loading ...; fig 5a
Santa Cruz Biotechnology cathepsin L antibody (Santa Cruz Biotechnology, sc-32320) was used in western blot on human samples (fig 5a). Autophagy (2018) ncbi
mouse monoclonal (H-1)
  • western blot; human; loading ...; fig 5a
Santa Cruz Biotechnology cathepsin L antibody (Santa Cruz Biotechnology, sc-376803) was used in western blot on human samples (fig 5a). Autophagy (2018) ncbi
mouse monoclonal (33/2)
  • immunohistochemistry - paraffin section; human; 1:1000
In order to investigate the association of giant cell polymyositis and myocarditis with myasthenia gravis and thymoma, Santa Cruz Biotechnology cathepsin L antibody (Santa Cruz Biotechnology, sc-32320) was used in immunohistochemistry - paraffin section on human samples at 1:1000. Neuropathology (2013) ncbi
BD Biosciences
mouse monoclonal (22/Cathepsin L)
  • western blot; human; 1:300; fig 6
BD Biosciences cathepsin L antibody (BD Transduction Laboratories, 611084) was used in western blot on human samples at 1:300 (fig 6). Nat Commun (2016) ncbi
Articles Reviewed
  1. Beumer J, Geurts M, Lamers M, Puschhof J, Zhang J, van der Vaart J, et al. A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses. Nat Commun. 2021;12:5498 pubmed publisher
  2. Wang X, Li X, Lin F, Sun H, Lin Y, Wang Z, et al. The lnc-CTSLP8 upregulates CTSL1 as a competitive endogenous RNA and promotes ovarian cancer metastasis. J Exp Clin Cancer Res. 2021;40:151 pubmed publisher
  3. Götz T, Puchkov D, Lysiuk V, Lützkendorf J, Nikonenko A, Quentin C, et al. Rab2 regulates presynaptic precursor vesicle biogenesis at the trans-Golgi. J Cell Biol. 2021;220: pubmed publisher
  4. Iwama H, Mehanna S, Imasaka M, Hashidume S, Nishiura H, Yamamura K, et al. Cathepsin B and D deficiency in the mouse pancreas induces impaired autophagy and chronic pancreatitis. Sci Rep. 2021;11:6596 pubmed publisher
  5. Shen S, Li B, Dai J, Wu Z, He Y, Wen L, et al. BRD4 Inhibition Protects Against Acute Pancreatitis Through Restoring Impaired Autophagic Flux. Front Pharmacol. 2020;11:618 pubmed publisher
  6. Wang W, Xia Z, Farre J, Subramani S. TRIM37 deficiency induces autophagy through deregulating the MTORC1-TFEB axis. Autophagy. 2018;14:1574-1585 pubmed publisher
  7. Novakovic P, Harding J, Ladinig A, Al Dissi A, MacPhee D, Detmer S. Relationships of CD163 and CD169 positive cell numbers in the endometrium and fetal placenta with type 2 PRRSV RNA concentration in fetal thymus. Vet Res. 2016;47:76 pubmed publisher
  8. Bento C, Ashkenazi A, Jimenez Sanchez M, Rubinsztein D. The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway. Nat Commun. 2016;7:11803 pubmed publisher
  9. Abu El Asrar A, Siddiquei M, Nawaz M, De Hertogh G, Mohammad G, Alam K, et al. Coexpression of heparanase activity, cathepsin L, tissue factor, tissue factor pathway inhibitor, and MMP-9 in proliferative diabetic retinopathy. Mol Vis. 2016;22:424-35 pubmed
  10. Yu L, Wu W, Gu C, Zhong D, Zhao X, Kong Y, et al. Obatoclax impairs lysosomal function to block autophagy in cisplatin-sensitive and -resistant esophageal cancer cells. Oncotarget. 2016;7:14693-707 pubmed publisher
  11. Wang W, Long L, Wang L, Tan C, Fei X, Chen L, et al. Knockdown of Cathepsin L promotes radiosensitivity of glioma stem cells both in vivo and in vitro. Cancer Lett. 2016;371:274-84 pubmed publisher
  12. Lenain C, Gusyatiner O, Douma S, van den Broek B, Peeper D. Autophagy-mediated degradation of nuclear envelope proteins during oncogene-induced senescence. Carcinogenesis. 2015;36:1263-74 pubmed publisher
  13. Kyostio Moore S, Piraino S, Berthelette P, Moran N, Serriello J, Bendele A, et al. Overexpression of cystatin C in synovium does not reduce synovitis or cartilage degradation in established osteoarthritis. Arthritis Res Ther. 2015;17:5 pubmed publisher
  14. Ihara K, Asanuma K, Fukuda T, Ohwada S, Yoshida M, Nishimori K. MAGI-2 is critical for the formation and maintenance of the glomerular filtration barrier in mouse kidney. Am J Pathol. 2014;184:2699-708 pubmed publisher
  15. Xu M, Yang L, Rong J, Ni Y, Gu W, Luo Y, et al. Inhibition of cysteine cathepsin B and L activation in astrocytes contributes to neuroprotection against cerebral ischemia via blocking the tBid-mitochondrial apoptotic signaling pathway. Glia. 2014;62:855-80 pubmed publisher
  16. Hsu C, Chuang Y, Chan Y. Changes in cellular degradation activity in young and old worker honeybees (Apis mellifera). Exp Gerontol. 2014;50:128-36 pubmed publisher
  17. Luo L, Lu A, Wang Y, Hong A, Chen Y, Hu J, et al. Chronic resistance training activates autophagy and reduces apoptosis of muscle cells by modulating IGF-1 and its receptors, Akt/mTOR and Akt/FOXO3a signaling in aged rats. Exp Gerontol. 2013;48:427-36 pubmed publisher
  18. Kon T, Mori F, Tanji K, Miki Y, Kimura T, Wakabayashi K. Giant cell polymyositis and myocarditis associated with myasthenia gravis and thymoma. Neuropathology. 2013;33:281-7 pubmed publisher