This is a Validated Antibody Database (VAD) review about human cathepsin D, based on 39 published articles (read how Labome selects the articles), using cathepsin D antibody in all methods. It is aimed to help Labome visitors find the most suited cathepsin D antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
cathepsin D synonym: CLN10; CPSD; HEL-S-130P

Knockout validation
Abcam
domestic rabbit monoclonal (EPR3057Y)
  • western blot knockout validation; human; loading ...; fig s3b
  • immunocytochemistry; human; fig 3b
Abcam cathepsin D antibody (Abcam, ab75852) was used in western blot knockout validation on human samples (fig s3b) and in immunocytochemistry on human samples (fig 3b). Invest Ophthalmol Vis Sci (2021) ncbi
Abcam
domestic rabbit monoclonal (EPR3057Y)
  • western blot knockout validation; human; loading ...; fig s3b
  • immunocytochemistry; human; fig 3b
Abcam cathepsin D antibody (Abcam, ab75852) was used in western blot knockout validation on human samples (fig s3b) and in immunocytochemistry on human samples (fig 3b). Invest Ophthalmol Vis Sci (2021) ncbi
domestic rabbit monoclonal (EPR3057Y)
  • western blot; human; loading ...; fig 5c
Abcam cathepsin D antibody (Abcam, ab75852) was used in western blot on human samples (fig 5c). J Exp Clin Cancer Res (2019) ncbi
domestic rabbit monoclonal (EPR3057Y)
  • immunocytochemistry; human; 1:50; loading ...; fig 2d
Abcam cathepsin D antibody (Abcam, ab75852) was used in immunocytochemistry on human samples at 1:50 (fig 2d). Nat Commun (2019) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 6b
Abcam cathepsin D antibody (Abcam, ab72915) was used in western blot on human samples (fig 6b). Autophagy (2019) ncbi
domestic rabbit monoclonal (EPR3057Y)
  • western blot; mouse; loading ...; fig 3d
Abcam cathepsin D antibody (Abcam, ab75852) was used in western blot on mouse samples (fig 3d). EMBO J (2018) ncbi
mouse monoclonal (CTD-19)
  • western blot; mouse; loading ...; fig 4a
In order to find that continued 26S proteasome dysfunction in mouse brain cortical neurons causes paranuclear accumulation of fragmented dysfunctional mitochondria, associated with earlier recruitment of Parkin and lysine 48-linked ubiquitination of mitochond, Abcam cathepsin D antibody (Abcam, ab6313) was used in western blot on mouse samples (fig 4a). Cell Death Dis (2017) ncbi
domestic rabbit polyclonal
  • immunocytochemistry; human; 1:100; loading ...; fig 8a
  • western blot; human; loading ...; fig 8b
In order to examine the role of Breast Cancer Associated gene 2 in EGFR endocytosis and down-regulation and to determine its links with breast cancer outcome, Abcam cathepsin D antibody (Abcam, ab72915) was used in immunocytochemistry on human samples at 1:100 (fig 8a) and in western blot on human samples (fig 8b). J Cancer (2016) ncbi
mouse monoclonal (CTD-19)
  • western blot; human; loading ...; fig 2b
In order to determine the role of SNAPIN in macrophages, Abcam cathepsin D antibody (Abcam, ab6313) was used in western blot on human samples (fig 2b). Autophagy (2017) ncbi
mouse monoclonal (CTD-19)
  • western blot; human; 1:2000; loading ...; fig 4e
Abcam cathepsin D antibody (Abcam, ab6313) was used in western blot on human samples at 1:2000 (fig 4e). Oncogene (2017) ncbi
mouse monoclonal (CTD-19)
  • immunocytochemistry; human; 1:200; loading ...; fig 1f
  • western blot; human; 1:1000; loading ...; fig 1g
Abcam cathepsin D antibody (Abcam, ab6313) was used in immunocytochemistry on human samples at 1:200 (fig 1f) and in western blot on human samples at 1:1000 (fig 1g). Br J Cancer (2016) ncbi
mouse monoclonal (CTD-19)
  • western blot; mouse; 1:1000; fig 5
In order to study the attenuation of Alzheimer's pathology in mice due to kallikrein-8 inhibition, Abcam cathepsin D antibody (abcam, ab6313) was used in western blot on mouse samples at 1:1000 (fig 5). Alzheimers Dement (2016) ncbi
domestic rabbit monoclonal (EPR3057Y)
  • immunohistochemistry - paraffin section; human; 1:750; fig 2
Abcam cathepsin D antibody (Epitomics, 2487-1) was used in immunohistochemistry - paraffin section on human samples at 1:750 (fig 2). Oncol Lett (2016) ncbi
domestic rabbit monoclonal (EPR3057Y)
  • immunohistochemistry; mouse; 1:300; loading ...; fig 6a
  • western blot; mouse; 1:1000; loading ...; fig 5a
In order to test if the beta-amyloid peptide disrupts microtubules, Abcam cathepsin D antibody (Abcam, ab75852) was used in immunohistochemistry on mouse samples at 1:300 (fig 6a) and in western blot on mouse samples at 1:1000 (fig 5a). Acta Neuropathol (2016) ncbi
mouse monoclonal (CTD-19)
  • immunohistochemistry - paraffin section; human; 1:500; tbl 2
In order to characterize autophagic and lysosomal defects in human tauopathies from post-mortem brain from patients with familial Alzheimer disease, progressive supranuclear palsy, and coricobasal degeneration, Abcam cathepsin D antibody (Abcam, Ab6313) was used in immunohistochemistry - paraffin section on human samples at 1:500 (tbl 2). Acta Neuropathol Commun (2016) ncbi
mouse monoclonal (CTD-19)
  • western blot; human; 1:20,000; fig 3
In order to discuss how mutations in superoxide dismutase-1 affect the motor system, Abcam cathepsin D antibody (Abcam, ab6313) was used in western blot on human samples at 1:20,000 (fig 3). Acta Neuropathol Commun (2016) ncbi
domestic rabbit monoclonal (EPR3057Y)
  • immunocytochemistry; human; 1:100; fig s5
In order to analyze how Serpina3n overexpression halts muscular dystrophy in mice, Abcam cathepsin D antibody (Abcam, ab75852) was used in immunocytochemistry on human samples at 1:100 (fig s5). Hum Mol Genet (2016) ncbi
mouse monoclonal (CTD-19)
  • western blot; human; fig 5
In order to study the fusion between lysosomes and amphisomes/MVBs regulated by mahogunin via ubiquitination of TSG101, Abcam cathepsin D antibody (Abcam, ab6313) was used in western blot on human samples (fig 5). Cell Death Dis (2015) ncbi
mouse monoclonal (CTD-19)
  • western blot; human; loading ...; fig 6d
Abcam cathepsin D antibody (Abcam, ab6313) was used in western blot on human samples (fig 6d). J Neurochem (2016) ncbi
mouse monoclonal (CTD-19)
  • western blot; human; 1:1000; fig 1
Abcam cathepsin D antibody (Abcam, ab6313) was used in western blot on human samples at 1:1000 (fig 1). Cell Death Dis (2015) ncbi
mouse monoclonal (CTD-19)
  • immunohistochemistry - paraffin section; human; 1:1000; fig 1g
  • immunocytochemistry; human; 1:200; fig 1
  • western blot; human; 1:500; fig 1
Abcam cathepsin D antibody (Abcam, CTD-19) was used in immunohistochemistry - paraffin section on human samples at 1:1000 (fig 1g), in immunocytochemistry on human samples at 1:200 (fig 1) and in western blot on human samples at 1:500 (fig 1). Lung Cancer (2015) ncbi
domestic rabbit monoclonal (EPR3057Y)
  • western blot; roundworm ; fig s5
Abcam cathepsin D antibody (Abcam, ab75852) was used in western blot on roundworm samples (fig s5). Autophagy (2014) ncbi
domestic rabbit monoclonal (EPR3057Y)
  • immunohistochemistry - frozen section; mouse; 1:500
Abcam cathepsin D antibody (Abcam, ab75852) was used in immunohistochemistry - frozen section on mouse samples at 1:500. J Muscle Res Cell Motil (2013) ncbi
domestic rabbit monoclonal (EPR3057Y)
  • western blot; mouse; 1:1000
Abcam cathepsin D antibody (Abcam, ab75852) was used in western blot on mouse samples at 1:1000. Traffic (2012) ncbi
Santa Cruz Biotechnology
mouse monoclonal (D-7)
  • western blot; human; 1:500; loading ...; fig 4e
Santa Cruz Biotechnology cathepsin D antibody (SantaCruz, sc-377299) was used in western blot on human samples at 1:500 (fig 4e). Antioxidants (Basel) (2021) ncbi
mouse monoclonal (D-7)
  • western blot; rat; fig 2
Santa Cruz Biotechnology cathepsin D antibody (Santa Cruz, sc377299) was used in western blot on rat samples (fig 2). J Neurochem (2015) ncbi
mouse monoclonal (D-7)
  • immunocytochemistry; rat
Santa Cruz Biotechnology cathepsin D antibody (Santa Cruz Biotechnology, sc-377299) was used in immunocytochemistry on rat samples . Life Sci (2015) ncbi
mouse monoclonal (F-12)
  • western blot; human; loading ...; fig 3
Santa Cruz Biotechnology cathepsin D antibody (Santa Cruz Biotechnology, sc-374381) was used in western blot on human samples (fig 3). Breast Cancer Res Treat (2014) ncbi
mouse monoclonal (E-7)
  • immunocytochemistry; human
Santa Cruz Biotechnology cathepsin D antibody (Santa Cruz Biotechnolog, sc-13148) was used in immunocytochemistry on human samples . FASEB J (2013) ncbi
R&D Systems
rat monoclonal (204712)
  • immunohistochemistry; mouse; 1:500; loading ...; fig 5d
  • western blot; mouse; 1:1000; loading ...; fig 5f
R&D Systems cathepsin D antibody (RD Biosystems, MAB 1029) was used in immunohistochemistry on mouse samples at 1:500 (fig 5d) and in western blot on mouse samples at 1:1000 (fig 5f). Proc Natl Acad Sci U S A (2021) ncbi
domestic goat polyclonal
  • immunohistochemistry; mouse; 1:500; fig 6h
R&D Systems cathepsin D antibody (R&D systems, AF1029) was used in immunohistochemistry on mouse samples at 1:500 (fig 6h). J Neuroinflammation (2021) ncbi
LifeSpan Biosciences
mouse monoclonal (4G2)
  • western blot; human; fig s6
LifeSpan Biosciences cathepsin D antibody (Lifespan Biosciences, LS-B2931) was used in western blot on human samples (fig s6). Carcinogenesis (2015) ncbi
MilliporeSigma
mouse monoclonal (CTD-19)
  • immunohistochemistry - frozen section; domestic rabbit; fig 1
  • western blot; domestic rabbit; 1:1000; fig 2
In order to characterize the role of endolysosomes in skeletal muscle pathology observed in a model of Alzheimer's disease with a cholesterol-fed rabbit, MilliporeSigma cathepsin D antibody (Sigma, c0715) was used in immunohistochemistry - frozen section on domestic rabbit samples (fig 1) and in western blot on domestic rabbit samples at 1:1000 (fig 2). Front Aging Neurosci (2016) ncbi
Cell Signaling Technology
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 1a
Cell Signaling Technology cathepsin D antibody (Cell signaling, 2284S) was used in western blot on human samples (fig 1a). Theranostics (2021) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 4b
Cell Signaling Technology cathepsin D antibody (Cell Signaling Technology, 2284) was used in western blot on human samples at 1:1000 (fig 4b). Nat Commun (2020) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 4e
Cell Signaling Technology cathepsin D antibody (Cell Signaling Technology, 2284) was used in western blot on human samples (fig 4e). Cell Death Dis (2018) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 4c
Cell Signaling Technology cathepsin D antibody (Cell Signaling Technology, 2284) was used in western blot on human samples (fig 4c). Nature (2017) ncbi
domestic rabbit polyclonal
  • immunocytochemistry; human; loading ...; fig 4a
  • western blot; human; loading ...; fig 2b
In order to determine the role of SNAPIN in macrophages, Cell Signaling Technology cathepsin D antibody (Cell Signaling, 2284) was used in immunocytochemistry on human samples (fig 4a) and in western blot on human samples (fig 2b). Autophagy (2017) ncbi
domestic rabbit polyclonal
  • immunocytochemistry; human; 1:50; fig s3
Cell Signaling Technology cathepsin D antibody (Cell Signaling, 2284) was used in immunocytochemistry on human samples at 1:50 (fig s3). Sci Rep (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; fig 7
In order to investigate the effect of Obatoclax in esophageal cancer cells, Cell Signaling Technology cathepsin D antibody (Cell Signaling Tech, 2284) was used in western blot on human samples at 1:1000 (fig 7). Oncotarget (2016) ncbi
BD Biosciences
mouse monoclonal (49/Cathepsin D)
  • immunocytochemistry; human; fig 4
BD Biosciences cathepsin D antibody (BD Biosciences, 610800) was used in immunocytochemistry on human samples (fig 4). Autophagy (2014) ncbi
Articles Reviewed
  1. Ashok A, Chaudhary S, Wise A, Rana N, McDonald D, Kritikos A, et al. Release of Iron-Loaded Ferritin in Sodium Iodate-Induced Model of Age Related Macular Degeneration: An In-Vitro and In-Vivo Study. Antioxidants (Basel). 2021;10: pubmed publisher
  2. Zhang Q, Wadgaonkar P, Xu L, Thakur C, Fu Y, Bi Z, et al. Environmentally-induced mdig contributes to the severity of COVID-19 through fostering expression of SARS-CoV-2 receptor NRPs and glycan metabolism. Theranostics. 2021;11:7970-7983 pubmed publisher
  3. Glajch K, Moors T, Chen Y, Bechade P, Nam A, Rajsombath M, et al. Wild-type GBA1 increases the α-synuclein tetramer-monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
  4. Escrevente C, Falcão A, Hall M, Lopes da Silva M, Antas P, Mesquita M, et al. Formation of Lipofuscin-Like Autofluorescent Granules in the Retinal Pigment Epithelium Requires Lysosome Dysfunction. Invest Ophthalmol Vis Sci. 2021;62:39 pubmed publisher
  5. Takahashi K, Nakamura S, Otsu W, Shimazawa M, Hara H. Progranulin deficiency in Iba-1+ myeloid cells exacerbates choroidal neovascularization by perturbation of lysosomal function and abnormal inflammation. J Neuroinflammation. 2021;18:164 pubmed publisher
  6. Silva M, Nandi G, Tentarelli S, Gurrell I, Jamier T, Lucente D, et al. Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons. Nat Commun. 2020;11:3258 pubmed publisher
  7. He R, Wang M, Zhao C, Shen M, Yu Y, He L, et al. TFEB-driven autophagy potentiates TGF-β induced migration in pancreatic cancer cells. J Exp Clin Cancer Res. 2019;38:340 pubmed publisher
  8. Sapmaz A, Berlin I, Bos E, Wijdeven R, Janssen H, Konietzny R, et al. USP32 regulates late endosomal transport and recycling through deubiquitylation of Rab7. Nat Commun. 2019;10:1454 pubmed publisher
  9. Xu Y, Ren J, He X, Chen H, Wei T, Feng W. YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization. Autophagy. 2019;15:1017-1030 pubmed publisher
  10. Wang H, Bu L, Wang C, Zhang Y, Zhou H, Zhang X, et al. The Hsp70 inhibitor 2-phenylethynesulfonamide inhibits replication and carcinogenicity of Epstein-Barr virus by inhibiting the molecular chaperone function of Hsp70. Cell Death Dis. 2018;9:734 pubmed publisher
  11. Hartlova A, Herbst S, Peltier J, Rodgers A, Bilkei Gorzo O, Fearns A, et al. LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages. EMBO J. 2018;37: pubmed publisher
  12. Wolfson R, Chantranupong L, Wyant G, Gu X, Orozco J, Shen K, et al. KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1. Nature. 2017;543:438-442 pubmed publisher
  13. Ugun Klusek A, Tatham M, Elkharaz J, Constantin Teodosiu D, Lawler K, Mohamed H, et al. Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway. Cell Death Dis. 2017;8:e2531 pubmed publisher
  14. Wymant J, Hiscox S, Westwell A, Urbé S, Clague M, Jones A. The Role of BCA2 in the Endocytic Trafficking of EGFR and Significance as a Prognostic Biomarker in Cancer. J Cancer. 2016;7:2388-2407 pubmed
  15. Shi B, Huang Q, Birkett R, Doyle R, Dorfleutner A, Stehlik C, et al. SNAPIN is critical for lysosomal acidification and autophagosome maturation in macrophages. Autophagy. 2017;13:285-301 pubmed publisher
  16. Walenbergh S, Houben T, Rensen S, Bieghs V, Hendrikx T, van Gorp P, et al. Plasma cathepsin D correlates with histological classifications of fatty liver disease in adults and responds to intervention. Sci Rep. 2016;6:38278 pubmed publisher
  17. Harrod A, Fulton J, Nguyen V, Periyasamy M, Ramos Garcia L, Lai C, et al. Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancer. Oncogene. 2017;36:2286-2296 pubmed publisher
  18. Karagounis I, Kalamida D, Mitrakas A, Pouliliou S, Liousia M, Giatromanolaki A, et al. Repression of the autophagic response sensitises lung cancer cells to radiation and chemotherapy. Br J Cancer. 2016;115:312-21 pubmed publisher
  19. Chen X, Wagener J, Ghribi O, Geiger J. Role of Endolysosomes in Skeletal Muscle Pathology Observed in a Cholesterol-Fed Rabbit Model of Alzheimer's Disease. Front Aging Neurosci. 2016;8:129 pubmed publisher
  20. Herring A, Münster Y, Akkaya T, Moghaddam S, Deinsberger K, Meyer J, et al. Kallikrein-8 inhibition attenuates Alzheimer's disease pathology in mice. Alzheimers Dement. 2016;12:1273-1287 pubmed publisher
  21. Zhang J, Jin Y, Xu S, Zheng J, Zhang Q, Wang Y, et al. AGR2 is associated with gastric cancer progression and poor survival. Oncol Lett. 2016;11:2075-2083 pubmed
  22. Sadleir K, Kandalepas P, Buggia Prevot V, Nicholson D, Thinakaran G, Vassar R. Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer's disease. Acta Neuropathol. 2016;132:235-56 pubmed publisher
  23. Piras A, Collin L, Grüninger F, Graff C, Rönnbäck A. Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy. Acta Neuropathol Commun. 2016;4:22 pubmed publisher
  24. Yu L, Wu W, Gu C, Zhong D, Zhao X, Kong Y, et al. Obatoclax impairs lysosomal function to block autophagy in cisplatin-sensitive and -resistant esophageal cancer cells. Oncotarget. 2016;7:14693-707 pubmed publisher
  25. Tokuda E, Brännström T, Andersen P, Marklund S. Low autophagy capacity implicated in motor system vulnerability to mutant superoxide dismutase. Acta Neuropathol Commun. 2016;4:6 pubmed publisher
  26. Tjondrokoesoemo A, Schips T, Kanisicak O, Sargent M, Molkentin J. Genetic overexpression of Serpina3n attenuates muscular dystrophy in mice. Hum Mol Genet. 2016;25:1192-202 pubmed publisher
  27. Majumder P, Chakrabarti O. Mahogunin regulates fusion between amphisomes/MVBs and lysosomes via ubiquitination of TSG101. Cell Death Dis. 2015;6:e1970 pubmed publisher
  28. Ivankovic D, Chau K, Schapira A, Gegg M. Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin-mediated mitophagy. J Neurochem. 2016;136:388-402 pubmed publisher
  29. Bae E, Yang N, Lee C, Kim S, Lee H, Lee S. Haploinsufficiency of cathepsin D leads to lysosomal dysfunction and promotes cell-to-cell transmission of α-synuclein aggregates. Cell Death Dis. 2015;6:e1901 pubmed publisher
  30. Lenain C, Gusyatiner O, Douma S, van den Broek B, Peeper D. Autophagy-mediated degradation of nuclear envelope proteins during oncogene-induced senescence. Carcinogenesis. 2015;36:1263-74 pubmed publisher
  31. Giatromanolaki A, Kalamida D, Sivridis E, Karagounis I, Gatter K, Harris A, et al. Increased expression of transcription factor EB (TFEB) is associated with autophagy, migratory phenotype and poor prognosis in non-small cell lung cancer. Lung Cancer. 2015;90:98-105 pubmed publisher
  32. Tome M, Schaefer C, Jacobs L, Zhang Y, Herndon J, Matty F, et al. Identification of P-glycoprotein co-fractionating proteins and specific binding partners in rat brain microvessels. J Neurochem. 2015;134:200-10 pubmed publisher
  33. Brandstaetter H, Kishi Itakura C, Tumbarello D, Manstein D, Buss F. Loss of functional MYO1C/myosin 1c, a motor protein involved in lipid raft trafficking, disrupts autophagosome-lysosome fusion. Autophagy. 2014;10:2310-23 pubmed publisher
  34. Liu H, Xie Q, Xin B, Liu J, Liu Y, Li Y, et al. Inhibition of autophagy recovers cardiac dysfunction and atrophy in response to tail-suspension. Life Sci. 2015;121:1-9 pubmed publisher
  35. Guo B, Huang J, Wu W, Feng D, Wang X, Chen Y, et al. The nascent polypeptide-associated complex is essential for autophagic flux. Autophagy. 2014;10:1738-48 pubmed publisher
  36. Varley K, Gertz J, Roberts B, Davis N, Bowling K, Kirby M, et al. Recurrent read-through fusion transcripts in breast cancer. Breast Cancer Res Treat. 2014;146:287-97 pubmed publisher
  37. Sharpe K, Premsukh M, Townsend D. Alterations of dystrophin-associated glycoproteins in the heart lacking dystrophin or dystrophin and utrophin. J Muscle Res Cell Motil. 2013;34:395-405 pubmed publisher
  38. Wu H, Downs D, Ghosh K, Ghosh A, Staib P, Monod M, et al. Candida albicans secreted aspartic proteases 4-6 induce apoptosis of epithelial cells by a novel Trojan horse mechanism. FASEB J. 2013;27:2132-44 pubmed publisher
  39. Durieux A, Vassilopoulos S, Laine J, Fraysse B, Brinas L, Prudhon B, et al. A centronuclear myopathy--dynamin 2 mutation impairs autophagy in mice. Traffic. 2012;13:869-79 pubmed publisher