This is a Validated Antibody Database (VAD) review about human caspase-2, based on 18 published articles (read how Labome selects the articles), using caspase-2 antibody in all methods. It is aimed to help Labome visitors find the most suited caspase-2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
caspase-2 synonym: CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57; caspase-2; caspase 2 apoptosis-related cysteine peptidase; neural precursor cell expressed developmentally down-regulated protein 2; protease ICH-1; protein phosphatase 1, regulatory subunit 57

Abcam
rabbit monoclonal (EPR16796)
  • western blot; mouse; loading ...; fig 6b
Abcam caspase-2 antibody (Abcam, ab179520) was used in western blot on mouse samples (fig 6b). Autophagy (2017) ncbi
rabbit polyclonal
  • immunohistochemistry - paraffin section; mouse
Abcam caspase-2 antibody (Abcam, ab2251) was used in immunohistochemistry - paraffin section on mouse samples . Hum Reprod (2014) ncbi
rabbit polyclonal
  • western blot; mouse
Abcam caspase-2 antibody (Abcam, ab18737) was used in western blot on mouse samples . Cell Death Differ (2014) ncbi
rabbit polyclonal
  • immunohistochemistry; mouse; 1:200
Abcam caspase-2 antibody (Abcam, ab2251) was used in immunohistochemistry on mouse samples at 1:200. Toxicol Appl Pharmacol (2013) ncbi
rabbit polyclonal
  • immunocytochemistry; human; 1:50
  • western blot; human
Abcam caspase-2 antibody (Abcam, ab 18737) was used in immunocytochemistry on human samples at 1:50 and in western blot on human samples . Cancer Cell Int (2013) ncbi
rabbit monoclonal (Y154)
  • western blot; human
Abcam caspase-2 antibody (Abcam, ab32021) was used in western blot on human samples . Cancer Cell Int (2013) ncbi
EMD Millipore
rat monoclonal (11B4)
  • western blot; human; loading ...; fig 2a
EMD Millipore caspase-2 antibody (EMD Millipore, 11B4) was used in western blot on human samples (fig 2a). J Cell Biol (2017) ncbi
rat monoclonal (11B4)
  • western blot; mouse
EMD Millipore caspase-2 antibody (Millipore, MAB3507) was used in western blot on mouse samples . PLoS ONE (2014) ncbi
rat monoclonal (10C6)
  • western blot; mouse
EMD Millipore caspase-2 antibody (Chemicon / EMD Millipore, MAB3501) was used in western blot on mouse samples . PLoS ONE (2014) ncbi
rat monoclonal (11B4)
  • western blot; human
EMD Millipore caspase-2 antibody (Millipore, MAB3507) was used in western blot on human samples . Cell Cycle (2014) ncbi
rat monoclonal (11B4)
  • western blot; mouse
In order to examine the possible role of caspase-2 as a tumor suppressor in the mouse mammary carcinogenesis model, EMD Millipore caspase-2 antibody (EMD Millipore, 11B4) was used in western blot on mouse samples . Cell Death Differ (2013) ncbi
rat monoclonal (11B4)
  • western blot; human; fig 7
EMD Millipore caspase-2 antibody (Millipore, MAB3507) was used in western blot on human samples (fig 7). Cell Death Dis (2012) ncbi
Cell Signaling Technology
mouse monoclonal (C2)
  • western blot; human; fig 5
Cell Signaling Technology caspase-2 antibody (Cell Signaling, 2224) was used in western blot on human samples (fig 5). Cancer Cell Int (2016) ncbi
mouse monoclonal (C2)
  • western blot; human; fig 3
Cell Signaling Technology caspase-2 antibody (Cell Signaling, 2224) was used in western blot on human samples (fig 3). Oncotarget (2016) ncbi
mouse monoclonal (C2)
  • western blot; human; fig 4c
Cell Signaling Technology caspase-2 antibody (Cell Signaling, 2224) was used in western blot on human samples (fig 4c). Mol Cancer (2014) ncbi
mouse monoclonal (C2)
  • western blot; human; fig 4
In order to analyze the effects of a HSP90 inhibitor, NVP-HSP990, on multiple myeloma cell proliferation and survival, Cell Signaling Technology caspase-2 antibody (Cell Signalling, #2224) was used in western blot on human samples (fig 4). Eur J Haematol (2012) ncbi
BD Biosciences
mouse monoclonal (35/Caspase-2/ICH-1L)
  • other; human; loading ...; fig st1
In order to use size exclusion chromatography-microsphere-based affinity proteomics to study clinical samples obtained from pediatric acute leukemia patients, BD Biosciences caspase-2 antibody (BD, 35) was used in other on human samples (fig st1). Mol Cell Proteomics (2016) ncbi
mouse monoclonal (35/Caspase-2/ICH-1L)
  • western blot; human
BD Biosciences caspase-2 antibody (BD Biosciences, 611022) was used in western blot on human samples . Cell Death Dis (2016) ncbi
mouse monoclonal (35/Caspase-2/ICH-1L)
  • immunocytochemistry; human
In order to evaluate the prognostic value of B-cell translocation gene 1 in hepatocellular carcinoma, BD Biosciences caspase-2 antibody (BD Biosciences, clone 35) was used in immunocytochemistry on human samples . Int J Oncol (2015) ncbi
Articles Reviewed
  1. Ando K, PARSONS M, Shah R, Charendoff C, Paris S, Liu P, et al. NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus. J Cell Biol. 2017;216:1795-1810 pubmed publisher
  2. Liu J, Wang H, Gu J, Deng T, Yuan Z, Hu B, et al. BECN1-dependent CASP2 incomplete autophagy induction by binding to rabies virus phosphoprotein. Autophagy. 2017;13:739-753 pubmed publisher
  3. Tagscherer K, Fassl A, Sinkovic T, Richter J, Schecher S, Macher Goeppinger S, et al. MicroRNA-210 induces apoptosis in colorectal cancer via induction of reactive oxygen. Cancer Cell Int. 2016;16:42 pubmed publisher
  4. Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed publisher
  5. Schirmer M, Trentin L, Queudeville M, Seyfried F, Demir S, Tausch E, et al. Intrinsic and chemo-sensitizing activity of SMAC-mimetics on high-risk childhood acute lymphoblastic leukemia. Cell Death Dis. 2016;7:e2052 pubmed publisher
  6. Alsafadi S, Tourpin S, Bessoltane N, Salomé Desnoulez S, Vassal G, André F, et al. Nuclear localization of the caspase-3-cleaved form of p73 in anoikis. Oncotarget. 2016;7:12331-43 pubmed publisher
  7. Kanda M, Sugimoto H, Nomoto S, Oya H, Hibino S, Shimizu D, et al. B‑cell translocation gene 1 serves as a novel prognostic indicator of hepatocellular carcinoma. Int J Oncol. 2015;46:641-8 pubmed publisher
  8. Sobinoff A, Sutherland J, Beckett E, Stanger S, Johnson R, Jarnicki A, et al. Damaging legacy: maternal cigarette smoking has long-term consequences for male offspring fertility. Hum Reprod. 2014;29:2719-35 pubmed publisher
  9. Harashima N, Minami T, Uemura H, Harada M. Transfection of poly(I:C) can induce reactive oxygen species-triggered apoptosis and interferon-β-mediated growth arrest in human renal cell carcinoma cells via innate adjuvant receptors and the 2-5A system. Mol Cancer. 2014;13:217 pubmed publisher
  10. Sharma R, Callaway D, Vanegas D, Bendele M, Lopez Cruzan M, Horn D, et al. Caspase-2 maintains bone homeostasis by inducing apoptosis of oxidatively-damaged osteoclasts. PLoS ONE. 2014;9:e93696 pubmed publisher
  11. Mahajan I, Chen M, Muro I, Robertson J, Wright C, Bratton S. BH3-only protein BIM mediates heat shock-induced apoptosis. PLoS ONE. 2014;9:e84388 pubmed publisher
  12. Sandow J, Dorstyn L, O Reilly L, Tailler M, Kumar S, Strasser A, et al. ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis. Cell Death Differ. 2014;21:475-80 pubmed publisher
  13. Del Nagro C, Choi J, Xiao Y, Rangell L, Mohan S, Pandita A, et al. Chk1 inhibition in p53-deficient cell lines drives rapid chromosome fragmentation followed by caspase-independent cell death. Cell Cycle. 2014;13:303-14 pubmed publisher
  14. Sobinoff A, Beckett E, Jarnicki A, Sutherland J, McCluskey A, Hansbro P, et al. Scrambled and fried: cigarette smoke exposure causes antral follicle destruction and oocyte dysfunction through oxidative stress. Toxicol Appl Pharmacol. 2013;271:156-67 pubmed publisher
  15. Jelinek M, Balusikova K, Kopperová D, Němcová Fürstová V, Srámek J, Fidlerova J, et al. Caspase-2 is involved in cell death induction by taxanes in breast cancer cells. Cancer Cell Int. 2013;13:42 pubmed publisher
  16. Parsons M, McCormick L, Janke L, Howard A, Bouchier Hayes L, Green D. Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice. Cell Death Differ. 2013;20:1174-82 pubmed publisher
  17. Orzáez M, Guevara T, Sancho M, Perez Paya E. Intrinsic caspase-8 activation mediates sensitization of erlotinib-resistant tumor cells to erlotinib/cell-cycle inhibitors combination treatment. Cell Death Dis. 2012;3:e415 pubmed publisher
  18. Lamottke B, Kaiser M, Mieth M, Heider U, Gao Z, Nikolova Z, et al. The novel, orally bioavailable HSP90 inhibitor NVP-HSP990 induces cell cycle arrest and apoptosis in multiple myeloma cells and acts synergistically with melphalan by increased cleavage of caspases. Eur J Haematol. 2012;88:406-15 pubmed publisher