This is a Validated Antibody Database (VAD) review about human XRCC1, based on 20 published articles (read how Labome selects the articles), using XRCC1 antibody in all methods. It is aimed to help Labome visitors find the most suited XRCC1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
XRCC1 synonym: RCC; SCAR26

Invitrogen
mouse monoclonal (144)
  • immunocytochemistry; human; 1:200; loading ...; fig 5c
Invitrogen XRCC1 antibody (Thermo Fisher, MA5-12071) was used in immunocytochemistry on human samples at 1:200 (fig 5c). Aging (Albany NY) (2021) ncbi
mouse monoclonal (144)
  • western blot; human
In order to test if base excision repair-deficient cells are a source of pre-cancerous cells, Invitrogen XRCC1 antibody (Neomarkers, MS-1393-P0) was used in western blot on human samples . Nucleic Acids Res (2015) ncbi
mouse monoclonal (144)
  • immunocytochemistry; human; fig 1
  • western blot; human; fig 2
In order to study the coordination of SSB repair and cell cycle progression where ATM prevents DSB formation, Invitrogen XRCC1 antibody (Thermo Scientific, MS-1393-P) was used in immunocytochemistry on human samples (fig 1) and in western blot on human samples (fig 2). Proc Natl Acad Sci U S A (2015) ncbi
mouse monoclonal (33-2-5)
  • western blot; mouse
Invitrogen XRCC1 antibody (Thermo Fisher Scientific, 33-2-5) was used in western blot on mouse samples . DNA Repair (Amst) (2015) ncbi
mouse monoclonal (33-2-5)
  • western blot; mouse
In order to investigate the effect of base excision repair defects on PARP inhibition, Invitrogen XRCC1 antibody (Thermo Fisher Scientific, 33-2-5) was used in western blot on mouse samples . Mol Cancer Res (2014) ncbi
mouse monoclonal (33-2-5)
  • western blot; mouse
In order to study the effect of cellular XRCC1 oxidation on PARP-mediated DNA damage responses, Invitrogen XRCC1 antibody (Thermo Fisher, 33-2-5) was used in western blot on mouse samples . DNA Repair (Amst) (2013) ncbi
mouse monoclonal (33-2-5)
  • western blot; human; fig s2
In order to study the functional significance of the DNA polymerase-beta interaction with BRCA1, Invitrogen XRCC1 antibody (Thermo Fisher Scientific, 33-2-5) was used in western blot on human samples (fig s2). PLoS ONE (2013) ncbi
mouse monoclonal (144)
  • immunohistochemistry - paraffin section; human
In order to assess the relationship between XRCC1, p53, and MDR1 protein and their prognostic values for breast cancer, Invitrogen XRCC1 antibody (Lab Vision, 144) was used in immunohistochemistry - paraffin section on human samples . Med Sci Monit (2011) ncbi
Abcam
domestic rabbit monoclonal (EPR4389(2))
  • immunocytochemistry; human; 1:200; loading ...; fig 2a
Abcam XRCC1 antibody (Abcam, ab134056) was used in immunocytochemistry on human samples at 1:200 (fig 2a). Sci Rep (2021) ncbi
domestic rabbit monoclonal (EPR4389(2))
  • immunohistochemistry - paraffin section; human; loading ...; fig s7
  • western blot; human; loading ...; fig s2b
Abcam XRCC1 antibody (Abcam, ab134056) was used in immunohistochemistry - paraffin section on human samples (fig s7) and in western blot on human samples (fig s2b). Nucleic Acids Res (2018) ncbi
domestic rabbit monoclonal (EPR4389(2))
  • immunocytochemistry; human; 1:1000; loading ...; fig 1a
In order to assess the effect of the ROS burst on DNA integrity, cell death and differentiation potential of monocytes, Abcam XRCC1 antibody (Abcam, ab134056) was used in immunocytochemistry on human samples at 1:1000 (fig 1a). PLoS ONE (2017) ncbi
domestic rabbit monoclonal (EPR4389(2))
  • western blot; mouse; 1:2000
Abcam XRCC1 antibody (Epitomics, 3631-1) was used in western blot on mouse samples at 1:2000. PLoS ONE (2014) ncbi
Santa Cruz Biotechnology
mouse monoclonal (33-2-5)
  • immunocytochemistry; human; fig 7
Santa Cruz Biotechnology XRCC1 antibody (Santa Cruz, sc-56254) was used in immunocytochemistry on human samples (fig 7). Nucleic Acids Res (2016) ncbi
Cell Signaling Technology
domestic rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 4b
  • western blot; mouse; 1:1000; loading ...; fig 3d
Cell Signaling Technology XRCC1 antibody (Cell Signaling, 2735) was used in western blot on human samples at 1:1000 (fig 4b) and in western blot on mouse samples at 1:1000 (fig 3d). Adv Sci (Weinh) (2022) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 6c
Cell Signaling Technology XRCC1 antibody (Cell Signaling, 2735S) was used in western blot on human samples (fig 6c). Sci Adv (2021) ncbi
domestic rabbit polyclonal
  • other; human; loading ...; fig 4c
Cell Signaling Technology XRCC1 antibody (Cell Signaling, 2735) was used in other on human samples (fig 4c). Cancer Cell (2018) ncbi
domestic rabbit polyclonal
  • reverse phase protein lysate microarray; human; loading ...; fig st6
In order to characterize the molecular identity of uterine carcinosarcomas., Cell Signaling Technology XRCC1 antibody (CST, 2735) was used in reverse phase protein lysate microarray on human samples (fig st6). Cancer Cell (2017) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig s7
In order to engineer and characterize a second-generation, high-affinity AXL decoy receptor, Cell Signaling Technology XRCC1 antibody (CST, 2735) was used in western blot on mouse samples (fig s7). J Clin Invest (2017) ncbi
domestic rabbit polyclonal
  • immunocytochemistry; human; 1:100; loading ...; fig 4f
  • western blot; human; 1:1000; loading ...; fig 6c
In order to study the DNA damage response in senescent epithelial cells, Cell Signaling Technology XRCC1 antibody (Cell Signaling, 2735) was used in immunocytochemistry on human samples at 1:100 (fig 4f) and in western blot on human samples at 1:1000 (fig 6c). Nat Commun (2016) ncbi
MilliporeSigma
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 4a
MilliporeSigma XRCC1 antibody (SIGMA, X0629) was used in western blot on human samples (fig 4a). Sci Rep (2016) ncbi
Articles Reviewed
  1. Kumar D, Das M, Oberg A, Sahoo D, Wu P, Sauceda C, et al. Hepatocyte Deletion of IGF2 Prevents DNA Damage and Tumor Formation in Hepatocellular Carcinoma. Adv Sci (Weinh). 2022;9:e2105120 pubmed publisher
  2. Ye Z, Xu S, Shi Y, Bacolla A, Syed A, Moiani D, et al. GRB2 enforces homology-directed repair initiation by MRE11. Sci Adv. 2021;7: pubmed publisher
  3. Bloniarz D, Adamczyk Grochala J, Lewinska A, Wnuk M. The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence. Aging (Albany NY). 2021;13:15833-15874 pubmed publisher
  4. Baquero J, Benitez Buelga C, Rajagopal V, Zhenjun Z, Torres Ruiz R, Muller S, et al. Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects. Sci Rep. 2021;11:3490 pubmed publisher
  5. Li M, Yang X, LU X, Dai N, Zhang S, Cheng Y, et al. APE1 deficiency promotes cellular senescence and premature aging features. Nucleic Acids Res. 2018;46:5664-5677 pubmed publisher
  6. Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher
  7. Cherniack A, Shen H, Walter V, Stewart C, Murray B, Bowlby R, et al. Integrated Molecular Characterization of Uterine Carcinosarcoma. Cancer Cell. 2017;31:411-423 pubmed publisher
  8. Ponath V, Kaina B. Death of Monocytes through Oxidative Burst of Macrophages and Neutrophils: Killing in Trans. PLoS ONE. 2017;12:e0170347 pubmed publisher
  9. Kariolis M, Miao Y, Diep A, Nash S, Olcina M, Jiang D, et al. Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies. J Clin Invest. 2017;127:183-198 pubmed publisher
  10. Bezine E, Malaisé Y, Loeuillet A, Chevalier M, Boutet Robinet E, Salles B, et al. Cell resistance to the Cytolethal Distending Toxin involves an association of DNA repair mechanisms. Sci Rep. 2016;6:36022 pubmed publisher
  11. Nassour J, Martien S, Martin N, Deruy E, Tomellini E, Malaquin N, et al. Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells. Nat Commun. 2016;7:10399 pubmed publisher
  12. Yu Z, Huang Y, Shieh S. Requirement for human Mps1/TTK in oxidative DNA damage repair and cell survival through MDM2 phosphorylation. Nucleic Acids Res. 2016;44:1133-50 pubmed publisher
  13. Markkanen E, Fischer R, Ledentcova M, Kessler B, Dianov G. Cells deficient in base-excision repair reveal cancer hallmarks originating from adjustments to genetic instability. Nucleic Acids Res. 2015;43:3667-79 pubmed publisher
  14. Khoronenkova S, Dianov G. ATM prevents DSB formation by coordinating SSB repair and cell cycle progression. Proc Natl Acad Sci U S A. 2015;112:3997-4002 pubmed publisher
  15. Horton J, Gassman N, Dunigan B, Stefanick D, Wilson S. DNA polymerase β-dependent cell survival independent of XRCC1 expression. DNA Repair (Amst). 2015;26:23-9 pubmed publisher
  16. Horton J, Stefanick D, Prasad R, Gassman N, Kedar P, Wilson S. Base excision repair defects invoke hypersensitivity to PARP inhibition. Mol Cancer Res. 2014;12:1128-39 pubmed publisher
  17. FAYZULLINA S, Martin L. Skeletal muscle DNA damage precedes spinal motor neuron DNA damage in a mouse model of Spinal Muscular Atrophy (SMA). PLoS ONE. 2014;9:e93329 pubmed publisher
  18. Horton J, Stefanick D, Gassman N, Williams J, Gabel S, Cuneo M, et al. Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses. DNA Repair (Amst). 2013;12:774-85 pubmed publisher
  19. Masaoka A, Gassman N, Horton J, Kedar P, Witt K, Hobbs C, et al. Interaction between DNA Polymerase ? and BRCA1. PLoS ONE. 2013;8:e66801 pubmed publisher
  20. Rybarova S, Vecanova J, Hodorová I, Mihalik J, Cizmáriková M, Mojzis J, et al. Association between polymorphisms of XRCC1, p53 and MDR1 genes, the expression of their protein products and prognostic significance in human breast cancer. Med Sci Monit. 2011;17:BR354-63 pubmed