This is a Validated Antibody Database (VAD) review about human UVRAG, based on 9 published articles (read how Labome selects the articles), using UVRAG antibody in all methods. It is aimed to help Labome visitors find the most suited UVRAG antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
UVRAG synonym: DHTX; VPS38; p63

MilliporeSigma
mouse monoclonal (UVRAG-11)
  • immunohistochemistry; human; 1:1000; fig 5
  • western blot; human; 1:1000; fig 1
In order to study the role of autophagy factors in cancer progression and treatment response, MilliporeSigma UVRAG antibody (Sigma-Aldrich, SAB4200005) was used in immunohistochemistry on human samples at 1:1000 (fig 5) and in western blot on human samples at 1:1000 (fig 1). Nat Commun (2015) ncbi
Cell Signaling Technology
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 1c, 3e, s5c
Cell Signaling Technology UVRAG antibody (CST, 5320) was used in western blot on mouse samples (fig 1c, 3e, s5c). Sci Rep (2020) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 6c
Cell Signaling Technology UVRAG antibody (Cell Signaling, 5320) was used in western blot on human samples (fig 6c). Autophagy (2019) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; fig 3a
In order to determine that Krupple-like factor 10 silencing correlates with enhanced pancreatic cancer clonogenic survival and murine tumor growth after radiation, Cell Signaling Technology UVRAG antibody (Cell Signaling, 5320) was used in western blot on human samples at 1:1000 (fig 3a). Radiother Oncol (2017) ncbi
MBL International
  • immunoprecipitation; rat; loading ...; fig 2h
  • western blot; rat; loading ...; fig 1d
MBL International UVRAG antibody (MBL, M160-3) was used in immunoprecipitation on rat samples (fig 2h) and in western blot on rat samples (fig 1d). J Clin Invest (2017) ncbi
  • western blot; human; 1:1000; loading ...; fig 3
In order to show that expression of von Hippel-Lindau-anti-green fluorescence protein-affinity-directed protein missile results in near-complete degradation of endogenous GFP-VPS34 and PAWS1-GFP, MBL International UVRAG antibody (MBL, M160-3) was used in western blot on human samples at 1:1000 (fig 3). Open Biol (2016) ncbi
  • western blot; mouse; fig 1
MBL International UVRAG antibody (MBL, M160-3) was used in western blot on mouse samples (fig 1). Arch Pharm Res (2016) ncbi
  • immunoprecipitation; mouse; fig 3
MBL International UVRAG antibody (MBL, M160-3) was used in immunoprecipitation on mouse samples (fig 3). Nat Commun (2015) ncbi
  • immunoprecipitation; human
In order to identify and characterize the Nrbf2-Beclin 1 interaction, MBL International UVRAG antibody (MBL, M160-3) was used in immunoprecipitation on human samples . J Biol Chem (2014) ncbi
Articles Reviewed
  1. Kim Y, Kim J, Gu S, Jo S, Kim S, Young Kim S, et al. Identification of highly potent and selective inhibitor, TIPTP, of the p22phox-Rubicon axis as a therapeutic agent for rheumatoid arthritis. Sci Rep. 2020;10:4570 pubmed publisher
  2. Zhang X, Wang L, Ireland S, Ahat E, Li J, Bekier Ii M, et al. GORASP2/GRASP55 collaborates with the PtdIns3K UVRAG complex to facilitate autophagosome-lysosome fusion. Autophagy. 2019;:1-14 pubmed publisher
  3. Bartolomeo R, Cinque L, De Leonibus C, Forrester A, Salzano A, Monfregola J, et al. mTORC1 hyperactivation arrests bone growth in lysosomal storage disorders by suppressing autophagy. J Clin Invest. 2017;127:3717-3729 pubmed publisher
  4. Chang V, Tsai Y, Tsai Y, Peng S, Chen S, Chang T, et al. Krüpple-like factor 10 regulates radio-sensitivity of pancreatic cancer via UV radiation resistance-associated gene. Radiother Oncol. 2017;122:476-484 pubmed publisher
  5. Fulcher L, MacArtney T, Bozatzi P, Hornberger A, Rojas Fernandez A, Sapkota G. An affinity-directed protein missile system for targeted proteolysis. Open Biol. 2016;6: pubmed
  6. Son J, Hwang E, Kim J. Systematic analyses of the ultraviolet radiation resistance-associated gene product (UVRAG) protein interactome by tandem affinity purification. Arch Pharm Res. 2016;39:370-9 pubmed publisher
  7. Nemazanyy I, Montagnac G, Russell R, Morzyglod L, Burnol A, Guan K, et al. Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling. Nat Commun. 2015;6:8283 pubmed publisher
  8. He S, Zhao Z, Yang Y, O Connell D, Zhang X, Oh S, et al. Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers. Nat Commun. 2015;6:7839 pubmed publisher
  9. Zhong Y, Morris D, Jin L, Patel M, Karunakaran S, Fu Y, et al. Nrbf2 protein suppresses autophagy by modulating Atg14L protein-containing Beclin 1-Vps34 complex architecture and reducing intracellular phosphatidylinositol-3 phosphate levels. J Biol Chem. 2014;289:26021-37 pubmed publisher