This is a Validated Antibody Database (VAD) review about human UBP43, based on 5 published articles (read how Labome selects the articles), using UBP43 antibody in all methods. It is aimed to help Labome visitors find the most suited UBP43 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
UBP43 synonym: ISG43; PTORCH2; UBP43; ubl carboxyl-terminal hydrolase 18; 43 kDa ISG15-specific protease; ISG15-specific-processing protease; hUBP43; ubiquitin specific protease 18; ubl thioesterase 18; ubl thiolesterase 18

Cell Signaling Technology
rabbit monoclonal (D4E7)
  • western blot; Human immunodeficiency virus 1; loading ...; fig 2c
Cell Signaling Technology UBP43 antibody (Cell Signaling, D4E7) was used in western blot on Human immunodeficiency virus 1 samples (fig 2c). J Leukoc Biol (2018) ncbi
rabbit monoclonal (D4E7)
  • western blot; mouse; loading ...; fig 2a
  • western blot; human; loading ...; fig 1c
In order to discover that PTEN is a substrate of the ISGylation post-translational modification pathway, Cell Signaling Technology UBP43 antibody (Cell Signaling, 4813) was used in western blot on mouse samples (fig 2a) and in western blot on human samples (fig 1c). Oncotarget (2017) ncbi
rabbit monoclonal (D4E7)
  • western blot; Influenzavirus B; 1:1000; loading ...; fig s1c
Cell Signaling Technology UBP43 antibody (Cell Signaling, 4813) was used in western blot on Influenzavirus B samples at 1:1000 (fig s1c). Nat Commun (2016) ncbi
rabbit monoclonal (D4E7)
  • immunoprecipitation; human; 1:250; fig 5
  • western blot; human; 1:5000; fig 5
In order to study increased viral resistance in humans and not mice by ISG15 deficiency, Cell Signaling Technology UBP43 antibody (Cell Signaling Technology, D4E7) was used in immunoprecipitation on human samples at 1:250 (fig 5) and in western blot on human samples at 1:5000 (fig 5). Nat Commun (2016) ncbi
rabbit monoclonal (D4E7)
  • western blot; mouse
  • immunohistochemistry; human; fig 5
Cell Signaling Technology UBP43 antibody (Cell Signaling, 4813) was used in western blot on mouse samples and in immunohistochemistry on human samples (fig 5). BMC Cancer (2015) ncbi
Articles Reviewed
  1. Taylor J, Cash M, Santostefano K, Nakanishi M, Terada N, Wallet M. CRISPR/Cas9 knockout of USP18 enhances type I IFN responsiveness and restricts HIV-1 infection in macrophages. J Leukoc Biol. 2018;: pubmed publisher
  2. Mustachio L, Kawakami M, Lu Y, Rodriguez Canales J, Mino B, Behrens C, et al. The ISG15-specific protease USP18 regulates stability of PTEN. Oncotarget. 2017;8:3-14 pubmed publisher
  3. Zhao C, Sridharan H, Chen R, Baker D, Wang S, Krug R. Influenza B virus non-structural protein 1 counteracts ISG15 antiviral activity by sequestering ISGylated viral proteins. Nat Commun. 2016;7:12754 pubmed publisher
  4. Speer S, Li Z, Buta S, Payelle Brogard B, Qian L, Vigant F, et al. ISG15 deficiency and increased viral resistance in humans but not mice. Nat Commun. 2016;7:11496 pubmed publisher
  5. Chinyengetere F, Sekula D, Lu Y, Giustini A, Sanglikar A, Kawakami M, et al. Mice null for the deubiquitinase USP18 spontaneously develop leiomyosarcomas. BMC Cancer. 2015;15:886 pubmed publisher