This is a Validated Antibody Database (VAD) review about human TYMS, based on 10 published articles (read how Labome selects the articles), using TYMS antibody in all methods. It is aimed to help Labome visitors find the most suited TYMS antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
TYMS synonym: HST422; TMS; TS

Santa Cruz Biotechnology
mouse monoclonal (TS 106)
  • immunohistochemistry - paraffin section; human; fig 8
  • western blot; human; loading ...; fig 6
Santa Cruz Biotechnology TYMS antibody (Santa Cruz, sc-33679) was used in immunohistochemistry - paraffin section on human samples (fig 8) and in western blot on human samples (fig 6). Cancers (Basel) (2021) ncbi
mouse monoclonal (F-7)
  • other; human; fig S2
Santa Cruz Biotechnology TYMS antibody (Santa Cruz, sc-376161) was used in other on human samples (fig S2). Nat Commun (2016) ncbi
Abcam
domestic rabbit monoclonal (EPR4545)
  • immunohistochemistry - paraffin section; human; 1:150; loading ...; fig 6c
  • western blot; human; loading ...; fig 4a
In order to investigate the relationship between thymidylate synthase and epithelial-to-mesenchymal transition, Abcam TYMS antibody (Abcam, EPR4545) was used in immunohistochemistry - paraffin section on human samples at 1:150 (fig 6c) and in western blot on human samples (fig 4a). J Pathol (2017) ncbi
domestic rabbit monoclonal (EPR4545)
  • western blot; human; loading ...; fig 1c
Abcam TYMS antibody (AbCam, EPR4545) was used in western blot on human samples (fig 1c). Oncotarget (2016) ncbi
domestic rabbit monoclonal (EPR4545)
  • western blot; human; 1:1000; fig 1d
Abcam TYMS antibody (Abcam, ab108995) was used in western blot on human samples at 1:1000 (fig 1d). PLoS ONE (2015) ncbi
Abnova
mouse monoclonal (3A1)
  • immunohistochemistry - paraffin section; human; 1:450; fig 1
Abnova TYMS antibody (Abnova, H00007298-M01) was used in immunohistochemistry - paraffin section on human samples at 1:450 (fig 1). Oncotarget (2015) ncbi
Rockland Immunochemicals
domestic sheep polyclonal
  • western blot; human; fig 1
Rockland Immunochemicals TYMS antibody (Rockland, 100-601-199) was used in western blot on human samples (fig 1). Oncotarget (2016) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D5B3)
  • western blot; human; 1:1000; loading ...; fig 4c
Cell Signaling Technology TYMS antibody (Cell Signaling, 9045) was used in western blot on human samples at 1:1000 (fig 4c). Cell Rep (2022) ncbi
domestic rabbit monoclonal (D5B3)
  • other; human
  • western blot; human; fig S7
Cell Signaling Technology TYMS antibody (Cell signaling, D5B3) was used in other on human samples and in western blot on human samples (fig S7). Nat Commun (2016) ncbi
Dako
mouse monoclonal (TS106)
  • immunohistochemistry - paraffin section; human; loading ...; fig 1
Dako TYMS antibody (Dako, TS106) was used in immunohistochemistry - paraffin section on human samples (fig 1). Head Neck (2016) ncbi
mouse monoclonal (TS106)
  • immunohistochemistry - paraffin section; human; 1:50
In order to study the predictive value of measuring TRAP1 and ERCC1 in oxaliplatin plus 5-fluorouracil combination-treated metastatic colorectal cancer, Dako TYMS antibody (Dako, TS106) was used in immunohistochemistry - paraffin section on human samples at 1:50. Cancer Res Treat (2014) ncbi
Articles Reviewed
  1. Abt E, Le T, Dann A, Capri J, Poddar S, Lok V, et al. Reprogramming of nucleotide metabolism by interferon confers dependence on the replication stress response pathway in pancreatic cancer cells. Cell Rep. 2022;38:110236 pubmed publisher
  2. Rather G, Anyanwu M, Minko T, Garbuzenko O, Szekely Z, Bertino J. Anti-Tumor Effects of a Penetratin Peptide Targeting Transcription of E2F-1, 2 and 3a Is Enhanced When Used in Combination with Pemetrexed or Cisplatin. Cancers (Basel). 2021;13: pubmed publisher
  3. Siddiqui A, Vazakidou M, Schwab A, Napoli F, Fernandez Molina C, Rapa I, et al. Thymidylate synthase is functionally associated with ZEB1 and contributes to the epithelial-to-mesenchymal transition of cancer cells. J Pathol. 2017;242:221-233 pubmed publisher
  4. Monica V, Lo Iacono M, Bracco E, Busso S, di Blasio L, Primo L, et al. Dasatinib modulates sensitivity to pemetrexed in malignant pleural mesothelioma cell lines. Oncotarget. 2016;7:76577-76589 pubmed publisher
  5. Almqvist H, Axelsson H, Jafari R, Dan C, Mateus A, Haraldsson M, et al. CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil. Nat Commun. 2016;7:11040 pubmed publisher
  6. Terranova Barberio M, Roca M, Zotti A, Leone A, Bruzzese F, Vitagliano C, et al. Valproic acid potentiates the anticancer activity of capecitabine in vitro and in vivo in breast cancer models via induction of thymidine phosphorylase expression. Oncotarget. 2016;7:7715-31 pubmed publisher
  7. Lund K, Dembinski J, Solberg N, Urbanucci A, Mills I, Krauss S. Slug-dependent upregulation of L1CAM is responsible for the increased invasion potential of pancreatic cancer cells following long-term 5-FU treatment. PLoS ONE. 2015;10:e0123684 pubmed publisher
  8. Burdelski C, Strauss C, Tsourlakis M, Kluth M, Hube Magg C, Melling N, et al. Overexpression of thymidylate synthase (TYMS) is associated with aggressive tumor features and early PSA recurrence in prostate cancer. Oncotarget. 2015;6:8377-87 pubmed
  9. Ko J, Klimowicz A, Jagdis A, Phan T, Laskin J, Lau H, et al. ATM, THMS, and RRM1 protein expression in nasopharyngeal carcinomas treated with curative intent. Head Neck. 2016;38 Suppl 1:E384-91 pubmed publisher
  10. Han J, Baek S, Lee J, Kim G, Kim S, Lee S. Combination of TRAP1 and ERCC1 Expression Predicts Clinical Outcomes in Metastatic Colorectal Cancer Treated with Oxaliplatin/5-Fluorouracil. Cancer Res Treat. 2014;46:55-64 pubmed publisher