This is a Validated Antibody Database (VAD) review about human TXNIP, based on 24 published articles (read how Labome selects the articles), using TXNIP antibody in all methods. It is aimed to help Labome visitors find the most suited TXNIP antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
TXNIP synonym: ARRDC6; EST01027; HHCPA78; THIF; VDUP1

Knockout validation
Cell Signaling Technology
domestic rabbit monoclonal (D5F3E)
  • western blot knockout validation; rat; 1:1000; loading ...; fig 3d
Cell Signaling Technology TXNIP antibody (Cell Signaling, 14715) was used in western blot knockout validation on rat samples at 1:1000 (fig 3d). Life Sci (2021) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D5F3E)
  • western blot knockout validation; human; fig 3c
Cell Signaling Technology TXNIP antibody (Cell Signaling, 14715) was used in western blot knockout validation on human samples (fig 3c). Nature (2017) ncbi
Abcam
domestic rabbit monoclonal (EPR14774)
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 4a
Abcam TXNIP antibody (Abcam, ab188865) was used in immunohistochemistry - paraffin section on mouse samples at 1:200 (fig 4a). Antioxidants (Basel) (2022) ncbi
domestic rabbit monoclonal (EPR14774)
  • western blot; mouse; 1:1000; loading ...; fig 5e
Abcam TXNIP antibody (Abcam, ab188865) was used in western blot on mouse samples at 1:1000 (fig 5e). J Neuroinflammation (2022) ncbi
domestic rabbit monoclonal (EPR14774)
  • western blot; mouse; 1:1000; loading ...; fig 4d
Abcam TXNIP antibody (Abcam, 188865) was used in western blot on mouse samples at 1:1000 (fig 4d). J Neuroinflammation (2021) ncbi
domestic rabbit monoclonal (EPR14774)
  • western blot; rat; 1:1000; loading ...; fig 5e
Abcam TXNIP antibody (Abcam, ab188865) was used in western blot on rat samples at 1:1000 (fig 5e). Mol Neurobiol (2021) ncbi
domestic rabbit monoclonal (EPR14774)
  • immunohistochemistry; rat; 1:100; loading ...; fig 7d
Abcam TXNIP antibody (Abcam, ab188865) was used in immunohistochemistry on rat samples at 1:100 (fig 7d). Life Sci (2021) ncbi
domestic rabbit monoclonal (EPR14774)
  • western blot; human; 1:1000; loading ...; fig 5h
Abcam TXNIP antibody (Abcam, ab188865) was used in western blot on human samples at 1:1000 (fig 5h). EMBO Mol Med (2019) ncbi
domestic rabbit monoclonal (EPR14774)
  • western blot; rat; loading ...; fig 7b
Abcam TXNIP antibody (Abcam, ab188865) was used in western blot on rat samples (fig 7b). Biomed Pharmacother (2019) ncbi
domestic rabbit monoclonal (EPR14774)
  • western blot; mouse; 1:1000; loading ...; fig 4e
  • immunohistochemistry - paraffin section; human; 1:100; loading ...; fig s5c
Abcam TXNIP antibody (Abcam, ab188865) was used in western blot on mouse samples at 1:1000 (fig 4e) and in immunohistochemistry - paraffin section on human samples at 1:100 (fig s5c). Cell Death Dis (2018) ncbi
domestic rabbit monoclonal (EPR14774)
  • western blot; human; loading ...; fig 5d
In order to report that A549 cell death induced by sodium butyrate and sodium 4-phenylbutyrate occur via distinct pathways, Abcam TXNIP antibody (Abcam, ab188865) was used in western blot on human samples (fig 5d). Cancer Med (2017) ncbi
Santa Cruz Biotechnology
mouse monoclonal (B-2)
  • western blot; human; fig 2
Santa Cruz Biotechnology TXNIP antibody (Santa Cruz, sc-166234) was used in western blot on human samples (fig 2). PLoS ONE (2016) ncbi
mouse monoclonal (H-12)
  • western blot; mouse; 1:250; fig 4
In order to test if bone morphogenetic proteins trigger reactive gliosis in retinal astrocytes and Muller glial cells, Santa Cruz Biotechnology TXNIP antibody (Santa Cruz, SC-271238) was used in western blot on mouse samples at 1:250 (fig 4). Mol Vis (2014) ncbi
Invitrogen
domestic rabbit polyclonal
  • immunoprecipitation; mouse; fig 4
In order to show that UCP2 regulates inflammatory responses in astrocytes and contributes to depression, Invitrogen TXNIP antibody (Invitrogen, 40?C3700) was used in immunoprecipitation on mouse samples (fig 4). Redox Biol (2016) ncbi
Novus Biologicals
mouse monoclonal (JY2)
  • proximity ligation assay; human; fig s3
  • immunohistochemistry - paraffin section; human; 1:5000; fig 1
  • western blot; human; 1:1000; fig 2
Novus Biologicals TXNIP antibody (Novus Biologicals, JY2) was used in proximity ligation assay on human samples (fig s3), in immunohistochemistry - paraffin section on human samples at 1:5000 (fig 1) and in western blot on human samples at 1:1000 (fig 2). Lab Invest (2016) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D5F3E)
  • other; mouse; 1:1000; loading ...; fig 5a
Cell Signaling Technology TXNIP antibody (Cell Signaling, 14715) was used in other on mouse samples at 1:1000 (fig 5a). Redox Biol (2021) ncbi
domestic rabbit monoclonal (D5F3E)
  • western blot; mouse; 1:1000; loading ...; fig 7b
Cell Signaling Technology TXNIP antibody (CST, 14715) was used in western blot on mouse samples at 1:1000 (fig 7b). Basic Res Cardiol (2021) ncbi
domestic rabbit monoclonal (D5F3E)
  • western blot knockout validation; rat; 1:1000; loading ...; fig 3d
Cell Signaling Technology TXNIP antibody (Cell Signaling, 14715) was used in western blot knockout validation on rat samples at 1:1000 (fig 3d). Life Sci (2021) ncbi
domestic rabbit monoclonal (D5F3E)
  • western blot; mouse; 1:1000; loading ...; fig 6c
Cell Signaling Technology TXNIP antibody (CST, 14715) was used in western blot on mouse samples at 1:1000 (fig 6c). Am J Physiol Endocrinol Metab (2020) ncbi
domestic rabbit monoclonal (D5F3E)
  • western blot; human; loading ...; fig 1e
Cell Signaling Technology TXNIP antibody (Cell Signaling, 14715) was used in western blot on human samples (fig 1e). J Exp Clin Cancer Res (2020) ncbi
domestic rabbit monoclonal (D5F3E)
  • western blot; human; 1:1000; loading ...; fig 4g
Cell Signaling Technology TXNIP antibody (Cell Signaling, D5F3E) was used in western blot on human samples at 1:1000 (fig 4g). Nat Immunol (2020) ncbi
domestic rabbit monoclonal (D5F3E)
  • western blot; human; 1:1000; loading ...; fig s20a, s20b
Cell Signaling Technology TXNIP antibody (Cell Signaling, D5F3E) was used in western blot on human samples at 1:1000 (fig s20a, s20b). Nat Commun (2019) ncbi
domestic rabbit monoclonal (D5F3E)
  • western blot knockout validation; human; fig 3c
Cell Signaling Technology TXNIP antibody (Cell Signaling, 14715) was used in western blot knockout validation on human samples (fig 3c). Nature (2017) ncbi
MBL International
monoclonal
  • immunohistochemistry; mouse; loading ...; fig s4d
MBL International TXNIP antibody (MBL International, K0204-3, K0205-3) was used in immunohistochemistry on mouse samples (fig s4d). PLoS Biol (2021) ncbi
monoclonal
  • western blot; human; 1:1000; fig 4
In order to study the contribution of TRPM2 in hyperglycemia-induced oxidative stress, MBL International TXNIP antibody (MBL Life science, K0204-3) was used in western blot on human samples at 1:1000 (fig 4). Sci Rep (2016) ncbi
monoclonal
  • western blot; human
MBL International TXNIP antibody (MBL Laboratories, K0204-3) was used in western blot on human samples . Nat Commun (2015) ncbi
monoclonal
  • immunohistochemistry; mouse
  • western blot; mouse; 1:1000
MBL International TXNIP antibody (MBL, k0204-3) was used in immunohistochemistry on mouse samples and in western blot on mouse samples at 1:1000. Endocrinology (2014) ncbi
Articles Reviewed
  1. Ramos H, Bogdanov P, Huerta J, De xe0 s Just A, Hern xe1 ndez C, Sim xf3 R. Antioxidant Effects of DPP-4 Inhibitors in Early Stages of Experimental Diabetic Retinopathy. Antioxidants (Basel). 2022;11: pubmed publisher
  2. Ding R, Li H, Liu Y, Ou W, Zhang X, Chai H, et al. Activating cGAS-STING axis contributes to neuroinflammation in CVST mouse model and induces inflammasome activation and microglia pyroptosis. J Neuroinflammation. 2022;19:137 pubmed publisher
  3. Carroll P, Freie B, Cheng P, Kasinathan S, Gu H, Hedrich T, et al. The glucose-sensing transcription factor MLX balances metabolism and stress to suppress apoptosis and maintain spermatogenesis. PLoS Biol. 2021;19:e3001085 pubmed publisher
  4. Zeng H, Chen H, Li M, Zhuang J, Peng Y, Zhou H, et al. Autophagy protein NRBF2 attenuates endoplasmic reticulum stress-associated neuroinflammation and oxidative stress via promoting autophagosome maturation by interacting with Rab7 after SAH. J Neuroinflammation. 2021;18:210 pubmed publisher
  5. Eckrich J, Frenis K, Rodriguez Blanco G, Ruan Y, Jiang S, Bayo Jimenez M, et al. Aircraft noise exposure drives the activation of white blood cells and induces microvascular dysfunction in mice. Redox Biol. 2021;46:102063 pubmed publisher
  6. Frenis K, Helmstädter J, Ruan Y, Schramm E, Kalinovic S, Kröller Schön S, et al. Ablation of lysozyme M-positive cells prevents aircraft noise-induced vascular damage without improving cerebral side effects. Basic Res Cardiol. 2021;116:31 pubmed publisher
  7. Li Y, Geng Y, Zhou B, Wu X, Zhang O, Guan X, et al. Long Non-coding RNA GAS5 Worsens Coronary Atherosclerosis Through MicroRNA-194-3p/TXNIP Axis. Mol Neurobiol. 2021;58:3198-3207 pubmed publisher
  8. Ao H, Li H, Zhao X, Liu B, Lu L. TXNIP positively regulates the autophagy and apoptosis in the rat müller cell of diabetic retinopathy. Life Sci. 2021;267:118988 pubmed publisher
  9. Zhou W, Shao W, Zhang Y, Liu D, Liu M, Jin T. Glucagon-like peptide-1 receptor mediates the beneficial effect of liraglutide in an acute lung injury mouse model involving the thioredoxin-interacting protein. Am J Physiol Endocrinol Metab. 2020;319:E568-E578 pubmed publisher
  10. Li H, Lan J, Wang G, Guo K, Han C, Li X, et al. KDM4B facilitates colorectal cancer growth and glucose metabolism by stimulating TRAF6-mediated AKT activation. J Exp Clin Cancer Res. 2020;39:12 pubmed publisher
  11. Zewinger S, Reiser J, Jankowski V, Alansary D, Hahm E, Triem S, et al. Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation. Nat Immunol. 2020;21:30-41 pubmed publisher
  12. Ghezzi C, Wong A, Chen B, Ribalet B, Damoiseaux R, Clark P. A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells. Nat Commun. 2019;10:5444 pubmed publisher
  13. Li H, Yang F, Hu A, Wang X, Fang E, Chen Y, et al. Therapeutic targeting of circ-CUX1/EWSR1/MAZ axis inhibits glycolysis and neuroblastoma progression. EMBO Mol Med. 2019;11:e10835 pubmed publisher
  14. Qin W, Wu X, Jia Y, Tong X, Guo C, Chen D, et al. Suhuang antitussive capsule inhibits NLRP3 inflammasome activation and ameliorates pulmonary dysfunction via suppression of endoplasmic reticulum stress in cough variant asthma. Biomed Pharmacother. 2019;118:109188 pubmed publisher
  15. Rivera Reyes A, Ye S, E Marino G, Egolf S, E Ciotti G, Chor S, et al. YAP1 enhances NF-κB-dependent and independent effects on clock-mediated unfolded protein responses and autophagy in sarcoma. Cell Death Dis. 2018;9:1108 pubmed publisher
  16. Chan L, Chen Z, Braas D, Lee J, Xiao G, Geng H, et al. Metabolic gatekeeper function of B-lymphoid transcription factors. Nature. 2017;542:479-483 pubmed publisher
  17. Jin X, Wu N, Dai J, Li Q, Xiao X. TXNIP mediates the differential responses of A549 cells to sodium butyrate and sodium 4-phenylbutyrate treatment. Cancer Med. 2017;6:424-438 pubmed publisher
  18. Tseng H, Vong C, Kwan Y, Lee S, Hoi M. TRPM2 regulates TXNIP-mediated NLRP3 inflammasome activation via interaction with p47 phox under high glucose in human monocytic cells. Sci Rep. 2016;6:35016 pubmed publisher
  19. Du R, Wu F, Lu M, Shu X, Ding J, Wu G, et al. Uncoupling protein 2 modulation of the NLRP3 inflammasome in astrocytes and its implications in depression. Redox Biol. 2016;9:178-187 pubmed publisher
  20. Yalon M, Tuval Kochen L, Castel D, Moshe I, Mazal I, Cohen O, et al. Overcoming Resistance of Cancer Cells to PARP-1 Inhibitors with Three Different Drug Combinations. PLoS ONE. 2016;11:e0155711 pubmed publisher
  21. Ahrens T, Timme S, Ostendorp J, Bogatyreva L, Hoeppner J, Hopt U, et al. Response of esophageal cancer cells to epigenetic inhibitors is mediated via altered thioredoxin activity. Lab Invest. 2016;96:307-16 pubmed publisher
  22. Qiao S, Dennis M, Song X, Vadysirisack D, Salunke D, Nash Z, et al. A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity. Nat Commun. 2015;6:7014 pubmed publisher
  23. Dharmarajan S, Gurel Z, Wang S, Sorenson C, Sheibani N, Belecky Adams T. Bone morphogenetic protein 7 regulates reactive gliosis in retinal astrocytes and Müller glia. Mol Vis. 2014;20:1085-108 pubmed
  24. Feuer S, Liu X, Donjacour A, Lin W, Simbulan R, Giritharan G, et al. Use of a mouse in vitro fertilization model to understand the developmental origins of health and disease hypothesis. Endocrinology. 2014;155:1956-69 pubmed publisher