This is a Validated Antibody Database (VAD) review about human TRIM21, based on 11 published articles (read how Labome selects the articles), using TRIM21 antibody in all methods. It is aimed to help Labome visitors find the most suited TRIM21 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
TRIM21 synonym: RNF81; RO52; Ro/SSA; SSA; SSA1

Knockout validation
Santa Cruz Biotechnology
mouse monoclonal (D-12)
  • western blot knockout validation; human; 1:1000; loading ...; fig s1a
Santa Cruz Biotechnology TRIM21 antibody (Santa Cruz, sc-25351) was used in western blot knockout validation on human samples at 1:1000 (fig s1a). Cell Host Microbe (2019) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D1O1D)
  • western blot knockout validation; human; loading ...; fig s7e
Cell Signaling Technology TRIM21 antibody (CST, D1O1D) was used in western blot knockout validation on human samples (fig s7e). Nature (2020) ncbi
Santa Cruz Biotechnology
mouse monoclonal (D-12)
  • immunohistochemistry - paraffin section; human; loading ...; fig 1a
  • western blot; human; loading ...; fig 3a
Santa Cruz Biotechnology TRIM21 antibody (Santa Cruz, SC-25351) was used in immunohistochemistry - paraffin section on human samples (fig 1a) and in western blot on human samples (fig 3a). Am J Cancer Res (2020) ncbi
mouse monoclonal (D-12)
  • western blot; human; loading ...; fig 4d
Santa Cruz Biotechnology TRIM21 antibody (Santa Cruz Biotechnology, sc-25351) was used in western blot on human samples (fig 4d). Sci Adv (2019) ncbi
mouse monoclonal (D-12)
  • western blot knockout validation; human; 1:1000; loading ...; fig s1a
Santa Cruz Biotechnology TRIM21 antibody (Santa Cruz, sc-25351) was used in western blot knockout validation on human samples at 1:1000 (fig s1a). Cell Host Microbe (2019) ncbi
mouse monoclonal (D-12)
  • western blot; human; loading ...; fig 5c
Santa Cruz Biotechnology TRIM21 antibody (Santa Cruz, sc-25351) was used in western blot on human samples (fig 5c). Front Immunol (2018) ncbi
mouse monoclonal (D-12)
  • western blot; human; 1:1000; fig 5
Santa Cruz Biotechnology TRIM21 antibody (santa Cruz, sc-25351) was used in western blot on human samples at 1:1000 (fig 5). Nat Commun (2016) ncbi
mouse monoclonal (D-12)
  • immunocytochemistry; human
  • western blot; human
Santa Cruz Biotechnology TRIM21 antibody (Santa Cruz, sc-25351) was used in immunocytochemistry on human samples and in western blot on human samples . Nature (2015) ncbi
mouse monoclonal (D-12)
  • western blot; human; fig 7
Santa Cruz Biotechnology TRIM21 antibody (santa Cruz, Sc-25351) was used in western blot on human samples (fig 7). PLoS Pathog (2015) ncbi
mouse monoclonal (D-12)
  • western blot; human
Santa Cruz Biotechnology TRIM21 antibody (Santa Cruz Biotechnology, sc-25351) was used in western blot on human samples . Arthritis Res Ther (2014) ncbi
Abcam
  • western blot; human; 1:100; fig 7
In order to test if a disruption in the structure of the nucleus contributes to the development of lupus autoimmunity, Abcam TRIM21 antibody (Abcam, ab96800) was used in western blot on human samples at 1:100 (fig 7). Dis Model Mech (2016) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D1O1D)
  • western blot knockout validation; human; loading ...; fig s7e
Cell Signaling Technology TRIM21 antibody (CST, D1O1D) was used in western blot knockout validation on human samples (fig s7e). Nature (2020) ncbi
domestic rabbit monoclonal (D1O1D)
  • western blot; human; 1:1000; loading ...; fig 4i
Cell Signaling Technology TRIM21 antibody (Cell Signaling, 92043) was used in western blot on human samples at 1:1000 (fig 4i). Nat Commun (2018) ncbi
Articles Reviewed
  1. Zhao Z, Wang Y, Yun D, Huang Q, Meng D, Li Q, et al. TRIM21 overexpression promotes tumor progression by regulating cell proliferation, cell migration and cell senescence in human glioma. Am J Cancer Res. 2020;10:114-130 pubmed
  2. Park J, Burckhardt C, Lazcano R, Solis L, Isogai T, Li L, et al. Mechanical regulation of glycolysis via cytoskeleton architecture. Nature. 2020;578:621-626 pubmed publisher
  3. Xu D, Li X, Shao F, Lv G, Lv H, Lee J, et al. The protein kinase activity of fructokinase A specifies the antioxidant responses of tumor cells by phosphorylating p62. Sci Adv. 2019;5:eaav4570 pubmed publisher
  4. Bottermann M, Foss S, Caddy S, Clift D, van Tienen L, Vaysburd M, et al. Complement C4 Prevents Viral Infection through Capsid Inactivation. Cell Host Microbe. 2019;25:617-629.e7 pubmed publisher
  5. Wei Z, Song J, Wang G, Cui X, Zheng J, Tang Y, et al. Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis. Nat Commun. 2018;9:4468 pubmed publisher
  6. Agod Z, Pazmandi K, Bencze D, Vereb G, Biro T, Szabo A, et al. Signaling Lymphocyte Activation Molecule Family 5 Enhances Autophagy and Fine-Tunes Cytokine Response in Monocyte-Derived Dendritic Cells via Stabilization of Interferon Regulatory Factor 8. Front Immunol. 2018;9:62 pubmed publisher
  7. Singh N, Johnstone D, Martin K, Tempera I, Kaplan M, Denny M. Alterations in nuclear structure promote lupus autoimmunity in a mouse model. Dis Model Mech. 2016;9:885-97 pubmed publisher
  8. Du L, LI Y, Fakih M, Wiatrek R, Duldulao M, Chen Z, et al. Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal. Nat Commun. 2016;7:12326 pubmed publisher
  9. Pankow S, Bamberger C, Calzolari D, Martínez Bartolomé S, Lavallée Adam M, Balch W, et al. ∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis. Nature. 2015;528:510-6 pubmed publisher
  10. Watkinson R, McEwan W, Tam J, Vaysburd M, James L. TRIM21 Promotes cGAS and RIG-I Sensing of Viral Genomes during Infection by Antibody-Opsonized Virus. PLoS Pathog. 2015;11:e1005253 pubmed publisher
  11. Vogelsang P, Karlsen M, Brun J, Jonsson R, Appel S. Altered phenotype and Stat1 expression in Toll-like receptor 7/8 stimulated monocyte-derived dendritic cells from patients with primary Sjögren's syndrome. Arthritis Res Ther. 2014;16:R166 pubmed publisher