This is a Validated Antibody Database (VAD) review about human TRF2, based on 27 published articles (read how Labome selects the articles), using TRF2 antibody in all methods. It is aimed to help Labome visitors find the most suited TRF2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
TRF2 synonym: TRBF2; TRF2

Abcam
mouse monoclonal (4A794)
  • western blot; human; loading ...; fig 1a
Abcam TRF2 antibody (Abcam, ab13579) was used in western blot on human samples (fig 1a). Genes Dev (2021) ncbi
mouse monoclonal (4A794)
  • immunocytochemistry; human; 1:200; loading ...; fig 2a, 5b
Abcam TRF2 antibody (Abcam, ab13579) was used in immunocytochemistry on human samples at 1:200 (fig 2a, 5b). Sci Rep (2021) ncbi
mouse monoclonal (4A794)
  • western blot; human; 1:1000; loading ...; fig 2h
Abcam TRF2 antibody (Abcam, ab13579) was used in western blot on human samples at 1:1000 (fig 2h). Sci Rep (2017) ncbi
mouse monoclonal (4A794)
  • immunocytochemistry; human; loading ...; fig 6a
Abcam TRF2 antibody (Abcam, ab13579) was used in immunocytochemistry on human samples (fig 6a). Nucleic Acids Res (2017) ncbi
mouse monoclonal (4A794)
  • immunocytochemistry; human; loading ...; fig 3e
In order to clarify the role of T cell aging in rheumatoid arthritis, Abcam TRF2 antibody (Abcam, ab13579) was used in immunocytochemistry on human samples (fig 3e). Immunity (2016) ncbi
mouse monoclonal (4A794)
  • western blot; human; 1:1000; fig 8
Abcam TRF2 antibody (abcam, ab13579) was used in western blot on human samples at 1:1000 (fig 8). J Cancer (2016) ncbi
mouse monoclonal (4A794)
  • western blot; human; loading ...; fig 2d
Abcam TRF2 antibody (abcam, ab13579) was used in western blot on human samples (fig 2d). PLoS ONE (2016) ncbi
mouse monoclonal (4A794)
  • immunocytochemistry; human; loading ...; fig 5a
Abcam TRF2 antibody (Abcam, ab13579) was used in immunocytochemistry on human samples (fig 5a). Oncotarget (2015) ncbi
domestic rabbit monoclonal (EPR3517(2))
  • immunocytochemistry; human; 1:500; fig 4
Abcam TRF2 antibody (Abcam, ab108997) was used in immunocytochemistry on human samples at 1:500 (fig 4). J Cell Sci (2015) ncbi
mouse monoclonal (4A794)
  • western blot; human
In order to investigate the role of TRF2/RAP1 and DNA-PK at telomeric fusion, Abcam TRF2 antibody (Abcam, 4A794) was used in western blot on human samples . EMBO J (2010) ncbi
Novus Biologicals
domestic rabbit polyclonal (5B12)
  • chromatin immunoprecipitation; human; loading ...; fig 6f
  • western blot; human; 1:1000; loading ...; fig 6a
Novus Biologicals TRF2 antibody (Novus Biologicals, NB110-57130) was used in chromatin immunoprecipitation on human samples (fig 6f) and in western blot on human samples at 1:1000 (fig 6a). PLoS Genet (2021) ncbi
domestic rabbit polyclonal (5B12)
  • chromatin immunoprecipitation; human; loading ...; fig 2c
  • western blot; human; loading ...; fig 4c
Novus Biologicals TRF2 antibody (Novus, NB110-57130) was used in chromatin immunoprecipitation on human samples (fig 2c) and in western blot on human samples (fig 4c). Int J Biol Sci (2019) ncbi
domestic rabbit polyclonal (5B12)
  • western blot; human; 1:20,000; loading ...; fig 3i
Novus Biologicals TRF2 antibody (Novus Biologicals, NB110-57130) was used in western blot on human samples at 1:20,000 (fig 3i). EMBO Mol Med (2019) ncbi
mouse monoclonal (4A794.15)
  • western blot; human; fig s4a
Novus Biologicals TRF2 antibody (Novus Biologicals, NB100-56506) was used in western blot on human samples (fig s4a). Nucleic Acids Res (2018) ncbi
domestic rabbit polyclonal (5B12)
  • immunocytochemistry; human; loading ...; fig s2f
  • immunocytochemistry; mouse; loading ...; fig s5a
Novus Biologicals TRF2 antibody (Novus Biologicals, NB110-57130) was used in immunocytochemistry on human samples (fig s2f) and in immunocytochemistry on mouse samples (fig s5a). Science (2017) ncbi
domestic rabbit polyclonal (5B12)
  • immunocytochemistry; mouse; 1:100; loading ...; fig 4i
Novus Biologicals TRF2 antibody (Novus Biologicals, NB110-57130) was used in immunocytochemistry on mouse samples at 1:100 (fig 4i). Proc Natl Acad Sci U S A (2017) ncbi
mouse monoclonal (4A794.15)
  • chromatin immunoprecipitation; human; loading ...; fig s5b
Novus Biologicals TRF2 antibody (Novus, NB100-56506) was used in chromatin immunoprecipitation on human samples (fig s5b). Proc Natl Acad Sci U S A (2016) ncbi
mouse monoclonal (4A794.15)
  • immunocytochemistry; human; fig 5a
In order to identify the enzymes and mechanisms responsible for human telomerase RNA degradation, Novus Biologicals TRF2 antibody (Novus Biologicals, NB100-56506) was used in immunocytochemistry on human samples (fig 5a). Nat Struct Mol Biol (2016) ncbi
domestic rabbit polyclonal (5B12)
  • immunocytochemistry; human; 1:100; fig 5
Novus Biologicals TRF2 antibody (Novus, NB110-57130) was used in immunocytochemistry on human samples at 1:100 (fig 5). Nat Commun (2016) ncbi
domestic rabbit polyclonal (5B12)
Novus Biologicals TRF2 antibody (Novus, NB110-57130) was used . Oncotarget (2015) ncbi
mouse monoclonal (4A794.15)
  • immunocytochemistry; human; fig s10
Novus Biologicals TRF2 antibody (Novus Biologicals, NB100-56506) was used in immunocytochemistry on human samples (fig s10). Nucleic Acids Res (2016) ncbi
domestic rabbit polyclonal (5B12)
In order to investigate how the interaction between TRF2 and lamin A/C regulates chromosome structure, Novus Biologicals TRF2 antibody (Novus Biologicals, NB110-57130) was used . Nat Commun (2014) ncbi
Invitrogen
mouse monoclonal (4A794.15)
  • western blot; human; loading ...; fig 5a
In order to report the effects of long-term lipopolysaccharide exposure on monocytes, Invitrogen TRF2 antibody (Thermo Fischer Scientific, MA1-41001) was used in western blot on human samples (fig 5a). Toxicol In Vitro (2017) ncbi
mouse monoclonal (4A794.15)
  • western blot; human; loading ...; fig 3e
In order to show that ROS-induced DNA damage reduces metabolic activity, inhibits proliferation, and induces cell cycle arrest followed by activation of p16-, p21-, and p27- mediated DNA damage response pathways, premature senescence, and apoptosis induction, Invitrogen TRF2 antibody (Thermo Scientific, MA1-41001) was used in western blot on human samples (fig 3e). Exp Cell Res (2017) ncbi
Santa Cruz Biotechnology
mouse monoclonal (B-5)
  • western blot; human; loading ...; fig 5a
Santa Cruz Biotechnology TRF2 antibody (Santa Cruz, sc-271710) was used in western blot on human samples (fig 5a). Nucleic Acids Res (2019) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D1Y5D)
  • western blot; human; loading ...; fig s5c
Cell Signaling Technology TRF2 antibody (Cell Signaling, 13136) was used in western blot on human samples (fig s5c). Nature (2019) ncbi
domestic rabbit monoclonal (D1Y5D)
  • western blot; human; fig 4d
In order to test if NOL1activates transcription of cyclin D1, Cell Signaling Technology TRF2 antibody (CellSignaling, D1Y5D) was used in western blot on human samples (fig 4d). J Cell Sci (2016) ncbi
Articles Reviewed
  1. Sanchez Vazquez R, Martinez P, Blasco M. AKT-dependent signaling of extracellular cues through telomeres impact on tumorigenesis. PLoS Genet. 2021;17:e1009410 pubmed publisher
  2. Innes A, Sun B, Wagner V, Brookes S, McHugh D, Pombo J, et al. XPO7 is a tumor suppressor regulating p21CIP1-dependent senescence. Genes Dev. 2021;35:379-391 pubmed publisher
  3. Baquero J, Benitez Buelga C, Rajagopal V, Zhenjun Z, Torres Ruiz R, Muller S, et al. Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects. Sci Rep. 2021;11:3490 pubmed publisher
  4. Sarek G, Kotsantis P, Ruis P, Van Ly D, Margalef P, Borel V, et al. CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle. Nature. 2019;: pubmed publisher
  5. Li P, Meng Y, Wang Y, Li J, Lam M, Wang L, et al. Nuclear localization of Desmoplakin and its involvement in telomere maintenance. Int J Biol Sci. 2019;15:2350-2362 pubmed publisher
  6. Benyelles M, Episkopou H, O Donohue M, Kermasson L, Frange P, Poulain F, et al. Impaired telomere integrity and rRNA biogenesis in PARN-deficient patients and knock-out models. EMBO Mol Med. 2019;: pubmed publisher
  7. Qiu W, Xu Z, Zhang M, Zhang D, Fan H, Li T, et al. Determination of local chromatin interactions using a combined CRISPR and peroxidase APEX2 system. Nucleic Acids Res. 2019;47:e52 pubmed publisher
  8. Li M, Yang X, LU X, Dai N, Zhang S, Cheng Y, et al. APE1 deficiency promotes cellular senescence and premature aging features. Nucleic Acids Res. 2018;46:5664-5677 pubmed publisher
  9. Mytych J, Romerowicz Misielak M, Koziorowski M. Long-term culture with lipopolysaccharide induces dose-dependent cytostatic and cytotoxic effects in THP-1 monocytes. Toxicol In Vitro. 2017;42:1-9 pubmed publisher
  10. Yang H, Zhang H, Zhong Y, Wang Q, Yang L, Kang H, et al. Concomitant underexpression of TGFBR2 and overexpression of hTERT are associated with poor prognosis in cervical cancer. Sci Rep. 2017;7:41670 pubmed publisher
  11. Li J, Miralles Fusté J, Simavorian T, Bartocci C, Tsai J, Karlseder J, et al. TZAP: A telomere-associated protein involved in telomere length control. Science. 2017;355:638-641 pubmed publisher
  12. Tu Z, Bayazit M, Liu H, Zhang J, Busayavalasa K, Risal S, et al. Speedy A-Cdk2 binding mediates initial telomere-nuclear envelope attachment during meiotic prophase I independent of Cdk2 activation. Proc Natl Acad Sci U S A. 2017;114:592-597 pubmed publisher
  13. Mytych J, Wos I, Solek P, Koziorowski M. Protective role of klotho protein on epithelial cells upon co-culture with activated or senescent monocytes. Exp Cell Res. 2017;350:358-367 pubmed publisher
  14. Hu M, Chen S, Wang B, Ou T, Gu L, Tan J, et al. Specific targeting of telomeric multimeric G-quadruplexes by a new triaryl-substituted imidazole. Nucleic Acids Res. 2017;45:1606-1618 pubmed publisher
  15. Bisht K, Smith E, Tesmer V, Nandakumar J. Structural and functional consequences of a disease mutation in the telomere protein TPP1. Proc Natl Acad Sci U S A. 2016;113:13021-13026 pubmed
  16. Li Y, Shen Y, Hohensinner P, Ju J, Wen Z, Goodman S, et al. Deficient Activity of the Nuclease MRE11A Induces T Cell Aging and Promotes Arthritogenic Effector Functions in Patients with Rheumatoid Arthritis. Immunity. 2016;45:903-916 pubmed publisher
  17. Yang H, Wu L, Ke S, Wang W, Yang L, Gao X, et al. Downregulation of Ubiquitin-conjugating Enzyme UBE2D3 Promotes Telomere Maintenance and Radioresistance of Eca-109 Human Esophageal Carcinoma Cells. J Cancer. 2016;7:1152-62 pubmed publisher
  18. Su C, Cheng C, Tzeng T, Lin I, Hsu M. An H2A Histone Isotype, H2ac, Associates with Telomere and Maintains Telomere Integrity. PLoS ONE. 2016;11:e0156378 pubmed publisher
  19. Shukla S, Schmidt J, Goldfarb K, Cech T, Parker R. Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects. Nat Struct Mol Biol. 2016;23:286-92 pubmed publisher
  20. Hong J, Lee J, Chung I. Telomerase activates transcription of cyclin D1 gene through an interaction with NOL1. J Cell Sci. 2016;129:1566-79 pubmed publisher
  21. Cipressa F, Morciano P, Bosso G, Mannini L, Galati A, Raffa G, et al. A role for Separase in telomere protection. Nat Commun. 2016;7:10405 pubmed publisher
  22. Ci X, Li B, Ma X, Kong F, Zheng C, Björkholm M, et al. Bortezomib-mediated down-regulation of telomerase and disruption of telomere homeostasis contributes to apoptosis of malignant cells. Oncotarget. 2015;6:38079-92 pubmed publisher
  23. Xiong Y, Su H, Lv P, Ma Y, Wang S, Miao H, et al. A newly identified berberine derivative induces cancer cell senescence by stabilizing endogenous G-quadruplexes and sparking a DNA damage response at the telomere region. Oncotarget. 2015;6:35625-35 pubmed publisher
  24. Saquilabon Cruz G, Kong X, Silva B, Khatibzadeh N, Thai R, Berns M, et al. Femtosecond near-infrared laser microirradiation reveals a crucial role for PARP signaling on factor assemblies at DNA damage sites. Nucleic Acids Res. 2016;44:e27 pubmed publisher
  25. Tang M, Li Y, Zhang Y, Chen Y, Huang W, Wang D, et al. Disease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere maintenance. J Cell Sci. 2015;128:331-41 pubmed publisher
  26. Wood A, Rendtlew Danielsen J, Lucas C, Rice E, Scalzo D, Shimi T, et al. TRF2 and lamin A/C interact to facilitate the functional organization of chromosome ends. Nat Commun. 2014;5:5467 pubmed publisher
  27. Bombarde O, Boby C, Gomez D, Frit P, Giraud Panis M, Gilson E, et al. TRF2/RAP1 and DNA-PK mediate a double protection against joining at telomeric ends. EMBO J. 2010;29:1573-84 pubmed publisher