This is a Validated Antibody Database (VAD) review about human TPH1, based on 16 published articles (read how Labome selects the articles), using TPH1 antibody in all methods. It is aimed to help Labome visitors find the most suited TPH1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
TPH1 synonym: TPRH; TRPH

Abcam
domestic rabbit monoclonal (EP1311Y)
  • immunohistochemistry - paraffin section; rat
  • western blot; human
Abcam TPH1 antibody (Abcam, ab52954) was used in immunohistochemistry - paraffin section on rat samples and in western blot on human samples . Physiol Rep (2015) ncbi
MilliporeSigma
mouse monoclonal (WH-3)
  • immunohistochemistry; rat; 1:400; fig 1g1
MilliporeSigma TPH1 antibody (Sigma, T0678) was used in immunohistochemistry on rat samples at 1:400 (fig 1g1). Alzheimers Res Ther (2019) ncbi
domestic sheep polyclonal
  • immunohistochemistry; Mongolian jird; 1:1000; fig 1
In order to investigate differential regulation of serotonergic and GABAergic activity in the dorsal raphe nucleus by ON and OFF retinal ganglion cells, MilliporeSigma TPH1 antibody (Sigma-Aldrich, T8575) was used in immunohistochemistry on Mongolian jird samples at 1:1000 (fig 1). Sci Rep (2016) ncbi
mouse monoclonal (WH-3)
  • immunohistochemistry; rat; 1:1000; loading ...; fig 5b
In order to study the role of neuromedin U in drugs of abuse and visualize its receptor, MilliporeSigma TPH1 antibody (Sigma, T0678) was used in immunohistochemistry on rat samples at 1:1000 (fig 5b). Biol Psychiatry (2016) ncbi
mouse monoclonal (WH-3)
  • immunohistochemistry; mouse; 1:3000; loading ...; tbl 1
In order to determine the neuron composition of the median raphe region, MilliporeSigma TPH1 antibody (Sigma, T0678) was used in immunohistochemistry on mouse samples at 1:3000 (tbl 1). Brain Struct Funct (2017) ncbi
mouse monoclonal (WH-3)
  • immunohistochemistry - frozen section; rat; 1:1000; fig 4
MilliporeSigma TPH1 antibody (Sigma, T0678) was used in immunohistochemistry - frozen section on rat samples at 1:1000 (fig 4). Front Neurosci (2015) ncbi
mouse monoclonal (WH-3)
  • immunocytochemistry; mouse; 1:500; fig 4
MilliporeSigma TPH1 antibody (Sigma, T0678) was used in immunocytochemistry on mouse samples at 1:500 (fig 4). J Neurosci (2015) ncbi
mouse monoclonal (WH-3)
  • immunohistochemistry - frozen section; mouse; 1:400
In order to study the firing of dorsal raphe serotonergic neurons, MilliporeSigma TPH1 antibody (Sigma-Aldrich, T0678) was used in immunohistochemistry - frozen section on mouse samples at 1:400. PLoS ONE (2014) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D10C10)
  • western blot; mouse; 1:1000; loading ...; fig 1g
Cell Signaling Technology TPH1 antibody (Cell Signaling, 12339) was used in western blot on mouse samples at 1:1000 (fig 1g). Sci Rep (2018) ncbi
EMD Millipore
domestic sheep polyclonal
  • immunohistochemistry - free floating section; mouse; 1:1000; loading ...; fig 3a
EMD Millipore TPH1 antibody (Millipore, AB1541) was used in immunohistochemistry - free floating section on mouse samples at 1:1000 (fig 3a). Mol Brain (2020) ncbi
domestic sheep polyclonal
  • immunohistochemistry - frozen section; human; 1:100; loading ...; fig 3c
EMD Millipore TPH1 antibody (EMD Millipore, AB1541) was used in immunohistochemistry - frozen section on human samples at 1:100 (fig 3c). Nature (2019) ncbi
domestic sheep polyclonal
  • immunohistochemistry - frozen section; mouse; 1:200; fig 4
In order to test if bone loss is a component of an Alzheimer's disease prodrome, EMD Millipore TPH1 antibody (Millipore, AB1541) was used in immunohistochemistry - frozen section on mouse samples at 1:200 (fig 4). J Alzheimers Dis (2017) ncbi
domestic sheep polyclonal
In order to compare the patterns of serotonin-containing neurons in major tetraconate taxa, EMD Millipore TPH1 antibody (Millipore, AB1541) was used . J Comp Neurol (2017) ncbi
domestic sheep polyclonal
  • immunohistochemistry - frozen section; chicken; 1:2000
EMD Millipore TPH1 antibody (Millipore, AB1541) was used in immunohistochemistry - frozen section on chicken samples at 1:2000. Dev Neurobiol (2016) ncbi
mouse monoclonal (PH8)
  • immunocytochemistry; human
EMD Millipore TPH1 antibody (EMD Millipore, MAB5278) was used in immunocytochemistry on human samples . J Biomed Mater Res B Appl Biomater (2014) ncbi
mouse monoclonal (PH8)
  • immunohistochemistry - frozen section; rat; 1:4000
EMD Millipore TPH1 antibody (Chemicon, MAB 5278) was used in immunohistochemistry - frozen section on rat samples at 1:4000. J Comp Neurol (2010) ncbi
Articles Reviewed
  1. Moriya S, Yamashita A, Masukawa D, Kambe Y, Sakaguchi J, Setoyama H, et al. Involvement of supralemniscal nucleus (B9) 5-HT neuronal system in nociceptive processing: a fiber photometry study. Mol Brain. 2020;13:14 pubmed publisher
  2. Ghosh A, Torraville S, Mukherjee B, Walling S, Martin G, Harley C, et al. An experimental model of Braak's pretangle proposal for the origin of Alzheimer's disease: the role of locus coeruleus in early symptom development. Alzheimers Res Ther. 2019;11:59 pubmed publisher
  3. Veres A, Faust A, Bushnell H, Engquist E, Kenty J, Harb G, et al. Charting cellular identity during human in vitro β-cell differentiation. Nature. 2019;569:368-373 pubmed publisher
  4. Kim H, Kim Y, Choi W, Moon J, Hwang I, Kim K, et al. Generation of a highly efficient and tissue-specific tryptophan hydroxylase 1 knockout mouse model. Sci Rep. 2018;8:17642 pubmed publisher
  5. Dengler Crish C, Smith M, Wilson G. Early Evidence of Low Bone Density and Decreased Serotonergic Synthesis in the Dorsal Raphe of a Tauopathy Model of Alzheimer's Disease. J Alzheimers Dis. 2017;55:1605-1619 pubmed publisher
  6. Stemme T, Stern M, Bicker G. Serotonin-containing neurons in basal insects: In search of ground patterns among tetraconata. J Comp Neurol. 2017;525:79-115 pubmed publisher
  7. Zhang T, Huang L, Zhang L, Tan M, Pu M, Pickard G, et al. ON and OFF retinal ganglion cells differentially regulate serotonergic and GABAergic activity in the dorsal raphe nucleus. Sci Rep. 2016;6:26060 pubmed publisher
  8. Kasper J, McCue D, Milton A, Szwed A, Sampson C, Huang M, et al. Gamma-Aminobutyric Acidergic Projections From the Dorsal Raphe to the Nucleus Accumbens Are Regulated by Neuromedin U. Biol Psychiatry. 2016;80:878-887 pubmed publisher
  9. Sos K, Mayer M, Cserép C, Takács F, Szonyi A, Freund T, et al. Cellular architecture and transmitter phenotypes of neurons of the mouse median raphe region. Brain Struct Funct. 2017;222:287-299 pubmed publisher
  10. Pomrenze M, Millan E, Hopf F, Keiflin R, Maiya R, Blasio A, et al. A Transgenic Rat for Investigating the Anatomy and Function of Corticotrophin Releasing Factor Circuits. Front Neurosci. 2015;9:487 pubmed publisher
  11. Ehrich J, Messinger D, Knakal C, Kuhar J, Schattauer S, Bruchas M, et al. Kappa Opioid Receptor-Induced Aversion Requires p38 MAPK Activation in VTA Dopamine Neurons. J Neurosci. 2015;35:12917-31 pubmed publisher
  12. Landry J, Hawkins C, Lee A, Coté A, Balaban E, Pompeiano M. Chick embryos have the same pattern of hypoxic lower-brain activation as fetal mammals. Dev Neurobiol. 2016;76:64-74 pubmed publisher
  13. Valdés Fuentes M, Vera Rivera G, De Ita Pérez D, Méndez I, Miranda M, Díaz Muñoz M. Effect of daytime-restricted feeding in the daily variations of liver metabolism and blood transport of serotonin in rat. Physiol Rep. 2015;3: pubmed publisher
  14. Dugué G, Lorincz M, Lottem E, Audero E, Matias S, Correia P, et al. Optogenetic recruitment of dorsal raphe serotonergic neurons acutely decreases mechanosensory responsivity in behaving mice. PLoS ONE. 2014;9:e105941 pubmed publisher
  15. Kao T, Lee H, Higuchi A, Ling Q, Yu W, Chou Y, et al. Suppression of cancer-initiating cells and selection of adipose-derived stem cells cultured on biomaterials having specific nanosegments. J Biomed Mater Res B Appl Biomater. 2014;102:463-76 pubmed publisher
  16. Geerling J, Shin J, Chimenti P, Loewy A. Paraventricular hypothalamic nucleus: axonal projections to the brainstem. J Comp Neurol. 2010;518:1460-99 pubmed publisher