This is a Validated Antibody Database (VAD) review about human TMEM173, based on 28 published articles (read how Labome selects the articles), using TMEM173 antibody in all methods. It is aimed to help Labome visitors find the most suited TMEM173 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
TMEM173 synonym: ERIS; MITA; MPYS; NET23; SAVI; STING; STING-beta; hMITA; hSTING; stimulator of interferon genes protein; N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner; endoplasmic reticulum IFN stimulator; endoplasmic reticulum interferon stimulator; mitochondrial mediator of IRF3 activation; stimulator of interferon protein

Knockout validation
Proteintech Group
rabbit polyclonal
  • western blot; human; 1:1000; fig 3
  • western blot knockout validation; mouse; 1:1000; fig 3
In order to learn the requirement of palmitoylation at the Golgi by activation of STING, Proteintech Group TMEM173 antibody (Proteintech, 19851-1-AP) was used in western blot on human samples at 1:1000 (fig 3) and in western blot knockout validation on mouse samples at 1:1000 (fig 3). Nat Commun (2016) ncbi
Abcam
rabbit polyclonal
  • western blot knockout validation; mouse; 1:1000; loading ...; fig 3c
  • immunocytochemistry; mouse; 1:50; loading ...; fig 5h, 6e
  • immunohistochemistry - frozen section; human; 1:50; loading ...; fig 2c
  • immunocytochemistry; human; 1:200; loading ...; fig 2k
  • western blot; human; 1:1000; loading ...; fig 2d, 2l
Abcam TMEM173 antibody (Abcam, ab92605) was used in western blot knockout validation on mouse samples at 1:1000 (fig 3c), in immunocytochemistry on mouse samples at 1:50 (fig 5h, 6e), in immunohistochemistry - frozen section on human samples at 1:50 (fig 2c), in immunocytochemistry on human samples at 1:200 (fig 2k) and in western blot on human samples at 1:1000 (fig 2d, 2l). Nat Commun (2018) ncbi
Cell Signaling Technology
rabbit monoclonal (D2P2F)
  • western blot knockout validation; human; fig 3a
Cell Signaling Technology TMEM173 antibody (Cell Signaling, 13647) was used in western blot knockout validation on human samples (fig 3a). MBio (2019) ncbi
Cell Signaling Technology
rabbit monoclonal (D2P2F)
  • immunoprecipitation; mouse; 1:100; loading ...; fig 7c
  • western blot knockout validation; human; 1:100; loading ...; fig s11a
Cell Signaling Technology TMEM173 antibody (Cell Signaling, 13647) was used in immunoprecipitation on mouse samples at 1:100 (fig 7c) and in western blot knockout validation on human samples at 1:100 (fig s11a). Nat Commun (2017) ncbi
Cell Signaling Technology
rabbit monoclonal (D2P2F)
  • western blot; human; loading ...; fig 1b
  • western blot knockout validation; mouse; loading ...; fig s5a
Cell Signaling Technology TMEM173 antibody (Cell Signaling, D2P2F) was used in western blot on human samples (fig 1b) and in western blot knockout validation on mouse samples (fig s5a). J Exp Med (2017) ncbi
R&D Systems
mouse monoclonal (723505)
  • immunocytochemistry; human; 1:100; loading ...; fig 5b
R&D Systems TMEM173 antibody (R&D Systems, MAB7169) was used in immunocytochemistry on human samples at 1:100 (fig 5b). Nat Commun (2018) ncbi
mouse monoclonal (723505)
  • western blot; human; loading ...; fig 3f
R&D Systems TMEM173 antibody (R&D Systems, MAB7169) was used in western blot on human samples (fig 3f). PLoS ONE (2018) ncbi
mouse monoclonal (723505)
  • immunocytochemistry; human
  • western blot; human; loading ...; fig 4b
R&D Systems TMEM173 antibody (R&D Systems, 723505) was used in immunocytochemistry on human samples and in western blot on human samples (fig 4b). J Exp Med (2017) ncbi
mouse monoclonal (723505)
  • immunocytochemistry; human; 1:200; loading ...; fig 4i
In order to research the effect of intracellular STING inactivation on the drug sensitivity of breast cancer cells, R&D Systems TMEM173 antibody (R&D Systems, MAB7169) was used in immunocytochemistry on human samples at 1:200 (fig 4i). Oncotarget (2016) ncbi
Proteintech Group
rabbit polyclonal
  • immunocytochemistry; human; 1:500; loading ...; fig 6d
Proteintech Group TMEM173 antibody (Proteintech, 19851-1-AP) was used in immunocytochemistry on human samples at 1:500 (fig 6d). Nat Commun (2017) ncbi
rabbit polyclonal
  • western blot; human; loading ...; fig 1c
Proteintech Group TMEM173 antibody (Proteintech, 19851?C1-AP) was used in western blot on human samples (fig 1c). Proc Natl Acad Sci U S A (2017) ncbi
rabbit polyclonal
  • western blot; human; 1:1000; fig 3
  • western blot knockout validation; mouse; 1:1000; fig 3
In order to learn the requirement of palmitoylation at the Golgi by activation of STING, Proteintech Group TMEM173 antibody (Proteintech, 19851-1-AP) was used in western blot on human samples at 1:1000 (fig 3) and in western blot knockout validation on mouse samples at 1:1000 (fig 3). Nat Commun (2016) ncbi
Abcam
rabbit polyclonal
  • western blot knockout validation; mouse; 1:1000; loading ...; fig 3c
  • immunocytochemistry; mouse; 1:50; loading ...; fig 5h, 6e
  • immunohistochemistry - frozen section; human; 1:50; loading ...; fig 2c
  • immunocytochemistry; human; 1:200; loading ...; fig 2k
  • western blot; human; 1:1000; loading ...; fig 2d, 2l
Abcam TMEM173 antibody (Abcam, ab92605) was used in western blot knockout validation on mouse samples at 1:1000 (fig 3c), in immunocytochemistry on mouse samples at 1:50 (fig 5h, 6e), in immunohistochemistry - frozen section on human samples at 1:50 (fig 2c), in immunocytochemistry on human samples at 1:200 (fig 2k) and in western blot on human samples at 1:1000 (fig 2d, 2l). Nat Commun (2018) ncbi
rabbit polyclonal
  • immunohistochemistry; mouse; 1:100; fig 5a
Abcam TMEM173 antibody (Abcam, ab92605) was used in immunohistochemistry on mouse samples at 1:100 (fig 5a). Sci Rep (2016) ncbi
LifeSpan Biosciences
rabbit polyclonal
  • immunocytochemistry; human
  • western blot; human; fig s3
LifeSpan Biosciences TMEM173 antibody (LSBio, LS-C108557) was used in immunocytochemistry on human samples and in western blot on human samples (fig s3). Proc Natl Acad Sci U S A (2016) ncbi
Cell Signaling Technology
monoclonal (D7C3S)
  • western blot; human; loading ...; fig 3i
Cell Signaling Technology TMEM173 antibody (CST, 19781) was used in western blot on human samples (fig 3i). Cell Death Dis (2019) ncbi
rabbit monoclonal (D2P2F)
  • western blot knockout validation; human; fig 3a
Cell Signaling Technology TMEM173 antibody (Cell Signaling, 13647) was used in western blot knockout validation on human samples (fig 3a). MBio (2019) ncbi
rabbit monoclonal (D2P2F)
  • western blot; mouse; loading ...; fig 4a
Cell Signaling Technology TMEM173 antibody (Cell Signaling Technology, 13647) was used in western blot on mouse samples (fig 4a). Cell Rep (2018) ncbi
rabbit monoclonal (D2P2F)
  • western blot; mouse; loading ...; fig 1a
Cell Signaling Technology TMEM173 antibody (Biosciences, 13647) was used in western blot on mouse samples (fig 1a). Cell Death Differ (2018) ncbi
monoclonal (D7C3S)
  • western blot; mouse; 1:500; loading ...; fig 1p, 5g, 6f
  • western blot; human; 1:500; loading ...; fig 2d, 2l
Cell Signaling Technology TMEM173 antibody (Cell Signaling, 19781) was used in western blot on mouse samples at 1:500 (fig 1p, 5g, 6f) and in western blot on human samples at 1:500 (fig 2d, 2l). Nat Commun (2018) ncbi
rabbit monoclonal (D2P2F)
  • western blot; human; loading ...; fig s10
Cell Signaling Technology TMEM173 antibody (Cell Signaling Technology, 13647s) was used in western blot on human samples (fig s10). J Clin Invest (2018) ncbi
rabbit monoclonal (D2P2F)
  • western blot; mouse; 1:500; loading ...; fig 4a
Cell Signaling Technology TMEM173 antibody (Cell Signaling, 13647) was used in western blot on mouse samples at 1:500 (fig 4a). Nat Commun (2018) ncbi
rabbit monoclonal (D2P2F)
  • western blot; human; loading ...; fig s6t
Cell Signaling Technology TMEM173 antibody (Cell Signaling Technology, 13647) was used in western blot on human samples (fig s6t). Sci Adv (2018) ncbi
rabbit monoclonal (D2P2F)
  • western blot; human; 1:1000; loading ...; fig 8c
Cell Signaling Technology TMEM173 antibody (Cell Signaling Technology, 13647) was used in western blot on human samples at 1:1000 (fig 8c). Sci Transl Med (2017) ncbi
rabbit monoclonal (D2P2F)
  • immunoprecipitation; mouse; 1:100; loading ...; fig 7c
  • western blot knockout validation; human; 1:100; loading ...; fig s11a
Cell Signaling Technology TMEM173 antibody (Cell Signaling, 13647) was used in immunoprecipitation on mouse samples at 1:100 (fig 7c) and in western blot knockout validation on human samples at 1:100 (fig s11a). Nat Commun (2017) ncbi
rabbit monoclonal (D2P2F)
  • immunocytochemistry; human; loading ...; fig 6b
Cell Signaling Technology TMEM173 antibody (Cell Signaling Technology, 13647) was used in immunocytochemistry on human samples (fig 6b). Cell (2017) ncbi
rabbit monoclonal (D2P2F)
  • western blot; human; loading ...; fig 2e
Cell Signaling Technology TMEM173 antibody (Cell Signaling, D2P2F) was used in western blot on human samples (fig 2e). EMBO Rep (2017) ncbi
rabbit monoclonal (D2P2F)
  • western blot; human; loading ...; fig 1b
  • western blot knockout validation; mouse; loading ...; fig s5a
Cell Signaling Technology TMEM173 antibody (Cell Signaling, D2P2F) was used in western blot on human samples (fig 1b) and in western blot knockout validation on mouse samples (fig s5a). J Exp Med (2017) ncbi
rabbit monoclonal (D2P2F)
  • western blot; human; 1:500; loading ...; fig s1c
In order to elucidate the role of TREX1 during the cell cycle, Cell Signaling Technology TMEM173 antibody (Cell Signaling, D2P2F) was used in western blot on human samples at 1:500 (fig s1c). Cell Rep (2017) ncbi
rabbit monoclonal (D2P2F)
  • western blot; human; loading ...; fig 5e
In order to identify factors that contribute to adenoviral transduction stimulation of IL-33 in endothelial cells, Cell Signaling Technology TMEM173 antibody (Cell Signaling, D2P2F) was used in western blot on human samples (fig 5e). J Immunol (2017) ncbi
rabbit monoclonal (D2P2F)
  • immunoprecipitation; human; loading ...; fig 3f
  • immunocytochemistry; human; loading ...; fig 3a
  • western blot; human; 1:1000; loading ...; fig 1a
Cell Signaling Technology TMEM173 antibody (Cell Signaling, D2P2F) was used in immunoprecipitation on human samples (fig 3f), in immunocytochemistry on human samples (fig 3a) and in western blot on human samples at 1:1000 (fig 1a). Nat Commun (2017) ncbi
rabbit monoclonal (D2P2F)
  • western blot; human; loading ...; fig 2b
  • western blot; mouse; fig 4a
Cell Signaling Technology TMEM173 antibody (Cell Signaling, 13647) was used in western blot on human samples (fig 2b) and in western blot on mouse samples (fig 4a). J Biol Chem (2017) ncbi
rabbit monoclonal (D2P2F)
  • immunoprecipitation; human; loading ...; fig 5a
  • immunohistochemistry; human; loading ...; fig 2e
  • western blot; human; loading ...; fig 2d
In order to find interferon-gamma inducible factor 16 functions in the cyclic GMP-AMP synthase-stimulator of interferon genes pathway, Cell Signaling Technology TMEM173 antibody (Cell Signaling, 13647) was used in immunoprecipitation on human samples (fig 5a), in immunohistochemistry on human samples (fig 2e) and in western blot on human samples (fig 2d). Nat Commun (2017) ncbi
rabbit monoclonal (D2P2F)
  • western blot; human; 1:1000; loading ...; fig 4h
In order to research the effect of intracellular STING inactivation on the drug sensitivity of breast cancer cells, Cell Signaling Technology TMEM173 antibody (Cell Signaling, 13647) was used in western blot on human samples at 1:1000 (fig 4h). Oncotarget (2016) ncbi
rabbit monoclonal (D2P2F)
  • immunoprecipitation; human; fig 7b
  • immunocytochemistry; human; 1:2000; loading ...; fig 5b
  • western blot; human; 1:2000; loading ...; fig 4f
  • immunocytochemistry; mouse; 1:2000; loading ...; fig 8a
  • western blot; mouse; 1:2000; loading ...; fig 6a
In order to explore the anti-viral effects of iRhom2, Cell Signaling Technology TMEM173 antibody (Cell Signaling, D2P2F) was used in immunoprecipitation on human samples (fig 7b), in immunocytochemistry on human samples at 1:2000 (fig 5b), in western blot on human samples at 1:2000 (fig 4f), in immunocytochemistry on mouse samples at 1:2000 (fig 8a) and in western blot on mouse samples at 1:2000 (fig 6a). Nat Immunol (2016) ncbi
rabbit monoclonal (D2P2F)
  • western blot; mouse; fig s2
Cell Signaling Technology TMEM173 antibody (Cell signaling, 13647) was used in western blot on mouse samples (fig s2). Nucleic Acids Res (2016) ncbi
rabbit monoclonal (D2P2F)
  • western blot; human; fig 5
Cell Signaling Technology TMEM173 antibody (Cell Signaling Technology, 13647) was used in western blot on human samples (fig 5). J Biol Chem (2015) ncbi
rabbit monoclonal (D2P2F)
  • western blot; human; loading ...; fig 4
Cell Signaling Technology TMEM173 antibody (Cell Signaling Technology, 13647) was used in western blot on human samples (fig 4). PLoS ONE (2015) ncbi
Articles Reviewed
  1. Majumdar T, Sharma S, Kumar M, Hussain M, Chauhan N, Kalia I, et al. Tryptophan-kynurenine pathway attenuates β-catenin-dependent pro-parasitic role of STING-TICAM2-IRF3-IDO1 signalosome in Toxoplasma gondii infection. Cell Death Dis. 2019;10:161 pubmed publisher
  2. Botto S, Abraham J, Mizuno N, Pryke K, Gall B, Landais I, et al. Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1β Protein during Virion-Mediated Activation of the AIM2 Inflammasome. MBio. 2019;10: pubmed publisher
  3. D Eletto M, Rossin F, Occhigrossi L, Farrace M, Faccenda D, Desai R, et al. Transglutaminase Type 2 Regulates ER-Mitochondria Contact Sites by Interacting with GRP75. Cell Rep. 2018;25:3573-3581.e4 pubmed publisher
  4. Liu D, Wu H, Wang C, Li Y, Tian H, Siraj S, et al. STING directly activates autophagy to tune the innate immune response. Cell Death Differ. 2018;: pubmed publisher
  5. Benmerzoug S, Rose S, Bounab B, Gosset D, Duneau L, Chenuet P, et al. STING-dependent sensing of self-DNA drives silica-induced lung inflammation. Nat Commun. 2018;9:5226 pubmed publisher
  6. Li F, Li Y, Liang H, Xu T, Kong Y, Huang M, et al. HECTD3 mediates TRAF3 polyubiquitination and type I interferon induction during bacterial infection. J Clin Invest. 2018;128:4148-4162 pubmed publisher
  7. Yang L, Wang L, Ketkar H, Ma J, Yang G, Cui S, et al. UBXN3B positively regulates STING-mediated antiviral immune responses. Nat Commun. 2018;9:2329 pubmed publisher
  8. Liu Q, Wu Y, Qin Y, Hu J, Xie W, Qin F, et al. Broad and diverse mechanisms used by deubiquitinase family members in regulating the type I interferon signaling pathway during antiviral responses. Sci Adv. 2018;4:eaar2824 pubmed publisher
  9. Ghosh R, Roy S, Franco S. PARP1 depletion induces RIG-I-dependent signaling in human cancer cells. PLoS ONE. 2018;13:e0194611 pubmed publisher
  10. Zeng L, Kang R, Zhu S, Wang X, Cao L, Wang H, et al. ALK is a therapeutic target for lethal sepsis. Sci Transl Med. 2017;9: pubmed publisher
  11. Xing J, Zhang A, Zhang H, Wang J, Li X, Zeng M, et al. TRIM29 promotes DNA virus infections by inhibiting innate immune response. Nat Commun. 2017;8:945 pubmed publisher
  12. Gaidt M, Ebert T, Chauhan D, Ramshorn K, Pinci F, Zuber S, et al. The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3. Cell. 2017;171:1110-1124.e18 pubmed publisher
  13. Luecke S, Holleufer A, Christensen M, Jønsson K, Boni G, Sørensen L, et al. cGAS is activated by DNA in a length-dependent manner. EMBO Rep. 2017;18:1707-1715 pubmed publisher
  14. Liu Y, Qu L, Liu Y, Roizman B, Zhou G. PUM1 is a biphasic negative regulator of innate immunity genes by suppressing LGP2. Proc Natl Acad Sci U S A. 2017;114:E6902-E6911 pubmed publisher
  15. Cerboni S, Jeremiah N, Gentili M, Gehrmann U, Conrad C, Stolzenberg M, et al. Intrinsic antiproliferative activity of the innate sensor STING in T lymphocytes. J Exp Med. 2017;214:1769-1785 pubmed publisher
  16. Kucej M, Fermaintt C, Yang K, Irizarry Caro R, Yan N. Mitotic Phosphorylation of TREX1 C Terminus Disrupts TREX1 Regulation of the Oligosaccharyltransferase Complex. Cell Rep. 2017;18:2600-2607 pubmed publisher
  17. Stav Noraas T, Edelmann R, Poulsen L, Sundnes O, Phung D, Küchler A, et al. Endothelial IL-33 Expression Is Augmented by Adenoviral Activation of the DNA Damage Machinery. J Immunol. 2017;198:3318-3325 pubmed publisher
  18. Almine J, O Hare C, Dunphy G, Haga I, Naik R, Atrih A, et al. IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes. Nat Commun. 2017;8:14392 pubmed publisher
  19. Hsia H, Hutti J, Baldwin A. Cytosolic DNA Promotes Signal Transducer and Activator of Transcription 3 (STAT3) Phosphorylation by TANK-binding Kinase 1 (TBK1) to Restrain STAT3 Activity. J Biol Chem. 2017;292:5405-5417 pubmed publisher
  20. Jønsson K, Laustsen A, Krapp C, Skipper K, Thavachelvam K, Hotter D, et al. IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP. Nat Commun. 2017;8:14391 pubmed publisher
  21. Gaston J, Cheradame L, Yvonnet V, Déas O, Poupon M, Judde J, et al. Intracellular STING inactivation sensitizes breast cancer cells to genotoxic agents. Oncotarget. 2016;7:77205-77224 pubmed publisher
  22. Luo W, Li S, Li C, Lian H, Yang Q, Zhong B, et al. iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING. Nat Immunol. 2016;17:1057-66 pubmed publisher
  23. Mukai K, Konno H, Akiba T, Uemura T, Waguri S, Kobayashi T, et al. Activation of STING requires palmitoylation at the Golgi. Nat Commun. 2016;7:11932 pubmed publisher
  24. Pépin G, Ferrand J, Höning K, Jayasekara W, Cain J, Behlke M, et al. Cre-dependent DNA recombination activates a STING-dependent innate immune response. Nucleic Acids Res. 2016;44:5356-64 pubmed publisher
  25. Zhang G, Chan B, Samarina N, Abere B, Weidner Glunde M, Buch A, et al. Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS. Proc Natl Acad Sci U S A. 2016;113:E1034-43 pubmed publisher
  26. Li T, Cheng H, Yuan H, Xu Q, Shu C, Zhang Y, et al. Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response. Sci Rep. 2016;6:19049 pubmed publisher
  27. Kemp M, Lindsey Boltz L, Sancar A. UV Light Potentiates STING (Stimulator of Interferon Genes)-dependent Innate Immune Signaling through Deregulation of ULK1 (Unc51-like Kinase 1). J Biol Chem. 2015;290:12184-94 pubmed publisher
  28. Kodigepalli K, Nanjundan M. Induction of PLSCR1 in a STING/IRF3-dependent manner upon vector transfection in ovarian epithelial cells. PLoS ONE. 2015;10:e0117464 pubmed publisher