This is a Validated Antibody Database (VAD) review about human TLR3, based on 25 published articles (read how Labome selects the articles), using TLR3 antibody in all methods. It is aimed to help Labome visitors find the most suited TLR3 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
TLR3 synonym: CD283; IIAE2; toll-like receptor 3

Knockout validation
Abcam
mouse monoclonal (40C1285)
  • western blot knockout validation; mouse; 1:500
  • immunohistochemistry - paraffin section; mouse; 1:200
  • immunocytochemistry; mouse; 1:200
Abcam TLR3 antibody (Abcam, ab13915) was used in western blot knockout validation on mouse samples at 1:500, in immunohistochemistry - paraffin section on mouse samples at 1:200 and in immunocytochemistry on mouse samples at 1:200. Mol Cell Endocrinol (2013) ncbi
Invitrogen
mouse monoclonal (TLR3.7)
  • flow cytometry; human; fig 1
  • immunohistochemistry; human; loading ...; fig 2
In order to investigate the expression of Toll-like receptors in satellite glial cells, Invitrogen TLR3 antibody (eBioscience, TLR3.7) was used in flow cytometry on human samples (fig 1) and in immunohistochemistry on human samples (fig 2). Eur J Immunol (2017) ncbi
mouse monoclonal (TLR3.7)
  • flow cytometry; human; fig st1
In order to find cell-surface markers specific to human neutrophils, Invitrogen TLR3 antibody (e- Bioscienc e, 12-9039-82) was used in flow cytometry on human samples (fig st1). Exp Cell Res (2016) ncbi
mouse monoclonal (TLR3.7)
  • flow cytometry; human; fig 3d
  • western blot; human; fig 3c
In order to determine the role of Anakinra in anthrofibrosis knee patients, Invitrogen TLR3 antibody (eBioscience, 12-9039) was used in flow cytometry on human samples (fig 3d) and in western blot on human samples (fig 3c). Sci Rep (2015) ncbi
mouse monoclonal (TLR3.7)
  • blocking or activating experiments; mouse; fig 2
Invitrogen TLR3 antibody (eBioscience, T3.7C3) was used in blocking or activating experiments on mouse samples (fig 2). Reprod Fertil Dev (2015) ncbi
mouse monoclonal (TLR3.7)
  • flow cytometry; human; tbl 1
In order to study the effect of innate lymphoid cells on B cells, Invitrogen TLR3 antibody (eBioscience, TLR3.7) was used in flow cytometry on human samples (tbl 1). Nat Immunol (2014) ncbi
mouse monoclonal (TLR3.7)
  • flow cytometry; human; fig 8
In order to explore the role of HIV in potentially modulating macrophage function, Invitrogen TLR3 antibody (eBioscience, TLR3.7) was used in flow cytometry on human samples (fig 8). Retrovirology (2013) ncbi
Abcam
rabbit polyclonal
  • immunocytochemistry; mouse; 1 ug/ml; loading ...; fig 5c
Abcam TLR3 antibody (AbCam, ab62566) was used in immunocytochemistry on mouse samples at 1 ug/ml (fig 5c). Science (2019) ncbi
rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 3a
In order to analyze the effects of dopamine related metabolite concentrations in M1 and M2 microglia phenotypes, Abcam TLR3 antibody (Abcam, ab62566) was used in western blot on mouse samples at 1:1000 (fig 3a). Front Cell Neurosci (2017) ncbi
mouse monoclonal (TLR3.7)
  • flow cytometry; human; fig 2
Abcam TLR3 antibody (Abcam, ab12085) was used in flow cytometry on human samples (fig 2). PLoS ONE (2015) ncbi
rabbit polyclonal
  • western blot; human
Abcam TLR3 antibody (Abcam, ab62566) was used in western blot on human samples . Autophagy (2014) ncbi
mouse monoclonal (40C1285)
  • western blot knockout validation; mouse; 1:500
  • immunohistochemistry - paraffin section; mouse; 1:200
  • immunocytochemistry; mouse; 1:200
Abcam TLR3 antibody (Abcam, ab13915) was used in western blot knockout validation on mouse samples at 1:500, in immunohistochemistry - paraffin section on mouse samples at 1:200 and in immunocytochemistry on mouse samples at 1:200. Mol Cell Endocrinol (2013) ncbi
mouse monoclonal (40C1285)
  • western blot; mouse; fig 2a
Abcam TLR3 antibody (Abcam, ab13915) was used in western blot on mouse samples (fig 2a). Sci Signal (2012) ncbi
Santa Cruz Biotechnology
mouse monoclonal (TLR3.7)
  • western blot; human; 1:300; fig 3
Santa Cruz Biotechnology TLR3 antibody (Santa Cruz, sc-32232) was used in western blot on human samples at 1:300 (fig 3). Sci Rep (2016) ncbi
mouse monoclonal (TLR3.7)
  • western blot; human; fig 1
Santa Cruz Biotechnology TLR3 antibody (Santa Cruz Biotechnology, 32232) was used in western blot on human samples (fig 1). Int J Mol Sci (2016) ncbi
mouse monoclonal (TLR3.7)
  • other; human; fig 2
In order to characterize capabilities and potentials of extracellular vesicle (EV) array, Santa Cruz Biotechnology TLR3 antibody (Santa Cruz Biotechnology, sc-32232) was used in other on human samples (fig 2). J Extracell Vesicles (2015) ncbi
R&D Systems
mouse monoclonal (512505)
  • western blot; human; loading ...; fig 4b
R&D Systems TLR3 antibody (R&D Systems, 512505) was used in western blot on human samples (fig 4b). Oncotarget (2016) ncbi
goat polyclonal
  • western blot; human; loading ...; fig s4a
R&D Systems TLR3 antibody (R&D Systems, AF1487) was used in western blot on human samples (fig s4a). Cell Death Dis (2016) ncbi
goat polyclonal
  • western blot; human; fig 6
In order to assess the effect of polyinosinic-polycytidylic acid on the barrier function and tight junction integrity of primary human lung microvascular endothelial cells, R&D Systems TLR3 antibody (R&D Systems, AF1487) was used in western blot on human samples (fig 6). PLoS ONE (2016) ncbi
Enzo Life Sciences
mouse monoclonal (40C1285.6)
  • western blot; human; 1:1000; loading ...; fig 6b
Enzo Life Sciences TLR3 antibody (Enzo, ALX-804-362-C100) was used in western blot on human samples at 1:1000 (fig 6b). F1000Res (2017) ncbi
GeneTex
rabbit polyclonal
  • western blot; human; loading ...; fig 3a
GeneTex TLR3 antibody (GeneTex, GTX113022) was used in western blot on human samples (fig 3a). Oncotarget (2016) ncbi
Cell Signaling Technology
rabbit monoclonal (D10F10)
  • western blot; human; loading ...; fig 3f
Cell Signaling Technology TLR3 antibody (Cell Signaling, D10F10) was used in western blot on human samples (fig 3f). PLoS ONE (2018) ncbi
rabbit monoclonal (D10F10)
  • flow cytometry; human; loading ...; fig 4b
Cell Signaling Technology TLR3 antibody (Cell Signaling, 6961) was used in flow cytometry on human samples (fig 4b). Invest New Drugs (2015) ncbi
rabbit monoclonal (D10F10)
  • western blot; human; fig 6a
Cell Signaling Technology TLR3 antibody (Cell Signaling, 6961) was used in western blot on human samples (fig 6a). Mol Cancer (2014) ncbi
rabbit monoclonal (D10F10)
  • western blot; human
Cell Signaling Technology TLR3 antibody (Cell Signaling Technology, D10F10) was used in western blot on human samples . PLoS Pathog (2014) ncbi
ProSci
rabbit polyclonal
  • immunohistochemistry; mouse; 1:200
  • western blot; mouse; 1:1,000
  • immunohistochemistry; human; 1:200
ProSci TLR3 antibody (Prosci Inc., 3643) was used in immunohistochemistry on mouse samples at 1:200, in western blot on mouse samples at 1:1,000 and in immunohistochemistry on human samples at 1:200. J Immunol (2011) ncbi
Articles Reviewed
  1. Sweere J, Van Belleghem J, Ishak H, Bach M, Popescu M, Sunkari V, et al. Bacteriophage trigger antiviral immunity and prevent clearance of bacterial infection. Science. 2019;363: pubmed publisher
  2. Ghosh R, Roy S, Franco S. PARP1 depletion induces RIG-I-dependent signaling in human cancer cells. PLoS ONE. 2018;13:e0194611 pubmed publisher
  3. McCarthy G, Bridges C, Blednov Y, Harris R. CNS cell-type localization and LPS response of TLR signaling pathways. F1000Res. 2017;6:1144 pubmed publisher
  4. Mitterreiter J, Ouwendijk W, van Velzen M, van Nierop G, Osterhaus A, Verjans G. Satellite glial cells in human trigeminal ganglia have a broad expression of functional Toll-like receptors. Eur J Immunol. 2017;47:1181-1187 pubmed publisher
  5. Shan M, Lin S, Li S, Du Y, Zhao H, Hong H, et al. TIR-Domain-Containing Adapter-Inducing Interferon-? (TRIF) Is Essential for MPTP-Induced Dopaminergic Neuroprotection via Microglial Cell M1/M2 Modulation. Front Cell Neurosci. 2017;11:35 pubmed publisher
  6. Veyrat M, Durand S, Classe M, Glavan T, Oker N, Kapetanakis N, et al. Stimulation of the toll-like receptor 3 promotes metabolic reprogramming in head and neck carcinoma cells. Oncotarget. 2016;7:82580-82593 pubmed publisher
  7. Narayanaswamy P, Tkachuk S, Haller H, Dumler I, Kiyan Y. CHK1 and RAD51 activation after DNA damage is regulated via urokinase receptor/TLR4 signaling. Cell Death Dis. 2016;7:e2383 pubmed publisher
  8. Huang L, Stuart C, Takeda K, D Agnillo F, Golding B. Poly(I:C) Induces Human Lung Endothelial Barrier Dysfunction by Disrupting Tight Junction Expression of Claudin-5. PLoS ONE. 2016;11:e0160875 pubmed publisher
  9. He M, Wang M, Huang Y, Peng W, Zheng Z, Xia N, et al. The ORF3 Protein of Genotype 1 Hepatitis E Virus Suppresses TLR3-induced NF-κB Signaling via TRADD and RIP1. Sci Rep. 2016;6:27597 pubmed publisher
  10. Song X, Yao Z, Yang J, Zhang Z, Deng Y, Li M, et al. HCV core protein binds to gC1qR to induce A20 expression and inhibit cytokine production through MAPKs and NF-κB signaling pathways. Oncotarget. 2016;7:33796-808 pubmed publisher
  11. Lakschevitz F, Hassanpour S, Rubin A, Fine N, Sun C, Glogauer M. Identification of neutrophil surface marker changes in health and inflammation using high-throughput screening flow cytometry. Exp Cell Res. 2016;342:200-9 pubmed publisher
  12. Peng Y, Norris J, Schwartz C, Alexov E. Revealing the Effects of Missense Mutations Causing Snyder-Robinson Syndrome on the Stability and Dimerization of Spermine Synthase. Int J Mol Sci. 2016;17: pubmed publisher
  13. Dixon D, Coates J, Del Carpio Pons A, Horabin J, Walker A, Abdul N, et al. A potential mode of action for Anakinra in patients with arthrofibrosis following total knee arthroplasty. Sci Rep. 2015;5:16466 pubmed publisher
  14. Hwang S, Cho H, Park S, Lee W, Lee H, Lee D, et al. Characteristics of Human Turbinate-Derived Mesenchymal Stem Cells Are Not Affected by Allergic Condition of Donor. PLoS ONE. 2015;10:e0138041 pubmed publisher
  15. Wang J, Yin T, Wen Y, Tian F, He X, Zhou D, et al. Potential effects of interferon regulatory factor 4 in a murine model of polyinosinic-polycytidylic acid-induced embryo resorption. Reprod Fertil Dev. 2015;: pubmed publisher
  16. Jørgensen M, Bæk R, Varming K. Potentials and capabilities of the Extracellular Vesicle (EV) Array. J Extracell Vesicles. 2015;4:26048 pubmed publisher
  17. Guzmán E, Maers K, Roberts J, Kemami Wangun H, Harmody D, Wright A. The marine natural product microsclerodermin A is a novel inhibitor of the nuclear factor kappa B and induces apoptosis in pancreatic cancer cells. Invest New Drugs. 2015;33:86-94 pubmed publisher
  18. Harashima N, Minami T, Uemura H, Harada M. Transfection of poly(I:C) can induce reactive oxygen species-triggered apoptosis and interferon-β-mediated growth arrest in human renal cell carcinoma cells via innate adjuvant receptors and the 2-5A system. Mol Cancer. 2014;13:217 pubmed publisher
  19. Chattergoon M, Latanich R, Quinn J, Winter M, Buckheit R, Blankson J, et al. HIV and HCV activate the inflammasome in monocytes and macrophages via endosomal Toll-like receptors without induction of type 1 interferon. PLoS Pathog. 2014;10:e1004082 pubmed publisher
  20. Magri G, Miyajima M, Bascones S, Mortha A, Puga I, Cassis L, et al. Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells. Nat Immunol. 2014;15:354-364 pubmed publisher
  21. Babu R, Brown A. A consensus surface activation marker signature is partially dependent on human immunodeficiency virus type 1 Nef expression within productively infected macrophages. Retrovirology. 2013;10:155 pubmed publisher
  22. Zhan Z, Xie X, Cao H, Zhou X, Zhang X, Fan H, et al. Autophagy facilitates TLR4- and TLR3-triggered migration and invasion of lung cancer cells through the promotion of TRAF6 ubiquitination. Autophagy. 2014;10:257-68 pubmed publisher
  23. Yan K, Zhu W, Yu L, Li N, Zhang X, Liu P, et al. Toll-like receptor 3 and RIG-I-like receptor activation induces innate antiviral responses in mouse ovarian granulosa cells. Mol Cell Endocrinol. 2013;372:73-85 pubmed publisher
  24. Yamashita M, Chattopadhyay S, Fensterl V, Saikia P, Wetzel J, Sen G. Epidermal growth factor receptor is essential for Toll-like receptor 3 signaling. Sci Signal. 2012;5:ra50 pubmed publisher
  25. Qi J, Buzas K, Fan H, Cohen J, Wang K, Mont E, et al. Painful pathways induced by TLR stimulation of dorsal root ganglion neurons. J Immunol. 2011;186:6417-26 pubmed publisher