This is a Validated Antibody Database (VAD) review about human TIGIT, based on 16 published articles (read how Labome selects the articles), using TIGIT antibody in all methods. It is aimed to help Labome visitors find the most suited TIGIT antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
TIGIT synonym: VSIG9; VSTM3; WUCAM

BioLegend
mouse monoclonal (A15153G)
  • flow cytometry; human; fig s4-1a
BioLegend TIGIT antibody (Biolegend, 372706) was used in flow cytometry on human samples (fig s4-1a). elife (2020) ncbi
mouse monoclonal (A15153G)
  • other; mouse
BioLegend TIGIT antibody (BioLegend, A15153G) was used in other on mouse samples . Nat Commun (2020) ncbi
mouse monoclonal (A15153G)
  • flow cytometry; human; fig 4d
BioLegend TIGIT antibody (BioLegend, A15153G) was used in flow cytometry on human samples (fig 4d). J Immunother Cancer (2020) ncbi
mouse monoclonal (A15153G)
  • flow cytometry; human; loading ...; fig 6b
BioLegend TIGIT antibody (Biolegend, 372706) was used in flow cytometry on human samples (fig 6b). Cell Mol Gastroenterol Hepatol (2020) ncbi
mouse monoclonal (A15153G)
  • flow cytometry; human; loading ...; fig s2b
BioLegend TIGIT antibody (Biolegend, 372711) was used in flow cytometry on human samples (fig s2b). Cell (2019) ncbi
mouse monoclonal (A15153G)
  • blocking or activating experiments; human; loading ...; fig 4d, 4e
BioLegend TIGIT antibody (Biolegend, A15153G) was used in blocking or activating experiments on human samples (fig 4d, 4e). Oncogene (2018) ncbi
Invitrogen
mouse monoclonal (MBSA43)
  • flow cytometry; mouse; loading ...; fig s3a
Invitrogen TIGIT antibody (Invitrogen, MBSA43) was used in flow cytometry on mouse samples (fig s3a). J Exp Med (2020) ncbi
mouse monoclonal (MBSA43)
  • flow cytometry; human; loading ...; fig 1b
Invitrogen TIGIT antibody (eBioscience, 46-9500-42) was used in flow cytometry on human samples (fig 1b). Cell Mol Gastroenterol Hepatol (2020) ncbi
mouse monoclonal (MBSA43)
  • flow cytometry; human; loading ...; fig 3f
Invitrogen TIGIT antibody (eBioscience, MBSA43) was used in flow cytometry on human samples (fig 3f). J Clin Invest (2018) ncbi
mouse monoclonal (MBSA43)
  • flow cytometry; human; loading ...; fig 5a
Invitrogen TIGIT antibody (eBioscience, MBSA43) was used in flow cytometry on human samples (fig 5a). J Exp Med (2018) ncbi
mouse monoclonal (MBSA43)
  • flow cytometry; human
In order to characterize activated T cells in joint tissue from patients with rheumatoid arthritis, Invitrogen TIGIT antibody (eBioscience, MBSA43) was used in flow cytometry on human samples . Nature (2017) ncbi
mouse monoclonal (MBSA43)
  • flow cytometry; human; loading ...
In order to show T cell immunoglobulin and ITIM domain expression increases over time despite early initiation of antiretroviral treatment, Invitrogen TIGIT antibody (eBioscience, MBSA43) was used in flow cytometry on human samples . Sci Rep (2017) ncbi
mouse monoclonal (MBSA43)
  • flow cytometry; human; fig 1
In order to test if CD4 positive T cells expressing immune checkpoint molecules are enriched in HIV-infected cells in patients receiving antiretroviral therapy, Invitrogen TIGIT antibody (eBioscience, 46-9500-41) was used in flow cytometry on human samples (fig 1). PLoS Pathog (2016) ncbi
mouse monoclonal (MBSA43)
  • flow cytometry; human; fig 4, 5
Invitrogen TIGIT antibody (eBioscience, MBSA43) was used in flow cytometry on human samples (fig 4, 5). PLoS Pathog (2016) ncbi
mouse monoclonal (MBSA43)
  • blocking or activating experiments; human; fig 2
Invitrogen TIGIT antibody (eBioscience, MBSA43) was used in blocking or activating experiments on human samples (fig 2). BMC Cancer (2015) ncbi
mouse monoclonal (MBSA43)
  • flow cytometry; human
Invitrogen TIGIT antibody (eBioscience, MBSA43) was used in flow cytometry on human samples . Hum Immunol (2015) ncbi
R&D Systems
mouse monoclonal (741182)
  • flow cytometry; human; loading ...; fig 2
R&D Systems TIGIT antibody (R&D systems, 741182) was used in flow cytometry on human samples (fig 2). Biol Blood Marrow Transplant (2018) ncbi
Articles Reviewed
  1. Neidleman J, Luo X, Frouard J, Xie G, Hsiao F, Ma T, et al. Phenotypic analysis of the unstimulated in vivo HIV CD4 T cell reservoir. elife. 2020;9: pubmed publisher
  2. Tseng H, Xiong W, Badeti S, Yang Y, Ma M, Liu T, et al. Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma. Nat Commun. 2020;11:4810 pubmed publisher
  3. Okumura G, Iguchi Manaka A, Murata R, Yamashita Kanemaru Y, Shibuya A, Shibuya K. Tumor-derived soluble CD155 inhibits DNAM-1-mediated antitumor activity of natural killer cells. J Exp Med. 2020;217: pubmed publisher
  4. Marotte L, Simon S, Vignard V, Dupré E, Gantier M, Cruard J, et al. Increased antitumor efficacy of PD-1-deficient melanoma-specific human lymphocytes. J Immunother Cancer. 2020;8: pubmed publisher
  5. Di Blasi D, Boldanova T, Mori L, Terracciano L, Heim M, De Libero G. Unique T-Cell Populations Define Immune-Inflamed Hepatocellular Carcinoma. Cell Mol Gastroenterol Hepatol. 2020;9:195-218 pubmed publisher
  6. Collins P, Cella M, Porter S, Li S, Gurewitz G, Hong H, et al. Gene Regulatory Programs Conferring Phenotypic Identities to Human NK Cells. Cell. 2019;176:348-360.e12 pubmed publisher
  7. Petrelli A, Mijnheer G, Hoytema van Konijnenburg D, van der Wal M, Giovannone B, Mocholí E, et al. PD-1+CD8+ T cells are clonally expanding effectors in human chronic inflammation. J Clin Invest. 2018;128:4669-4681 pubmed publisher
  8. Stamm H, Klingler F, Grossjohann E, Muschhammer J, Vettorazzi E, Heuser M, et al. Immune checkpoints PVR and PVRL2 are prognostic markers in AML and their blockade represents a new therapeutic option. Oncogene. 2018;37:5269-5280 pubmed publisher
  9. Seki A, Rutz S. Optimized RNP transfection for highly efficient CRISPR/Cas9-mediated gene knockout in primary T cells. J Exp Med. 2018;215:985-997 pubmed publisher
  10. Hutten T, Norde W, Woestenenk R, Wang R, Maas F, Kester M, et al. Increased Coexpression of PD-1, TIGIT, and KLRG-1 on Tumor-Reactive CD8+ T Cells During Relapse after Allogeneic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2018;24:666-677 pubmed publisher
  11. Rao D, Gurish M, Marshall J, Slowikowski K, Fonseka C, Liu Y, et al. Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis. Nature. 2017;542:110-114 pubmed publisher
  12. Tauriainen J, Scharf L, Frederiksen J, Naji A, Ljunggren H, Sonnerborg A, et al. Perturbed CD8+ T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals. Sci Rep. 2017;7:40354 pubmed publisher
  13. Fromentin R, Bakeman W, Lawani M, Khoury G, Hartogensis W, DaFonseca S, et al. CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART. PLoS Pathog. 2016;12:e1005761 pubmed publisher
  14. Yasuma K, Yasunaga J, Takemoto K, Sugata K, Mitobe Y, Takenouchi N, et al. HTLV-1 bZIP Factor Impairs Anti-viral Immunity by Inducing Co-inhibitory Molecule, T Cell Immunoglobulin and ITIM Domain (TIGIT). PLoS Pathog. 2016;12:e1005372 pubmed publisher
  15. Fionda C, Abruzzese M, Zingoni A, Soriani A, Ricci B, Molfetta R, et al. Nitric oxide donors increase PVR/CD155 DNAM-1 ligand expression in multiple myeloma cells: role of DNA damage response activation. BMC Cancer. 2015;15:17 pubmed publisher
  16. Rueda C, Wells C, Gisslen T, Jobe A, Kallapur S, Chougnet C. Effect of chorioamnionitis on regulatory T cells in moderate/late preterm neonates. Hum Immunol. 2015;76:65-73 pubmed publisher