This is a Validated Antibody Database (VAD) review about human TGM2, based on 29 published articles (read how Labome selects the articles), using TGM2 antibody in all methods. It is aimed to help Labome visitors find the most suited TGM2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
TGM2 synonym: TG(C); TGC

Knockout validation
Invitrogen
mouse monoclonal (CUB 7402)
  • immunohistochemistry knockout validation; mouse; 1:200; loading ...; fig 1c
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig s1a
  • western blot; mouse; loading ...; fig 1e
Invitrogen TGM2 antibody (Thermo, MA5-12739) was used in immunohistochemistry knockout validation on mouse samples at 1:200 (fig 1c), in immunohistochemistry - paraffin section on mouse samples at 1:200 (fig s1a) and in western blot on mouse samples (fig 1e). Nat Commun (2022) ncbi
Abcam
mouse monoclonal (CUB 7402)
  • immunocytochemistry knockout validation; human; loading ...; fig 6a
  • western blot; human; loading ...; fig 1a
Abcam TGM2 antibody (Abcam, Cub7402) was used in immunocytochemistry knockout validation on human samples (fig 6a) and in western blot on human samples (fig 1a). Amino Acids (2021) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D11A6)
  • western blot knockout validation; mouse; loading ...; fig 4a
  • western blot; human; loading ...; fig 4b
In order to examine the role of tissue transglutaminase 2 in the biogenesis of exosomes, Cell Signaling Technology TGM2 antibody (Cell Signaling, D11A6) was used in western blot knockout validation on mouse samples (fig 4a) and in western blot on human samples (fig 4b). Biochim Biophys Acta (2016) ncbi
Invitrogen
mouse monoclonal (CUB 7402)
  • immunohistochemistry knockout validation; mouse; 1:200; loading ...; fig 1c
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig s1a
  • western blot; mouse; loading ...; fig 1e
Invitrogen TGM2 antibody (Thermo, MA5-12739) was used in immunohistochemistry knockout validation on mouse samples at 1:200 (fig 1c), in immunohistochemistry - paraffin section on mouse samples at 1:200 (fig s1a) and in western blot on mouse samples (fig 1e). Nat Commun (2022) ncbi
mouse monoclonal (CUB 7402)
  • reverse phase protein lysate microarray; human; loading ...; fig 7a
In order to characterize the molecular identity of uterine carcinosarcomas., Invitrogen TGM2 antibody (Lab Vision, MS-224) was used in reverse phase protein lysate microarray on human samples (fig 7a). Cancer Cell (2017) ncbi
mouse monoclonal (CUB 7402)
  • reverse phase protein lysate microarray; human; loading ...; fig 3a
In order to describe the features of 228 primary cervical cancers, Invitrogen TGM2 antibody (Lab Vision, MS-224) was used in reverse phase protein lysate microarray on human samples (fig 3a). Nature (2017) ncbi
mouse monoclonal (CUB 7402)
  • western blot; human; loading ...
In order to analyze the context specificity of signaling networks within a causal conceptual framework using reverse-phase protein array time-course assays and network analysis approaches, Invitrogen TGM2 antibody (Lab Vision, MS-224-P1) was used in western blot on human samples . Cell Syst (2017) ncbi
mouse monoclonal (CUB 7402)
  • immunocytochemistry; human
  • western blot; human; 1:5000
In order to discover factors that contribution to the formation of neutrophil extracellular trap, Invitrogen TGM2 antibody (Thermo Fisher, MS-224-P) was used in immunocytochemistry on human samples and in western blot on human samples at 1:5000. Cell Death Dis (2016) ncbi
mouse monoclonal (CUB 7402)
  • immunoprecipitation; human; fig 3
  • western blot; human; fig 2
In order to study interplay in autophagy regulation between transglutaminase type 2 and pyruvate kinase isoenzyme M2, Invitrogen TGM2 antibody (Thermo Scientific, CUB7402) was used in immunoprecipitation on human samples (fig 3) and in western blot on human samples (fig 2). Oncotarget (2015) ncbi
mouse monoclonal (CUB 7402)
  • western blot; mouse; fig 6
In order to examine TG2 function during adipocyte differentiation, Invitrogen TGM2 antibody (Fisher Scientific, CUB 7402) was used in western blot on mouse samples (fig 6). Cell Death Dis (2015) ncbi
mouse monoclonal (CUB 7402)
  • immunohistochemistry - frozen section; human; 1:1000; fig 1f
In order to characterize celiac disease and responsive population dynamics and wide seeding in transglutaminase-2-specific plasma cells in the duodenal lamina propria, Invitrogen TGM2 antibody (Neomarkers, CUB7402) was used in immunohistochemistry - frozen section on human samples at 1:1000 (fig 1f). Mucosal Immunol (2016) ncbi
mouse monoclonal (CUB 7402)
  • immunocytochemistry; human
Invitrogen TGM2 antibody (Thermo Scientific, CUB 7402) was used in immunocytochemistry on human samples . Cell Tissue Res (2014) ncbi
mouse monoclonal (CUB 7402)
  • immunohistochemistry - paraffin section; human; 1:100
In order to determine the role and diagnostic efficacy of RB1, CDK4, CHMP2B, HSP90, and cPLA2G4A as markers in myxofibrosarcomas and myxoid liposarcomas, Invitrogen TGM2 antibody (Thermo Scientific, MS-107-B) was used in immunohistochemistry - paraffin section on human samples at 1:100. Int J Surg Pathol (2014) ncbi
mouse monoclonal (CUB 7402)
  • western blot; rat; fig 5
In order to study transglutaminase 2-regulated S100A4-related mediated cell migration, Invitrogen TGM2 antibody (Neomarkers, Cub7402) was used in western blot on rat samples (fig 5). PLoS ONE (2013) ncbi
mouse monoclonal (CUB 7402)
  • immunocytochemistry; rat
In order to study the role of transglutaminase 2 in cartilage degradation in rheumatid arthritis, Invitrogen TGM2 antibody (Thermo Scientific, CUB7402) was used in immunocytochemistry on rat samples . Arthritis Res Ther (2012) ncbi
mouse monoclonal (CUB 7402)
  • flow cytometry; human; fig 4
  • western blot; human; 1:200; fig 4
In order to elucidate the cellular functions of GPR56 receptor and how they contribute to bilateral frontoparietal polymicrogyria, Invitrogen TGM2 antibody (Thermo, CUB 7402) was used in flow cytometry on human samples (fig 4) and in western blot on human samples at 1:200 (fig 4). J Biol Chem (2011) ncbi
mouse monoclonal (CUB 7402)
  • immunohistochemistry; human; 1:100; fig 8A
  • western blot; human; 1:2000
  • immunohistochemistry; mouse; 1:100; fig 8A
In order to study the role of SPARC expression in impaired tumor growth, inhibited angiogenesis and extracellular matrix changes, Invitrogen TGM2 antibody (Neomarkers, Ab-1) was used in immunohistochemistry on human samples at 1:100 (fig 8A), in western blot on human samples at 1:2000 and in immunohistochemistry on mouse samples at 1:100 (fig 8A). Int J Cancer (2006) ncbi
mouse monoclonal (CUB 7402)
  • immunoprecipitation; human; fig 4
  • western blot; human; fig 4
In order to investigate the interaction of tissue transglutaminase with proteins that regulate apoptosis, Invitrogen TGM2 antibody (NeoMarkers, CUB 7402) was used in immunoprecipitation on human samples (fig 4) and in western blot on human samples (fig 4). J Biol Chem (2004) ncbi
Abcam
domestic rabbit monoclonal (EP2957)
  • western blot; human; 1:1000; loading ...; fig 1g, 1h, 1i
Abcam TGM2 antibody (Abcam, ab109200) was used in western blot on human samples at 1:1000 (fig 1g, 1h, 1i). J Exp Clin Cancer Res (2021) ncbi
mouse monoclonal (CUB 7402)
  • immunohistochemistry; human; 1:100; loading ...; fig 1a
Abcam TGM2 antibody (Abcam, CUB7402) was used in immunohistochemistry on human samples at 1:100 (fig 1a). Oncogene (2021) ncbi
mouse monoclonal (CUB 7402)
  • immunocytochemistry knockout validation; human; loading ...; fig 6a
  • western blot; human; loading ...; fig 1a
Abcam TGM2 antibody (Abcam, Cub7402) was used in immunocytochemistry knockout validation on human samples (fig 6a) and in western blot on human samples (fig 1a). Amino Acids (2021) ncbi
mouse monoclonal (CUB 7402)
  • western blot; rat; 1:500; loading ...; fig 1a
Abcam TGM2 antibody (Abcam, ab2386) was used in western blot on rat samples at 1:500 (fig 1a). Science (2020) ncbi
mouse monoclonal (CUB 7402)
  • western blot; human; 1:1000; loading ...; fig 3a
Abcam TGM2 antibody (Abcam, ab2386) was used in western blot on human samples at 1:1000 (fig 3a). PLoS ONE (2020) ncbi
mouse monoclonal (CUB 7402)
  • western blot; human; 1:500; loading ...; fig e2c, e2d
  • western blot; mouse; 1:500; loading ...; fig e2a
Abcam TGM2 antibody (Abcam, ab2386) was used in western blot on human samples at 1:500 (fig e2c, e2d) and in western blot on mouse samples at 1:500 (fig e2a). Nature (2019) ncbi
Santa Cruz Biotechnology
mouse monoclonal (4G3)
  • western blot; human; 1:1000; tbl 1
Santa Cruz Biotechnology TGM2 antibody (santa Cruz, sc-73612) was used in western blot on human samples at 1:1000 (tbl 1). Oncol Lett (2015) ncbi
mouse monoclonal (4G3)
  • western blot; human
Santa Cruz Biotechnology TGM2 antibody (Santa Cruz, sc-73612) was used in western blot on human samples . J Biomed Mater Res A (2015) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D11A6)
  • immunohistochemistry; mouse; 1:500; loading ...; fig 6b
Cell Signaling Technology TGM2 antibody (Cell Signaling Technology, 3557S) was used in immunohistochemistry on mouse samples at 1:500 (fig 6b). JID Innov (2022) ncbi
domestic rabbit monoclonal (D11A6)
  • western blot; human; 1:500; loading ...; fig 1a
Cell Signaling Technology TGM2 antibody (Cell Signaling, D11A6) was used in western blot on human samples at 1:500 (fig 1a). Science (2020) ncbi
domestic rabbit monoclonal (D11A6)
  • western blot; human; loading ...; fig 1b
Cell Signaling Technology TGM2 antibody (Cell Signaling Technology, 3557) was used in western blot on human samples (fig 1b). J Biol Chem (2019) ncbi
domestic rabbit monoclonal (D11A6)
  • western blot; mouse; loading ...; fig 4a
Cell Signaling Technology TGM2 antibody (Cell Signaling Technology, 3557) was used in western blot on mouse samples (fig 4a). Cell Rep (2018) ncbi
domestic rabbit monoclonal (D11A6)
  • western blot; mouse; 1:1000; loading ...; fig 1f
Cell Signaling Technology TGM2 antibody (Cell Signaling, D11A6) was used in western blot on mouse samples at 1:1000 (fig 1f). Mol Biol Cell (2018) ncbi
domestic rabbit monoclonal (D11A6)
  • western blot knockout validation; mouse; loading ...; fig 4a
  • western blot; human; loading ...; fig 4b
In order to examine the role of tissue transglutaminase 2 in the biogenesis of exosomes, Cell Signaling Technology TGM2 antibody (Cell Signaling, D11A6) was used in western blot knockout validation on mouse samples (fig 4a) and in western blot on human samples (fig 4b). Biochim Biophys Acta (2016) ncbi
domestic rabbit monoclonal (D11A6)
  • western blot; mouse; 1:500; tbl 4
Cell Signaling Technology TGM2 antibody (Cell Signaling Technology, 3557S) was used in western blot on mouse samples at 1:500 (tbl 4). PLoS ONE (2014) ncbi
Articles Reviewed
  1. Eggink L, Hoober J. Resolution of Eczema with Multivalent Peptides. JID Innov. 2022;2:100142 pubmed publisher
  2. Sharpen J, Dolan B, Nystr xf6 m E, Birchenough G, Arike L, Martínez Abad B, et al. Transglutaminase 3 crosslinks the secreted gel-forming mucus component Mucin-2 and stabilizes the colonic mucus layer. Nat Commun. 2022;13:45 pubmed publisher
  3. Lei X, Cao K, Chen Y, Shen H, Liu Z, Qin H, et al. Nuclear Transglutaminase 2 interacts with topoisomerase II⍺ to promote DNA damage repair in lung cancer cells. J Exp Clin Cancer Res. 2021;40:224 pubmed publisher
  4. Malkomes P, Lunger I, Oppermann E, Abou El Ardat K, Oellerich T, Günther S, et al. Transglutaminase 2 promotes tumorigenicity of colon cancer cells by inactivation of the tumor suppressor p53. Oncogene. 2021;40:4352-4367 pubmed publisher
  5. Fell S, Wang Z, Blanchard A, Nanthakumar C, Griffin M. Transglutaminase 2: a novel therapeutic target for idiopathic pulmonary fibrosis using selective small molecule inhibitors. Amino Acids. 2021;53:205-217 pubmed publisher
  6. Lepack A, Werner C, Stewart A, Fulton S, Zhong P, Farrelly L, et al. Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking. Science. 2020;368:197-201 pubmed publisher
  7. Potilinski M, Ortiz G, Salica J, Lopez E, Fernández Acquier M, Chuluyan E, et al. Elucidating the mechanism of action of alpha-1-antitrypsin using retinal pigment epithelium cells exposed to high glucose. Potential use in diabetic retinopathy. PLoS ONE. 2020;15:e0228895 pubmed publisher
  8. Jobin P, Solis N, Machado Y, Bell P, Kwon N, Kim S, et al. Matrix metalloproteinases inactivate the proinflammatory functions of secreted moonlighting tryptophanyl-tRNA synthetase. J Biol Chem. 2019;294:12866-12879 pubmed publisher
  9. Farrelly L, Thompson R, Zhao S, Lepack A, Lyu Y, Bhanu N, et al. Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3. Nature. 2019;567:535-539 pubmed publisher
  10. D Eletto M, Rossin F, Occhigrossi L, Farrace M, Faccenda D, Desai R, et al. Transglutaminase Type 2 Regulates ER-Mitochondria Contact Sites by Interacting with GRP75. Cell Rep. 2018;25:3573-3581.e4 pubmed publisher
  11. Li R, Serrano J, Xing H, Lee T, Azizgolshani H, Zaman M, et al. Interstitial flow promotes macrophage polarization toward an M2 phenotype. Mol Biol Cell. 2018;29:1927-1940 pubmed publisher
  12. Cherniack A, Shen H, Walter V, Stewart C, Murray B, Bowlby R, et al. Integrated Molecular Characterization of Uterine Carcinosarcoma. Cancer Cell. 2017;31:411-423 pubmed publisher
  13. . Integrated genomic and molecular characterization of cervical cancer. Nature. 2017;543:378-384 pubmed publisher
  14. Hill S, Nesser N, Johnson Camacho K, Jeffress M, Johnson A, Boniface C, et al. Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling. Cell Syst. 2017;4:73-83.e10 pubmed publisher
  15. Csomós K, Kristóf E, Jakob B, Csomós I, Kovács G, Rotem O, et al. Protein cross-linking by chlorinated polyamines and transglutamylation stabilizes neutrophil extracellular traps. Cell Death Dis. 2016;7:e2332 pubmed publisher
  16. Diaz Hidalgo L, Altuntas S, Rossin F, D Eletto M, Marsella C, Farrace M, et al. Transglutaminase type 2-dependent selective recruitment of proteins into exosomes under stressful cellular conditions. Biochim Biophys Acta. 2016;1863:2084-92 pubmed publisher
  17. Wang G, Fu L, Chen F. Study of the mechanism underlying the inhibitory effects of transglutaminase II on apoptosis in the osteosarcoma MG-63 cell line under hypoxic conditions. Oncol Lett. 2015;10:3425-3428 pubmed
  18. Altuntas S, Rossin F, Marsella C, D Eletto M, Diaz Hidalgo L, Farrace M, et al. The transglutaminase type 2 and pyruvate kinase isoenzyme M2 interplay in autophagy regulation. Oncotarget. 2015;6:44941-54 pubmed publisher
  19. Myneni V, Melino G, Kaartinen M. Transglutaminase 2--a novel inhibitor of adipogenesis. Cell Death Dis. 2015;6:e1868 pubmed publisher
  20. Di Niro R, Snir O, Kaukinen K, Yaari G, Lundin K, Gupta N, et al. Responsive population dynamics and wide seeding into the duodenal lamina propria of transglutaminase-2-specific plasma cells in celiac disease. Mucosal Immunol. 2016;9:254-64 pubmed publisher
  21. Piacentini M, D Eletto M, Farrace M, Rodolfo C, Del Nonno F, Ippolito G, et al. Characterization of distinct sub-cellular location of transglutaminase type II: changes in intracellular distribution in physiological and pathological states. Cell Tissue Res. 2014;358:793-805 pubmed publisher
  22. McNally A, Anderson J. Phenotypic expression in human monocyte-derived interleukin-4-induced foreign body giant cells and macrophages in vitro: dependence on material surface properties. J Biomed Mater Res A. 2015;103:1380-90 pubmed publisher
  23. Menalled L, Kudwa A, Oakeshott S, Farrar A, Paterson N, Filippov I, et al. Genetic deletion of transglutaminase 2 does not rescue the phenotypic deficits observed in R6/2 and zQ175 mouse models of Huntington's disease. PLoS ONE. 2014;9:e99520 pubmed publisher
  24. Wang T, Goodman M, McGough R, Weiss K, Rao U. Immunohistochemical analysis of expressions of RB1, CDK4, HSP90, cPLA2G4A, and CHMP2B is helpful in distinction between myxofibrosarcoma and myxoid liposarcoma. Int J Surg Pathol. 2014;22:589-99 pubmed publisher
  25. Wang Z, Griffin M. The role of TG2 in regulating S100A4-mediated mammary tumour cell migration. PLoS ONE. 2013;8:e57017 pubmed publisher
  26. Lauzier A, Charbonneau M, Paquette M, Harper K, Dubois C. Transglutaminase 2 cross-linking activity is linked to invadopodia formation and cartilage breakdown in arthritis. Arthritis Res Ther. 2012;14:R159 pubmed publisher
  27. Chiang N, Hsiao C, Huang Y, Chen H, Hsieh I, Chang G, et al. Disease-associated GPR56 mutations cause bilateral frontoparietal polymicrogyria via multiple mechanisms. J Biol Chem. 2011;286:14215-25 pubmed publisher
  28. Chlenski A, Liu S, Guerrero L, Yang Q, Tian Y, Salwen H, et al. SPARC expression is associated with impaired tumor growth, inhibited angiogenesis and changes in the extracellular matrix. Int J Cancer. 2006;118:310-6 pubmed
  29. Rodolfo C, Mormone E, Matarrese P, Ciccosanti F, Farrace M, Garofano E, et al. Tissue transglutaminase is a multifunctional BH3-only protein. J Biol Chem. 2004;279:54783-92 pubmed