This is a Validated Antibody Database (VAD) review about human TGFBR2, based on 29 published articles (read how Labome selects the articles), using TGFBR2 antibody in all methods. It is aimed to help Labome visitors find the most suited TGFBR2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
TGFBR2 synonym: AAT3; FAA3; LDS1B; LDS2; LDS2B; MFS2; RIIC; TAAD2; TBR-ii; TBRII; TGFR-2; TGFbeta-RII

Knockout validation
Santa Cruz Biotechnology
mouse monoclonal (D-2)
  • western blot knockout validation; human; 1:1000; loading ...; fig 5e
Santa Cruz Biotechnology TGFBR2 antibody (Santa Cruz, sc-17799) was used in western blot knockout validation on human samples at 1:1000 (fig 5e). Nat Commun (2021) ncbi
Abcam
mouse monoclonal (MM0056-4F14)
  • immunocytochemistry; human; loading ...; fig 6
Abcam TGFBR2 antibody (Abcam, ab78419) was used in immunocytochemistry on human samples (fig 6). Cancers (Basel) (2021) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:2000; loading ...; fig 5c
Abcam TGFBR2 antibody (Abcam, ab186838) was used in western blot on human samples at 1:2000 (fig 5c). Int J Oncol (2021) ncbi
domestic rabbit polyclonal
  • immunohistochemistry; human; loading ...; fig 2c
  • western blot; human; loading ...; fig 2e, 5a
  • western blot; mouse; loading ...; fig 4h
Abcam TGFBR2 antibody (Abcam, ab61213) was used in immunohistochemistry on human samples (fig 2c), in western blot on human samples (fig 2e, 5a) and in western blot on mouse samples (fig 4h). Clin Transl Med (2021) ncbi
domestic rabbit polyclonal
  • immunoprecipitation; human; 1:100; loading ...; fig 5f
Abcam TGFBR2 antibody (Abcam, ab225902) was used in immunoprecipitation on human samples at 1:100 (fig 5f). J Exp Clin Cancer Res (2021) ncbi
domestic rabbit monoclonal (EPR14673)
  • western blot; mouse; 1:1000; fig 6b
Abcam TGFBR2 antibody (Abcam, ab184948) was used in western blot on mouse samples at 1:1000 (fig 6b). Aging (Albany NY) (2021) ncbi
mouse monoclonal (MM0056-4F14)
  • immunohistochemistry - paraffin section; human; 1:100; fig 2b
Abcam TGFBR2 antibody (Abcam, ab78419) was used in immunohistochemistry - paraffin section on human samples at 1:100 (fig 2b). Pflugers Arch (2021) ncbi
domestic rabbit polyclonal
  • immunohistochemistry; human; loading ...; fig 4a
  • western blot; human; loading ...; fig 4c
Abcam TGFBR2 antibody (Abcam, ab186838) was used in immunohistochemistry on human samples (fig 4a) and in western blot on human samples (fig 4c). Front Oncol (2020) ncbi
domestic rabbit polyclonal
  • other; mouse; 1:200; loading ...; fig 2c
Abcam TGFBR2 antibody (Abcam, Ab61213) was used in other on mouse samples at 1:200 (fig 2c). Sci Rep (2020) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 5c
Abcam TGFBR2 antibody (Abcam, ab186838) was used in western blot on mouse samples (fig 5c). Proc Natl Acad Sci U S A (2019) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:500; fig 6c
In order to explore the roles of activated portal fibroblasts and myofibroblasts in the pathogenesis of liver fibrosis induced by bile duct ligation, Abcam TGFBR2 antibody (Abcam, ab61213) was used in western blot on mouse samples at 1:500 (fig 6c). J Clin Invest (2017) ncbi
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; human; 1:100; fig 1a, 1d
  • western blot; human; 1:1000; loading ...; fig 2b
Abcam TGFBR2 antibody (Abcam, ab61213) was used in immunohistochemistry - paraffin section on human samples at 1:100 (fig 1a, 1d) and in western blot on human samples at 1:1000 (fig 2b). Sci Rep (2017) ncbi
domestic rabbit polyclonal
  • immunohistochemistry; mouse; loading ...; fig 2c
Abcam TGFBR2 antibody (abcam, ab61213) was used in immunohistochemistry on mouse samples (fig 2c). Circulation (2017) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:500; fig 5
Abcam TGFBR2 antibody (Abcam, ab61213) was used in western blot on mouse samples at 1:500 (fig 5). PLoS ONE (2016) ncbi
mouse monoclonal (MM0056-4F14)
  • flow cytometry; human; 1:20; fig s10
In order to analyze propagation of oestrogen-responsive and oestrogen receptor-positive normal human breast cells in culture, Abcam TGFBR2 antibody (Abcam, ab78419) was used in flow cytometry on human samples at 1:20 (fig s10). Nat Commun (2015) ncbi
mouse monoclonal (MM0056-4F14)
  • immunohistochemistry; human; fig 1
Abcam TGFBR2 antibody (abcam, ab78419) was used in immunohistochemistry on human samples (fig 1). Mol Cancer (2015) ncbi
Santa Cruz Biotechnology
mouse monoclonal (D-2)
  • western blot knockout validation; human; 1:1000; loading ...; fig 5e
Santa Cruz Biotechnology TGFBR2 antibody (Santa Cruz, sc-17799) was used in western blot knockout validation on human samples at 1:1000 (fig 5e). Nat Commun (2021) ncbi
mouse monoclonal (E-6)
  • western blot; human; 1:500; fig 4
In order to examine TGFBR1 and TGFBR2 mutations in human vemurafenib-induced skin lesions and in sporadic cutaneous squamous cell carcinoma, Santa Cruz Biotechnology TGFBR2 antibody (Santa Cruz, 17792) was used in western blot on human samples at 1:500 (fig 4). Nat Commun (2016) ncbi
mouse monoclonal (D-2)
  • western blot; human; 1:500
Santa Cruz Biotechnology TGFBR2 antibody (Santa Cruz, sc-17799) was used in western blot on human samples at 1:500. PLoS ONE (2015) ncbi
mouse monoclonal (E-6)
  • western blot; human; fig s2
Santa Cruz Biotechnology TGFBR2 antibody (Santa Cruz, sc-17792) was used in western blot on human samples (fig s2). Sci Rep (2015) ncbi
mouse monoclonal (D-2)
  • western blot; human; fig s3
Santa Cruz Biotechnology TGFBR2 antibody (santa Cruz, sc-17799) was used in western blot on human samples (fig s3). Oncotarget (2015) ncbi
mouse monoclonal (C-4)
  • western blot; human; fig 3
Santa Cruz Biotechnology TGFBR2 antibody (Santa Cruz, Sc-17791) was used in western blot on human samples (fig 3). Sci Rep (2015) ncbi
mouse monoclonal (E-6)
  • western blot; human; fig 2
Santa Cruz Biotechnology TGFBR2 antibody (Santa Cruz Biotechnology, sc-17792) was used in western blot on human samples (fig 2). FASEB J (2014) ncbi
R&D Systems
domestic goat polyclonal
  • blocking or activating experiments; mouse; 2.5 ug/ul; loading ...; fig 4d
R&D Systems TGFBR2 antibody (R&D System, AF-241-NA) was used in blocking or activating experiments on mouse samples at 2.5 ug/ul (fig 4d). Signal Transduct Target Ther (2021) ncbi
domestic goat polyclonal
  • immunohistochemistry; mouse; 1:100; loading ...; fig 1a
R&D Systems TGFBR2 antibody (R&D, AF-241) was used in immunohistochemistry on mouse samples at 1:100 (fig 1a). elife (2019) ncbi
domestic goat polyclonal
  • western blot; mouse; 1:400; loading ...; fig s2
R&D Systems TGFBR2 antibody (R&D Systems, AF532) was used in western blot on mouse samples at 1:400 (fig s2). Nat Commun (2018) ncbi
Invitrogen
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 6j
Invitrogen TGFBR2 antibody (Invitrogen, PA5-36115) was used in western blot on mouse samples (fig 6j). Sci Adv (2021) ncbi
domestic rabbit polyclonal
  • western blot; rat; 1:1000; loading ...; fig 5c
Invitrogen TGFBR2 antibody (Thermal scientific, PA5-37755) was used in western blot on rat samples at 1:1000 (fig 5c). Front Pharmacol (2020) ncbi
OriGene
domestic rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 6a
OriGene TGFBR2 antibody (OriGene, TA311643) was used in western blot on human samples at 1:1000 (fig 6a). Nat Commun (2020) ncbi
MilliporeSigma
domestic rabbit polyclonal
  • western blot; human; 1:2500; loading ...; fig 4a
MilliporeSigma TGFBR2 antibody (Sigma-Aldrich, SAB4504269) was used in western blot on human samples at 1:2500 (fig 4a). Mol Med Rep (2018) ncbi
Articles Reviewed
  1. Nakamura I, Asumda F, Moser C, Kang Y, Lai J, Roberts L. Sulfatase-2 Regulates Liver Fibrosis through the TGF-β Signaling Pathway. Cancers (Basel). 2021;13: pubmed publisher
  2. Zhang M, Pan X, Fujiwara K, Jurcak N, Muth S, Zhou J, et al. Pancreatic cancer cells render tumor-associated macrophages metabolically reprogrammed by a GARP and DNA methylation-mediated mechanism. Signal Transduct Target Ther. 2021;6:366 pubmed publisher
  3. Xi Y, Li Y, Xu P, Li S, Liu Z, Tung H, et al. The anti-fibrotic drug pirfenidone inhibits liver fibrosis by targeting the small oxidoreductase glutaredoxin-1. Sci Adv. 2021;7:eabg9241 pubmed publisher
  4. Huang J, Xiao R, Wang X, Khadka B, Fang Z, Yu M, et al. MicroRNA‑93 knockdown inhibits acute myeloid leukemia cell growth via inactivating the PI3K/AKT pathway by upregulating DAB2. Int J Oncol. 2021;59: pubmed publisher
  5. Gu P, Wang D, Zhang J, Wang X, Chen Z, Gu L, et al. Protective function of interleukin-22 in pulmonary fibrosis. Clin Transl Med. 2021;11:e509 pubmed publisher
  6. Bruce J, To K, Lui V, Chung G, Chan Y, Tsang C, et al. Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape. Nat Commun. 2021;12:4193 pubmed publisher
  7. Sun X, He Z, Guo L, Wang C, Lin C, Ye L, et al. ALG3 contributes to stemness and radioresistance through regulating glycosylation of TGF-β receptor II in breast cancer. J Exp Clin Cancer Res. 2021;40:149 pubmed publisher
  8. Shen K, Li R, Zhang X, Qu G, Li R, Wang Y, et al. Acetyl oxygen benzoate engeletin ester promotes KLF4 degradation leading to the attenuation of pulmonary fibrosis via inhibiting TGFβ1-smad/p38MAPK-lnc865/lnc556-miR-29b-2-5p-STAT3 signal pathway. Aging (Albany NY). 2021;13:13807-13821 pubmed publisher
  9. Schilpp C, Lochbaum R, Braubach P, Jonigk D, Frick M, Dietl P, et al. TGF-β1 increases permeability of ciliated airway epithelia via redistribution of claudin 3 from tight junction into cell nuclei. Pflugers Arch. 2021;473:287-311 pubmed publisher
  10. Lee T, Yeh C, Lee Y, Shih Y, Chen Y, Hung C, et al. Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization. Nat Commun. 2020;11:4254 pubmed publisher
  11. Yang L, Han B, Zhang M, Wang Y, Tao K, Zhu M, et al. Activation of BK Channels Prevents Hepatic Stellate Cell Activation and Liver Fibrosis Through the Suppression of TGFβ1/SMAD3 and JAK/STAT3 Profibrotic Signaling Pathways. Front Pharmacol. 2020;11:165 pubmed publisher
  12. Fu X, Qie J, Fu Q, Chen J, Jin Y, Ding Z. miR-20a-5p/TGFBR2 Axis Affects Pro-inflammatory Macrophages and Aggravates Liver Fibrosis. Front Oncol. 2020;10:107 pubmed publisher
  13. Voisin A, Damon Soubeyrand C, Bravard S, Saez F, Drevet J, Guiton R. Differential expression and localisation of TGF-β isoforms and receptors in the murine epididymis. Sci Rep. 2020;10:995 pubmed publisher
  14. Wang W, Chun H, Baek J, Sadik J, Shirazyan A, Razavi P, et al. The TGFβ type I receptor TGFβRI functions as an inhibitor of BMP signaling in cartilage. Proc Natl Acad Sci U S A. 2019;116:15570-15579 pubmed publisher
  15. Ma W, Silverman S, Zhao L, Villasmil R, Campos M, Amaral J, et al. Absence of TGFβ signaling in retinal microglia induces retinal degeneration and exacerbates choroidal neovascularization. elife. 2019;8: pubmed publisher
  16. Lam J, van den Bosch M, Wegrzyn J, Parker J, Ibrahim R, Slowski K, et al. miR-143/145 differentially regulate hematopoietic stem and progenitor activity through suppression of canonical TGFβ signaling. Nat Commun. 2018;9:2418 pubmed publisher
  17. Li T, Zhao J. Knockdown of elF3a inhibits TGF??1?induced extracellular matrix protein expression in keloid fibroblasts. Mol Med Rep. 2018;17:4057-4061 pubmed publisher
  18. Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, et al. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. J Clin Invest. 2017;127:1254-1270 pubmed publisher
  19. Yang H, Zhang H, Zhong Y, Wang Q, Yang L, Kang H, et al. Concomitant underexpression of TGFBR2 and overexpression of hTERT are associated with poor prognosis in cervical cancer. Sci Rep. 2017;7:41670 pubmed publisher
  20. Zangi L, Oliveira M, Ye L, Ma Q, Sultana N, Hadas Y, et al. Insulin-Like Growth Factor 1 Receptor-Dependent Pathway Drives Epicardial Adipose Tissue Formation After Myocardial Injury. Circulation. 2017;135:59-72 pubmed publisher
  21. Cammareri P, Rose A, Vincent D, Wang J, Nagano A, Libertini S, et al. Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma. Nat Commun. 2016;7:12493 pubmed publisher
  22. Bianchi E, Boekelheide K, Sigman M, Lamb D, Hall S, Hwang K. Ghrelin Inhibits Post-Operative Adhesions via Blockage of the TGF-β Signaling Pathway. PLoS ONE. 2016;11:e0153968 pubmed publisher
  23. Fridriksdottir A, Kim J, Villadsen R, Klitgaard M, Hopkinson B, Petersen O, et al. Propagation of oestrogen receptor-positive and oestrogen-responsive normal human breast cells in culture. Nat Commun. 2015;6:8786 pubmed publisher
  24. Bauer J, Ozden O, Akagi N, Carroll T, Principe D, Staudacher J, et al. Activin and TGFβ use diverging mitogenic signaling in advanced colon cancer. Mol Cancer. 2015;14:182 pubmed publisher
  25. Lee J, Fricke F, Warnken U, Schnölzer M, Kopitz J, Gebert J. Reconstitution of TGFBR2-Mediated Signaling Causes Upregulation of GDF-15 in HCT116 Colorectal Cancer Cells. PLoS ONE. 2015;10:e0131506 pubmed publisher
  26. Rojas Fernandez A, Herhaus L, MacArtney T, Lachaud C, Hay R, Sapkota G. Rapid generation of endogenously driven transcriptional reporters in cells through CRISPR/Cas9. Sci Rep. 2015;5:9811 pubmed publisher
  27. Uppal A, Wightman S, Mallon S, Oshima G, Pitroda S, Zhang Q, et al. 14q32-encoded microRNAs mediate an oligometastatic phenotype. Oncotarget. 2015;6:3540-52 pubmed
  28. Rao R, Dhele N, Cheemadan S, Ketkar A, Jayandharan G, Palakodeti D, et al. Ezh2 mediated H3K27me3 activity facilitates somatic transition during human pluripotent reprogramming. Sci Rep. 2015;5:8229 pubmed publisher
  29. Holtzhausen A, Golzio C, How T, Lee Y, Schiemann W, Katsanis N, et al. Novel bone morphogenetic protein signaling through Smad2 and Smad3 to regulate cancer progression and development. FASEB J. 2014;28:1248-67 pubmed publisher