This is a Validated Antibody Database (VAD) review about human TFAM, based on 24 published articles (read how Labome selects the articles), using TFAM antibody in all methods. It is aimed to help Labome visitors find the most suited TFAM antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
TFAM synonym: MTDPS15; MTTF1; MTTFA; TCF6; TCF6L1; TCF6L2; TCF6L3

Knockout validation
Santa Cruz Biotechnology
mouse monoclonal (F-6)
  • western blot knockout validation; human; loading ...; fig s5a
Santa Cruz Biotechnology TFAM antibody (Santa Cruz, sc-166965) was used in western blot knockout validation on human samples (fig s5a). iScience (2022) ncbi
Abcam
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig s7c
Abcam TFAM antibody (Abcam, ab131607) was used in western blot on mouse samples (fig s7c). Commun Biol (2022) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:500-1:2000; loading ...; fig 3b
Abcam TFAM antibody (Abcam, ab131607) was used in western blot on mouse samples at 1:500-1:2000 (fig 3b). Redox Biol (2021) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 4e
Abcam TFAM antibody (Abcam, ab131607) was used in western blot on mouse samples at 1:1000 (fig 4e). Nat Commun (2021) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 3b
Abcam TFAM antibody (Abcam, ab138351) was used in western blot on mouse samples (fig 3b). Int J Mol Sci (2021) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 1a
Abcam TFAM antibody (Abcam, ab131607) was used in western blot on mouse samples at 1:1000 (fig 1a). J Transl Med (2020) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...
Abcam TFAM antibody (Abcam, ab138351) was used in western blot on human samples . elife (2019) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 2f
Abcam TFAM antibody (Abcam, ab131607) was used in western blot on mouse samples (fig 2f). Science (2018) ncbi
domestic rabbit monoclonal (EPR12285)
  • western blot; human; loading ...; fig 1c, 1d
Abcam TFAM antibody (Abcam, ab176558) was used in western blot on human samples (fig 1c, 1d). Biosci Rep (2017) ncbi
mouse monoclonal (18G102B2E11)
  • immunocytochemistry; human; 1:500; loading ...; fig 3c
In order to investigate the role of CHCHD2 in the differentiation of human induced pluripotent stem cell, Abcam TFAM antibody (Abcam, ab119684) was used in immunocytochemistry on human samples at 1:500 (fig 3c). J Cell Biol (2016) ncbi
domestic rabbit polyclonal
  • western blot; rat; loading ...; fig 2a
Abcam TFAM antibody (Abcam, ab131607) was used in western blot on rat samples (fig 2a). Pflugers Arch (2016) ncbi
domestic rabbit polyclonal
  • immunocytochemistry; human; 1:400; loading ...; fig s7
  • western blot; human; loading ...; fig s4a
In order to screen for genes involved in mitochondrial DNA maintenance, Abcam TFAM antibody (Abcam, ab131607) was used in immunocytochemistry on human samples at 1:400 (fig s7) and in western blot on human samples (fig s4a). Nat Chem Biol (2016) ncbi
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; human; loading ...; fig 4a
In order to study respiratory chain abnormalities and the contribution of mitochondrial DNA to the loss of respiratory chain complexes of idiopathic Parkinson disease patients at the single-neuron level, Abcam TFAM antibody (Abcam, ab47517) was used in immunohistochemistry - paraffin section on human samples (fig 4a). Ann Neurol (2016) ncbi
Santa Cruz Biotechnology
mouse monoclonal (F-6)
  • western blot knockout validation; human; loading ...; fig s5a
Santa Cruz Biotechnology TFAM antibody (Santa Cruz, sc-166965) was used in western blot knockout validation on human samples (fig s5a). iScience (2022) ncbi
mouse monoclonal (F-6)
  • immunohistochemistry; mouse; 1:400; loading ...; fig 6a
Santa Cruz Biotechnology TFAM antibody (Santa, sc-166965) was used in immunohistochemistry on mouse samples at 1:400 (fig 6a). Cancer Commun (Lond) (2021) ncbi
mouse monoclonal (F-6)
  • western blot; rat; 1:200; loading ...; fig 4a
Santa Cruz Biotechnology TFAM antibody (Santa Cruz Biotechnology, sc-166965) was used in western blot on rat samples at 1:200 (fig 4a). Signal Transduct Target Ther (2021) ncbi
mouse monoclonal (F-6)
  • western blot; rat; loading ...; fig 4c
Santa Cruz Biotechnology TFAM antibody (Santa Cruz, sc-166965) was used in western blot on rat samples (fig 4c). Biosci Rep (2019) ncbi
mouse monoclonal (F-6)
  • western blot; mouse; 1:200
Santa Cruz Biotechnology TFAM antibody (Santa Cruz Biotechnology, sc-166965) was used in western blot on mouse samples at 1:200. Oxid Med Cell Longev (2015) ncbi
Abnova
mouse polyclonal
  • western blot; human; 1:1000; loading ...; fig 1d
Abnova TFAM antibody (Abnova, H00007019-B01P) was used in western blot on human samples at 1:1000 (fig 1d). Int J Oncol (2017) ncbi
Novus Biologicals
domestic rabbit polyclonal
  • immunohistochemistry; human; 1:800; loading ...; fig 3a
  • western blot; human; 1:1000; loading ...; fig 4a
Novus Biologicals TFAM antibody (Novus, NBP2-19437) was used in immunohistochemistry on human samples at 1:800 (fig 3a) and in western blot on human samples at 1:1000 (fig 4a). Cancer Commun (Lond) (2021) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D5C8)
  • western blot; human; 1:1000; loading ...; fig 7d
Cell Signaling Technology TFAM antibody (Cell Signaling, 8076) was used in western blot on human samples at 1:1000 (fig 7d). Nat Commun (2019) ncbi
domestic rabbit monoclonal (D5C8)
  • immunohistochemistry - paraffin section; human; 1:200; loading ...; fig s4e
  • western blot; human; 1:1000; loading ...; fig 2d
Cell Signaling Technology TFAM antibody (Cell Signaling, 8076S) was used in immunohistochemistry - paraffin section on human samples at 1:200 (fig s4e) and in western blot on human samples at 1:1000 (fig 2d). Cancer Res (2019) ncbi
domestic rabbit monoclonal (D5C8)
  • western blot; human; 1:1000; loading ...; fig 6h
Cell Signaling Technology TFAM antibody (Cell Signaling, 8076BC) was used in western blot on human samples at 1:1000 (fig 6h). Nat Cell Biol (2018) ncbi
domestic rabbit polyclonal
  • other; human; loading ...; fig 4c
Cell Signaling Technology TFAM antibody (Cell Signaling, 7495) was used in other on human samples (fig 4c). Cancer Cell (2018) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:200; fig 9
In order to investigate the dysfunction found in mitochondria in fibroblasts received from patients with Niemann-Pick type C disease, Cell Signaling Technology TFAM antibody (Cell signaling, 7495) was used in western blot on human samples at 1:200 (fig 9). Arch Biochem Biophys (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:500; fig 6
In order to investigate how lactate affects neuron metabolism, Cell Signaling Technology TFAM antibody (Cell Signaling Technology, 7495) was used in western blot on human samples at 1:500 (fig 6). Biochem Pharmacol (2016) ncbi
Articles Reviewed
  1. Dufour C, Xia H, B chir W, Perry M, Kuzmanov U, Gainullina A, et al. Integrated multi-omics analysis of adverse cardiac remodeling and metabolic inflexibility upon ErbB2 and ERRα deficiency. Commun Biol. 2022;5:955 pubmed publisher
  2. Tan H, Yong Y, Xue Y, Liu H, Furihata T, Shankar E, et al. cGAS and DDX41-STING mediated intrinsic immunity spreads intercellularly to promote neuroinflammation in SOD1 ALS model. iScience. 2022;25:104404 pubmed publisher
  3. Chiang S, Braidy N, Maleki S, Lal S, Richardson D, Huang M. Mechanisms of impaired mitochondrial homeostasis and NAD+ metabolism in a model of mitochondrial heart disease exhibiting redox active iron accumulation. Redox Biol. 2021;46:102038 pubmed publisher
  4. Yang S, He X, Zhao J, Wang D, Guo S, Gao T, et al. Mitochondrial transcription factor A plays opposite roles in the initiation and progression of colitis-associated cancer. Cancer Commun (Lond). 2021;41:695-714 pubmed publisher
  5. Sato M, Kadomatsu T, Miyata K, Warren J, Tian Z, Zhu S, et al. The lncRNA Caren antagonizes heart failure by inactivating DNA damage response and activating mitochondrial biogenesis. Nat Commun. 2021;12:2529 pubmed publisher
  6. Xu S, Tao H, Cao W, Cao L, Lin Y, Zhao S, et al. Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis. Signal Transduct Target Ther. 2021;6:54 pubmed publisher
  7. Ha B, Heo J, Jang Y, Park T, Choi J, Jang W, et al. Depletion of Mitochondrial Components from Extracellular Vesicles Secreted from Astrocytes in a Mouse Model of Fragile X Syndrome. Int J Mol Sci. 2021;22: pubmed publisher
  8. Gao Y, Dai X, Li Y, Li G, Lin X, Ai C, et al. Role of Parkin-mediated mitophagy in the protective effect of polydatin in sepsis-induced acute kidney injury. J Transl Med. 2020;18:114 pubmed publisher
  9. Wang J, Dong Z, Gui M, Yao L, Li J, Zhou X, et al. HuoXue QianYang QuTan Recipe attenuates left ventricular hypertrophy in obese hypertensive rats by improving mitochondrial function through SIRT1/PGC-1α deacetylation pathway. Biosci Rep. 2019;39: pubmed publisher
  10. Moriyama M, Koshiba T, Ichinohe T. Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses. Nat Commun. 2019;10:4624 pubmed publisher
  11. Sohoni S, Ghosh P, Wang T, Kalainayakan S, Vidal C, Dey S, et al. Elevated Heme Synthesis and Uptake Underpin Intensified Oxidative Metabolism and Tumorigenic Functions in Non-Small Cell Lung Cancer Cells. Cancer Res. 2019;79:2511-2525 pubmed publisher
  12. Yambire K, Fernández Mosquera L, Steinfeld R, Mühle C, Ikonen E, Milosevic I, et al. Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases. elife. 2019;8: pubmed publisher
  13. Chhipa R, Fan Q, Anderson J, Muraleedharan R, Huang Y, Ciraolo G, et al. AMP kinase promotes glioblastoma bioenergetics and tumour growth. Nat Cell Biol. 2018;20:823-835 pubmed publisher
  14. Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher
  15. McArthur K, Whitehead L, Heddleston J, Li L, Padman B, Oorschot V, et al. BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis. Science. 2018;359: pubmed publisher
  16. Lan L, Guo M, Ai Y, Chen F, Zhang Y, Xia L, et al. Tetramethylpyrazine blocks TFAM degradation and up-regulates mitochondrial DNA copy number by interacting with TFAM. Biosci Rep. 2017;37: pubmed publisher
  17. Morishita M, Kawamoto T, Hara H, Onishi Y, Ueha T, Minoda M, et al. AICAR induces mitochondrial apoptosis in human osteosarcoma cells through an AMPK-dependent pathway. Int J Oncol. 2017;50:23-30 pubmed publisher
  18. Zhu L, Gómez Durán A, Saretzki G, Jin S, Tilgner K, Melguizo Sanchís D, et al. The mitochondrial protein CHCHD2 primes the differentiation potential of human induced pluripotent stem cells to neuroectodermal lineages. J Cell Biol. 2016;215:187-202 pubmed
  19. Zoladz J, Koziel A, Woyda Ploszczyca A, Celichowski J, Jarmuszkiewicz W. Endurance training increases the efficiency of rat skeletal muscle mitochondria. Pflugers Arch. 2016;468:1709-24 pubmed publisher
  20. Wisnovsky S, Jean S, Kelley S. Mitochondrial DNA repair and replication proteins revealed by targeted chemical probes. Nat Chem Biol. 2016;12:567-73 pubmed publisher
  21. Woś M, Szczepanowska J, Pikuła S, Tylki Szymańska A, Zabłocki K, Bandorowicz Pikuła J. Mitochondrial dysfunction in fibroblasts derived from patients with Niemann-Pick type C disease. Arch Biochem Biophys. 2016;593:50-9 pubmed publisher
  22. Grünewald A, Rygiel K, Hepplewhite P, Morris C, Picard M, Turnbull D. Mitochondrial DNA Depletion in Respiratory Chain-Deficient Parkinson Disease Neurons. Ann Neurol. 2016;79:366-78 pubmed publisher
  23. E L, Swerdlow R. Lactate's effect on human neuroblastoma cell bioenergetic fluxes. Biochem Pharmacol. 2016;99:88-100 pubmed publisher
  24. Schloesser A, Esatbeyoglu T, Piegholdt S, Dose J, Ikuta N, Okamoto H, et al. Dietary Tocotrienol/γ-Cyclodextrin Complex Increases Mitochondrial Membrane Potential and ATP Concentrations in the Brains of Aged Mice. Oxid Med Cell Longev. 2015;2015:789710 pubmed publisher