This is a Validated Antibody Database (VAD) review about human TCF7, based on 42 published articles (read how Labome selects the articles), using TCF7 antibody in all methods. It is aimed to help Labome visitors find the most suited TCF7 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
TCF7 synonym: TCF-1

Knockout validation
Cell Signaling Technology
domestic rabbit monoclonal (C63D9)
  • western blot knockout validation; mouse; fig 1c
Cell Signaling Technology TCF7 antibody (Cell Signaling Technology, 2203S) was used in western blot knockout validation on mouse samples (fig 1c). J Immunol (2011) ncbi
BioLegend
mouse monoclonal (7F11A10)
  • flow cytometry; human; loading ...; fig s2b
BioLegend TCF7 antibody (Biolegend, 655207) was used in flow cytometry on human samples (fig s2b). Cell (2019) ncbi
mouse monoclonal (7F11A10)
  • flow cytometry; human; loading ...; fig s5e
In order to characterize CD8 T cells isolated patients with stage IV melanoma before and after treatment with pembrolizumab, BioLegend TCF7 antibody (Biolegend, 7F11A10) was used in flow cytometry on human samples (fig s5e). Nature (2017) ncbi
Santa Cruz Biotechnology
mouse monoclonal (A-79)
  • western blot; human; 1:1000; fig 7
Santa Cruz Biotechnology TCF7 antibody (santa Cruz, sc-101170) was used in western blot on human samples at 1:1000 (fig 7). Oncotarget (2015) ncbi
mouse monoclonal (A-79)
  • chromatin immunoprecipitation; mouse
  • western blot; mouse
In order to show that KLF8 and MMP14 signaling promotes human breast cancer invasion and metastasis, Santa Cruz Biotechnology TCF7 antibody (Santa Cruz Biotechnology, sc-101170) was used in chromatin immunoprecipitation on mouse samples and in western blot on mouse samples . Oncogene (2014) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (C63D9)
  • flow cytometry; human; 1:100; loading ...; fig s4e
Cell Signaling Technology TCF7 antibody (Cell Signaling, C63D9) was used in flow cytometry on human samples at 1:100 (fig s4e). Nature (2021) ncbi
domestic rabbit monoclonal (C63D9)
  • flow cytometry; mouse; loading ...
Cell Signaling Technology TCF7 antibody (Cell Signaling Technology, 2203) was used in flow cytometry on mouse samples . Cancer Cell (2021) ncbi
domestic rabbit monoclonal (C63D9)
  • western blot; human; 1:1000; loading ...; fig 3f
Cell Signaling Technology TCF7 antibody (CST, 2203) was used in western blot on human samples at 1:1000 (fig 3f). J Exp Clin Cancer Res (2021) ncbi
domestic rabbit monoclonal (C63D9)
  • flow cytometry; human; loading ...; fig 6d
Cell Signaling Technology TCF7 antibody (Cell Signaling, 6709S) was used in flow cytometry on human samples (fig 6d). Science (2021) ncbi
domestic rabbit monoclonal (C63D9)
  • flow cytometry; mouse; 1:100; fig 6d
Cell Signaling Technology TCF7 antibody (Cell Signaling Technology, 2203) was used in flow cytometry on mouse samples at 1:100 (fig 6d). elife (2021) ncbi
domestic rabbit monoclonal (C63D9)
  • flow cytometry; human; 1:100; loading ...
Cell Signaling Technology TCF7 antibody (CellSignaling, 6709S) was used in flow cytometry on human samples at 1:100. bioRxiv (2020) ncbi
domestic rabbit monoclonal (C63D9)
  • immunohistochemistry; mouse; 1:500; loading ...; fig 6s4
Cell Signaling Technology TCF7 antibody (Cell Signaling, C63D9) was used in immunohistochemistry on mouse samples at 1:500 (fig 6s4). elife (2020) ncbi
domestic rabbit monoclonal (C63D9)
  • flow cytometry; mouse; loading ...; fig e9b
Cell Signaling Technology TCF7 antibody (Cell Signaling Technology, C63D9) was used in flow cytometry on mouse samples (fig e9b). Nature (2020) ncbi
domestic rabbit monoclonal (C63D9)
  • flow cytometry; mouse; fig 3b
  • immunohistochemistry; mouse; loading ...
Cell Signaling Technology TCF7 antibody (Cell Signaling Technology, C63D9) was used in flow cytometry on mouse samples (fig 3b) and in immunohistochemistry on mouse samples . Nature (2019) ncbi
domestic rabbit monoclonal (C63D9)
  • western blot; human; loading ...; fig 3d
Cell Signaling Technology TCF7 antibody (CST, 2203) was used in western blot on human samples (fig 3d). Cell Commun Signal (2019) ncbi
domestic rabbit monoclonal (C46C7)
  • immunocytochemistry; human; 1:500; loading ...; fig 4c29
Cell Signaling Technology TCF7 antibody (Cell Signaling, C2206) was used in immunocytochemistry on human samples at 1:500 (fig 4c29). Ocul Surf (2019) ncbi
domestic rabbit monoclonal (C63D9)
  • flow cytometry; mouse; loading ...; fig ex8d
Cell Signaling Technology TCF7 antibody (Cell Signaling, 9066S) was used in flow cytometry on mouse samples (fig ex8d). Nature (2019) ncbi
domestic rabbit monoclonal (C63D9)
  • flow cytometry; mouse; loading ...; fig 2f
Cell Signaling Technology TCF7 antibody (Cell Signaling Technology, C63D9) was used in flow cytometry on mouse samples (fig 2f). Front Immunol (2018) ncbi
domestic rabbit monoclonal (C63D9)
  • flow cytometry; mouse; loading ...; fig 7c
  • immunoprecipitation; mouse; loading ...; fig 4e
Cell Signaling Technology TCF7 antibody (Cell Signaling, C63D9) was used in flow cytometry on mouse samples (fig 7c) and in immunoprecipitation on mouse samples (fig 4e). Nat Commun (2018) ncbi
domestic rabbit monoclonal (C63D9)
  • flow cytometry; mouse; loading ...; fig 1d, 3e
Cell Signaling Technology TCF7 antibody (Cell Signaling, C63D9) was used in flow cytometry on mouse samples (fig 1d, 3e). Nature (2019) ncbi
domestic rabbit monoclonal (C63D9)
  • flow cytometry; mouse; loading ...; fig 5e
Cell Signaling Technology TCF7 antibody (Cell Signaling Technology, C63D9) was used in flow cytometry on mouse samples (fig 5e). J Clin Invest (2018) ncbi
domestic rabbit monoclonal (C63D9)
  • flow cytometry; mouse; loading ...; fig 1g
Cell Signaling Technology TCF7 antibody (Cell Signaling Technoogy, C63D9) was used in flow cytometry on mouse samples (fig 1g). J Exp Med (2018) ncbi
domestic rabbit monoclonal (C63D9)
  • flow cytometry; mouse; loading ...; fig 5b
Cell Signaling Technology TCF7 antibody (Cell Signaling Technologies, C63D9) was used in flow cytometry on mouse samples (fig 5b). J Exp Med (2018) ncbi
domestic rabbit monoclonal (C46C7)
  • western blot; mouse; 1:500; loading ...; fig 2d
Cell Signaling Technology TCF7 antibody (Cell Signal Technology, 2206S) was used in western blot on mouse samples at 1:500 (fig 2d). Biol Open (2017) ncbi
domestic rabbit monoclonal (C63D9)
  • immunoprecipitation; mouse; fig 6f
  • western blot; mouse; fig 6f
In order to characterize Aire-mediated signaling in medullary thymic epithelial cells, Cell Signaling Technology TCF7 antibody (Cell Signaling, C63D9) was used in immunoprecipitation on mouse samples (fig 6f) and in western blot on mouse samples (fig 6f). Nat Immunol (2017) ncbi
domestic rabbit monoclonal (C63D9)
  • flow cytometry; mouse; loading ...; fig 1a
  • immunocytochemistry; mouse; loading ...; fig 5a
In order to report that differentiation and self-renewal arise as opposing outcomes of sibling CD4 positive T cells during challenge with influenza, Cell Signaling Technology TCF7 antibody (Cell Signaling, C63D9) was used in flow cytometry on mouse samples (fig 1a) and in immunocytochemistry on mouse samples (fig 5a). J Exp Med (2017) ncbi
domestic rabbit monoclonal (C63D9)
  • flow cytometry; mouse; loading ...; fig s6
Cell Signaling Technology TCF7 antibody (cell signalling, C63D9) was used in flow cytometry on mouse samples (fig s6). Nature (2016) ncbi
domestic rabbit monoclonal (C63D9)
  • flow cytometry; mouse; loading ...
In order to demonstrate that DNMT3a directs early CD8 positive T-cell effector and memory fate decisions, Cell Signaling Technology TCF7 antibody (Cell Signaling, C63D9) was used in flow cytometry on mouse samples . Proc Natl Acad Sci U S A (2016) ncbi
domestic rabbit monoclonal (C63D9)
  • western blot; human; loading ...; fig 1a
Cell Signaling Technology TCF7 antibody (CST, 2203) was used in western blot on human samples (fig 1a). Tumour Biol (2016) ncbi
domestic rabbit monoclonal (C63D9)
  • flow cytometry; mouse; 1:400; loading ...; tbl s2
In order to identify and characterize follicular cytotoxic T cells, Cell Signaling Technology TCF7 antibody (Cell signalling, C63D9) was used in flow cytometry on mouse samples at 1:400 (tbl s2). Nat Immunol (2016) ncbi
domestic rabbit monoclonal (C63D9)
  • western blot; mouse; fig 2
In order to determine maintenance of mouse embryonic stem cell identity by a myc-driven self-reinforcing regulatory network, Cell Signaling Technology TCF7 antibody (Cell Signalling, 2203) was used in western blot on mouse samples (fig 2). Nat Commun (2016) ncbi
domestic rabbit monoclonal (C63D9)
  • immunoprecipitation; mouse; fig 6
  • western blot; mouse; fig 6
  • western blot; human; fig 5
Cell Signaling Technology TCF7 antibody (Cell signaling, 2203S) was used in immunoprecipitation on mouse samples (fig 6), in western blot on mouse samples (fig 6) and in western blot on human samples (fig 5). Mol Cell Biol (2016) ncbi
domestic rabbit monoclonal (C63D9)
  • flow cytometry; mouse; loading ...; fig 6c
In order to study the effect of atypical protein kinase C i on asymmetric division and CD8(+) T Lymphocyte, Cell Signaling Technology TCF7 antibody (Cell Signaling, C63D9) was used in flow cytometry on mouse samples (fig 6c). Sci Rep (2016) ncbi
domestic rabbit monoclonal (C63D9)
  • western blot; mouse; fig 7
Cell Signaling Technology TCF7 antibody (Cell Signaling Tech, 2203S) was used in western blot on mouse samples (fig 7). Cell Death Dis (2015) ncbi
domestic rabbit monoclonal (C46C7)
  • western blot; human; loading ...; fig 6
Cell Signaling Technology TCF7 antibody (Cell Signaling, C46C7) was used in western blot on human samples (fig 6). Mol Cell Proteomics (2015) ncbi
domestic rabbit monoclonal (C63D9)
  • flow cytometry; mouse
Cell Signaling Technology TCF7 antibody (Cell Signaling, C63D9) was used in flow cytometry on mouse samples . J Immunol (2014) ncbi
domestic rabbit monoclonal (C63D9)
  • western blot; human
Cell Signaling Technology TCF7 antibody (Cell Signaling Technology, 2203) was used in western blot on human samples . Mol Oncol (2013) ncbi
domestic rabbit monoclonal (C63D9)
  • western blot; mouse; 1:2000
Cell Signaling Technology TCF7 antibody (Cell Signalling, C63D9) was used in western blot on mouse samples at 1:2000. Nucleic Acids Res (2012) ncbi
domestic rabbit monoclonal (C63D9)
  • western blot knockout validation; mouse; fig 1c
Cell Signaling Technology TCF7 antibody (Cell Signaling Technology, 2203S) was used in western blot knockout validation on mouse samples (fig 1c). J Immunol (2011) ncbi
BD Biosciences
mouse monoclonal (S33-966)
  • flow cytometry; mouse; loading ...; fig 5a
BD Biosciences TCF7 antibody (BD Biosciences, 564217) was used in flow cytometry on mouse samples (fig 5a). Immunity (2019) ncbi
mouse monoclonal (S33-966)
  • flow cytometry; mouse; loading ...; fig 3f
BD Biosciences TCF7 antibody (BD Biosciences, S33-966) was used in flow cytometry on mouse samples (fig 3f). Nature (2019) ncbi
mouse monoclonal (S33-966)
  • flow cytometry; human; loading ...; fig 2b
BD Biosciences TCF7 antibody (BD Biosciences, 564217) was used in flow cytometry on human samples (fig 2b). Cell Rep (2018) ncbi
MilliporeSigma
mouse monoclonal (1D2)
  • other; human; loading ...; fig st1
  • western blot; human; loading ...; fig st4
In order to use size exclusion chromatography-microsphere-based affinity proteomics to study clinical samples obtained from pediatric acute leukemia patients, MilliporeSigma TCF7 antibody (SIGMA, 1D2) was used in other on human samples (fig st1) and in western blot on human samples (fig st4). Mol Cell Proteomics (2016) ncbi
Articles Reviewed
  1. Oberhardt V, Luxenburger H, Kemming J, Schulien I, Ciminski K, Giese S, et al. Rapid and stable mobilization of CD8+ T cells by SARS-CoV-2 mRNA vaccine. Nature. 2021;597:268-273 pubmed publisher
  2. Hutton C, Heider F, Blanco Gómez A, Banyard A, Kononov A, Zhang X, et al. Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity. Cancer Cell. 2021;: pubmed publisher
  3. Zhu X, Chen L, Huang B, Li X, Yang L, Hu X, et al. Efficacy and mechanism of the combination of PARP and CDK4/6 inhibitors in the treatment of triple-negative breast cancer. J Exp Clin Cancer Res. 2021;40:122 pubmed publisher
  4. Weber E, Parker K, Sotillo E, Lynn R, Anbunathan H, Lattin J, et al. Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling. Science. 2021;372: pubmed publisher
  5. Sun Z, Yao Y, You M, Liu J, Guo W, Qi Z, et al. The kinase PDK1 is critical for promoting T follicular helper cell differentiation. elife. 2021;10: pubmed publisher
  6. Mathew D, Giles J, Baxter A, Greenplate A, Wu J, Alanio C, et al. Deep immune profiling of COVID-19 patients reveals patient heterogeneity and distinct immunotypes with implications for therapeutic interventions. bioRxiv. 2020;: pubmed publisher
  7. Matos I, Asare A, Levorse J, Ouspenskaia T, de la Cruz Racelis J, Schuhmacher L, et al. Progenitors oppositely polarize WNT activators and inhibitors to orchestrate tissue development. elife. 2020;9: pubmed publisher
  8. Song E, Mao T, Dong H, Boisserand L, Antila S, Bosenberg M, et al. VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours. Nature. 2020;577:689-694 pubmed publisher
  9. Wei J, Long L, Zheng W, Dhungana Y, Lim S, Guy C, et al. Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy. Nature. 2019;576:471-476 pubmed publisher
  10. Chen Z, Ji Z, Ngiow S, Manne S, Cai Z, Huang A, et al. TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision. Immunity. 2019;51:840-855.e5 pubmed publisher
  11. Jiang S, Zhang M, Zhang Y, Zhou W, Zhu T, Ruan Q, et al. WNT5B governs the phenotype of basal-like breast cancer by activating WNT signaling. Cell Commun Signal. 2019;17:109 pubmed publisher
  12. Khan O, Giles J, McDonald S, Manne S, Ngiow S, Patel K, et al. TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion. Nature. 2019;: pubmed publisher
  13. An S, Raju I, Surenkhuu B, Kwon J, Gulati S, Karaman M, et al. Neutrophil extracellular traps (NETs) contribute to pathological changes of ocular graft-vs.-host disease (oGVHD) dry eye: Implications for novel biomarkers and therapeutic strategies. Ocul Surf. 2019;: pubmed publisher
  14. Chen J, López Moyado I, Seo H, Lio C, Hempleman L, Sekiya T, et al. NR4A transcription factors limit CAR T cell function in solid tumours. Nature. 2019;567:530-534 pubmed publisher
  15. Li J, He Y, Hao J, Ni L, Dong C. High Levels of Eomes Promote Exhaustion of Anti-tumor CD8+ T Cells. Front Immunol. 2018;9:2981 pubmed publisher
  16. Collins P, Cella M, Porter S, Li S, Gurewitz G, Hong H, et al. Gene Regulatory Programs Conferring Phenotypic Identities to Human NK Cells. Cell. 2019;176:348-360.e12 pubmed publisher
  17. Li F, Zeng Z, Xing S, Gullicksrud J, Shan Q, Choi J, et al. Ezh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf. Nat Commun. 2018;9:5452 pubmed publisher
  18. Karmaus P, Chen X, Lim S, Herrada A, Nguyen T, Xu B, et al. Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity. Nature. 2019;565:101-105 pubmed publisher
  19. Kim C, Hu B, Jadhav R, Jin J, Zhang H, Cavanagh M, et al. Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells. Cell Rep. 2018;25:2148-2162.e5 pubmed publisher
  20. Tilstra J, Avery L, Menk A, Gordon R, Smita S, Kane L, et al. Kidney-infiltrating T cells in murine lupus nephritis are metabolically and functionally exhausted. J Clin Invest. 2018;128:4884-4897 pubmed publisher
  21. Omilusik K, Nadjsombati M, Shaw L, Yu B, Milner J, Goldrath A. Sustained Id2 regulation of E proteins is required for terminal differentiation of effector CD8+ T cells. J Exp Med. 2018;215:773-783 pubmed publisher
  22. Harly C, Cam M, Kaye J, Bhandoola A. Development and differentiation of early innate lymphoid progenitors. J Exp Med. 2018;215:249-262 pubmed publisher
  23. Huang A, Postow M, Orlowski R, Mick R, Bengsch B, Manne S, et al. T-cell invigoration to tumour burden ratio associated with anti-PD-1 response. Nature. 2017;545:60-65 pubmed publisher
  24. Ye S, Zhang T, Tong C, Zhou X, He K, Ban Q, et al. Depletion of Tcf3 and Lef1 maintains mouse embryonic stem cell self-renewal. Biol Open. 2017;6:511-517 pubmed publisher
  25. Herzig Y, Nevo S, Bornstein C, Brezis M, Ben Hur S, Shkedy A, et al. Transcriptional programs that control expression of the autoimmune regulator gene Aire. Nat Immunol. 2017;18:161-172 pubmed publisher
  26. Nish S, Zens K, Kratchmarov R, Lin W, Adams W, Chen Y, et al. CD4+ T cell effector commitment coupled to self-renewal by asymmetric cell divisions. J Exp Med. 2017;214:39-47 pubmed publisher
  27. Yu Y, Tsang J, Wang C, Clare S, Wang J, Chen X, et al. Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its development pathway. Nature. 2016;539:102-106 pubmed publisher
  28. Ladle B, Li K, Phillips M, Pucsek A, Haile A, Powell J, et al. De novo DNA methylation by DNA methyltransferase 3a controls early effector CD8+ T-cell fate decisions following activation. Proc Natl Acad Sci U S A. 2016;113:10631-6 pubmed publisher
  29. Xu X, Tang X, Guo W, Yang K, Ren T. TCF-1 participates in the occurrence of dedifferentiated chondrosarcoma. Tumour Biol. 2016;37:14129-14140 pubmed
  30. Leong Y, Chen Y, Ong H, Wu D, Man K, Deléage C, et al. CXCR5(+) follicular cytotoxic T cells control viral infection in B cell follicles. Nat Immunol. 2016;17:1187-96 pubmed publisher
  31. Fagnocchi L, Cherubini A, Hatsuda H, Fasciani A, Mazzoleni S, Poli V, et al. A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity. Nat Commun. 2016;7:11903 pubmed publisher
  32. Kumar A, Chalamalasetty R, Kennedy M, Thomas S, Inala S, Garriock R, et al. Zfp703 Is a Wnt/?-Catenin Feedback Suppressor Targeting the ?-Catenin/Tcf1 Complex. Mol Cell Biol. 2016;36:1793-802 pubmed publisher
  33. Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed publisher
  34. Metz P, Lopez J, Kim S, Akimoto K, Ohno S, Chang J. Regulation of Asymmetric Division by Atypical Protein Kinase C Influences Early Specification of CD8(+) T Lymphocyte Fates. Sci Rep. 2016;6:19182 pubmed publisher
  35. Cao J, Zhang X, Wang Q, Qiu G, Hou C, Wang J, et al. Smad4 represses the generation of memory-precursor effector T cells but is required for the differentiation of central memory T cells. Cell Death Dis. 2015;6:e1984 pubmed publisher
  36. Leal L, Bueno A, Gomes D, Abduch R, de Castro M, Antonini S. Inhibition of the Tcf/beta-catenin complex increases apoptosis and impairs adrenocortical tumor cell proliferation and adrenal steroidogenesis. Oncotarget. 2015;6:43016-32 pubmed publisher
  37. Traenkle B, Emele F, Anton R, Poetz O, Haeussler R, Maier J, et al. Monitoring interactions and dynamics of endogenous beta-catenin with intracellular nanobodies in living cells. Mol Cell Proteomics. 2015;14:707-23 pubmed publisher
  38. Kim E, Gasper D, Lee S, Plisch E, Svaren J, Suresh M. Bach2 regulates homeostasis of Foxp3+ regulatory T cells and protects against fatal lung disease in mice. J Immunol. 2014;192:985-95 pubmed publisher
  39. Lu H, Hu L, Yu L, Wang X, Urvalek A, Li T, et al. KLF8 and FAK cooperatively enrich the active MMP14 on the cell surface required for the metastatic progression of breast cancer. Oncogene. 2014;33:2909-17 pubmed publisher
  40. Li L, Yang G, Ren C, Tanimoto R, Hirayama T, Wang J, et al. Glioma pathogenesis-related protein 1 induces prostate cancer cell death through Hsc70-mediated suppression of AURKA and TPX2. Mol Oncol. 2013;7:484-96 pubmed publisher
  41. Wallmen B, Schrempp M, Hecht A. Intrinsic properties of Tcf1 and Tcf4 splice variants determine cell-type-specific Wnt/?-catenin target gene expression. Nucleic Acids Res. 2012;40:9455-69 pubmed publisher
  42. Wang R, Xie H, Huang Z, Ma J, Fang X, Ding Y, et al. T cell factor 1 regulates thymocyte survival via a RORγt-dependent pathway. J Immunol. 2011;187:5964-73 pubmed publisher