This is a Validated Antibody Database (VAD) review about human SYVN1, based on 5 published articles (read how Labome selects the articles), using SYVN1 antibody in all methods. It is aimed to help Labome visitors find the most suited SYVN1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
SYVN1 synonym: DER3; HRD1; E3 ubiquitin-protein ligase synoviolin; HMG-coA reductase degradation 1 homolog; RING-type E3 ubiquitin transferase synoviolin; synovial apoptosis inhibitor 1, synoviolin

Knockout validation
Abcam
rabbit monoclonal (EP7459)
  • western blot knockout validation; mouse; fig s1
Abcam SYVN1 antibody (Abcam, EP7459) was used in western blot knockout validation on mouse samples (fig s1). Proc Natl Acad Sci U S A (2016) ncbi
Novus Biologicals
rabbit polyclonal
  • western blot; human; 1:8000; fig 2
  • western blot knockout validation; mouse; 1:8000; fig 1
Novus Biologicals SYVN1 antibody (Novus Biologicals, NB100-2526) was used in western blot on human samples at 1:8000 (fig 2) and in western blot knockout validation on mouse samples at 1:8000 (fig 1). Nat Cell Biol (2015) ncbi
Sigma-Aldrich
rabbit polyclonal
  • western blot knockout validation; human; loading ...; fig 2d
Sigma-Aldrich SYVN1 antibody (Sigma-Aldrich, H7915) was used in western blot knockout validation on human samples (fig 2d). Sci Rep (2018) ncbi
Abcam
rabbit monoclonal (EP7459)
  • western blot; human; loading ...; fig 1h
In order to discover that endoplasmic reticulum membrane-spanning ubiquitin ligase SYVN1/HRD1 enhances the degradation of the Z variant of SERPINA1 through the autophagy-lysosome pathway, Abcam SYVN1 antibody (Abcam, ab170901) was used in western blot on human samples (fig 1h). Autophagy (2017) ncbi
rabbit monoclonal (EP7459)
  • western blot knockout validation; mouse; fig s1
Abcam SYVN1 antibody (Abcam, EP7459) was used in western blot knockout validation on mouse samples (fig s1). Proc Natl Acad Sci U S A (2016) ncbi
Novus Biologicals
rabbit polyclonal
  • western blot; human; 1:8000; fig 2
  • western blot knockout validation; mouse; 1:8000; fig 1
Novus Biologicals SYVN1 antibody (Novus Biologicals, NB100-2526) was used in western blot on human samples at 1:8000 (fig 2) and in western blot knockout validation on mouse samples at 1:8000 (fig 1). Nat Cell Biol (2015) ncbi
Bethyl
rabbit polyclonal
  • western blot; human; loading ...; fig 4b
Bethyl SYVN1 antibody (Bethyl, A302-946A) was used in western blot on human samples (fig 4b). Mol Biol Cell (2017) ncbi
Sigma-Aldrich
rabbit polyclonal
  • western blot knockout validation; human; loading ...; fig 2d
Sigma-Aldrich SYVN1 antibody (Sigma-Aldrich, H7915) was used in western blot knockout validation on human samples (fig 2d). Sci Rep (2018) ncbi
mouse monoclonal (HRD1-5)
  • western blot; mouse
Sigma-Aldrich SYVN1 antibody (Sigma, HRD1-5) was used in western blot on mouse samples . Proc Natl Acad Sci U S A (2016) ncbi
Articles Reviewed
  1. Kadowaki H, Satrimafitrah P, Takami Y, Nishitoh H. Molecular mechanism of ER stress-induced pre-emptive quality control involving association of the translocon, Derlin-1, and HRD1. Sci Rep. 2018;8:7317 pubmed publisher
  2. Feng L, Zhang J, Zhu N, Ding Q, Zhang X, Yu J, et al. Ubiquitin ligase SYVN1/HRD1 facilitates degradation of the SERPINA1 Z variant/?-1-antitrypsin Z variant via SQSTM1/p62-dependent selective autophagy. Autophagy. 2017;13:686-702 pubmed publisher
  3. To M, Peterson C, Roberts M, Counihan J, Wu T, Forster M, et al. Lipid disequilibrium disrupts ER proteostasis by impairing ERAD substrate glycan trimming and dislocation. Mol Biol Cell. 2017;28:270-284 pubmed publisher
  4. Kong S, Yang Y, Xu Y, Wang Y, Zhang Y, Melo Cardenas J, et al. Endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 controls B-cell immunity through degradation of the death receptor CD95/Fas. Proc Natl Acad Sci U S A. 2016;113:10394-9 pubmed publisher
  5. Sun S, Shi G, Sha H, Ji Y, Han X, Shu X, et al. IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation. Nat Cell Biol. 2015;17:1546-55 pubmed publisher