This is a Validated Antibody Database (VAD) review about human STXBP1, based on 11 published articles (read how Labome selects the articles), using STXBP1 antibody in all methods. It is aimed to help Labome visitors find the most suited STXBP1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
STXBP1 synonym: MUNC18-1; NSEC1; P67; RBSEC1; UNC18; syntaxin-binding protein 1; N-Sec1; neuronal SEC1; protein unc-18 homolog 1; protein unc-18 homolog A; unc-18A; unc18-1

Knockout validation
BD Biosciences
mouse monoclonal (31/Munc-18)
  • western blot knockout validation; human; fig 2b
  • immunocytochemistry; human; fig 8
BD Biosciences STXBP1 antibody (BD Bioscience, 610336) was used in western blot knockout validation on human samples (fig 2b) and in immunocytochemistry on human samples (fig 8). J Cell Biol (2016) ncbi
Synaptic Systems
rabbit polyclonal (/)
  • western blot; mouse; 1:2000; loading ...; fig s6a
Synaptic Systems STXBP1 antibody (Synaptic Systems, 116002) was used in western blot on mouse samples at 1:2000 (fig s6a). Proc Natl Acad Sci U S A (2018) ncbi
rabbit polyclonal (/)
  • immunohistochemistry; mouse; fig s5h
Synaptic Systems STXBP1 antibody (Synaptic Systems, 116003) was used in immunohistochemistry on mouse samples (fig s5h). Cell (2018) ncbi
rabbit polyclonal (/)
  • western blot; human
Synaptic Systems STXBP1 antibody (Synaptic Systems, 116002) was used in western blot on human samples . FEBS J (2015) ncbi
Abnova
mouse monoclonal (6D1)
  • immunohistochemistry; mouse; loading ...; fig 1c
  • western blot; mouse; loading ...; fig 2a
Abnova STXBP1 antibody (Abnova, H00006812-M01) was used in immunohistochemistry on mouse samples (fig 1c) and in western blot on mouse samples (fig 2a). Acta Neuropathol Commun (2017) ncbi
Invitrogen
rabbit polyclonal
  • western blot; mouse; 1:2000; loading ...; fig 2
In order to report the proteome of V1, V2M, and V2L from P0-enucleated, anophthalmic, and sighted mice, Invitrogen STXBP1 antibody (Thermo Scientific, PA1-742) was used in western blot on mouse samples at 1:2000 (fig 2). PLoS ONE (2016) ncbi
Abcam
rabbit monoclonal (EPR4850)
  • western blot; rat; 1:4000; fig 9
Abcam STXBP1 antibody (Abcam, ab124920) was used in western blot on rat samples at 1:4000 (fig 9). Int J Neuropsychopharmacol (2015) ncbi
BD Biosciences
mouse monoclonal (31/Munc-18)
  • western blot; human; loading ...; fig 3b
BD Biosciences STXBP1 antibody (BD Biosciences, 31/Munc-18) was used in western blot on human samples (fig 3b). J Biol Chem (2018) ncbi
mouse monoclonal (31/Munc-18)
  • western blot knockout validation; human; fig 2b
  • immunocytochemistry; human; fig 8
BD Biosciences STXBP1 antibody (BD Bioscience, 610336) was used in western blot knockout validation on human samples (fig 2b) and in immunocytochemistry on human samples (fig 8). J Cell Biol (2016) ncbi
mouse monoclonal (31/Munc-18)
  • western blot; rat; 1:1000; fig 2
BD Biosciences STXBP1 antibody (BD Biosciences, 610336) was used in western blot on rat samples at 1:1000 (fig 2). Sci Rep (2015) ncbi
mouse monoclonal (31/Munc-18)
  • immunohistochemistry - paraffin section; mouse; fig 2
BD Biosciences STXBP1 antibody (BD -Transduction Laboratories, 610337) was used in immunohistochemistry - paraffin section on mouse samples (fig 2). Oncotarget (2015) ncbi
mouse monoclonal (31/Munc-18)
  • western blot; mouse; fig 6
In order to test if presenilin and nicastrin regulate synaptic function in a gamma-secretase-dependent or -independent manner, BD Biosciences STXBP1 antibody (BD Transduction, 610337) was used in western blot on mouse samples (fig 6). Proc Natl Acad Sci U S A (2014) ncbi
Articles Reviewed
  1. Shen C, Liu Y, Yu H, Gulbranson D, Kogut I, Bilousova G, et al. The N-peptide-binding mode is critical to Munc18-1 function in synaptic exocytosis. J Biol Chem. 2018;293:18309-18317 pubmed publisher
  2. Wang Y, Figueiredo D, Sun X, Dong Z, Chen W, Cui W, et al. Controlling of glutamate release by neuregulin3 via inhibiting the assembly of the SNARE complex. Proc Natl Acad Sci U S A. 2018;115:2508-2513 pubmed publisher
  3. Liu C, Kershberg L, Wang J, Schneeberger S, Kaeser P. Dopamine Secretion Is Mediated by Sparse Active Zone-like Release Sites. Cell. 2018;172:706-718.e15 pubmed publisher
  4. Hamada N, Iwamoto I, Tabata H, Nagata K. MUNC18-1 gene abnormalities are involved in neurodevelopmental disorders through defective cortical architecture during brain development. Acta Neuropathol Commun. 2017;5:92 pubmed publisher
  5. Chai Y, Sierecki E, Tomatis V, Gormal R, Giles N, Morrow I, et al. Munc18-1 is a molecular chaperone for α-synuclein, controlling its self-replicating aggregation. J Cell Biol. 2016;214:705-18 pubmed publisher
  6. Laramée M, Smolders K, Hu T, Bronchti G, Boire D, Arckens L. Congenital Anophthalmia and Binocular Neonatal Enucleation Differently Affect the Proteome of Primary and Secondary Visual Cortices in Mice. PLoS ONE. 2016;11:e0159320 pubmed publisher
  7. Craig T, Anderson D, Evans A, Girach F, Henley J. SUMOylation of Syntaxin1A regulates presynaptic endocytosis. Sci Rep. 2015;5:17669 pubmed publisher
  8. Jeannot P, Callot C, Baer R, Duquesnes N, Guerra C, Guillermet Guibert J, et al. Loss of p27Kip¹ promotes metaplasia in the pancreas via the regulation of Sox9 expression. Oncotarget. 2015;6:35880-92 pubmed publisher
  9. Zhou J, Liu Z, Yu J, Han X, Fan S, Shao W, et al. Quantitative Proteomic Analysis Reveals Molecular Adaptations in the Hippocampal Synaptic Active Zone of Chronic Mild Stress-Unsusceptible Rats. Int J Neuropsychopharmacol. 2015;19: pubmed publisher
  10. Inoue M, Hur J, Kihara T, Teranishi Y, Yamamoto N, Ishikawa T, et al. Human brain proteins showing neuron-specific interactions with γ-secretase. FEBS J. 2015;282:2587-99 pubmed publisher
  11. Lee S, Sharma M, S dhof T, Shen J. Synaptic function of nicastrin in hippocampal neurons. Proc Natl Acad Sci U S A. 2014;111:8973-8 pubmed publisher