This is a Validated Antibody Database (VAD) review about human STAT4, based on 17 published articles (read how Labome selects the articles), using STAT4 antibody in all methods. It is aimed to help Labome visitors find the most suited STAT4 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
STAT4 synonym: SLEB11; signal transducer and activator of transcription 4; signal transducer and activator of transcription 4 variant 3

Knockout validation
Invitrogen
rabbit polyclonal
  • western blot knockout validation; mouse; loading ...; fig 1c
  • western blot; human; loading ...; fig 1c
In order to explore the role of focal adhesion kinase in pediatric renal tumors, Invitrogen STAT4 antibody (Invitrogen, 71-7900) was used in western blot knockout validation on mouse samples (fig 1c) and in western blot on human samples (fig 1c). Mol Cancer Res (2014) ncbi
Invitrogen
mouse monoclonal (4LURPIE)
  • flow cytometry; human; loading ...; fig 2
Invitrogen STAT4 antibody (Thermo Fisher, 4LURPLE) was used in flow cytometry on human samples (fig 2). AIDS Res Ther (2017) ncbi
mouse monoclonal (4LURPIE)
  • flow cytometry; human; loading ...; fig 7a
Invitrogen STAT4 antibody (eBioscience, 4LURPIE) was used in flow cytometry on human samples (fig 7a). Oncotarget (2017) ncbi
rabbit polyclonal
  • immunohistochemistry - paraffin section; human; 1:500; fig 1a
  • western blot; human; loading ...; fig 1d
In order to test if focal adhesion kinase present in rhabdomyosarcoma affect cellular survival, Invitrogen STAT4 antibody (Invitrogen, 71-7900) was used in immunohistochemistry - paraffin section on human samples at 1:500 (fig 1a) and in western blot on human samples (fig 1d). Transl Oncol (2016) ncbi
rabbit monoclonal (H.56.9)
  • western blot; human; fig 3
In order to elucidate an increased mRNA and protein expression in the minor allele of rs7574865 in the STAT4 gene, Invitrogen STAT4 antibody (Thermo Fisher Scientific, H.56.9) was used in western blot on human samples (fig 3). PLoS ONE (2015) ncbi
rabbit polyclonal
  • western blot; human; 1:1000
In order to investigate the interactions between focal adhesion kinase and p53 in neuroblastoma, Invitrogen STAT4 antibody (Invitrogen, 71-7900) was used in western blot on human samples at 1:1000. J Surg Res (2015) ncbi
rabbit polyclonal
  • western blot knockout validation; mouse; loading ...; fig 1c
  • western blot; human; loading ...; fig 1c
In order to explore the role of focal adhesion kinase in pediatric renal tumors, Invitrogen STAT4 antibody (Invitrogen, 71-7900) was used in western blot knockout validation on mouse samples (fig 1c) and in western blot on human samples (fig 1c). Mol Cancer Res (2014) ncbi
rabbit polyclonal
  • western blot; human; fig 8
In order to study lipoxygenases in obese Zucker rats, Invitrogen STAT4 antibody (Invitrogen, 71-4500) was used in western blot on human samples (fig 8). Am J Physiol Endocrinol Metab (2011) ncbi
rabbit polyclonal
In order to identify PTP-Basophil like as a STAT protein tyrosine phosphatase, Invitrogen STAT4 antibody (Zymed, 71-7900) was used . Immunity (2007) ncbi
rabbit polyclonal
In order to test if fatty liver due to chronic choline-deficient diet exacerbates concanavalin A-induced liver hepatitis, Invitrogen STAT4 antibody (Zymed, 71?C7900) was used . Hepatology (2006) ncbi
rabbit polyclonal
In order to propose that chronic obstructive pulmonary disease is associated with an active T-helper 1 cell and type-1 cytotoxic T-cell inflammatory process, Invitrogen STAT4 antibody (Zymed Laboratories, 71-7900) was used . Eur Respir J (2004) ncbi
Abcam
rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig s1g
Abcam STAT4 antibody (Abcam, 28815) was used in western blot on mouse samples at 1:1000 (fig s1g). Nat Commun (2018) ncbi
rabbit monoclonal (EP1900Y)
  • chromatin immunoprecipitation; human; loading ...; fig 8b
Abcam STAT4 antibody (Abcam, EP1900Y) was used in chromatin immunoprecipitation on human samples (fig 8b). Oncotarget (2017) ncbi
Abnova
mouse monoclonal (1C2-1C12)
  • other; human; loading ...; fig st1
In order to use size exclusion chromatography-microsphere-based affinity proteomics to study clinical samples obtained from pediatric acute leukemia patients, Abnova STAT4 antibody (Abnova, H00006775-M01) was used in other on human samples (fig st1). Mol Cell Proteomics (2016) ncbi
Cell Signaling Technology
rabbit monoclonal (C46B10)
  • western blot; mouse; loading ...; fig 4a
Cell Signaling Technology STAT4 antibody (Cell Signaling Technology, 2653) was used in western blot on mouse samples (fig 4a). J Immunol (2019) ncbi
rabbit polyclonal
  • western blot; human; loading ...; fig 4b
Cell Signaling Technology STAT4 antibody (Cell Signaling Technologies, 5267) was used in western blot on human samples (fig 4b). Oncoimmunology (2017) ncbi
rabbit monoclonal (C46B10)
  • western blot; human; loading ...; fig 4b
Cell Signaling Technology STAT4 antibody (Cell Signaling Technologies, 2653) was used in western blot on human samples (fig 4b). Oncoimmunology (2017) ncbi
mouse monoclonal (2A2)
  • western blot; human; loading ...; fig 4
Cell Signaling Technology STAT4 antibody (Cell Signaling Technology, 2A2) was used in western blot on human samples (fig 4). Oncotarget (2016) ncbi
rabbit monoclonal (D2E4)
  • western blot; human; loading ...; fig 4
Cell Signaling Technology STAT4 antibody (Cell Signaling Technology, D2E4) was used in western blot on human samples (fig 4). Oncotarget (2016) ncbi
BD Biosciences
mouse monoclonal (38/p-Stat4)
  • western blot; mouse; loading ...; fig 4a
BD Biosciences STAT4 antibody (BD Transduction Laboratories, 38/pSTAT4) was used in western blot on mouse samples (fig 4a). J Immunol (2019) ncbi
mouse monoclonal (38/p-Stat4)
  • flow cytometry; human
BD Biosciences STAT4 antibody (BD, 38/pStat4) was used in flow cytometry on human samples . J Exp Med (2014) ncbi
Sigma-Aldrich
mouse monoclonal (1C2-1C12)
  • chromatin immunoprecipitation; zebrafish ; 1:100; loading ...; fig 7l
In order to investigate the genetic regulators of endothelial precursors in great vessel vasculogenesis, Sigma-Aldrich STAT4 antibody (Sigma, WH0006775M1) was used in chromatin immunoprecipitation on zebrafish samples at 1:100 (fig 7l). Nat Commun (2017) ncbi
Articles Reviewed
  1. Simonović N, Witalisz Siepracka A, Meissl K, Lassnig C, Reichart U, Kolbe T, et al. NK Cells Require Cell-Extrinsic and -Intrinsic TYK2 for Full Functionality in Tumor Surveillance and Antibacterial Immunity. J Immunol. 2019;202:1724-1734 pubmed publisher
  2. Zhang C, Wang C, Jiang M, Gu C, Xiao J, Chen X, et al. Act1 is a negative regulator in T and B cells via direct inhibition of STAT3. Nat Commun. 2018;9:2745 pubmed publisher
  3. Penafuerte C, Feldhammer M, Mills J, Vinette V, Pike K, Hall A, et al. Downregulation of PTP1B and TC-PTP phosphatases potentiate dendritic cell-based immunotherapy through IL-12/IFN? signaling. Oncoimmunology. 2017;6:e1321185 pubmed publisher
  4. Zhao G, Liu L, Su B, Zhang T, Chen P, Li W, et al. The dynamic changes of interferon lambdas related genes and proteins in JAK/STAT pathway in both acute and chronic HIV-1 infected patients. AIDS Res Ther. 2017;14:31 pubmed publisher
  5. Domae E, Hirai Y, Ikeo T, Goda S, Shimizu Y. Cytokine-mediated activation of human ex vivo-expanded V?9V?2 T cells. Oncotarget. 2017;8:45928-45942 pubmed publisher
  6. Meng Z, Liu W, Xia Y, Yin H, Zhang C, Su D, et al. The pro-inflammatory signalling regulator Stat4 promotes vasculogenesis of great vessels derived from endothelial precursors. Nat Commun. 2017;8:14640 pubmed publisher
  7. Ma Y, Chen L, Xie G, Zhou Y, Yue C, Yuan X, et al. Elevated level of interleukin-35 in colorectal cancer induces conversion of T cells into iTr35 by activating STAT1/STAT3. Oncotarget. 2016;7:73003-73015 pubmed publisher
  8. Waters A, Stafman L, Garner E, Mruthyunjayappa S, Stewart J, Mroczek Musulman E, et al. Targeting Focal Adhesion Kinase Suppresses the Malignant Phenotype in Rhabdomyosarcoma Cells. Transl Oncol. 2016;9:263-73 pubmed publisher
  9. Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed publisher
  10. Lamana A, López Santalla M, Castillo González R, Ortiz A, Martín J, García Vicuña R, et al. The Minor Allele of rs7574865 in the STAT4 Gene Is Associated with Increased mRNA and Protein Expression. PLoS ONE. 2015;10:e0142683 pubmed publisher
  11. Gillory L, Stewart J, Megison M, Waters A, Beierle E. Focal adhesion kinase and p53 synergistically decrease neuroblastoma cell survival. J Surg Res. 2015;196:339-49 pubmed publisher
  12. Kurktschiev P, Raziorrouh B, Schraut W, Backmund M, Wächtler M, Wendtner C, et al. Dysfunctional CD8+ T cells in hepatitis B and C are characterized by a lack of antigen-specific T-bet induction. J Exp Med. 2014;211:2047-59 pubmed publisher
  13. Megison M, Gillory L, Stewart J, Nabers H, Mrozcek Musulman E, Beierle E. FAK inhibition abrogates the malignant phenotype in aggressive pediatric renal tumors. Mol Cancer Res. 2014;12:514-26 pubmed publisher
  14. Chakrabarti S, Wen Y, Dobrian A, Cole B, Ma Q, Pei H, et al. Evidence for activation of inflammatory lipoxygenase pathways in visceral adipose tissue of obese Zucker rats. Am J Physiol Endocrinol Metab. 2011;300:E175-87 pubmed publisher
  15. Nakahira M, Tanaka T, Robson B, Mizgerd J, Grusby M. Regulation of signal transducer and activator of transcription signaling by the tyrosine phosphatase PTP-BL. Immunity. 2007;26:163-76 pubmed
  16. Kremer M, Hines I, Milton R, Wheeler M. Favored T helper 1 response in a mouse model of hepatosteatosis is associated with enhanced T cell-mediated hepatitis. Hepatology. 2006;44:216-27 pubmed
  17. Di Stefano A, Caramori G, Capelli A, Gnemmi I, Ricciardolo F, Oates T, et al. STAT4 activation in smokers and patients with chronic obstructive pulmonary disease. Eur Respir J. 2004;24:78-85 pubmed