This is a Validated Antibody Database (VAD) review about human SREBF2, based on 24 published articles (read how Labome selects the articles), using SREBF2 antibody in all methods. It is aimed to help Labome visitors find the most suited SREBF2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
SREBF2 synonym: SREBP-2; SREBP2; bHLHd2

Santa Cruz Biotechnology
mouse monoclonal (A-12)
  • flow cytometry; human; loading ...; fig 6b
Santa Cruz Biotechnology SREBF2 antibody (Santa Cruz Biotechnology, A-12) was used in flow cytometry on human samples (fig 6b). Cell Mol Gastroenterol Hepatol (2021) ncbi
mouse monoclonal
  • western blot; human; loading ...; fig 4f
Santa Cruz Biotechnology SREBF2 antibody (Santa Cruz Biotechnology, 1C6) was used in western blot on human samples (fig 4f). Sci Adv (2020) ncbi
mouse monoclonal (1C6)
  • western blot; human; loading ...; fig 4f
Santa Cruz Biotechnology SREBF2 antibody (Santa Cruz Biotechnology, 1C6) was used in western blot on human samples (fig 4f). Sci Adv (2020) ncbi
mouse monoclonal (A-12)
  • western blot; rat; loading ...; fig 9a
Santa Cruz Biotechnology SREBF2 antibody (Santa Cruz, sc-271616) was used in western blot on rat samples (fig 9a). Redox Biol (2016) ncbi
mouse monoclonal (1C6)
  • western blot; human; loading ...; fig 4b
  • western blot; hamsters; loading ...; fig 5c, d
Santa Cruz Biotechnology SREBF2 antibody (Santa Cruz, 1C6) was used in western blot on human samples (fig 4b) and in western blot on hamsters samples (fig 5c, d). PLoS ONE (2015) ncbi
mouse monoclonal (1C6)
  • immunohistochemistry; human; 1:100
  • western blot; human
Santa Cruz Biotechnology SREBF2 antibody (Santa Cruz Biotechnology, sc-13552) was used in immunohistochemistry on human samples at 1:100 and in western blot on human samples . PLoS ONE (2015) ncbi
mouse monoclonal (1C6)
  • EMSA; human; fig 4
  • immunocytochemistry; human; 1:100; fig 3
  • western blot; human; fig 2
Santa Cruz Biotechnology SREBF2 antibody (Santa Cruz Biotechnology, SC-13 552) was used in EMSA on human samples (fig 4), in immunocytochemistry on human samples at 1:100 (fig 3) and in western blot on human samples (fig 2). Br J Nutr (2015) ncbi
mouse monoclonal (1C6)
  • western blot; mouse; fig 4a
Santa Cruz Biotechnology SREBF2 antibody (Santa, sc-13552) was used in western blot on mouse samples (fig 4a). J Biol Chem (2011) ncbi
Abcam
domestic rabbit polyclonal
  • western blot; human; loading ...; fig s6a
  • western blot; mouse; loading ...; fig 5f
Abcam SREBF2 antibody (Abcam, ab30682) was used in western blot on human samples (fig s6a) and in western blot on mouse samples (fig 5f). iScience (2021) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 1f
Abcam SREBF2 antibody (Abcam, ab30682) was used in western blot on mouse samples (fig 1f). Aging Dis (2021) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:500; fig 4d
  • western blot; human; 1:500; loading ...; fig 4b
Abcam SREBF2 antibody (Abcam, ab30682) was used in western blot on mouse samples at 1:500 (fig 4d) and in western blot on human samples at 1:500 (fig 4b). Nat Commun (2021) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig s4a
Abcam SREBF2 antibody (Abcam, ab30682) was used in western blot on mouse samples at 1:1000 (fig s4a). Mol Ther Nucleic Acids (2021) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1 ug/ml; loading ...; fig 1e
Abcam SREBF2 antibody (Abcam, ab30682) was used in western blot on mouse samples at 1 ug/ml (fig 1e). J Biol Chem (2021) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 5b
  • western blot; human; loading ...; fig 2c
Abcam SREBF2 antibody (Abcam, ab30682) was used in western blot on mouse samples (fig 5b) and in western blot on human samples (fig 2c). FASEB Bioadv (2020) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:500; loading ...; fig 1b
Abcam SREBF2 antibody (Abcam, ab28482) was used in western blot on human samples at 1:500 (fig 1b). Aging (Albany NY) (2020) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:500; loading ...; fig 2k
Abcam SREBF2 antibody (Abcam, Ab30682) was used in western blot on mouse samples at 1:500 (fig 2k). Cell (2019) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 2a
Abcam SREBF2 antibody (Abcam, ab30682) was used in western blot on mouse samples (fig 2a). Sci Rep (2017) ncbi
domestic rabbit polyclonal
  • western blot; rat; fig 7
Abcam SREBF2 antibody (Abcam, ab28482) was used in western blot on rat samples (fig 7). Physiol Rep (2016) ncbi
domestic rabbit polyclonal
  • immunocytochemistry; human; fig s2
  • immunohistochemistry; human; 1:100; fig 6
Abcam SREBF2 antibody (abcam, 30682) was used in immunocytochemistry on human samples (fig s2) and in immunohistochemistry on human samples at 1:100 (fig 6). Oncotarget (2016) ncbi
Novus Biologicals
mouse monoclonal (1D2)
  • western blot; human; fig 2d
Novus Biologicals SREBF2 antibody (Novus, NBP1-54446) was used in western blot on human samples (fig 2d). Science (2019) ncbi
Active Motif
mouse monoclonal (IgG-1C6)
  • chromatin immunoprecipitation; human; fig 5
Active Motif SREBF2 antibody (Active Motif, 39941) was used in chromatin immunoprecipitation on human samples (fig 5). Mar Drugs (2016) ncbi
mouse monoclonal (IgG-1C6)
  • western blot; human; 1:25
Active Motif SREBF2 antibody (Active Motif, 39941) was used in western blot on human samples at 1:25. PLoS ONE (2014) ncbi
BD Biosciences
mouse monoclonal (IgG-1C6)
  • western blot; human; 1:250; loading ...; fig 5g
BD Biosciences SREBF2 antibody (BD Biosciences, 557037) was used in western blot on human samples at 1:250 (fig 5g). Nat Metab (2020) ncbi
mouse monoclonal (IgG-1C6)
  • western blot; human; loading ...; fig 4a
BD Biosciences SREBF2 antibody (BD Biosciences, 557037) was used in western blot on human samples (fig 4a). Cell Death Dis (2019) ncbi
mouse monoclonal (IgG-1C6)
  • chromatin immunoprecipitation; human
In order to study the regulation of Niemann-Pick C1 gene in human fibroblasts, BD Biosciences SREBF2 antibody (BD BioSciences, IgG-1C6) was used in chromatin immunoprecipitation on human samples . J Lipid Res (2008) ncbi
Articles Reviewed
  1. Sugiyama T, Murao N, Kadowaki H, Takao K, Miyakawa T, Matsushita Y, et al. ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function. iScience. 2021;24:102758 pubmed publisher
  2. Li D, Liu M, Li Z, Zheng G, Chen A, Zhao L, et al. Sterol-resistant SCAP Overexpression in Vascular Smooth Muscle Cells Accelerates Atherosclerosis by Increasing Local Vascular Inflammation through Activation of the NLRP3 Inflammasome in Mice. Aging Dis. 2021;12:747-763 pubmed publisher
  3. Shin S, Zhou H, He C, Wei Y, Wang Y, Shingu T, et al. Qki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency. Nat Commun. 2021;12:3005 pubmed publisher
  4. Zhang Z, Wen H, Peng B, Weng J, Zeng F. HFD-induced TRAF6 upregulation promotes liver cholesterol accumulation and fatty liver development via EZH2-mediated miR-429/PPARα axis. Mol Ther Nucleic Acids. 2021;24:711-727 pubmed publisher
  5. Muramatsu M, Osawa T, Miyamura Y, Nakagawa S, Tanaka T, Kodama T, et al. Loss of Down syndrome critical region-1 leads to cholesterol metabolic dysfunction that exaggerates hypercholesterolemia in ApoE-null background. J Biol Chem. 2021;296:100697 pubmed publisher
  6. Sun R, Hedl M, Abraham C. TNFSF15 Promotes Antimicrobial Pathways in Human Macrophages and These Are Modulated by TNFSF15 Disease-Risk Variants. Cell Mol Gastroenterol Hepatol. 2021;11:249-272 pubmed publisher
  7. Aregger M, Lawson K, Billmann M, Costanzo M, Tong A, Chan K, et al. Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism. Nat Metab. 2020;2:499-513 pubmed publisher
  8. Howell M, Green R, Khalil R, Foran E, Quarni W, Nair R, et al. Lung cancer cells survive epidermal growth factor receptor tyrosine kinase inhibitor exposure through upregulation of cholesterol synthesis. FASEB Bioadv. 2020;2:90-105 pubmed publisher
  9. Aldonza M, Ku J, Hong J, Kim D, Yu S, Lee M, et al. Prior acquired resistance to paclitaxel relays diverse EGFR-targeted therapy persistence mechanisms. Sci Adv. 2020;6:eaav7416 pubmed publisher
  10. Arenas F, Castro F, Núñez S, Gay G, Garcia Ruiz C, Fernandez Checa J. STARD1 and NPC1 expression as pathological markers associated with astrogliosis in post-mortem brains from patients with Alzheimer's disease and Down syndrome. Aging (Albany NY). 2020;12:571-592 pubmed publisher
  11. Yu H, Rimbert A, Palmer A, Toyohara T, Xia Y, Xia F, et al. GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis. Cell. 2019;179:1276-1288.e14 pubmed publisher
  12. Gu Q, Yang X, Lv J, Zhang J, Xia B, Kim J, et al. AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate. Science. 2019;363:1085-1088 pubmed publisher
  13. Göbel A, Breining D, Rauner M, Hofbauer L, Rachner T. Induction of 3-hydroxy-3-methylglutaryl-CoA reductase mediates statin resistance in breast cancer cells. Cell Death Dis. 2019;10:91 pubmed publisher
  14. Vienken H, Mabrouki N, Grabau K, Claas R, Rudowski A, Schömel N, et al. Characterization of cholesterol homeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts reveals a Niemann-Pick disease type C-like phenotype with enhanced lysosomal Ca2+ storage. Sci Rep. 2017;7:43575 pubmed publisher
  15. Serviddio G, Bellanti F, Villani R, Tamborra R, Zerbinati C, Blonda M, et al. Effects of dietary fatty acids and cholesterol excess on liver injury: A lipidomic approach. Redox Biol. 2016;9:296-305 pubmed publisher
  16. Ratovitski E. Tumor Protein (TP)-p53 Members as Regulators of Autophagy in Tumor Cells upon Marine Drug Exposure. Mar Drugs. 2016;14: pubmed publisher
  17. Zinkhan E, Zalla J, Carpenter J, Yu B, Yu X, Chan G, et al. Intrauterine growth restriction combined with a maternal high-fat diet increases hepatic cholesterol and low-density lipoprotein receptor activity in rats. Physiol Rep. 2016;4: pubmed publisher
  18. Li X, Wu J, Li Q, Shigemura K, Chung L, Huang W. SREBP-2 promotes stem cell-like properties and metastasis by transcriptional activation of c-Myc in prostate cancer. Oncotarget. 2016;7:12869-84 pubmed publisher
  19. Ochiai A, Miyata S, Shimizu M, Inoue J, Sato R. Piperine Induces Hepatic Low-Density Lipoprotein Receptor Expression through Proteolytic Activation of Sterol Regulatory Element-Binding Proteins. PLoS ONE. 2015;10:e0139799 pubmed publisher
  20. Wong T, Lin S, Leung L. The Flavone Luteolin Suppresses SREBP-2 Expression and Post-Translational Activation in Hepatic Cells. PLoS ONE. 2015;10:e0135637 pubmed publisher
  21. Wong T, Lin S, Leung L. The flavone apigenin blocks nuclear translocation of sterol regulatory element-binding protein-2 in the hepatic cells WRL-68. Br J Nutr. 2015;113:1844-52 pubmed publisher
  22. Daniëls V, Smans K, Royaux I, Chypre M, Swinnen J, Zaidi N. Cancer cells differentially activate and thrive on de novo lipid synthesis pathways in a low-lipid environment. PLoS ONE. 2014;9:e106913 pubmed publisher
  23. Fukushima M, Villar J, Tsai Morris C, Dufau M. Gonadotropin-regulated testicular RNA helicase (GRTH/DDX25), a negative regulator of luteinizing/chorionic gonadotropin hormone-induced steroidogenesis in Leydig cells: central role of steroidogenic acute regulatory protein (StAR). J Biol Chem. 2011;286:29932-40 pubmed publisher
  24. Garver W, Jelinek D, Francis G, Murphy B. The Niemann-Pick C1 gene is downregulated by feedback inhibition of the SREBP pathway in human fibroblasts. J Lipid Res. 2008;49:1090-102 pubmed publisher