This is a Validated Antibody Database (VAD) review about human SPOP, based on 5 published articles (read how Labome selects the articles), using SPOP antibody in all methods. It is aimed to help Labome visitors find the most suited SPOP antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
SPOP synonym: BTBD32; TEF2

Knockout validation
Abcam
domestic rabbit polyclonal
  • western blot knockout validation; human; loading ...; fig 2d, 2e
Abcam SPOP antibody (Abcam, 137537) was used in western blot knockout validation on human samples (fig 2d, 2e). Cell Death Differ (2022) ncbi
Abcam
domestic rabbit polyclonal
  • western blot knockout validation; human; loading ...; fig 2d, 2e
Abcam SPOP antibody (Abcam, 137537) was used in western blot knockout validation on human samples (fig 2d, 2e). Cell Death Differ (2022) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig s7f
Abcam SPOP antibody (Abcam, ab137537) was used in western blot on human samples (fig s7f). Mol Cancer (2021) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 1b
Abcam SPOP antibody (Abcam, ab137537) was used in western blot on human samples (fig 1b). Nat Med (2017) ncbi
Invitrogen
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 6e
Invitrogen SPOP antibody (Invitrogen, PA5-28522) was used in western blot on human samples (fig 6e). Cancer Discov (2022) ncbi
Santa Cruz Biotechnology
mouse monoclonal (B-8)
  • western blot; mouse; fig 1d
In order to investigate the regulation of prostate epithelial cell proliferation and MYC oncoprotein metabolism by E3 ubiquitin ligase adaptor speckle-type POZ protein, Santa Cruz Biotechnology SPOP antibody (Santa Cruz, SC-377206) was used in western blot on mouse samples (fig 1d). Oncogene (2017) ncbi
Articles Reviewed
  1. Chen S, Vedula R, Cuevas Navarro A, Lu B, Hogg S, Wang E, et al. Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation. Cancer Discov. 2022;12:2434-2453 pubmed publisher
  2. Fan Y, Hou T, Dan W, Zhu Y, Liu B, Wei Y, et al. ERK1/2 inhibits Cullin 3/SPOP-mediated PrLZ ubiquitination and degradation to modulate prostate cancer progression. Cell Death Differ. 2022;: pubmed publisher
  3. Liu Z, Wang T, She Y, Wu K, Gu S, Li L, et al. N6-methyladenosine-modified circIGF2BP3 inhibits CD8+ T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer. Mol Cancer. 2021;20:105 pubmed publisher
  4. Zhang P, Wang D, Zhao Y, Ren S, Gao K, Ye Z, et al. Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation. Nat Med. 2017;23:1055-1062 pubmed publisher
  5. Geng C, Kaochar S, Li M, Rajapakshe K, Fiskus W, Dong J, et al. SPOP regulates prostate epithelial cell proliferation and promotes ubiquitination and turnover of c-MYC oncoprotein. Oncogene. 2017;36:4767-4777 pubmed publisher