This is a Validated Antibody Database (VAD) review about human SORT1, based on 10 published articles (read how Labome selects the articles), using SORT1 antibody in all methods. It is aimed to help Labome visitors find the most suited SORT1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
SORT1 synonym: Gp95; LDLCQ6; NT3; NTR3; sortilin; 100 kDa NT receptor; glycoprotein 95; neurotensin receptor 3

Knockout validation
Abcam
rabbit polyclonal
  • western blot knockout validation; mouse; loading ...; fig 5g
Abcam SORT1 antibody (Abcam, ab16640) was used in western blot knockout validation on mouse samples (fig 5g). Exp Neurol (2018) ncbi
R&D Systems
goat polyclonal
  • western blot; human; fig 6
  • western blot knockout validation; mouse; fig 6
R&D Systems SORT1 antibody (RnD Systems, AF3154) was used in western blot on human samples (fig 6) and in western blot knockout validation on mouse samples (fig 6). J Biol Chem (2017) ncbi
Abcam
rabbit polyclonal
  • western blot knockout validation; mouse; loading ...; fig 5g
Abcam SORT1 antibody (Abcam, ab16640) was used in western blot knockout validation on mouse samples (fig 5g). Exp Neurol (2018) ncbi
rabbit polyclonal
  • immunocytochemistry; human; loading ...; fig 12a
  • western blot; human; loading ...; fig 12b
Abcam SORT1 antibody (Abcam, ab16640) was used in immunocytochemistry on human samples (fig 12a) and in western blot on human samples (fig 12b). Hum Mol Genet (2017) ncbi
rabbit monoclonal (EPR15010)
  • western blot; human; loading ...; fig 5b
In order to report the proteome of CADA-treated SUP-T1 human CD4+ T lymphocytes, Abcam SORT1 antibody (Abcam, EPR15010) was used in western blot on human samples (fig 5b). Mol Cell Proteomics (2017) ncbi
rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 3c
Abcam SORT1 antibody (Abcam, ab16640) was used in western blot on human samples at 1:1000 (fig 3c). Oncotarget (2016) ncbi
Santa Cruz Biotechnology
mouse monoclonal (E-9)
  • immunohistochemistry - frozen section; mouse; loading ...; fig s10
Santa Cruz Biotechnology SORT1 antibody (SantaCruz, sc-376576) was used in immunohistochemistry - frozen section on mouse samples (fig s10). EBioMedicine (2016) ncbi
LifeSpan Biosciences
rabbit polyclonal
  • immunohistochemistry - paraffin section; human
  • western blot; human
LifeSpan Biosciences SORT1 antibody (Lifespan Biosciences, LS-C94912) was used in immunohistochemistry - paraffin section on human samples and in western blot on human samples . Hum Mol Genet (2013) ncbi
R&D Systems
goat polyclonal
  • western blot; human; fig 6
  • western blot knockout validation; mouse; fig 6
R&D Systems SORT1 antibody (RnD Systems, AF3154) was used in western blot on human samples (fig 6) and in western blot knockout validation on mouse samples (fig 6). J Biol Chem (2017) ncbi
BD Biosciences
mouse monoclonal (48/Neurotensin Receptor 3)
  • western blot; mouse; fig 1d
BD Biosciences SORT1 antibody (BD Biosciences, 612100) was used in western blot on mouse samples (fig 1d). Eur J Immunol (2017) ncbi
EMD Millipore
rabbit polyclonal
  • immunocytochemistry; human; 1:500; fig 2
EMD Millipore SORT1 antibody (Millipore, AB9712) was used in immunocytochemistry on human samples at 1:500 (fig 2). J Neuroimmune Pharmacol (2016) ncbi
rabbit polyclonal
  • immunocytochemistry; human; 1:500
EMD Millipore SORT1 antibody (Millipore, AB9712) was used in immunocytochemistry on human samples at 1:500. J Neuroimmunol (2015) ncbi
Articles Reviewed
  1. Ruan C, Liu J, Yang M, Saadipour K, Zeng Y, Liao H, et al. Sortilin inhibits amyloid pathology by regulating non-specific degradation of APP. Exp Neurol. 2018;299:75-85 pubmed publisher
  2. Pirault J, Polyzos K, Petri M, Ketelhuth D, Bäck M, Hansson G. The inflammatory cytokine interferon-gamma inhibits sortilin-1 expression in hepatocytes via the JAK/STAT pathway. Eur J Immunol. 2017;47:1918-1924 pubmed publisher
  3. Tanaka Y, Suzuki G, Matsuwaki T, Hosokawa M, Serrano G, Beach T, et al. Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes. Hum Mol Genet. 2017;26:969-988 pubmed publisher
  4. Van Puyenbroeck V, Claeys E, Schols D, Bell T, Vermeire K. A Proteomic Survey Indicates Sortilin as a Secondary Substrate of the ER Translocation Inhibitor Cyclotriazadisulfonamide (CADA). Mol Cell Proteomics. 2017;16:157-167 pubmed publisher
  5. Li J, Wang Y, Matye D, Chavan H, Krishnamurthy P, Li F, et al. Sortilin 1 Modulates Hepatic Cholesterol Lipotoxicity in Mice via Functional Interaction with Liver Carboxylesterase 1. J Biol Chem. 2017;292:146-160 pubmed publisher
  6. Jian J, Tian Q, Hettinghouse A, Zhao S, Liu H, Wei J, et al. Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease. EBioMedicine. 2016;13:212-224 pubmed publisher
  7. Pinet S, Bessette B, Vedrenne N, Lacroix A, Richard L, Jauberteau M, et al. TrkB-containing exosomes promote the transfer of glioblastoma aggressiveness to YKL-40-inactivated glioblastoma cells. Oncotarget. 2016;7:50349-50364 pubmed publisher
  8. WILLIAMS K, KILLEBREW D, Clary G, Meeker R. Opposing Effects of NGF and proNGF on HIV Induced Macrophage Activation. J Neuroimmune Pharmacol. 2016;11:98-120 pubmed publisher
  9. WILLIAMS K, KILLEBREW D, Clary G, Seawell J, Meeker R. Differential regulation of macrophage phenotype by mature and pro-nerve growth factor. J Neuroimmunol. 2015;285:76-93 pubmed publisher
  10. Jones G, Bown M, Gretarsdottir S, Romaine S, Helgadottir A, Yu G, et al. A sequence variant associated with sortilin-1 (SORT1) on 1p13.3 is independently associated with abdominal aortic aneurysm. Hum Mol Genet. 2013;22:2941-7 pubmed publisher