This is a Validated Antibody Database (VAD) review about human SNAP, based on 36 published articles (read how Labome selects the articles), using SNAP antibody in all methods. It is aimed to help Labome visitors find the most suited SNAP antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
SNAP synonym: CMS18; RIC-4; RIC4; SEC9; SNAP; SNAP-25; SUP; bA416N4.2; dJ1068F16.2

Synaptic Systems
mouse monoclonal (71.1)
  • western blot; mouse; loading ...; fig 1b, 5h, s1g
Synaptic Systems SNAP antibody (Synaptic Systems, 111 011) was used in western blot on mouse samples (fig 1b, 5h, s1g). Sci Adv (2022) ncbi
mouse monoclonal (71.1)
  • immunocytochemistry; rat; loading ...
Synaptic Systems SNAP antibody (Synaptic Systems, 111 011) was used in immunocytochemistry on rat samples . Sci Adv (2021) ncbi
mouse monoclonal (71.1)
  • western blot; mouse; loading ...; fig 3g
Synaptic Systems SNAP antibody (Synaptic Systems, 111011) was used in western blot on mouse samples (fig 3g). Neuron (2021) ncbi
mouse monoclonal (71.1)
  • immunohistochemistry; mouse; 1:1000; loading ...
Synaptic Systems SNAP antibody (Synaptic Systems, 111 011) was used in immunohistochemistry on mouse samples at 1:1000. Physiol Rep (2020) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 2a
Synaptic Systems SNAP antibody (Synaptic Systems, 111002) was used in western blot on human samples (fig 2a). J Neurosci (2019) ncbi
mouse monoclonal (71.1)
  • western blot; mouse; loading ...; fig 1f
Synaptic Systems SNAP antibody (Synaptic Systems, 111011) was used in western blot on mouse samples (fig 1f). Science (2019) ncbi
domestic rabbit polyclonal
  • immunohistochemistry; rat; loading ...; fig 8a
Synaptic Systems SNAP antibody (Synaptic Systems, 111 002) was used in immunohistochemistry on rat samples (fig 8a). EMBO J (2018) ncbi
domestic rabbit polyclonal
  • western blot; mouse; fig s1c
Synaptic Systems SNAP antibody (Synaptic Systems, 111002) was used in western blot on mouse samples (fig s1c). Cell (2018) ncbi
mouse monoclonal (71.1)
  • western blot; mouse; 1:1000; fig 3i
Synaptic Systems SNAP antibody (Synaptic Systems, 71.1) was used in western blot on mouse samples at 1:1000 (fig 3i). Nat Commun (2017) ncbi
mouse monoclonal (71.2)
  • western blot; mouse; loading ...; fig 3a
Synaptic Systems SNAP antibody (Synaptic systems, 111111) was used in western blot on mouse samples (fig 3a). J Immunol Methods (2017) ncbi
mouse monoclonal (71.1)
  • western blot; mouse; loading ...; fig 4
  • immunocytochemistry; rat; loading ...; fig 8a
In order to generate an atoxic derivative of Botulism neurotoxin/C1 and assess whether it retains neuron-specific targeting without concomitant toxic host responses, Synaptic Systems SNAP antibody (Synaptic Systems, 111011) was used in western blot on mouse samples (fig 4) and in immunocytochemistry on rat samples (fig 8a). Sci Rep (2017) ncbi
mouse monoclonal (71.1)
  • western blot; rat; 1:1000; loading ...; fig 5a
In order to develop methods to study vesicle-associated proteins and exocytosis in stellate astrocytes, Synaptic Systems SNAP antibody (Synaptic Systems, 111011) was used in western blot on rat samples at 1:1000 (fig 5a). J Gen Physiol (2017) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 5e
In order to discover strain-dependent differences in presynaptic and postsynaptic function in basolateral amygdala neurons, Synaptic Systems SNAP antibody (Synaptic systems, 111 002) was used in western blot on mouse samples (fig 5e). J Neurosci (2016) ncbi
mouse monoclonal (71.1)
  • immunoprecipitation; rat; fig 4a
  • western blot; rat; 1:1000; fig 3a
Synaptic Systems SNAP antibody (Synaptic Systems, 111011) was used in immunoprecipitation on rat samples (fig 4a) and in western blot on rat samples at 1:1000 (fig 3a). PLoS ONE (2016) ncbi
mouse monoclonal (71.1)
  • immunohistochemistry; rat; 1:2000; fig 4
Synaptic Systems SNAP antibody (Synaptic System, 111011) was used in immunohistochemistry on rat samples at 1:2000 (fig 4). Alzheimers Res Ther (2016) ncbi
mouse monoclonal (71.1)
  • western blot; mouse; 1:1000; loading ...; fig 4e
Synaptic Systems SNAP antibody (Synaptic Systems, 111011) was used in western blot on mouse samples at 1:1000 (fig 4e). Mol Biol Cell (2016) ncbi
domestic rabbit polyclonal
  • western blot; mouse; fig 2
Synaptic Systems SNAP antibody (Synaptic Systems, 111002) was used in western blot on mouse samples (fig 2). Sci Rep (2016) ncbi
mouse monoclonal (71.1)
  • western blot; rat; fig 1
In order to characterize inhibition of clathrin-mediated and bulk endocytosis by synaptotagmin-11, Synaptic Systems SNAP antibody (Synaptic Systems, 111011) was used in western blot on rat samples (fig 1). EMBO Rep (2016) ncbi
Santa Cruz Biotechnology
mouse monoclonal (H-1)
  • western blot; mouse; 1:500; loading ...; fig 4h
Santa Cruz Biotechnology SNAP antibody (Santa Cruz, Sc-376713) was used in western blot on mouse samples at 1:500 (fig 4h). elife (2020) ncbi
mouse monoclonal (SP12)
  • western blot; mouse; loading ...; fig 5a
Santa Cruz Biotechnology SNAP antibody (Santa Cruz, SC-20038) was used in western blot on mouse samples (fig 5a). J Neurosci (2020) ncbi
mouse monoclonal (SP12)
  • immunoprecipitation; human; 1:50; loading ...; fig 5c
Santa Cruz Biotechnology SNAP antibody (Santa Cruz, SC20038) was used in immunoprecipitation on human samples at 1:50 (fig 5c). Proc Natl Acad Sci U S A (2018) ncbi
mouse monoclonal (SP12)
  • western blot; human; 1:300
Santa Cruz Biotechnology SNAP antibody (Santa Cruz, sc-20038) was used in western blot on human samples at 1:300. PLoS ONE (2015) ncbi
mouse monoclonal (H-1)
  • ELISA; human; tbl 4
Santa Cruz Biotechnology SNAP antibody (Santa Cruz, sc-376713) was used in ELISA on human samples (tbl 4). Neuropathol Appl Neurobiol (2015) ncbi
mouse monoclonal (4E203)
  • western blot; mouse
Santa Cruz Biotechnology SNAP antibody (Santa, sc-73044) was used in western blot on mouse samples . J Neurosci (2011) ncbi
BioLegend
mouse monoclonal (SMI 81)
  • western blot; mouse; loading ...; fig s1
BioLegend SNAP antibody (BioLegend, SMI 81) was used in western blot on mouse samples (fig s1). J Biol Chem (2019) ncbi
mouse monoclonal (SMI 81)
  • western blot; mouse; loading ...; fig ev2f
BioLegend SNAP antibody (Sternberger Monoclonals, SMI81) was used in western blot on mouse samples (fig ev2f). EMBO J (2019) ncbi
mouse monoclonal (SMI 81)
  • immunohistochemistry; mouse; loading ...; fig s6a
BioLegend SNAP antibody (BioLegend, SMI81) was used in immunohistochemistry on mouse samples (fig s6a). Nature (2017) ncbi
mouse monoclonal (SMI 81)
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 1c
  • immunoprecipitation; mouse; loading ...; fig 7c
  • western blot; mouse; loading ...; fig 7c
BioLegend SNAP antibody (Covance, SMI-81) was used in immunohistochemistry - paraffin section on mouse samples (fig 1c), in immunoprecipitation on mouse samples (fig 7c) and in western blot on mouse samples (fig 7c). J Cell Biol (2016) ncbi
mouse monoclonal (SMI 81)
  • western blot; human; 1:10,000; fig 6B
BioLegend SNAP antibody (Covance, SMI81) was used in western blot on human samples at 1:10,000 (fig 6B). Acta Neuropathol Commun (2015) ncbi
mouse monoclonal (SMI 81)
  • proximity ligation assay; mouse; fig 4
  • immunohistochemistry - frozen section; mouse; fig 4
BioLegend SNAP antibody (Covance, SMI-81R) was used in proximity ligation assay on mouse samples (fig 4) and in immunohistochemistry - frozen section on mouse samples (fig 4). PLoS ONE (2015) ncbi
mouse monoclonal (SMI 81)
  • western blot; mouse; fig 6
In order to test if presenilin and nicastrin regulate synaptic function in a gamma-secretase-dependent or -independent manner, BioLegend SNAP antibody (Sternberger Monoclonals, SMI81) was used in western blot on mouse samples (fig 6). Proc Natl Acad Sci U S A (2014) ncbi
Abcam
domestic goat polyclonal
  • immunocytochemistry; mouse; 1:100; fig 2c
Abcam SNAP antibody (Abcam, ab31281) was used in immunocytochemistry on mouse samples at 1:100 (fig 2c). Protein Cell (2021) ncbi
domestic rabbit monoclonal (EPR3275)
  • immunocytochemistry; human; 1:100; fig 6
In order to research differentiation of functional glutamatergic neurons from placenta-derived multipotent cells by knocking down of heat-shock protein 27, Abcam SNAP antibody (Abcam, AB109105) was used in immunocytochemistry on human samples at 1:100 (fig 6). Sci Rep (2016) ncbi
domestic rabbit monoclonal (EP3274)
  • western blot; human; 1:2000
In order to correlate TREM2 expression with neurodegenerative markers in Alzheimer's disease, Abcam SNAP antibody (Abcam, ab108990) was used in western blot on human samples at 1:2000. Brain Pathol (2015) ncbi
Invitrogen
mouse monoclonal (SP12)
  • western blot; human; loading ...; fig 4b
Invitrogen SNAP antibody (Thermo Fisher, MA5-17609) was used in western blot on human samples (fig 4b). Structure (2017) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D7B4)
  • western blot; mouse; loading ...; fig s2c
Cell Signaling Technology SNAP antibody (CST, 5308) was used in western blot on mouse samples (fig s2c). Theranostics (2020) ncbi
domestic rabbit monoclonal (D7B4)
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 1c
  • immunoprecipitation; mouse; loading ...; fig 7c
  • western blot; mouse; loading ...; fig 7c
Cell Signaling Technology SNAP antibody (Cell Signaling, 5308) was used in immunohistochemistry - paraffin section on mouse samples (fig 1c), in immunoprecipitation on mouse samples (fig 7c) and in western blot on mouse samples (fig 7c). J Cell Biol (2016) ncbi
Articles Reviewed
  1. Azarnia Tehran D, Kochlamazashvili G, Pampaloni N, Sposini S, Shergill J, Lehmann M, et al. Selective endocytosis of Ca2+-permeable AMPARs by the Alzheimer's disease risk factor CALM bidirectionally controls synaptic plasticity. Sci Adv. 2022;8:eabl5032 pubmed publisher
  2. Ivanova D, Dobson K, Gajbhiye A, Davenport E, Hacker D, Ultanir S, et al. Control of synaptic vesicle release probability via VAMP4 targeting to endolysosomes. Sci Adv. 2021;7: pubmed publisher
  3. Liang D, Xue Z, Xue J, Xie D, Xiong K, Zhou H, et al. Sinoatrial node pacemaker cells share dominant biological properties with glutamatergic neurons. Protein Cell. 2021;12:545-556 pubmed publisher
  4. Bele S, Girada S, Ray A, Gupta A, Oruganti S, Prakash Babu P, et al. MS-275, a class 1 histone deacetylase inhibitor augments glucagon-like peptide-1 receptor agonism to improve glycemic control and reduce obesity in diet-induced obese mice. elife. 2020;9: pubmed publisher
  5. Kuijpers M, Kochlamazashvili G, Stumpf A, Puchkov D, Swaminathan A, Lucht M, et al. Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum. Neuron. 2021;109:299-313.e9 pubmed publisher
  6. Arias Hervert E, Xu N, Njus M, Murphy G, Hou Y, Williams J, et al. Actions of Rab27B-GTPase on mammalian central excitatory synaptic transmission. Physiol Rep. 2020;8:e14428 pubmed publisher
  7. Zhang W, Zhou M, Lu W, Gong J, Gao F, Li Y, et al. CNTNAP4 deficiency in dopaminergic neurons initiates parkinsonian phenotypes. Theranostics. 2020;10:3000-3021 pubmed publisher
  8. Fan Q, He W, Gayen M, Benoit M, Luo X, Hu X, et al. Activated CX3CL1/Smad2 Signals Prevent Neuronal Loss and Alzheimer's Tau Pathology-Mediated Cognitive Dysfunction. J Neurosci. 2020;40:1133-1144 pubmed publisher
  9. Yao W, Tambini M, Liu X, D ADAMIO L. Tuning of glutamate, but not GABA, release by an intra-synaptic vesicles APP domain whose function can be modulated by β- or α-secretase cleavage. J Neurosci. 2019;: pubmed publisher
  10. Silverman J, Christy D, Shyu C, Moon K, Fernando S, Gidden Z, et al. CNS-derived extracellular vesicles from superoxide dismutase 1 (SOD1)G93A ALS mice originate from astrocytes and neurons and carry misfolded SOD1. J Biol Chem. 2019;294:3744-3759 pubmed publisher
  11. Awasthi A, Ramachandran B, Ahmed S, Benito E, Shinoda Y, Nitzan N, et al. Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting. Science. 2019;363: pubmed publisher
  12. Fossati G, Pozzi D, Canzi A, Mirabella F, Valentino S, Morini R, et al. Pentraxin 3 regulates synaptic function by inducing AMPA receptor clustering via ECM remodeling and β1-integrin. EMBO J. 2019;38: pubmed publisher
  13. Truckenbrodt S, Viplav A, Jähne S, Vogts A, Denker A, Wildhagen H, et al. Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission. EMBO J. 2018;37: pubmed publisher
  14. Wang Y, Figueiredo D, Sun X, Dong Z, Chen W, Cui W, et al. Controlling of glutamate release by neuregulin3 via inhibiting the assembly of the SNARE complex. Proc Natl Acad Sci U S A. 2018;115:2508-2513 pubmed publisher
  15. Liu C, Kershberg L, Wang J, Schneeberger S, Kaeser P. Dopamine Secretion Is Mediated by Sparse Active Zone-like Release Sites. Cell. 2018;172:706-718.e15 pubmed publisher
  16. Lüningschrör P, Binotti B, Dombert B, Heimann P, Pérez Lara A, Slotta C, et al. Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease. Nat Commun. 2017;8:678 pubmed publisher
  17. Yadirgi G, Stickings P, Rajagopal S, Liu Y, Sesardic D. Immuno-detection of cleaved SNAP-25 from differentiated mouse embryonic stem cells provides a sensitive assay for determination of botulinum A toxin and antitoxin potency. J Immunol Methods. 2017;451:90-99 pubmed publisher
  18. Wallrapp A, Riesenfeld S, Burkett P, Abdulnour R, Nyman J, Dionne D, et al. The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation. Nature. 2017;549:351-356 pubmed publisher
  19. Verardi R, Kim J, Ghirlando R, Banerjee A. Structural Basis for Substrate Recognition by the Ankyrin Repeat Domain of Human DHHC17 Palmitoyltransferase. Structure. 2017;25:1337-1347.e6 pubmed publisher
  20. Vazquez Cintron E, Beske P, Tenezaca L, Tran B, Oyler J, Glotfelty E, et al. Engineering Botulinum Neurotoxin C1 as a Molecular Vehicle for Intra-Neuronal Drug Delivery. Sci Rep. 2017;7:42923 pubmed publisher
  21. Wolfes A, Ahmed S, Awasthi A, Stahlberg M, Rajput A, Magruder D, et al. A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes. J Gen Physiol. 2017;149:149-170 pubmed publisher
  22. Gioia D, Alexander N, McCool B. Differential Expression of Munc13-2 Produces Unique Synaptic Phenotypes in the Basolateral Amygdala of C57BL/6J and DBA/2J Mice. J Neurosci. 2016;36:10964-10977 pubmed
  23. Takeuchi S, Iwama S, Takagi H, Kiyota A, Nakashima K, Izumida H, et al. Tomosyn Negatively Regulates Arginine Vasopressin Secretion in Embryonic Stem Cell-Derived Neurons. PLoS ONE. 2016;11:e0164544 pubmed publisher
  24. Kunii M, Ohara Imaizumi M, Takahashi N, Kobayashi M, Kawakami R, Kondoh Y, et al. Opposing roles for SNAP23 in secretion in exocrine and endocrine pancreatic cells. J Cell Biol. 2016;215:121-138 pubmed
  25. Zhang S, Wang P, Ren L, Hu C, Bi J. Protective effect of melatonin on soluble A?1-42-induced memory impairment, astrogliosis, and synaptic dysfunction via the Musashi1/Notch1/Hes1 signaling pathway in the rat hippocampus. Alzheimers Res Ther. 2016;8:40 pubmed publisher
  26. Toft Bertelsen T, Ziomkiewicz I, Houy S, Pinheiro P, Sørensen J. Regulation of Ca2+ channels by SNAP-25 via recruitment of syntaxin-1 from plasma membrane clusters. Mol Biol Cell. 2016;27:3329-3341 pubmed
  27. Cheng Y, Huang C, Lee Y, Tien L, Ku W, Chien R, et al. Knocking down of heat-shock protein 27 directs differentiation of functional glutamatergic neurons from placenta-derived multipotent cells. Sci Rep. 2016;6:30314 pubmed publisher
  28. Bodaleo F, Montenegro Venegas C, Henríquez D, Court F, Gonzalez Billault C. Microtubule-associated protein 1B (MAP1B)-deficient neurons show structural presynaptic deficiencies in vitro and altered presynaptic physiology. Sci Rep. 2016;6:30069 pubmed publisher
  29. Benítez B, Cairns N, Schmidt R, Morris J, Norton J, Cruchaga C, et al. Clinically early-stage CSPα mutation carrier exhibits remarkable terminal stage neuronal pathology with minimal evidence of synaptic loss. Acta Neuropathol Commun. 2015;3:73 pubmed publisher
  30. Wang C, Wang Y, Hu M, Chai Z, Wu Q, Huang R, et al. Synaptotagmin-11 inhibits clathrin-mediated and bulk endocytosis. EMBO Rep. 2016;17:47-63 pubmed publisher
  31. Zulliger R, Conley S, Mwoyosvi M, Stuck M, Azadi S, Naash M. SNAREs Interact with Retinal Degeneration Slow and Rod Outer Segment Membrane Protein-1 during Conventional and Unconventional Outer Segment Targeting. PLoS ONE. 2015;10:e0138508 pubmed publisher
  32. Tsukamoto K, Ozeki C, Kohda T, Tsuji T. CRISPR/Cas9-Mediated Genomic Deletion of the Beta-1, 4 N-acetylgalactosaminyltransferase 1 Gene in Murine P19 Embryonal Carcinoma Cells Results in Low Sensitivity to Botulinum Neurotoxin Type C. PLoS ONE. 2015;10:e0132363 pubmed publisher
  33. Sinclair L, Tayler H, Love S. Synaptic protein levels altered in vascular dementia. Neuropathol Appl Neurobiol. 2015;41:533-43 pubmed publisher
  34. Lue L, Schmitz C, Serrano G, Sue L, Beach T, Walker D. TREM2 Protein Expression Changes Correlate with Alzheimer's Disease Neurodegenerative Pathologies in Post-Mortem Temporal Cortices. Brain Pathol. 2015;25:469-80 pubmed publisher
  35. Lee S, Sharma M, S dhof T, Shen J. Synaptic function of nicastrin in hippocampal neurons. Proc Natl Acad Sci U S A. 2014;111:8973-8 pubmed publisher
  36. Kolesnikov A, Rikimaru L, Hennig A, Lukasiewicz P, Fliesler S, Govardovskii V, et al. G-protein betagamma-complex is crucial for efficient signal amplification in vision. J Neurosci. 2011;31:8067-77 pubmed publisher