This is a Validated Antibody Database (VAD) review about human SLC7A11, based on 26 published articles (read how Labome selects the articles), using SLC7A11 antibody in all methods. It is aimed to help Labome visitors find the most suited SLC7A11 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
SLC7A11 synonym: CCBR1; xCT

Knockout validation
Invitrogen
domestic rabbit polyclonal
  • western blot knockout validation; mouse; loading ...; fig 5h
  • immunohistochemistry; mouse; loading ...; fig 1e
  • western blot knockout validation; human; loading ...; fig 7e
  • immunohistochemistry; human; fig 7f
Invitrogen SLC7A11 antibody (Thermo Fisher Scientific, PA1-C16893) was used in western blot knockout validation on mouse samples (fig 5h), in immunohistochemistry on mouse samples (fig 1e), in western blot knockout validation on human samples (fig 7e) and in immunohistochemistry on human samples (fig 7f). Cell Metab (2019) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D2M7A)
  • western blot knockout validation; human; 1:4000; loading ...; fig 1f
Cell Signaling Technology SLC7A11 antibody (Cell Signaling Technology, 12691) was used in western blot knockout validation on human samples at 1:4000 (fig 1f). Nat Commun (2021) ncbi
Abcam
domestic rabbit monoclonal (EPR8290(2))
  • western blot; human; 1:1000; loading ...; fig 6b
  • immunohistochemistry - paraffin section; rat; 1:200; loading ...; fig 8b
Abcam SLC7A11 antibody (Abcam, ab175186) was used in western blot on human samples at 1:1000 (fig 6b) and in immunohistochemistry - paraffin section on rat samples at 1:200 (fig 8b). Dis Markers (2022) ncbi
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; human; 1:400; loading ...; fig 6b
  • western blot; human; loading ...; fig 6c
Abcam SLC7A11 antibody (Abcam, ab37185) was used in immunohistochemistry - paraffin section on human samples at 1:400 (fig 6b) and in western blot on human samples (fig 6c). Front Endocrinol (Lausanne) (2022) ncbi
domestic rabbit polyclonal
  • immunohistochemistry - frozen section; mouse; loading ...; fig 4d
  • western blot; mouse; loading ...; fig 3g
Abcam SLC7A11 antibody (Abcam, ab216876) was used in immunohistochemistry - frozen section on mouse samples (fig 4d) and in western blot on mouse samples (fig 3g). Redox Biol (2022) ncbi
domestic rabbit polyclonal
  • immunohistochemistry; mouse; 1:100; loading ...; fig 1e
  • western blot; human; fig 1c
Abcam SLC7A11 antibody (Abcam, ab37185) was used in immunohistochemistry on mouse samples at 1:100 (fig 1e) and in western blot on human samples (fig 1c). Front Mol Biosci (2021) ncbi
domestic rabbit monoclonal (EPR8290(2))
  • western blot; rat; loading ...; fig 4a, 4c
Abcam SLC7A11 antibody (Abcam, ab175186) was used in western blot on rat samples (fig 4a, 4c). Front Mol Biosci (2021) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:2000; fig s8i
Abcam SLC7A11 antibody (Abcam, ab37185) was used in western blot on mouse samples at 1:2000 (fig s8i). Nat Commun (2021) ncbi
domestic rabbit monoclonal (EPR8290(2))
  • immunohistochemistry; human; loading ...; fig 4c
  • western blot; human; loading ...; fig s4f
Abcam SLC7A11 antibody (Abcam, ab175186) was used in immunohistochemistry on human samples (fig 4c) and in western blot on human samples (fig s4f). Redox Biol (2021) ncbi
domestic rabbit monoclonal (EPR8290(2))
  • western blot; mouse; 1:500; loading ...; fig 3e
Abcam SLC7A11 antibody (Abcam, ab175186) was used in western blot on mouse samples at 1:500 (fig 3e). J Neuroinflammation (2020) ncbi
domestic rabbit monoclonal (EPR8290(2))
  • western blot; rat; loading ...; fig 6a
  • western blot; human; loading ...; fig 6a
Abcam SLC7A11 antibody (Abcam, ab175186) was used in western blot on rat samples (fig 6a) and in western blot on human samples (fig 6a). Cancer Lett (2018) ncbi
domestic rabbit polyclonal
In order to demonstrate the key role of essential amino acid transport in the control of mTORC1 and tumor growth caused by genetic disruption of the multifunctional CD98/LAT1 complex, Abcam SLC7A11 antibody (Abcam, ab37185) was used . Cancer Res (2016) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 4d
Abcam SLC7A11 antibody (Abcam, ab37185) was used in western blot on mouse samples (fig 4d). Oncotarget (2016) ncbi
domestic rabbit polyclonal
  • western blot; mouse; fig 2
In order to analyze antibodies to xCT (Slc7a11) comparatively, Abcam SLC7A11 antibody (Abcam, ab37185) was used in western blot on mouse samples (fig 2). J Comp Neurol (2016) ncbi
Novus Biologicals
domestic rabbit polyclonal
  • immunohistochemistry; mouse; 1:200; loading ...; fig 5a
Novus Biologicals SLC7A11 antibody (Novus Biologicals, nb300-318) was used in immunohistochemistry on mouse samples at 1:200 (fig 5a). Stem Cell Res Ther (2021) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:3000; loading ...
Novus Biologicals SLC7A11 antibody (Novusbio, NB300-318) was used in western blot on mouse samples at 1:3000. Cell Death Dis (2021) ncbi
domestic rabbit polyclonal
  • western blot; mouse; fig 2
In order to analyze antibodies to xCT (Slc7a11) comparatively, Novus Biologicals SLC7A11 antibody (Novus Biologicals, NB 300-318) was used in western blot on mouse samples (fig 2). J Comp Neurol (2016) ncbi
Invitrogen
domestic rabbit polyclonal
  • western blot knockout validation; mouse; loading ...; fig 5h
  • immunohistochemistry; mouse; loading ...; fig 1e
  • western blot knockout validation; human; loading ...; fig 7e
  • immunohistochemistry; human; fig 7f
Invitrogen SLC7A11 antibody (Thermo Fisher Scientific, PA1-C16893) was used in western blot knockout validation on mouse samples (fig 5h), in immunohistochemistry on mouse samples (fig 1e), in western blot knockout validation on human samples (fig 7e) and in immunohistochemistry on human samples (fig 7f). Cell Metab (2019) ncbi
domestic rabbit monoclonal (3HCLC)
  • western blot; human; 1:1000; loading ...; fig ex5g
Invitrogen SLC7A11 antibody (Thermo Fisher, 711589) was used in western blot on human samples at 1:1000 (fig ex5g). Nature (2019) ncbi
domestic rabbit polyclonal
  • western blot; mouse; fig 2
In order to analyze antibodies to xCT (Slc7a11) comparatively, Invitrogen SLC7A11 antibody (Thermo Fisher Scientific, PA1-16893) was used in western blot on mouse samples (fig 2). J Comp Neurol (2016) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D2M7A)
  • western blot; mouse; 1:1000; loading ...; fig 5b
Cell Signaling Technology SLC7A11 antibody (Cell Signaling Technology, 12691) was used in western blot on mouse samples at 1:1000 (fig 5b). Int J Mol Sci (2022) ncbi
domestic rabbit monoclonal (D2M7A)
  • western blot; human; loading ...; fig 3a
Cell Signaling Technology SLC7A11 antibody (Cell Signaling, 12691) was used in western blot on human samples (fig 3a). Sci Adv (2022) ncbi
domestic rabbit monoclonal (D2M7A)
  • western blot; human; loading ...; fig 1a
Cell Signaling Technology SLC7A11 antibody (Cell Signaling Technology, 12691 S) was used in western blot on human samples (fig 1a). iScience (2021) ncbi
domestic rabbit monoclonal (D2M7A)
  • western blot knockout validation; human; 1:4000; loading ...; fig 1f
Cell Signaling Technology SLC7A11 antibody (Cell Signaling Technology, 12691) was used in western blot knockout validation on human samples at 1:4000 (fig 1f). Nat Commun (2021) ncbi
domestic rabbit monoclonal (D2M7A)
  • western blot; human; 1:1000; loading ...; fig 5g
Cell Signaling Technology SLC7A11 antibody (CST, 12691S) was used in western blot on human samples at 1:1000 (fig 5g). elife (2021) ncbi
domestic rabbit monoclonal (D2M7A)
  • western blot; human; loading ...; fig s3a
Cell Signaling Technology SLC7A11 antibody (Cell Signaling, 12691) was used in western blot on human samples (fig s3a). Nat Commun (2020) ncbi
domestic rabbit monoclonal (D2M7A)
  • western blot; human; loading ...; fig 3i
Cell Signaling Technology SLC7A11 antibody (Cell Signaling, 12691) was used in western blot on human samples (fig 3i). Cancer Discov (2019) ncbi
domestic rabbit monoclonal (D2M7A)
  • western blot; human; 1:500; loading ...; fig 4a
Cell Signaling Technology SLC7A11 antibody (Cell Signaling Technology, 12691S) was used in western blot on human samples at 1:500 (fig 4a). Cell Death Dis (2019) ncbi
domestic rabbit monoclonal (D2M7A)
  • western blot; human; 1:1000; loading ...; fig 2g
Cell Signaling Technology SLC7A11 antibody (cell signaling, 12691) was used in western blot on human samples at 1:1000 (fig 2g). Nature (2019) ncbi
domestic rabbit monoclonal (D2M7A)
  • western blot; human; 1:5000; loading ...; fig 2a
Cell Signaling Technology SLC7A11 antibody (Cell Signaling, 12691) was used in western blot on human samples at 1:5000 (fig 2a). Nat Commun (2017) ncbi
domestic rabbit monoclonal (D2M7A)
  • western blot; human; fig 6a
Cell Signaling Technology SLC7A11 antibody (Cell Signaling, 12691) was used in western blot on human samples (fig 6a). Cell Death Dis (2016) ncbi
Articles Reviewed
  1. Zhao Y, Du Y, Gao Y, Xu Z, Zhao D, Yang M. ATF3 Regulates Osteogenic Function by Mediating Osteoblast Ferroptosis in Type 2 Diabetic Osteoporosis. Dis Markers. 2022;2022:9872243 pubmed publisher
  2. Stancic A, Velickovic K, Markelic M, Grigorov I, Saksida T, Savić N, et al. Involvement of Ferroptosis in Diabetes-Induced Liver Pathology. Int J Mol Sci. 2022;23: pubmed publisher
  3. Ji F, Fu X, Li G, He Q, Qiu X. FTO Prevents Thyroid Cancer Progression by SLC7A11 m6A Methylation in a Ferroptosis-Dependent Manner. Front Endocrinol (Lausanne). 2022;13:857765 pubmed publisher
  4. Dang G, Li T, Yang D, Yang G, Du X, Yang J, et al. T lymphocyte-derived extracellular vesicles aggravate abdominal aortic aneurysm by promoting macrophage lipid peroxidation and migration via pyruvate kinase muscle isozyme 2. Redox Biol. 2022;50:102257 pubmed publisher
  5. von M xe4 ssenhausen A, Zamora Gonzalez N, Maremonti F, Belavgeni A, Tonnus W, Meyer C, et al. Dexamethasone sensitizes to ferroptosis by glucocorticoid receptor-induced dipeptidase-1 expression and glutathione depletion. Sci Adv. 2022;8:eabl8920 pubmed publisher
  6. Guo X, Zhang H, Huang J, Wang S, Lu Y, Cheng B, et al. PIEZO1 Ion Channel Mediates Ionizing Radiation-Induced Pulmonary Endothelial Cell Ferroptosis via Ca2+/Calpain/VE-Cadherin Signaling. Front Mol Biosci. 2021;8:725274 pubmed publisher
  7. Ku C, Wuputra K, Kato K, Pan J, Li C, Tsai M, et al. Deletion of Jdp2 enhances Slc7a11 expression in Atoh-1 positive cerebellum granule cell progenitors in vivo. Stem Cell Res Ther. 2021;12:369 pubmed publisher
  8. Koppula P, Olszewski K, Zhang Y, Kondiparthi L, Liu X, Lei G, et al. KEAP1 deficiency drives glucose dependency and sensitizes lung cancer cells and tumors to GLUT inhibition. iScience. 2021;24:102649 pubmed publisher
  9. Chang B, Guan H, Wang X, Chen Z, Zhu W, Wei X, et al. Cox4i2 Triggers an Increase in Reactive Oxygen Species, Leading to Ferroptosis and Apoptosis in HHV7 Infected Schwann Cells. Front Mol Biosci. 2021;8:660072 pubmed publisher
  10. Wang Q, Bin C, Xue Q, Gao Q, Huang A, Wang K, et al. GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis. Cell Death Dis. 2021;12:426 pubmed publisher
  11. Bebber C, Thomas E, Stroh J, Chen Z, Androulidaki A, Schmitt A, et al. Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes. Nat Commun. 2021;12:2048 pubmed publisher
  12. Zhang Y, Swanda R, Nie L, Liu X, Wang C, Lee H, et al. mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation. Nat Commun. 2021;12:1589 pubmed publisher
  13. Zeitler L, Fiore A, Meyer C, Russier M, Zanella G, Suppmann S, et al. Anti-ferroptotic mechanism of IL4i1-mediated amino acid metabolism. elife. 2021;10: pubmed publisher
  14. Ma L, Chen T, Zhang X, Miao Y, Tian X, Yu K, et al. The m6A reader YTHDC2 inhibits lung adenocarcinoma tumorigenesis by suppressing SLC7A11-dependent antioxidant function. Redox Biol. 2021;38:101801 pubmed publisher
  15. Cao J, Chen X, Jiang L, Lu B, Yuan M, Zhu D, et al. DJ-1 suppresses ferroptosis through preserving the activity of S-adenosyl homocysteine hydrolase. Nat Commun. 2020;11:1251 pubmed publisher
  16. Charles Messance H, Blot G, Couturier A, Vignaud L, Touhami S, Beguier F, et al. IL-1β induces rod degeneration through the disruption of retinal glutamate homeostasis. J Neuroinflammation. 2020;17:1 pubmed publisher
  17. Lang X, Green M, Wang W, Yu J, Choi J, Jiang L, et al. Radiotherapy and Immunotherapy Promote Tumoral Lipid Oxidation and Ferroptosis via Synergistic Repression of SLC7A11. Cancer Discov. 2019;9:1673-1685 pubmed publisher
  18. Bi J, Yang S, Li L, Dai Q, Borcherding N, Wagner B, et al. Metadherin enhances vulnerability of cancer cells to ferroptosis. Cell Death Dis. 2019;10:682 pubmed publisher
  19. Choi W, Kim H, Kim M, Cinar R, Yi H, Eun H, et al. Glutamate Signaling in Hepatic Stellate Cells Drives Alcoholic Steatosis. Cell Metab. 2019;30:877-889.e7 pubmed publisher
  20. Wang W, Green M, Choi J, Gijon M, Kennedy P, Johnson J, et al. CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy. Nature. 2019;569:270-274 pubmed publisher
  21. Wang Z, Ding Y, Wang X, Lu S, Wang C, He C, et al. Pseudolaric acid B triggers ferroptosis in glioma cells via activation of Nox4 and inhibition of xCT. Cancer Lett. 2018;428:21-33 pubmed publisher
  22. Shin C, Mishra P, Watrous J, Carelli V, D Aurelio M, Jain M, et al. The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility. Nat Commun. 2017;8:15074 pubmed publisher
  23. Ma S, Henson E, Chen Y, Gibson S. Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells. Cell Death Dis. 2016;7:e2307 pubmed publisher
  24. Cormerais Y, Giuliano S, Lefloch R, Front B, Durivault J, Tambutte E, et al. Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth. Cancer Res. 2016;76:4481-92 pubmed publisher
  25. Li T, Liu X, Jiang L, MANFREDI J, Zha S, Gu W. Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging. Oncotarget. 2016;7:11838-49 pubmed publisher
  26. Van Liefferinge J, Bentea E, Demuyser T, Albertini G, Follin Arbelet V, Holmseth S, et al. Comparative analysis of antibodies to xCT (Slc7a11): Forewarned is forearmed. J Comp Neurol. 2016;524:1015-32 pubmed publisher