This is a Validated Antibody Database (VAD) review about human SIRT2, based on 16 published articles (read how Labome selects the articles), using SIRT2 antibody in all methods. It is aimed to help Labome visitors find the most suited SIRT2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
SIRT2 synonym: SIR2; SIR2L; SIR2L2

Knockout validation
Cell Signaling Technology
domestic rabbit monoclonal (D4O5O)
  • western blot; human; loading ...; fig 1h
  • western blot knockout validation; mouse; loading ...; fig 5a
Cell Signaling Technology SIRT2 antibody (Cell Signaling, 12650) was used in western blot on human samples (fig 1h) and in western blot knockout validation on mouse samples (fig 5a). Cell Rep (2017) ncbi
Abcam
domestic rabbit polyclonal
  • western blot; mouse; 1:500; loading ...; fig 1a, 1d
Abcam SIRT2 antibody (Abcam, ab67299) was used in western blot on mouse samples at 1:500 (fig 1a, 1d). elife (2022) ncbi
domestic rabbit monoclonal (EP1668Y)
  • western blot; mouse; 1:1000; loading ...; fig 1a
Abcam SIRT2 antibody (Abcam, ab51023) was used in western blot on mouse samples at 1:1000 (fig 1a). Aging Cell (2021) ncbi
domestic rabbit monoclonal
  • immunohistochemistry; mouse; loading ...; fig 2a
  • western blot; mouse; loading ...; fig 1g
Abcam SIRT2 antibody (Abcam, EPR20411) was used in immunohistochemistry on mouse samples (fig 2a) and in western blot on mouse samples (fig 1g). elife (2020) ncbi
domestic rabbit monoclonal
  • western blot; human; 1:1500; loading ...; fig 2d
Abcam SIRT2 antibody (Abcam, ab211033) was used in western blot on human samples at 1:1500 (fig 2d). Nucleic Acids Res (2020) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:500; loading ...; fig 3c
Abcam SIRT2 antibody (abcam, 67299) was used in western blot on mouse samples at 1:500 (fig 3c). elife (2019) ncbi
domestic rabbit polyclonal
  • immunohistochemistry; mouse; loading ...; fig 1a
Abcam SIRT2 antibody (Abcam, ab19388) was used in immunohistochemistry on mouse samples (fig 1a). Cell Rep (2017) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:500; fig 1b
Abcam SIRT2 antibody (Abcam, ab67299) was used in western blot on mouse samples at 1:500 (fig 1b). Sci Rep (2016) ncbi
Santa Cruz Biotechnology
mouse monoclonal (A-5)
  • immunoprecipitation; human; loading ...; fig 8b
Santa Cruz Biotechnology SIRT2 antibody (Santa Cruz, A-5) was used in immunoprecipitation on human samples (fig 8b). Mol Neurobiol (2016) ncbi
mouse monoclonal (A-5)
  • immunohistochemistry - paraffin section; human; 1:50; fig 1
  • western blot; human; fig 1
Santa Cruz Biotechnology SIRT2 antibody (Santa Cruz, sc-28298) was used in immunohistochemistry - paraffin section on human samples at 1:50 (fig 1) and in western blot on human samples (fig 1). PLoS ONE (2015) ncbi
Invitrogen
domestic rabbit polyclonal
  • immunocytochemistry; rat; loading ...; fig 2a
Invitrogen SIRT2 antibody (Thermo Fisher, PA5-20487) was used in immunocytochemistry on rat samples (fig 2a). J Clin Invest (2020) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D4O5O)
  • western blot; human; 1:1000; fig 4
Cell Signaling Technology SIRT2 antibody (Cell Signaling, 12650) was used in western blot on human samples at 1:1000 (fig 4). Int J Mol Sci (2022) ncbi
domestic rabbit monoclonal (D4S6J)
  • immunocytochemistry; mouse; loading ...; fig 1d
Cell Signaling Technology SIRT2 antibody (Cell Signaling Technology, 12672) was used in immunocytochemistry on mouse samples (fig 1d). Redox Biol (2021) ncbi
domestic rabbit monoclonal (D4O5O)
  • western blot; human; loading ...; fig s2
Cell Signaling Technology SIRT2 antibody (CST, 12650) was used in western blot on human samples (fig s2). Cell Commun Signal (2019) ncbi
domestic rabbit monoclonal (D4O5O)
  • western blot; mouse; 1:1000; loading ...; fig 1e
Cell Signaling Technology SIRT2 antibody (Cell Signaling, 12650) was used in western blot on mouse samples at 1:1000 (fig 1e). elife (2018) ncbi
domestic rabbit monoclonal (D4O5O)
  • western blot; human; loading ...; fig 1h
  • western blot knockout validation; mouse; loading ...; fig 5a
Cell Signaling Technology SIRT2 antibody (Cell Signaling, 12650) was used in western blot on human samples (fig 1h) and in western blot knockout validation on mouse samples (fig 5a). Cell Rep (2017) ncbi
domestic rabbit monoclonal (D4S6J)
  • western blot; human; loading ...; fig 7a
Cell Signaling Technology SIRT2 antibody (CST, 12672) was used in western blot on human samples (fig 7a). Cell Death Dis (2017) ncbi
domestic rabbit monoclonal (D4O5O)
  • western blot; human; 1:1000; loading ...; fig 1b
Cell Signaling Technology SIRT2 antibody (Cell Signaling, 12650) was used in western blot on human samples at 1:1000 (fig 1b). J Cell Sci (2016) ncbi
Articles Reviewed
  1. Buscham T, Eichel Vogel M, Steyer A, Jahn O, Strenzke N, Dardawal R, et al. Progressive axonopathy when oligodendrocytes lack the myelin protein CMTM5. elife. 2022;11: pubmed publisher
  2. Capitanio D, Moriggi M, Barbacini P, Torretta E, Moroni I, Blasevich F, et al. Molecular Fingerprint of BMD Patients Lacking a Portion in the Rod Domain of Dystrophin. Int J Mol Sci. 2022;23: pubmed publisher
  3. Zhao Y, Xie L, Shen C, Qi Q, Qin Y, Xing J, et al. SIRT2-knockdown rescues GARS-induced Charcot-Marie-Tooth neuropathy. Aging Cell. 2021;20:e13391 pubmed publisher
  4. Siegel D, Bersie S, Harris P, Di Francesco A, Armstrong M, Reisdorph N, et al. A redox-mediated conformational change in NQO1 controls binding to microtubules and α-tubulin acetylation. Redox Biol. 2021;39:101840 pubmed publisher
  5. Bhaskar A, Kumar S, Khan M, Singh A, Dwivedi V, Nandicoori V. Host sirtuin 2 as an immunotherapeutic target against tuberculosis. elife. 2020;9: pubmed publisher
  6. Zhang M, Du W, Acklin S, Jin S, Xia F. SIRT2 protects peripheral neurons from cisplatin-induced injury by enhancing nucleotide excision repair. J Clin Invest. 2020;130:2953-2965 pubmed publisher
  7. Liu H, Liu Y, Yang F, Zhang L, Zhang F, Hu X, et al. Acetylation of MORC2 by NAT10 regulates cell-cycle checkpoint control and resistance to DNA-damaging chemotherapy and radiotherapy in breast cancer. Nucleic Acids Res. 2020;48:3638-3656 pubmed publisher
  8. Zhou H, Zeng H, Yuan D, Ren J, Cheng S, Yu H, et al. NQO1 potentiates apoptosis evasion and upregulates XIAP via inhibiting proteasome-mediated degradation SIRT6 in hepatocellular carcinoma. Cell Commun Signal. 2019;17:168 pubmed publisher
  9. Erwig M, Patzig J, Steyer A, Dibaj P, Heilmann M, Heilmann I, et al. Anillin facilitates septin assembly to prevent pathological outfoldings of central nervous system myelin. elife. 2019;8: pubmed publisher
  10. Sarikhani M, Mishra S, Maity S, Kotyada C, Wolfgeher D, Gupta M, et al. SIRT2 deacetylase regulates the activity of GSK3 isoforms independent of inhibitory phosphorylation. elife. 2018;7: pubmed publisher
  11. Wang G, Li S, Gilbert J, Gritton H, Wang Z, Li Z, et al. Crucial Roles for SIRT2 and AMPA Receptor Acetylation in Synaptic Plasticity and Memory. Cell Rep. 2017;20:1335-1347 pubmed publisher
  12. Yuan H, Tan B, Gao S. Tenovin-6 impairs autophagy by inhibiting autophagic flux. Cell Death Dis. 2017;8:e2608 pubmed publisher
  13. Kaufmann T, Kukolj E, Brachner A, Beltzung E, Bruno M, Kostrhon S, et al. SIRT2 regulates nuclear envelope reassembly through ANKLE2 deacetylation. J Cell Sci. 2016;129:4607-4621 pubmed
  14. Thakurela S, Garding A, Jung R, Müller C, Goebbels S, White R, et al. The transcriptome of mouse central nervous system myelin. Sci Rep. 2016;6:25828 pubmed publisher
  15. Smith C, D Mello S. Cell and Context-Dependent Effects of the Heat Shock Protein DNAJB6 on Neuronal Survival. Mol Neurobiol. 2016;53:5628-39 pubmed publisher
  16. Grbesa I, Pajares M, Martínez Terroba E, Agorreta J, Mikecin A, Larrayoz M, et al. Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients. PLoS ONE. 2015;10:e0124670 pubmed publisher