This is a Validated Antibody Database (VAD) review about human SIGLECL1, based on 4 published articles (read how Labome selects the articles), using SIGLECL1 antibody in all methods. It is aimed to help Labome visitors find the most suited SIGLECL1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
SIGLECL1 synonym: C19orf75; SIGLEC23P; SIGLECP7; SIGLEC family-like protein 1; sialic acid binding Ig-like lectin, pseudogene 7

R&D Systems
sheep polyclonal
  • flow cytometry; human; loading ...; fig 1a
R&D Systems SIGLECL1 antibody (R&D Systems, AF5197) was used in flow cytometry on human samples (fig 1a). PLoS Pathog (2017) ncbi
rat monoclonal (645608)
  • flow cytometry; human; 1:20; loading ...
In order to find that leukocyte cell-derived chemotaxin 2 promotes expansion and mobilization of hematopoietic stem cells, R&D Systems SIGLECL1 antibody (R&D Systems, 645608) was used in flow cytometry on human samples at 1:20. Nat Commun (2016) ncbi
rat monoclonal (645608)
  • western blot; mouse; loading ...; fig 7a
R&D Systems SIGLECL1 antibody (R&D Systems, MAB5610) was used in western blot on mouse samples (fig 7a). J Biol Chem (2016) ncbi
sheep polyclonal
  • western blot; mouse; 1:500; loading ...; fig s4a
In order to find that central nervous system infiltration of peripheral monocytes correlates with improved motor neuron survival in a genetic amyotrophic lateral sclerosis mouse model, R&D Systems SIGLECL1 antibody (R&D Systems, AF5610) was used in western blot on mouse samples at 1:500 (fig s4a). Acta Neuropathol (2016) ncbi
Articles Reviewed
  1. Hammonds J, Beeman N, Ding L, Takushi S, Francis A, Wang J, et al. Siglec-1 initiates formation of the virus-containing compartment and enhances macrophage-to-T cell transmission of HIV-1. PLoS Pathog. 2017;13:e1006181 pubmed publisher
  2. Lu X, Chen Q, Rong Y, Yang G, Li C, Xu N, et al. LECT2 drives haematopoietic stem cell expansion and mobilization via regulating the macrophages and osteolineage cells. Nat Commun. 2016;7:12719 pubmed publisher
  3. Wu Y, Lan C, Ren D, Chen G. Induction of Siglec-1 by Endotoxin Tolerance Suppresses the Innate Immune Response by Promoting TGF-?1 Production. J Biol Chem. 2016;291:12370-82 pubmed publisher
  4. Zondler L, Müller K, Khalaji S, Bliederhäuser C, Ruf W, Grozdanov V, et al. Peripheral monocytes are functionally altered and invade the CNS in ALS patients. Acta Neuropathol. 2016;132:391-411 pubmed publisher