This is a Validated Antibody Database (VAD) review about human SETD2, based on 6 published articles (read how Labome selects the articles), using SETD2 antibody in all methods. It is aimed to help Labome visitors find the most suited SETD2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
SETD2 synonym: HBP231; HIF-1; HIP-1; HSPC069; HYPB; KMT3A; LLS; SET2; p231HBP

Knockout validation
Abcam
domestic rabbit monoclonal (EPR20927-67)
  • western blot knockout validation; mouse; 1:1000; loading ...; fig 2d
Abcam SETD2 antibody (Abcam, ab239350) was used in western blot knockout validation on mouse samples at 1:1000 (fig 2d). Nat Commun (2022) ncbi
Abcam
domestic rabbit polyclonal
  • western blot knockout validation; mouse; loading ...; fig e4a
Abcam SETD2 antibody (Abcam, ab31358) was used in western blot knockout validation on mouse samples (fig e4a). Nature (2019) ncbi
Abcam
domestic rabbit monoclonal (EPR20927-67)
  • western blot knockout validation; mouse; 1:1000; loading ...; fig 2d
Abcam SETD2 antibody (Abcam, ab239350) was used in western blot knockout validation on mouse samples at 1:1000 (fig 2d). Nat Commun (2022) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig s6b
Abcam SETD2 antibody (Abcam, ab31358) was used in western blot on mouse samples (fig s6b). iScience (2020) ncbi
domestic rabbit polyclonal
  • western blot knockout validation; mouse; loading ...; fig e4a
Abcam SETD2 antibody (Abcam, ab31358) was used in western blot knockout validation on mouse samples (fig e4a). Nature (2019) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 4a
Abcam SETD2 antibody (Abcam, ab31358) was used in western blot on human samples (fig 4a). Nat Genet (2017) ncbi
Invitrogen
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; human; 1:500; fig 2
In order to study clear cell renal cell carcinoma and snail heterogeneity, Invitrogen SETD2 antibody (Pierce, PA5-34934) was used in immunohistochemistry - paraffin section on human samples at 1:500 (fig 2). BMC Cancer (2016) ncbi
domestic rabbit polyclonal
In order to demonstrate that edimethylaminoparthenolide is an epigenetic modulator and acts in a NF-kappaB-dependent and -independent manner, Invitrogen SETD2 antibody (ThermoFisher Scientific, PA5-34934) was used . Cell Death Dis (2015) ncbi
Articles Reviewed
  1. Zhang Y, Fang Y, Tang Y, Han S, Jia J, Wan X, et al. SMYD5 catalyzes histone H3 lysine 36 trimethylation at promoters. Nat Commun. 2022;13:3190 pubmed publisher
  2. Chu S, Chabon J, Matovina C, Minehart J, Chen B, Zhang J, et al. Loss of H3K36 Methyltransferase SETD2 Impairs V(D)J Recombination during Lymphoid Development. iScience. 2020;23:100941 pubmed publisher
  3. Weinberg D, Papillon Cavanagh S, Chen H, Yue Y, Chen X, Rajagopalan K, et al. The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape. Nature. 2019;573:281-286 pubmed publisher
  4. Papillon Cavanagh S, Lu C, Gayden T, Mikael L, Bechet D, Karamboulas C, et al. Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas. Nat Genet. 2017;49:180-185 pubmed publisher
  5. Zaldumbide L, Erramuzpe A, Guarch R, Pulido R, Cortés J, López J. Snail heterogeneity in clear cell renal cell carcinoma. BMC Cancer. 2016;16:194 pubmed publisher
  6. Nakshatri H, Appaiah H, Anjanappa M, Gilley D, Tanaka H, Badve S, et al. NF-κB-dependent and -independent epigenetic modulation using the novel anti-cancer agent DMAPT. Cell Death Dis. 2015;6:e1608 pubmed publisher