This is a Validated Antibody Database (VAD) review about human SESN2, based on 9 published articles (read how Labome selects the articles), using SESN2 antibody in all methods. It is aimed to help Labome visitors find the most suited SESN2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
SESN2 synonym: HI95; SES2; SEST2; sestrin-2; hypoxia induced gene 95; hypoxia-induced

Knockout validation
Proteintech Group
rabbit polyclonal
  • western blot knockout validation; mouse; fig s7h
Proteintech Group SESN2 antibody (Proteintech, 10795-1-AP) was used in western blot knockout validation on mouse samples (fig s7h). Cell (2014) ncbi
Proteintech Group
rabbit polyclonal
  • immunoprecipitation; human; loading ...; fig 2b
Proteintech Group SESN2 antibody (Proteintech, 10795-1-AP) was used in immunoprecipitation on human samples (fig 2b). Nature (2017) ncbi
rabbit polyclonal
  • western blot; mouse; fig 7
  • western blot; human; fig 1
Proteintech Group SESN2 antibody (ProteinTech, 10795-1-AP) was used in western blot on mouse samples (fig 7) and in western blot on human samples (fig 1). Cell Signal (2016) ncbi
rabbit polyclonal
  • western blot; human; fig 7f
In order to analyze colitis and colon carcinogenesis and the role of sestrin2 in suppressing tumors, Proteintech Group SESN2 antibody (Proteintech, 10795-1-AP) was used in western blot on human samples (fig 7f). elife (2016) ncbi
rabbit polyclonal
  • western blot; human; 1:1000; fig s10
Proteintech Group SESN2 antibody (Proteintech, 10795-1-AP) was used in western blot on human samples at 1:1000 (fig s10). Nat Commun (2015) ncbi
rabbit polyclonal
  • western blot; rat; fig 5
Proteintech Group SESN2 antibody (ProteinTech Group, 10795-1-AP) was used in western blot on rat samples (fig 5). J Nutr (2015) ncbi
rabbit polyclonal
  • immunocytochemistry; human; 1:100; fig s3
  • western blot; human; fig 6
  • western blot; mouse; fig 6
Proteintech Group SESN2 antibody (Proteintech, 10795-1-AP) was used in immunocytochemistry on human samples at 1:100 (fig s3), in western blot on human samples (fig 6) and in western blot on mouse samples (fig 6). Mol Cancer Res (2016) ncbi
rabbit polyclonal
  • western blot knockout validation; mouse; fig s7h
Proteintech Group SESN2 antibody (Proteintech, 10795-1-AP) was used in western blot knockout validation on mouse samples (fig s7h). Cell (2014) ncbi
rabbit polyclonal
  • immunoprecipitation; mouse
  • immunocytochemistry; mouse
  • western blot; mouse
  • immunoprecipitation; human
  • immunocytochemistry; human
  • western blot; human
Proteintech Group SESN2 antibody (Proteintech, 10795-1-AP) was used in immunoprecipitation on mouse samples , in immunocytochemistry on mouse samples , in western blot on mouse samples , in immunoprecipitation on human samples , in immunocytochemistry on human samples and in western blot on human samples . FEBS J (2014) ncbi
Cell Signaling Technology
rabbit monoclonal (D1B6)
  • immunoprecipitation; human; loading ...; fig 2b
  • western blot; human; loading ...; fig 2b
Cell Signaling Technology SESN2 antibody (Cell Signaling, 8487) was used in immunoprecipitation on human samples (fig 2b) and in western blot on human samples (fig 2b). Nature (2017) ncbi
rabbit monoclonal (D1B6)
  • immunoprecipitation; human; 1:100; fig s10
Cell Signaling Technology SESN2 antibody (Cell signaling, 8487) was used in immunoprecipitation on human samples at 1:100 (fig s10). Nat Commun (2015) ncbi
Sigma-Aldrich
mouse monoclonal (3B8)
  • western blot; mouse; loading ...; fig 2d
  • western blot; human; loading ...; fig 3a
Sigma-Aldrich SESN2 antibody (Sigma, WH0083667M3) was used in western blot on mouse samples (fig 2d) and in western blot on human samples (fig 3a). Oncotarget (2016) ncbi
Articles Reviewed
  1. Peng M, Yin N, Li M. SZT2 dictates GATOR control of mTORC1 signalling. Nature. 2017;543:433-437 pubmed publisher
  2. Kimball S, Gordon B, Moyer J, Dennis M, Jefferson L. Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation. Cell Signal. 2016;28:896-906 pubmed publisher
  3. Saveljeva S, Cleary P, Mnich K, Ayo A, Pakos Zebrucka K, Patterson J, et al. Endoplasmic reticulum stress-mediated induction of SESTRIN 2 potentiates cell survival. Oncotarget. 2016;7:12254-66 pubmed publisher
  4. Ro S, Xue X, Ramakrishnan S, Cho C, Namkoong S, Jang I, et al. Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis. elife. 2016;5:e12204 pubmed publisher
  5. Kim H, An S, Ro S, Teixeira F, Park G, Kim C, et al. Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains. Nat Commun. 2015;6:10025 pubmed publisher
  6. Kimball S, Ravi S, Gordon B, Dennis M, Jefferson L. Amino Acid-Induced Activation of mTORC1 in Rat Liver Is Attenuated by Short-Term Consumption of a High-Fat Diet. J Nutr. 2015;145:2496-502 pubmed publisher
  7. Agarwal S, Bell C, Taylor S, Moran R. p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb. Mol Cancer Res. 2016;14:66-77 pubmed publisher
  8. Peng M, Yin N, Li M. Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling. Cell. 2014;159:122-133 pubmed publisher
  9. Ro S, Semple I, Park H, Park H, Park H, Kim M, et al. Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1. FEBS J. 2014;281:3816-27 pubmed publisher