This is a Validated Antibody Database (VAD) review about human SAV1, based on 13 published articles (read how Labome selects the articles), using SAV1 antibody in all methods. It is aimed to help Labome visitors find the most suited SAV1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
SAV1 synonym: SAV; WW45; WWP4

Knockout validation
Santa Cruz Biotechnology
mouse monoclonal (JJ-6)
  • western blot knockout validation; human; loading ...; fig 3b
Santa Cruz Biotechnology SAV1 antibody (Santa Cruz, sc-101205) was used in western blot knockout validation on human samples (fig 3b). elife (2020) ncbi
Cell Signaling Technology
domestic rabbit polyclonal
  • western blot knockout validation; human; 1:2000; loading ...; fig 4c
Cell Signaling Technology SAV1 antibody (Cell Signaling, 3507) was used in western blot knockout validation on human samples at 1:2000 (fig 4c). Nat Commun (2021) ncbi
Santa Cruz Biotechnology
mouse monoclonal (JJ-6)
  • western blot knockout validation; human; loading ...; fig 3b
Santa Cruz Biotechnology SAV1 antibody (Santa Cruz, sc-101205) was used in western blot knockout validation on human samples (fig 3b). elife (2020) ncbi
mouse monoclonal (F-5)
  • western blot; human; loading ...; fig 2a
Santa Cruz Biotechnology SAV1 antibody (Santa Cruz Biotechnology, sc-374366) was used in western blot on human samples (fig 2a). Cancer Res (2017) ncbi
mouse monoclonal (JJ-6)
  • immunohistochemistry; mouse; 1:200
In order to study the repression of adult heart regeneration by Hippo signaling, Santa Cruz Biotechnology SAV1 antibody (Santa Cruz, sc-101205) was used in immunohistochemistry on mouse samples at 1:200. Development (2013) ncbi
Abnova
mouse monoclonal (3B2)
  • immunohistochemistry - paraffin section; mouse; 1:400; fig 1
In order to study a kidney-specific knockout of Sav1 in the mouse suppresses the Hippo pathway which promotes hyperproliferation of renal tubular epithelium, Abnova SAV1 antibody (Abnova, H00060485-M02) was used in immunohistochemistry - paraffin section on mouse samples at 1:400 (fig 1). J Pathol (2016) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D6M6X)
  • western blot; mouse; 1:1000; loading ...; fig s1b, s3a
Cell Signaling Technology SAV1 antibody (CST, 13301) was used in western blot on mouse samples at 1:1000 (fig s1b, s3a). Aging Cell (2021) ncbi
domestic rabbit monoclonal (D6M6X)
  • western blot; mouse; 1:1000; loading ...; fig 3d
Cell Signaling Technology SAV1 antibody (Cell Signaling, 13301) was used in western blot on mouse samples at 1:1000 (fig 3d). J Clin Invest (2021) ncbi
domestic rabbit polyclonal
  • western blot knockout validation; human; 1:2000; loading ...; fig 4c
Cell Signaling Technology SAV1 antibody (Cell Signaling, 3507) was used in western blot knockout validation on human samples at 1:2000 (fig 4c). Nat Commun (2021) ncbi
domestic rabbit monoclonal (D6M6X)
  • western blot; human; loading ...; fig 9a
Cell Signaling Technology SAV1 antibody (Cell Signaling, 13301) was used in western blot on human samples (fig 9a). Oncotarget (2017) ncbi
domestic rabbit monoclonal (D6M6X)
  • western blot; human; loading ...; fig 3d
Cell Signaling Technology SAV1 antibody (Cell Signaling, 13301) was used in western blot on human samples (fig 3d). Stem Cells Dev (2017) ncbi
domestic rabbit monoclonal (D6M6X)
  • western blot; human; loading ...; fig 4
Cell Signaling Technology SAV1 antibody (Cell Signaling, 13301) was used in western blot on human samples (fig 4). Mol Clin Oncol (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 1
Cell Signaling Technology SAV1 antibody (Cell signaling, 3507) was used in western blot on human samples (fig 1). J Biol Chem (2016) ncbi
domestic rabbit monoclonal (D6M6X)
  • western blot; human; 1:2000; fig 6
Cell Signaling Technology SAV1 antibody (Cell signaling, 13301) was used in western blot on human samples at 1:2000 (fig 6). Nat Commun (2015) ncbi
domestic rabbit monoclonal (D6M6X)
  • western blot; rat; 1:5000
Cell Signaling Technology SAV1 antibody (Cell Signaling, 13301) was used in western blot on rat samples at 1:5000. Nat Cell Biol (2015) ncbi
Articles Reviewed
  1. Xu X, Shen X, Wang J, Feng W, Wang M, Miao X, et al. YAP prevents premature senescence of astrocytes and cognitive decline of Alzheimer's disease through regulating CDK6 signaling. Aging Cell. 2021;20:e13465 pubmed publisher
  2. Tamura T, Kodama T, Sato K, Murai K, Yoshioka T, Shigekawa M, et al. Dysregulation of PI3K and Hippo signaling pathways synergistically induces chronic pancreatitis via CTGF upregulation. J Clin Invest. 2021;131: pubmed publisher
  3. Dai M, Yan G, Wang N, Daliah G, Edick A, Poulet S, et al. In vivo genome-wide CRISPR screen reveals breast cancer vulnerabilities and synergistic mTOR/Hippo targeted combination therapy. Nat Commun. 2021;12:3055 pubmed publisher
  4. Bae S, Ni L, Luo X. STK25 suppresses Hippo signaling by regulating SAV1-STRIPAK antagonism. elife. 2020;9: pubmed publisher
  5. Toloczko A, Guo F, Yuen H, Wen Q, Wood S, Ong Y, et al. Deubiquitinating Enzyme USP9X Suppresses Tumor Growth via LATS Kinase and Core Components of the Hippo Pathway. Cancer Res. 2017;77:4921-4933 pubmed publisher
  6. Kapil S, Sharma B, Patil M, Elattar S, Yuan J, Hou S, et al. The cell polarity protein Scrib functions as a tumor suppressor in liver cancer. Oncotarget. 2017;8:26515-26531 pubmed publisher
  7. Chorzalska A, Kim J, Roder K, Tepper A, Ahsan N, Rao R, et al. Long-Term Exposure to Imatinib Mesylate Downregulates Hippo Pathway and Activates YAP in a Model of Chronic Myelogenous Leukemia. Stem Cells Dev. 2017;26:656-677 pubmed publisher
  8. Galoian K, Luo S, Qureshi A, Patel P, Price R, Morse A, et al. Effect of cytostatic proline rich polypeptide-1 on tumor suppressors of inflammation pathway signaling in chondrosarcoma. Mol Clin Oncol. 2016;5:618-624 pubmed
  9. Chen X, Stauffer S, Chen Y, Dong J. Ajuba Phosphorylation by CDK1 Promotes Cell Proliferation and Tumorigenesis. J Biol Chem. 2016;291:14761-72 pubmed publisher
  10. Kai T, Tsukamoto Y, Hijiya N, Tokunaga A, Nakada C, Uchida T, et al. Kidney-specific knockout of Sav1 in the mouse promotes hyperproliferation of renal tubular epithelium through suppression of the Hippo pathway. J Pathol. 2016;239:97-108 pubmed publisher
  11. Meng Z, Moroishi T, Mottier Pavie V, Plouffe S, Hansen C, Hong A, et al. MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway. Nat Commun. 2015;6:8357 pubmed publisher
  12. Iglesias Bartolomé R, Torres D, Marone R, Feng X, Martin D, Simaan M, et al. Inactivation of a Gα(s)-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis. Nat Cell Biol. 2015;17:793-803 pubmed publisher
  13. Heallen T, Morikawa Y, Leach J, Tao G, Willerson J, Johnson R, et al. Hippo signaling impedes adult heart regeneration. Development. 2013;140:4683-90 pubmed publisher