This is a Validated Antibody Database (VAD) review about human RPS6KA3, based on 28 published articles (read how Labome selects the articles), using RPS6KA3 antibody in all methods. It is aimed to help Labome visitors find the most suited RPS6KA3 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
RPS6KA3 synonym: CLS; HU-3; ISPK-1; MAPKAPK1B; MRX19; RSK; RSK2; S6K-alpha3; p90-RSK2; pp90RSK2

Santa Cruz Biotechnology
mouse monoclonal (E-1)
  • western blot; human; loading ...; fig 2e
Santa Cruz Biotechnology RPS6KA3 antibody (Santa Cruz Biotechnology, SC-9986) was used in western blot on human samples (fig 2e). Int J Mol Sci (2019) ncbi
mouse monoclonal (C-6)
  • immunohistochemistry; human; loading ...; fig 1e
Santa Cruz Biotechnology RPS6KA3 antibody (Santa Cruz, SC-377501) was used in immunohistochemistry on human samples (fig 1e). Cell Death Dis (2018) ncbi
mouse monoclonal (E-1)
  • western blot; human; fig 1a
Santa Cruz Biotechnology RPS6KA3 antibody (Santa Cruz, sc-9986) was used in western blot on human samples (fig 1a). Exp Mol Med (2016) ncbi
mouse monoclonal (E-1)
  • western blot; human; fig 4
In order to determine how sensitivity is restored in resistant ovarian cancer cells by targeting the Ras-MAPK pathway by miR-634, Santa Cruz Biotechnology RPS6KA3 antibody (Santa Cruz, SC-9986) was used in western blot on human samples (fig 4). Mol Cancer (2015) ncbi
mouse monoclonal (E-1)
  • western blot; human
Santa Cruz Biotechnology RPS6KA3 antibody (Santa Cruz, sc-9986) was used in western blot on human samples . Cell Signal (2014) ncbi
LifeSpan Biosciences
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; human; 1:200; loading ...; fig 6e, 6f
LifeSpan Biosciences RPS6KA3 antibody (Life Span BioSciences, LS-B7708) was used in immunohistochemistry - paraffin section on human samples at 1:200 (fig 6e, 6f). Oncotarget (2016) ncbi
Cell Signaling Technology
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...
Cell Signaling Technology RPS6KA3 antibody (Cell signaling, 9344) was used in western blot on mouse samples at 1:1000. Nature (2019) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig s1a
Cell Signaling Technology RPS6KA3 antibody (Cell Signaling, 9346) was used in western blot on human samples (fig s1a). Breast Cancer Res (2019) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig s2f
Cell Signaling Technology RPS6KA3 antibody (Cell signaling, 9344) was used in western blot on human samples (fig s2f). Cell Death Dis (2018) ncbi
domestic rabbit polyclonal
  • other; human; loading ...; fig 4c
Cell Signaling Technology RPS6KA3 antibody (Cell Signaling, 9346) was used in other on human samples (fig 4c). Cancer Cell (2018) ncbi
domestic rabbit monoclonal (9D9)
  • western blot; human; fig 6d
Cell Signaling Technology RPS6KA3 antibody (Cell Signaling, 9335) was used in western blot on human samples (fig 6d). Cell (2018) ncbi
domestic rabbit monoclonal (D21B2)
  • western blot; human; loading ...; fig 2d
Cell Signaling Technology RPS6KA3 antibody (Cell Signaling, 5528) was used in western blot on human samples (fig 2d). Mol Cell Proteomics (2018) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 4a
Cell Signaling Technology RPS6KA3 antibody (Cell Signaling, 9344) was used in western blot on mouse samples (fig 4a). J Biol Chem (2018) ncbi
domestic rabbit monoclonal (9D9)
  • western blot; human; loading ...; fig 3a
Cell Signaling Technology RPS6KA3 antibody (Cell Signaling, 9335) was used in western blot on human samples (fig 3a). J Biol Chem (2017) ncbi
domestic rabbit polyclonal
  • reverse phase protein lysate microarray; human; loading ...; fig st6
In order to characterize the molecular identity of uterine carcinosarcomas., Cell Signaling Technology RPS6KA3 antibody (CST, 9344) was used in reverse phase protein lysate microarray on human samples (fig st6). Cancer Cell (2017) ncbi
domestic rabbit polyclonal
  • immunocytochemistry; human; loading ...; fig s1
In order to use machine-learning modeling with high-throughput cellular imaging to predict cellular sensitivity to tumor necrosis factor alpha, Cell Signaling Technology RPS6KA3 antibody (Cell Signaling, 9346) was used in immunocytochemistry on human samples (fig s1). Sci Rep (2017) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 2a
Cell Signaling Technology RPS6KA3 antibody (cell signalling, 9344) was used in western blot on mouse samples (fig 2a). Proc Natl Acad Sci U S A (2017) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig S8
Cell Signaling Technology RPS6KA3 antibody (Cell Signaling, 9344) was used in western blot on human samples (fig S8). Oncotarget (2016) ncbi
domestic rabbit monoclonal (9D9)
  • western blot; human; loading ...; fig 4a
Cell Signaling Technology RPS6KA3 antibody (Cell Signaling, 9335) was used in western blot on human samples (fig 4a). Oncotarget (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:200; fig st1
In order to identify and characterize alterations in signal transduction that occur during the development Lapatinib resistance, Cell Signaling Technology RPS6KA3 antibody (Cell Signaling, 9341) was used in western blot on human samples at 1:200 (fig st1). Nat Commun (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 1d
Cell Signaling Technology RPS6KA3 antibody (cell signalling, 9344) was used in western blot on human samples at 1:1000 (fig 1d). Oncotarget (2016) ncbi
domestic rabbit monoclonal (9D9)
  • western blot; human; fig 3
Cell Signaling Technology RPS6KA3 antibody (Cell signaling, 9335) was used in western blot on human samples (fig 3). FASEB J (2016) ncbi
domestic rabbit polyclonal
  • western blot; mouse; fig 3
Cell Signaling Technology RPS6KA3 antibody (Cell Signaling Tech, 9346) was used in western blot on mouse samples (fig 3). Sci Rep (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 8c
Cell Signaling Technology RPS6KA3 antibody (Cell Signaling, 9344) was used in western blot on human samples (fig 8c). J Biol Chem (2016) ncbi
domestic rabbit polyclonal
  • western blot; mouse; fig 3
In order to analyze the rescue of intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation due to ERK5 signaling, Cell Signaling Technology RPS6KA3 antibody (Cell signaling, 9344) was used in western blot on mouse samples (fig 3). Nat Commun (2016) ncbi
domestic rabbit polyclonal
  • immunocytochemistry; human; 1:200; fig 4
Cell Signaling Technology RPS6KA3 antibody (Cell Signaling Tech, 9341) was used in immunocytochemistry on human samples at 1:200 (fig 4). Aging (Albany NY) (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 4
Cell Signaling Technology RPS6KA3 antibody (Cell Signaling Technology, 9341) was used in western blot on human samples (fig 4). Cell Commun Signal (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 6
In order to study signal transduction pathways that result in L-plastin Ser5 phosphorylation using 4 human breast cancer cell lines, Cell Signaling Technology RPS6KA3 antibody (Cell Signaling Technology, 9340) was used in western blot on human samples (fig 6). FASEB J (2016) ncbi
domestic rabbit monoclonal (9D9)
  • western blot; mouse; fig 4
In order to learn the requirement for embryonic poly(A)-binding protein (EPAB) in female mice to provide granulosa cell EGF signaling and cumulus expansion, Cell Signaling Technology RPS6KA3 antibody (Cell Signaling Technology, 9335p) was used in western blot on mouse samples (fig 4). Endocrinology (2016) ncbi
domestic rabbit monoclonal (9D9)
  • western blot; human; 1:1000; loading ...; fig 3e
In order to identify and study roles for MAP3K8 in high-grade serous ovarian carcinomas, Cell Signaling Technology RPS6KA3 antibody (Cell Signalling, 9335) was used in western blot on human samples at 1:1000 (fig 3e). Nat Commun (2015) ncbi
domestic rabbit monoclonal (D21B2)
  • immunocytochemistry; human; 1:75
  • western blot; human
Cell Signaling Technology RPS6KA3 antibody (Cell Signaling Technology, 5528) was used in immunocytochemistry on human samples at 1:75 and in western blot on human samples . Biochim Biophys Acta (2014) ncbi
domestic rabbit monoclonal (9D9)
  • western blot; human
Cell Signaling Technology RPS6KA3 antibody (Cell Signaling Technology, 9335) was used in western blot on human samples . Biochim Biophys Acta (2014) ncbi
Articles Reviewed
  1. Hamilton W, Mosesson Y, Monteiro R, Emdal K, Knudsen T, Francavilla C, et al. Dynamic lineage priming is driven via direct enhancer regulation by ERK. Nature. 2019;: pubmed publisher
  2. Yoo S, Lee C, An H, Lee J, Lee H, Kang H, et al. RSK2-Mediated ELK3 Activation Enhances Cell Transformation and Breast Cancer Cell Growth by Regulation of c-fos Promoter Activity. Int J Mol Sci. 2019;20: pubmed publisher
  3. Greer Y, Gilbert S, Gril B, Narwal R, Peacock Brooks D, Tice D, et al. MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer. Breast Cancer Res. 2019;21:27 pubmed publisher
  4. Lee C, Moon S, Jeong J, Lee S, Lee M, Yoo S, et al. Kaempferol targeting on the fibroblast growth factor receptor 3-ribosomal S6 kinase 2 signaling axis prevents the development of rheumatoid arthritis. Cell Death Dis. 2018;9:401 pubmed publisher
  5. Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher
  6. Su S, Chen J, Yao H, Liu J, Yu S, Lao L, et al. CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness. Cell. 2018;172:841-856.e16 pubmed publisher
  7. Kostas M, Haugsten E, Zhen Y, Sørensen V, Szybowska P, Fiorito E, et al. Protein Tyrosine Phosphatase Receptor Type G (PTPRG) Controls Fibroblast Growth Factor Receptor (FGFR) 1 Activity and Influences Sensitivity to FGFR Kinase Inhibitors. Mol Cell Proteomics. 2018;17:850-870 pubmed publisher
  8. Sutavani R, Phair I, Barker R, McFarlane A, Shpiro N, Lang S, et al. Differential control of Toll-like receptor 4-induced interleukin-10 induction in macrophages and B cells reveals a role for p90 ribosomal S6 kinases. J Biol Chem. 2018;293:2302-2317 pubmed publisher
  9. Juhasz A, Markel S, Gaur S, Liu H, Lu J, Jiang G, et al. NADPH oxidase 1 supports proliferation of colon cancer cells by modulating reactive oxygen species-dependent signal transduction. J Biol Chem. 2017;292:7866-7887 pubmed publisher
  10. Cherniack A, Shen H, Walter V, Stewart C, Murray B, Bowlby R, et al. Integrated Molecular Characterization of Uterine Carcinosarcoma. Cancer Cell. 2017;31:411-423 pubmed publisher
  11. Loo L, Bougen Zhukov N, Tan W. Early spatiotemporal-specific changes in intermediate signals are predictive of cytotoxic sensitivity to TNFα and co-treatments. Sci Rep. 2017;7:43541 pubmed publisher
  12. Kidger A, Rushworth L, Stellzig J, Davidson J, Bryant C, Bayley C, et al. Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling. Proc Natl Acad Sci U S A. 2017;114:E317-E326 pubmed publisher
  13. Piasecka D, Kitowska K, Czaplinska D, Mieczkowski K, Mieszkowska M, Turczyk L, et al. Fibroblast growth factor signalling induces loss of progesterone receptor in breast cancer cells. Oncotarget. 2016;7:86011-86025 pubmed publisher
  14. Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  15. Krepler C, Xiao M, Samanta M, Vultur A, Chen H, Brafford P, et al. Targeting Notch enhances the efficacy of ERK inhibitors in BRAF-V600E melanoma. Oncotarget. 2016;7:71211-71222 pubmed publisher
  16. Park Y, Nam H, Do M, Lee J. The p90 ribosomal S6 kinase 2 specifically affects mitotic progression by regulating the basal level, distribution and stability of mitotic spindles. Exp Mol Med. 2016;48:e250 pubmed publisher
  17. Subramaniam S, Ozdener M, Abdoul Azize S, Saito K, Malik B, Maquart G, et al. ERK1/2 activation in human taste bud cells regulates fatty acid signaling and gustatory perception of fat in mice and humans. FASEB J. 2016;30:3489-3500 pubmed
  18. Park J, Xu X, Cho S, Hur K, Lee M, Kersten S, et al. CREBH-FGF21 axis improves hepatic steatosis by suppressing adipose tissue lipolysis. Sci Rep. 2016;6:27938 pubmed publisher
  19. Zhou B, Ritt D, Morrison D, Der C, Cox A. Protein Kinase CK2? Maintains Extracellular Signal-regulated Kinase (ERK) Activity in a CK2? Kinase-independent Manner to Promote Resistance to Inhibitors of RAF and MEK but Not ERK in BRAF Mutant Melanoma. J Biol Chem. 2016;291:17804-15 pubmed publisher
  20. de Jong P, Taniguchi K, Harris A, Bertin S, Takahashi N, Duong J, et al. ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation. Nat Commun. 2016;7:11551 pubmed publisher
  21. Moiseeva O, Lopes Paciencia S, Huot G, Lessard F, Ferbeyre G. Permanent farnesylation of lamin A mutants linked to progeria impairs its phosphorylation at serine 22 during interphase. Aging (Albany NY). 2016;8:366-81 pubmed
  22. Hennig A, Markwart R, Wolff K, Schubert K, Cui Y, Prior I, et al. Feedback activation of neurofibromin terminates growth factor-induced Ras activation. Cell Commun Signal. 2016;14:5 pubmed publisher
  23. Lommel M, Trairatphisan P, Gäbler K, Laurini C, Muller A, Kaoma T, et al. L-plastin Ser5 phosphorylation in breast cancer cells and in vitro is mediated by RSK downstream of the ERK/MAPK pathway. FASEB J. 2016;30:1218-33 pubmed publisher
  24. van Jaarsveld M, van Kuijk P, Boersma A, Helleman J, Van Ijcken W, Mathijssen R, et al. miR-634 restores drug sensitivity in resistant ovarian cancer cells by targeting the Ras-MAPK pathway. Mol Cancer. 2015;14:196 pubmed publisher
  25. Yang C, Lowther K, Lalioti M, Seli E. Embryonic Poly(A)-Binding Protein (EPAB) Is Required for Granulosa Cell EGF Signaling and Cumulus Expansion in Female Mice. Endocrinology. 2016;157:405-16 pubmed publisher
  26. Gruosso T, Garnier C, Abélanet S, Kieffer Y, Lemesre V, Bellanger D, et al. MAP3K8/TPL-2/COT is a potential predictive marker for MEK inhibitor treatment in high-grade serous ovarian carcinomas. Nat Commun. 2015;6:8583 pubmed publisher
  27. Czaplinska D, Turczyk L, Grudowska A, Mieszkowska M, Lipinska A, Skladanowski A, et al. Phosphorylation of RSK2 at Tyr529 by FGFR2-p38 enhances human mammary epithelial cells migration. Biochim Biophys Acta. 2014;1843:2461-70 pubmed publisher
  28. Nam H, Lee I, Jang S, Bae C, Kwak S, Lee J. p90 ribosomal S6 kinase 1 (RSK1) isoenzyme specifically regulates cytokinesis progression. Cell Signal. 2014;26:208-19 pubmed publisher