This is a Validated Antibody Database (VAD) review about human ROS1, based on 9 published articles (read how Labome selects the articles), using ROS1 antibody in all methods. It is aimed to help Labome visitors find the most suited ROS1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
ROS1 synonym: MCF3; ROS; c-ros-1

Abcam
mouse monoclonal (4-6G)
  • western blot; human; loading ...; fig s3
Abcam ROS1 antibody (Abcam, 108492) was used in western blot on human samples (fig s3). Int J Biol Sci (2019) ncbi
mouse monoclonal (4-6G)
  • western blot; human; 1:1000; loading ...; fig 5a
  • western blot; rat; 1:1000; loading ...; fig 4a
Abcam ROS1 antibody (Abcam, ab108492) was used in western blot on human samples at 1:1000 (fig 5a) and in western blot on rat samples at 1:1000 (fig 4a). Biosci Rep (2019) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D4D6)
  • western blot; human; 1:1000; loading ...; fig 5f
Cell Signaling Technology ROS1 antibody (CST, 3287) was used in western blot on human samples at 1:1000 (fig 5f). Nat Commun (2019) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 1c, 4b, 5d
Cell Signaling Technology ROS1 antibody (Cell Signaling Technology, 3078) was used in western blot on human samples (fig 1c, 4b, 5d). Cancer Res (2019) ncbi
domestic rabbit monoclonal (D4D6)
  • immunocytochemistry; human; loading ...; fig 3
  • western blot; human; loading ...; fig 1c, 4b, 5d
Cell Signaling Technology ROS1 antibody (Cell Signaling Technology, 3287) was used in immunocytochemistry on human samples (fig 3) and in western blot on human samples (fig 1c, 4b, 5d). Cancer Res (2019) ncbi
domestic rabbit monoclonal (D4D6)
  • western blot; mouse; loading ...; fig 3a
Cell Signaling Technology ROS1 antibody (Cell Signaling Technology, D4D6) was used in western blot on mouse samples (fig 3a). Sci Rep (2017) ncbi
domestic rabbit monoclonal (D4D6)
  • western blot; human; loading ...; fig 1b
Cell Signaling Technology ROS1 antibody (Cell Signaling, D4D6) was used in western blot on human samples (fig 1b). Cancer Res (2017) ncbi
mouse monoclonal (69D6)
In order to characterize multiple molecularly defined cancer indications by studying ROS1, ALK inhibitor, Entrectinib, a Pan-TRK activity, Cell Signaling Technology ROS1 antibody (Cell signaling, 3266) was used . Mol Cancer Ther (2016) ncbi
domestic rabbit polyclonal
In order to characterize multiple molecularly defined cancer indications by studying ROS1, ALK inhibitor, Entrectinib, a Pan-TRK activity, Cell Signaling Technology ROS1 antibody (Cell signaling, 3078) was used . Mol Cancer Ther (2016) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; fig 3
In order to study a novel crizotinib-resistant solvent-front mutation in a patient with ROS1-rearranged lung cancer that is responsive to cabozantinib therapy, Cell Signaling Technology ROS1 antibody (Cell signaling, 3078) was used in western blot on mouse samples at 1:1000 (fig 3). Clin Cancer Res (2016) ncbi
mouse monoclonal (69D6)
  • western blot; mouse; 1:1000; fig s3
In order to study a novel crizotinib-resistant solvent-front mutation in a patient with ROS1-rearranged lung cancer that is responsive to cabozantinib therapy, Cell Signaling Technology ROS1 antibody (Cell signaling, 3266) was used in western blot on mouse samples at 1:1000 (fig s3). Clin Cancer Res (2016) ncbi
mouse monoclonal (69D6)
  • western blot; human; 1:1000
In order to discuss the sensitivity and selectivity of seven ROS1 and/or ALK inhibitors, Cell Signaling Technology ROS1 antibody (Cell Signaling Technology, 3266) was used in western blot on human samples at 1:1000. Proc Natl Acad Sci U S A (2015) ncbi
Articles Reviewed
  1. Esfahani M, Lee L, Jeon Y, Flynn R, Stehr H, Hui A, et al. Functional significance of U2AF1 S34F mutations in lung adenocarcinomas. Nat Commun. 2019;10:5712 pubmed publisher
  2. Zhang X, Du K, Lou Z, Ding K, Zhang F, Zhu J, et al. The CtBP1-HDAC1/2-IRF1 transcriptional complex represses the expression of the long noncoding RNA GAS5 in human osteosarcoma cells. Int J Biol Sci. 2019;15:1460-1471 pubmed publisher
  3. Fei J, Sun Y, Duan Y, Xia J, Yu S, Ouyang P, et al. Low concentration of rutin treatment might alleviate the cardiotoxicity effect of pirarubicin on cardiomyocytes via activation of PI3K/AKT/mTOR signaling pathway. Biosci Rep. 2019;: pubmed publisher
  4. Neel D, Allegakoen D, Olivas V, Mayekar M, Hemmati G, Chatterjee N, et al. Differential Subcellular Localization Regulates Oncogenic Signaling by ROS1 Kinase Fusion Proteins. Cancer Res. 2019;79:546-556 pubmed publisher
  5. Ogura H, Nagatake Kobayashi Y, Adachi J, Tomonaga T, Fujita N, Katayama R. TKI-addicted ROS1-rearranged cells are destined to survival or death by the intensity of ROS1 kinase activity. Sci Rep. 2017;7:5519 pubmed publisher
  6. Vaishnavi A, Schubert L, Rix U, Marek L, Le A, Keysar S, et al. EGFR Mediates Responses to Small-Molecule Drugs Targeting Oncogenic Fusion Kinases. Cancer Res. 2017;77:3551-3563 pubmed publisher
  7. Ardini E, Menichincheri M, Banfi P, Bosotti R, De Ponti C, Pulci R, et al. Entrectinib, a Pan-TRK, ROS1, and ALK Inhibitor with Activity in Multiple Molecularly Defined Cancer Indications. Mol Cancer Ther. 2016;15:628-39 pubmed publisher
  8. Drilon A, Somwar R, Wagner J, Vellore N, Eide C, Zabriskie M, et al. A Novel Crizotinib-Resistant Solvent-Front Mutation Responsive to Cabozantinib Therapy in a Patient with ROS1-Rearranged Lung Cancer. Clin Cancer Res. 2016;22:2351-8 pubmed publisher
  9. Davare M, Vellore N, Wagner J, Eide C, Goodman J, Drilon A, et al. Structural insight into selectivity and resistance profiles of ROS1 tyrosine kinase inhibitors. Proc Natl Acad Sci U S A. 2015;112:E5381-90 pubmed publisher