This is a Validated Antibody Database (VAD) review about human RIT1, based on 4 published articles (read how Labome selects the articles), using RIT1 antibody in all methods. It is aimed to help Labome visitors find the most suited RIT1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
RIT1 synonym: NS8; RIBB; RIT; ROC1

Knockout validation
Abcam
domestic rabbit polyclonal
  • western blot; mouse; 1:1500; loading ...; fig 1a
  • western blot knockout validation; human; 1:1500; loading ...; fig 4g, s1c, s5l
Abcam RIT1 antibody (Abcam, Ab53720) was used in western blot on mouse samples at 1:1500 (fig 1a) and in western blot knockout validation on human samples at 1:1500 (fig 4g, s1c, s5l). Nat Commun (2021) ncbi
Abcam
domestic rabbit polyclonal
  • western blot; mouse; fig 1e
Abcam RIT1 antibody (Abcam, ab53720) was used in western blot on mouse samples (fig 1e). Cancer Discov (2022) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1500; loading ...; fig 1a
  • western blot knockout validation; human; 1:1500; loading ...; fig 4g, s1c, s5l
Abcam RIT1 antibody (Abcam, Ab53720) was used in western blot on mouse samples at 1:1500 (fig 1a) and in western blot knockout validation on human samples at 1:1500 (fig 4g, s1c, s5l). Nat Commun (2021) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 1e
Abcam RIT1 antibody (Abcam, ab53720) was used in western blot on mouse samples at 1:1000 (fig 1e). Science (2019) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig s17d
Abcam RIT1 antibody (Abcam, ab127041) was used in western blot on human samples (fig s17d). Science (2018) ncbi
Articles Reviewed
  1. Chen S, Vedula R, Cuevas Navarro A, Lu B, Hogg S, Wang E, et al. Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation. Cancer Discov. 2022;12:2434-2453 pubmed publisher
  2. Vichas A, Riley A, Nkinsi N, Kamlapurkar S, Parrish P, Lo A, et al. Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer. Nat Commun. 2021;12:4789 pubmed publisher
  3. Castel P, Cheng A, Cuevas Navarro A, Everman D, Papageorge A, Simanshu D, et al. RIT1 oncoproteins escape LZTR1-mediated proteolysis. Science. 2019;363:1226-1230 pubmed publisher
  4. Bigenzahn J, Collu G, Kartnig F, Pieraks M, Vladimer G, Heinz L, et al. LZTR1 is a regulator of RAS ubiquitination and signaling. Science. 2018;362:1171-1177 pubmed publisher