This is a Validated Antibody Database (VAD) review about human RBCK1, based on 7 published articles (read how Labome selects the articles), using RBCK1 antibody in all methods. It is aimed to help Labome visitors find the most suited RBCK1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
RBCK1 synonym: C20orf18; HOIL-1; HOIL1; PBMEI; PGBM1; RBCK2; RNF54; UBCE7IP3; XAP3; XAP4; ZRANB4; ranBP-type and C3HC4-type zinc finger-containing protein 1; HBV-associated factor 4; RBCC protein interacting with PKC1; RING finger protein 54; RING-type E3 ubiquitin transferase HOIL-1; heme-oxidized IRP2 ubiquitin ligase 1; hepatitis B virus X-associated protein 4; ubiquitin conjugating enzyme 7 interacting protein 3

Knockout validation
Novus Biologicals
rabbit polyclonal
  • western blot knockout validation; mouse; loading ...; fig 2a
In order to discover that Tax recruits linear (Met1-linked) ubiquitin chain assembly complex to the IkB kinase complex, Novus Biologicals RBCK1 antibody (Novus, NBP-1-88301) was used in western blot knockout validation on mouse samples (fig 2a). PLoS Pathog (2017) ncbi
Santa Cruz Biotechnology
mouse monoclonal (E-2)
  • western blot; human; fig 1
Santa Cruz Biotechnology RBCK1 antibody (Santa Cruz, sc-365523) was used in western blot on human samples (fig 1). Proc Natl Acad Sci U S A (2016) ncbi
Novus Biologicals
rabbit polyclonal
  • western blot knockout validation; mouse; loading ...; fig 2a
In order to discover that Tax recruits linear (Met1-linked) ubiquitin chain assembly complex to the IkB kinase complex, Novus Biologicals RBCK1 antibody (Novus, NBP-1-88301) was used in western blot knockout validation on mouse samples (fig 2a). PLoS Pathog (2017) ncbi
rabbit polyclonal
  • western blot; human; 1:1000; fig s15
Novus Biologicals RBCK1 antibody (Novus Biologicals, NBP1-88301) was used in western blot on human samples at 1:1000 (fig s15). Nat Commun (2016) ncbi
Sigma-Aldrich
rabbit polyclonal
  • western blot; human; loading ...; fig s1d
Sigma-Aldrich RBCK1 antibody (Proteintech Group, HPA024185) was used in western blot on human samples (fig s1d). Proc Natl Acad Sci U S A (2017) ncbi
rabbit polyclonal
  • western blot; human; loading ...; fig 4b
Sigma-Aldrich RBCK1 antibody (Sigma-Aldrich, HPA024185) was used in western blot on human samples (fig 4b). Nat Microbiol (2016) ncbi
rabbit polyclonal
  • western blot; human; loading ...; fig 4c
Sigma-Aldrich RBCK1 antibody (Sigma, HPA024185) was used in western blot on human samples (fig 4c). Nat Commun (2015) ncbi
rabbit polyclonal
  • western blot; human; fig 4
Sigma-Aldrich RBCK1 antibody (Sigma, HPA024185) was used in western blot on human samples (fig 4). Am J Hum Genet (2015) ncbi
Articles Reviewed
  1. Strickson S, Emmerich C, Goh E, Zhang J, Kelsall I, MacArtney T, et al. Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling. Proc Natl Acad Sci U S A. 2017;114:E3481-E3489 pubmed publisher
  2. Shibata Y, Tokunaga F, Goto E, Komatsu G, Gohda J, Saeki Y, et al. HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains. PLoS Pathog. 2017;13:e1006162 pubmed publisher
  3. de Jong M, Liu Z, Chen D, Alto N. Shigella flexneri suppresses NF-?B activation by inhibiting linear ubiquitin chain ligation. Nat Microbiol. 2016;1:16084 pubmed publisher
  4. Zhou Q, Yu X, Demirkaya E, Deuitch N, Stone D, Tsai W, et al. Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease. Proc Natl Acad Sci U S A. 2016;113:10127-32 pubmed publisher
  5. Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, et al. Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis. Nat Commun. 2016;7:12547 pubmed publisher
  6. Klein T, Fung S, Renner F, Blank M, Dufour A, Kang S, et al. The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling. Nat Commun. 2015;6:8777 pubmed publisher
  7. Lewis M, Vyse S, Shields A, Boeltz S, Gordon P, Spector T, et al. UBE2L3 polymorphism amplifies NF-κB activation and promotes plasma cell development, linking linear ubiquitination to multiple autoimmune diseases. Am J Hum Genet. 2015;96:221-34 pubmed publisher