This is a Validated Antibody Database (VAD) review about human Pak2, based on 18 published articles (read how Labome selects the articles), using Pak2 antibody in all methods. It is aimed to help Labome visitors find the most suited Pak2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Pak2 synonym: PAK65; PAKgamma

Santa Cruz Biotechnology
mouse monoclonal (A-6)
  • western blot; mouse; loading ...; fig 5D
Santa Cruz Biotechnology Pak2 antibody (Santa Cruz, sc-166887) was used in western blot on mouse samples (fig 5D). elife (2017) ncbi
mouse monoclonal (D-8)
  • immunohistochemistry; human; loading ...; fig 2a
  • western blot; human; loading ...; fig 3b
Santa Cruz Biotechnology Pak2 antibody (Santa Cruz Biotechnology, sc-166174) was used in immunohistochemistry on human samples (fig 2a) and in western blot on human samples (fig 3b). Oncotarget (2016) ncbi
mouse monoclonal (A-6)
  • western blot; human; 1:400
Santa Cruz Biotechnology Pak2 antibody (Santa Cruz, sc-166887) was used in western blot on human samples at 1:400. PLoS ONE (2016) ncbi
mouse monoclonal (E-9)
  • western blot; human; 1:400
Santa Cruz Biotechnology Pak2 antibody (Santa Cruz, sc-373740) was used in western blot on human samples at 1:400. PLoS ONE (2016) ncbi
mouse monoclonal (A-6)
  • immunoprecipitation; human; fig 6
  • western blot; human; fig 5
Santa Cruz Biotechnology Pak2 antibody (Santa Cruz Biotechnologies, sc-166887) was used in immunoprecipitation on human samples (fig 6) and in western blot on human samples (fig 5). Blood (2015) ncbi
Invitrogen
domestic rabbit polyclonal
  • western blot; human; 1:1000; fig st1
In order to identify and characterize alterations in signal transduction that occur during the development Lapatinib resistance, Invitrogen Pak2 antibody (Biosource, 44-940G) was used in western blot on human samples at 1:1000 (fig st1). Nat Commun (2016) ncbi
domestic rabbit polyclonal
  • immunocytochemistry; African green monkey; 1:150; fig s8
In order to determine regulation of spine structural plasticity and memory and learning by the calcium sensor Copine-6, Invitrogen Pak2 antibody (Life Technologies, 44940G) was used in immunocytochemistry on African green monkey samples at 1:150 (fig s8). Nat Commun (2016) ncbi
domestic rabbit polyclonal
In order to assess the contribution of tissue damage and extracellular matrix fragmentation during inflammation, Invitrogen Pak2 antibody (Invitrogen, 44940G) was used . Sci Adv (2015) ncbi
domestic rabbit polyclonal
In order to study the molecular mechanisms underlying malignant changes of meningioma cells, Invitrogen Pak2 antibody (Invitrogen, 44940G) was used . Oncotarget (2015) ncbi
Abcam
domestic rabbit monoclonal (EPR658(2))
  • western blot; human; loading ...; fig 6i
Abcam Pak2 antibody (Abcam, ab76419) was used in western blot on human samples (fig 6i). Cell (2017) ncbi
Cell Signaling Technology
domestic rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 2b
Cell Signaling Technology Pak2 antibody (Cell Signaling, 2608S) was used in western blot on human samples at 1:1000 (fig 2b). Nat Commun (2022) ncbi
domestic rabbit monoclonal (C17A10)
  • western blot; mouse; 1:500; loading ...; fig 5c
Cell Signaling Technology Pak2 antibody (Cell signaling, 2615) was used in western blot on mouse samples at 1:500 (fig 5c). Front Physiol (2021) ncbi
domestic rabbit polyclonal
  • immunocytochemistry; mouse; 1:200; loading ...; fig 6i
  • western blot; mouse; 1:1000; loading ...; fig 6f
Cell Signaling Technology Pak2 antibody (Cell Signaling, 2608) was used in immunocytochemistry on mouse samples at 1:200 (fig 6i) and in western blot on mouse samples at 1:1000 (fig 6f). elife (2019) ncbi
domestic rabbit monoclonal (C17A10)
  • western blot; human; 1:2000; loading ...; fig 2c
Cell Signaling Technology Pak2 antibody (Cell Signaling, 2615) was used in western blot on human samples at 1:2000 (fig 2c). Genes Dev (2017) ncbi
domestic rabbit monoclonal (C17A10)
  • western blot; human; loading ...; fig 9e
Cell Signaling Technology Pak2 antibody (Cell Signaling, 2615) was used in western blot on human samples (fig 9e). J Clin Invest (2017) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; fig st1
In order to identify and characterize alterations in signal transduction that occur during the development Lapatinib resistance, Cell Signaling Technology Pak2 antibody (Cell Signaling, 2608) was used in western blot on human samples at 1:1000 (fig st1). Nat Commun (2016) ncbi
domestic rabbit monoclonal (C17A10)
  • western blot; human; 1:2000; fig 4
Cell Signaling Technology Pak2 antibody (Cell Signalling, 2615) was used in western blot on human samples at 1:2000 (fig 4). Nat Commun (2015) ncbi
mouse monoclonal (3B5)
  • western blot; human; 1:1000; loading ...; fig 4c
Cell Signaling Technology Pak2 antibody (Cell Signaling, 4825S) was used in western blot on human samples at 1:1000 (fig 4c). Mol Biol Cell (2015) ncbi
domestic rabbit monoclonal (C17A10)
  • western blot; human; 1:1000; fig  7
Cell Signaling Technology Pak2 antibody (Cell Signalling Technology, 2615) was used in western blot on human samples at 1:1000 (fig  7). Cell Signal (2015) ncbi
domestic rabbit monoclonal (C17A10)
  • western blot; human
Cell Signaling Technology Pak2 antibody (Cell Signaling, 2615) was used in western blot on human samples . PLoS ONE (2014) ncbi
Articles Reviewed
  1. Esposito D, Pant I, Shen Y, Qiao R, Yang X, Bai Y, et al. ROCK1 mechano-signaling dependency of human malignancies driven by TEAD/YAP activation. Nat Commun. 2022;13:703 pubmed publisher
  2. Barbé C, Loumaye A, Lause P, Ritvos O, Thissen J. p21-Activated Kinase 1 Is Permissive for the Skeletal Muscle Hypertrophy Induced by Myostatin Inhibition. Front Physiol. 2021;12:677746 pubmed publisher
  3. Laurin M, Gomez N, Levorse J, Sendoel A, Sribour M, Fuchs E. An RNAi screen unravels the complexities of Rho GTPase networks in skin morphogenesis. elife. 2019;8: pubmed publisher
  4. Yue X, Zhang C, Zhao Y, Liu J, Lin A, Tan V, et al. Gain-of-function mutant p53 activates small GTPase Rac1 through SUMOylation to promote tumor progression. Genes Dev. 2017;31:1641-1654 pubmed publisher
  5. Kim J, Kim Y, Kim J, Park D, Bae H, Lee D, et al. YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation. J Clin Invest. 2017;127:3441-3461 pubmed publisher
  6. Jeannot P, Nowosad A, Perchey R, Callot C, Bennana E, Katsube T, et al. p27Kip1 promotes invadopodia turnover and invasion through the regulation of the PAK1/Cortactin pathway. elife. 2017;6: pubmed publisher
  7. Wang T, Yu H, Hughes N, Liu B, Kendirli A, Klein K, et al. Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras. Cell. 2017;168:890-903.e15 pubmed publisher
  8. Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  9. Yuan W, Guo Y, Li X, Deng M, Shen Z, Bo C, et al. MicroRNA-126 inhibits colon cancer cell proliferation and invasion by targeting the chemokine (C-X-C motif) receptor 4 and Ras homolog gene family, member A, signaling pathway. Oncotarget. 2016;7:60230-60244 pubmed publisher
  10. Reinhard J, Kriz A, Galic M, Angliker N, Rajalu M, Vogt K, et al. The calcium sensor Copine-6 regulates spine structural plasticity and learning and memory. Nat Commun. 2016;7:11613 pubmed publisher
  11. Wang Y, Gratzke C, Tamalunas A, Wiemer N, Ciotkowska A, Rutz B, et al. P21-Activated Kinase Inhibitors FRAX486 and IPA3: Inhibition of Prostate Stromal Cell Growth and Effects on Smooth Muscle Contraction in the Human Prostate. PLoS ONE. 2016;11:e0153312 pubmed publisher
  12. Hahn C, Scott D, Xu X, Roda M, Payne G, Wells J, et al. The matrikine N-α-PGP couples extracellular matrix fragmentation to endothelial permeability. Sci Adv. 2015;1: pubmed
  13. Whalley H, Porter A, Diamantopoulou Z, White G, Castañeda Saucedo E, Malliri A. Cdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation. Nat Commun. 2015;6:7437 pubmed publisher
  14. Wu J, Pipathsouk A, Keizer Gunnink A, Fusetti F, Alkema W, Liu S, et al. Homer3 regulates the establishment of neutrophil polarity. Mol Biol Cell. 2015;26:1629-39 pubmed publisher
  15. Tanaka T, Iino M. Sec8 regulates cytokeratin8 phosphorylation and cell migration by controlling the ERK and p38 MAPK signalling pathways. Cell Signal. 2015;27:1110-9 pubmed publisher
  16. Chow H, Dong B, Duron S, Campbell D, Ong C, Hoeflich K, et al. Group I Paks as therapeutic targets in NF2-deficient meningioma. Oncotarget. 2015;6:1981-94 pubmed
  17. Badolia R, Manne B, Dangelmaier C, Chernoff J, Kunapuli S. Gq-mediated Akt translocation to the membrane: a novel PIP3-independent mechanism in platelets. Blood. 2015;125:175-84 pubmed publisher
  18. Kuzelova K, Grebenová D, Holoubek A, Roselova P, Obr A. Group I PAK inhibitor IPA-3 induces cell death and affects cell adhesivity to fibronectin in human hematopoietic cells. PLoS ONE. 2014;9:e92560 pubmed publisher