This is a Validated Antibody Database (VAD) review about human PSEN2, based on 8 published articles (read how Labome selects the articles), using PSEN2 antibody in all methods. It is aimed to help Labome visitors find the most suited PSEN2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
PSEN2 synonym: AD3L; AD4; CMD1V; PS2; STM2; presenilin-2; AD3LP; AD5; Alzheimer disease 4; E5-1; PS-2; STM-2

Knockout validation
Abcam
rabbit monoclonal (EP1515Y)
  • western blot knockout validation; mouse; fig 6a
In order to assess the effects of presenilin dosage on cortical neuron survival in mice, Abcam PSEN2 antibody (Abcam, ab51249) was used in western blot knockout validation on mouse samples (fig 6a). J Neurosci (2014) ncbi
Abcam
rabbit monoclonal (EP1515Y)
  • western blot knockout validation; mouse; fig 6a
In order to assess the effects of presenilin dosage on cortical neuron survival in mice, Abcam PSEN2 antibody (Abcam, ab51249) was used in western blot knockout validation on mouse samples (fig 6a). J Neurosci (2014) ncbi
Cell Signaling Technology
rabbit monoclonal (D30G3)
  • western blot; human; fig s2
Cell Signaling Technology PSEN2 antibody (Cell Signaling Tech, 9979) was used in western blot on human samples (fig s2). Oncotarget (2016) ncbi
rabbit monoclonal (D30G3)
  • western blot; human
In order to investigate presenilin assembly and catalytic activity, Cell Signaling Technology PSEN2 antibody (Cell Signaling, D30G3) was used in western blot on human samples . J Biol Chem (2015) ncbi
rabbit polyclonal
  • immunohistochemistry - paraffin section; rat; 1:1000
  • western blot; rat; 1:1000
Cell Signaling Technology PSEN2 antibody (Cell Signaling Technology, 2192S) was used in immunohistochemistry - paraffin section on rat samples at 1:1000 and in western blot on rat samples at 1:1000. Mol Neurobiol (2016) ncbi
rabbit monoclonal (D30G3)
  • western blot; human; loading ...; fig 6b
Cell Signaling Technology PSEN2 antibody (Cell Signaling Technology Inc., 9979) was used in western blot on human samples (fig 6b). Mol Carcinog (2015) ncbi
rabbit polyclonal
  • immunohistochemistry; rat
Cell Signaling Technology PSEN2 antibody (Cell Signaling Technology, 2192S) was used in immunohistochemistry on rat samples . Toxicol Sci (2015) ncbi
Sigma-Aldrich
rabbit polyclonal
  • western blot; mouse; loading ...; fig 2a
In order to show that Egr-1 plays role in BACE-1 activation, Sigma-Aldrich PSEN2 antibody (Sigma, P0070) was used in western blot on mouse samples (fig 2a). J Biol Chem (2016) ncbi
rabbit polyclonal
  • western blot; mouse; fig 3b
  • western blot; rat; fig 5a
In order to study the activity-driven interaction between presenilin 1 and synaptotagmin 1 and links to calcium, amyloid beta, and synapse, Sigma-Aldrich PSEN2 antibody (Sigma-Aldrich, P5622) was used in western blot on mouse samples (fig 3b) and in western blot on rat samples (fig 5a). BMC Biol (2016) ncbi
Articles Reviewed
  1. Qin X, Wang Y, Paudel H. Early Growth Response 1 (Egr-1) Is a Transcriptional Activator of ?-Secretase 1 (BACE-1) in the Brain. J Biol Chem. 2016;291:22276-22287 pubmed
  2. Kuzuya A, Zoltowska K, Post K, Arimon M, Li X, Svirsky S, et al. Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta. BMC Biol. 2016;14:25 pubmed publisher
  3. Noh H, Hah Y, Ha J, Kang M, Zada S, Rha S, et al. Regulation of the epithelial to mesenchymal transition and metastasis by Raf kinase inhibitory protein-dependent Notch1 activity. Oncotarget. 2016;7:4632-46 pubmed publisher
  4. Marinangeli C, Tasiaux B, Opsomer R, Hage S, Sodero A, Dewachter I, et al. Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex. J Biol Chem. 2015;290:7169-84 pubmed publisher
  5. Maurya S, Mishra J, Abbas S, Bandyopadhyay S. Cypermethrin Stimulates GSK3β-Dependent Aβ and p-tau Proteins and Cognitive Loss in Young Rats: Reduced HB-EGF Signaling and Downstream Neuroinflammation as Critical Regulators. Mol Neurobiol. 2016;53:968-82 pubmed publisher
  6. Kaushik G, Venugopal A, Ramamoorthy P, Standing D, Subramaniam D, Umar S, et al. Honokiol inhibits melanoma stem cells by targeting notch signaling. Mol Carcinog. 2015;54:1710-21 pubmed publisher
  7. Watanabe H, Iqbal M, Zheng J, Wines Samuelson M, Shen J. Partial loss of presenilin impairs age-dependent neuronal survival in the cerebral cortex. J Neurosci. 2014;34:15912-22 pubmed publisher
  8. Ashok A, Rai N, Tripathi S, Bandyopadhyay S. Exposure to As-, Cd-, and Pb-mixture induces Aβ, amyloidogenic APP processing and cognitive impairments via oxidative stress-dependent neuroinflammation in young rats. Toxicol Sci. 2015;143:64-80 pubmed publisher