This is a Validated Antibody Database (VAD) review about human PRMT6, based on 7 published articles (read how Labome selects the articles), using PRMT6 antibody in all methods. It is aimed to help Labome visitors find the most suited PRMT6 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
PRMT6 synonym: HRMT1L6

Knockout validation
Santa Cruz Biotechnology
mouse monoclonal (D-5)
  • western blot knockout validation; human; 1:2000; loading ...; fig s1e
Santa Cruz Biotechnology PRMT6 antibody (Santa Cruz Biotechnology, sc-271744) was used in western blot knockout validation on human samples at 1:2000 (fig s1e). Nat Commun (2021) ncbi
Santa Cruz Biotechnology
mouse monoclonal (D-5)
  • western blot knockout validation; human; 1:2000; loading ...; fig s1e
Santa Cruz Biotechnology PRMT6 antibody (Santa Cruz Biotechnology, sc-271744) was used in western blot knockout validation on human samples at 1:2000 (fig s1e). Nat Commun (2021) ncbi
mouse monoclonal (D-5)
  • western blot; mouse
In order to investigate how PRMT6 promotes ERalpha activity, Santa Cruz Biotechnology PRMT6 antibody (Santa Cruz Biotechnology, sc-271744) was used in western blot on mouse samples . Biochim Biophys Acta (2014) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D5A2N)
  • western blot; mouse; 1:1000; loading ...; fig s1l, s5f, s5m
  • western blot; human; 1:1000; loading ...; fig s1k
Cell Signaling Technology PRMT6 antibody (Cell Signaling, 14641) was used in western blot on mouse samples at 1:1000 (fig s1l, s5f, s5m) and in western blot on human samples at 1:1000 (fig s1k). Nat Commun (2022) ncbi
domestic rabbit monoclonal (D5A2N)
  • western blot; human; 1:1000; fig 1j
Cell Signaling Technology PRMT6 antibody (CST, 14641) was used in western blot on human samples at 1:1000 (fig 1j). Nat Commun (2021) ncbi
domestic rabbit monoclonal (D5A2N)
  • western blot; mouse; 1:500; loading ...; fig 1b
Cell Signaling Technology PRMT6 antibody (Cell Signaling, 14641) was used in western blot on mouse samples at 1:500 (fig 1b). Theranostics (2020) ncbi
domestic rabbit monoclonal (D5A2N)
  • western blot; human; 1:5000; loading ...; fig s1b
In order to investigate the impact of protein arginine methyltransferase 5 in lung and breast cancer, Cell Signaling Technology PRMT6 antibody (Cell Signaling, 14641) was used in western blot on human samples at 1:5000 (fig s1b). Oncogene (2017) ncbi
domestic rabbit monoclonal (D5A2N)
  • western blot; human; 1:1000; fig 4
In order to report that PRMT6 dysregulates p21 functions in human cancer, Cell Signaling Technology PRMT6 antibody (Cell Signaling Technology, D5A2N) was used in western blot on human samples at 1:1000 (fig 4). Oncotarget (2015) ncbi
Articles Reviewed
  1. Günes Günsel G, Conlon T, Jeridi A, Kim R, Ertuz Z, Lang N, et al. The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD. Nat Commun. 2022;13:1303 pubmed publisher
  2. Giuliani V, Miller M, Liu C, Hartono S, Class C, Bristow C, et al. PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma. Nat Commun. 2021;12:4626 pubmed publisher
  3. Yin S, Liu L, Brobbey C, PALANISAMY V, Ball L, Olsen S, et al. PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis. Nat Commun. 2021;12:3444 pubmed publisher
  4. He Y, Li W, Zheng Z, Zhao L, Li W, Wang Y, et al. Inhibition of Protein arginine methyltransferase 6 reduces reactive oxygen species production and attenuates aminoglycoside- and cisplatin-induced hair cell death. Theranostics. 2020;10:133-150 pubmed publisher
  5. Chen H, Lorton B, Gupta V, Shechter D. A TGFβ-PRMT5-MEP50 axis regulates cancer cell invasion through histone H3 and H4 arginine methylation coupled transcriptional activation and repression. Oncogene. 2017;36:373-386 pubmed publisher
  6. Nakakido M, Deng Z, Suzuki T, Dohmae N, Nakamura Y, Hamamoto R. PRMT6 increases cytoplasmic localization of p21CDKN1A in cancer cells through arginine methylation and makes more resistant to cytotoxic agents. Oncotarget. 2015;6:30957-67 pubmed publisher
  7. Sun Y, Chung H, Woo A, Lin V. Protein arginine methyltransferase 6 enhances ligand-dependent and -independent activity of estrogen receptor ? via distinct mechanisms. Biochim Biophys Acta. 2014;1843:2067-78 pubmed publisher